The effectiveness of cognitive behavioral therapy in patients with motor neuron disease: A systematic review.

IF 1.4 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Medicine Pub Date : 2025-07-25 DOI:10.1097/MD.0000000000043597

Yue He, Wei Ming, Yinhu Tan, Yang Wang, Mengyao Wang, Hang Li, Zhenzhu Jiao, Yao Hou

{"title":"The effectiveness of cognitive behavioral therapy in patients with motor neuron disease: A systematic review.","authors":"Yue He, Wei Ming, Yinhu Tan, Yang Wang, Mengyao Wang, Hang Li, Zhenzhu Jiao, Yao Hou","doi":"10.1097/MD.0000000000043597","DOIUrl":null,"url":null,"abstract":"Background: Motor neuron disease (MND) is a neurodegenerative disorder that causes progressive loss of motor function. With limited disease-modifying drug therapies, cognitive behavioral therapy (CBT) has emerged as a key nonpharmacological intervention. This systematic review evaluated CBT's therapeutic potential across clinical domains to inform psychosocial care of patients with MND.Methods: Comprehensive searches were performed in PubMed, Web of Science, Cochrane Library, and Embase, from inception until February 2025. Two researchers independently screened the literature, extracted data, assessed study quality, and resolved disagreements via consensus or third-party consultation.Results: Five studies involving 561 patients were included. Compared with conventional care, CBT significantly improves patients' quality of life and psychological flexibility. However, the effects on caregiver burden and physical health were not statistically significant. CBT modalities included acceptance and commitment therapy, dialectical behavior therapy, rational-emotive behavior therapy, mindfulness cognitive therapy, and metacognitive training. Traditional CBT demonstrated superior efficacy in reducing anxiety and depression compared to acceptance and commitment therapy.Conclusion: CBT effectively enhances psychological flexibility and quality of life and reduces anxiety and depression in patients with MND. The standardization of outcome measures requires improvement. High-quality randomized controlled trials are needed to further assess CBT's impact of CBT on caregiver burden and patients' physical health.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 30","pages":"e43597"},"PeriodicalIF":1.4000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303493/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MD.0000000000043597","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Motor neuron disease (MND) is a neurodegenerative disorder that causes progressive loss of motor function. With limited disease-modifying drug therapies, cognitive behavioral therapy (CBT) has emerged as a key nonpharmacological intervention. This systematic review evaluated CBT's therapeutic potential across clinical domains to inform psychosocial care of patients with MND.

Methods: Comprehensive searches were performed in PubMed, Web of Science, Cochrane Library, and Embase, from inception until February 2025. Two researchers independently screened the literature, extracted data, assessed study quality, and resolved disagreements via consensus or third-party consultation.

Results: Five studies involving 561 patients were included. Compared with conventional care, CBT significantly improves patients' quality of life and psychological flexibility. However, the effects on caregiver burden and physical health were not statistically significant. CBT modalities included acceptance and commitment therapy, dialectical behavior therapy, rational-emotive behavior therapy, mindfulness cognitive therapy, and metacognitive training. Traditional CBT demonstrated superior efficacy in reducing anxiety and depression compared to acceptance and commitment therapy.

Conclusion: CBT effectively enhances psychological flexibility and quality of life and reduces anxiety and depression in patients with MND. The standardization of outcome measures requires improvement. High-quality randomized controlled trials are needed to further assess CBT's impact of CBT on caregiver burden and patients' physical health.

查看原文本刊更多论文

认知行为疗法在运动神经元疾病患者中的有效性：一项系统综述。

背景：运动神经元病（MND）是一种导致运动功能进行性丧失的神经退行性疾病。由于疾病改善药物治疗有限，认知行为疗法（CBT）已成为一种关键的非药物干预手段。本系统综述评估了CBT在临床领域的治疗潜力，为MND患者的心理社会护理提供信息。方法：在PubMed、Web of Science、Cochrane Library和Embase中进行综合检索，从成立到2025年2月。两位研究者独立筛选文献，提取数据，评估研究质量，并通过共识或第三方咨询解决分歧。结果：纳入5项研究，共561例患者。与常规护理相比，CBT显著提高了患者的生活质量和心理灵活性。然而，对照顾者负担和身体健康的影响没有统计学意义。认知行为疗法包括接受承诺疗法、辩证行为疗法、理性情绪行为疗法、正念认知疗法和元认知训练。传统认知行为疗法在减少焦虑和抑郁方面的效果优于接受和承诺疗法。结论：CBT能有效提高MND患者的心理灵活性和生活质量，减轻焦虑和抑郁。结果衡量标准的标准化需要改进。需要高质量的随机对照试验来进一步评估CBT对照顾者负担和患者身体健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

期刊介绍： Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.