Systematic review and meta-analysis of Guipi Decoction in the treatment of anemia.

Background: Anemia is a common and widely influential public health problem worldwide. The objective was to conduct a comprehensive and in-depth systematic evaluation of the therapeutic efficacy of Guipi Decoction as an adjuvant treatment for patients with anemia and to offer new ideas for the clinical treatment of anemia.

Methods: A comprehensive and systematic literature search was meticulously executed across multiple authoritative databases, including CNKI, Wanfang, VIP, EMBase, Scopus, Web of Science, PubMed, and the Cochrane Library. The search was designed to identify all relevant randomized controlled trials that investigated the application of Guipi Decoction as an adjuvant therapy for Anemia patients. Considering that 1 researcher had written article of this kind in 2020, so the time frame of the search spanned from January 2020 to January 2025. Two independent reviewers selected eligible trials, extracted data, and assessed methodological quality using predefined criteria. Meta-analysis was performed using the standardized software RevMan 5.3.

Results: A total of 13 studies were included in the final analysis, involving a cumulative sample size of 954 participants. These participants were randomly allocated to the experimental group and the control group. Pretreatment physiological parameters were comparable between the 2 groups, with no statistically significant differences, indicating a balanced randomization. Posttreatment, the experimental group demonstrated significantly better outcomes across multiple clinically relevant endpoints compared to the control group. The indicators include the effective rate, adverse event rate, hemoglobin, red blood cell, serum iron, serum ferritin, and hematocrit. For the experimental group, there are statistically significant differences in various indicators before and after treatment. At the same time, when compared with the indicators of the control group after treatment, the outcome indicators of the experimental group show a better therapeutic effect, and the differences are statistically significant. This can strongly prove that Guipi Decoction has a definite therapeutic effect on treating anemia.

Conclusion: Guipi Decoction can effectively relieve symptoms in anemia patients and reduce risk indicators. It is worthy of further research and promotion.