Metabolites最新文献

筛选
英文 中文
Interaction Between CYP1A2-Related Caffeine Metabolism and Vitamin B12/Folate Status in Patients with Metabolic Syndrome: A Novel Biomarker Axis. 代谢综合征患者cyp1a2相关的咖啡因代谢与维生素B12/叶酸状态之间的相互作用:一个新的生物标志物轴
IF 3.4 3区 生物学
Metabolites Pub Date : 2025-07-04 DOI: 10.3390/metabo15070450
Laura Claudia Popa, Ahmed Abu-Awwad, Simona Sorina Farcas, Simona-Alina Abu-Awwad, Nicoleta Ioana Andreescu
{"title":"Interaction Between CYP1A2-Related Caffeine Metabolism and Vitamin B12/Folate Status in Patients with Metabolic Syndrome: A Novel Biomarker Axis.","authors":"Laura Claudia Popa, Ahmed Abu-Awwad, Simona Sorina Farcas, Simona-Alina Abu-Awwad, Nicoleta Ioana Andreescu","doi":"10.3390/metabo15070450","DOIUrl":"https://doi.org/10.3390/metabo15070450","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The prevalence of metabolic syndrome (MetS) is steadily increasing worldwide, driven by complex genetic, nutritional, and environmental factors. Caffeine metabolism, primarily mediated by CYP1A2 (though other enzymes such as CYP1A1 may also be involved), and the status of micronutrients such as vitamin B12 and folate have each been linked to MetS components. This study investigates the interaction between CYP1A2 genetic variants and vitamin B12/folate levels in patients with MetS, aiming to identify a novel biomarker axis with potential implications for personalized interventions. <b>Methods</b>: This cross-sectional observational study included 356 adults diagnosed with MetS, recruited from Western Romania. Genotyping for CYP1A2 rs762551 was performed using TaqMan PCR assays. Daily caffeine intake was assessed via validated dietary questionnaires. Serum levels of folate and vitamin B12 were measured using chemiluminescence immunoassays. <b>Results</b>: AA genotype patients with a moderate coffee intake (1-2 cups/day) had significantly higher folate and B12 levels than AC or CC carriers. These nutritional advantages were associated with more favorable BMI and triglyceride profiles. The interaction between CYP1A2 genotype and coffee intake was significant for both micronutrient levels and metabolic parameters, particularly in the AA group. No significant associations were found in high-coffee-intake subgroups (≥3 cups/day). <b>Conclusions</b>: The interplay between CYP1A2 polymorphisms and B-vitamin status may represent a clinically relevant biomarker axis in MetS. Moderate caffeine intake in slow metabolizers (AA genotype) may boost micronutrient status and metabolic health, supporting personalized nutrition.</p>","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Digestive Physiology and Evolutionary Diet: A Metabolomic Perspective on Carnivorous and Scavenger Adaptations. 人类消化生理学和进化饮食:从代谢组学角度看肉食和食腐动物的适应。
IF 3.4 3区 生物学
Metabolites Pub Date : 2025-07-04 DOI: 10.3390/metabo15070453
Vicente Javier Clemente-Suárez, Laura Redondo-Flórez, Ana Isabel Beltrán-Velasco, Rodrigo Yáñez-Sepúlveda, Alejandro Rubio-Zarapuz, Alexandra Martín-Rodríguez, Eduardo Navarro-Jimenez, José Francisco Tornero-Aguilera
{"title":"Human Digestive Physiology and Evolutionary Diet: A Metabolomic Perspective on Carnivorous and Scavenger Adaptations.","authors":"Vicente Javier Clemente-Suárez, Laura Redondo-Flórez, Ana Isabel Beltrán-Velasco, Rodrigo Yáñez-Sepúlveda, Alejandro Rubio-Zarapuz, Alexandra Martín-Rodríguez, Eduardo Navarro-Jimenez, José Francisco Tornero-Aguilera","doi":"10.3390/metabo15070453","DOIUrl":"https://doi.org/10.3390/metabo15070453","url":null,"abstract":"<p><p>This review examines human digestive physiology and metabolic adaptations in the context of evolutionary dietary patterns, particularly those emphasizing carnivorous and scavenging behaviors. By integrating metabolomic data with archaeological, anatomical, and microbiological evidence, the study explores how early hominins adapted to intermittent but energy-dense animal-based diets. The analysis highlights the development of hepatic insulin resistance, enhanced fat and protein metabolism, and shifts in gut microbiota diversity as physiological signatures of meat consumption. Comparative evaluations of digestive enzyme profiles, intestinal morphology, and salivary composition underscore humans' omnivorous flexibility and partial carnivorous specialization. Additionally, biomarkers such as ketone bodies, branched-chain amino acids, and trimethylamine-N-oxide are identified as metabolic indicators of habitual meat intake. These adaptations, though once evolutionarily advantageous, are discussed in relation to current metabolic disorders in modern nutritional contexts. Overall, this review presents a metabolomic framework for understanding the evolutionary trajectory of human digestion and its implications for health and dietary recommendations.</p>","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Metabolic Alterations Induced by Halogenated Additives and Antifungal Activity of Extracts from the Endophytic Fungus Fusarium sp. Associated with Dizygostemon riparius (Plantaginaceae). 卤代添加剂诱导的代谢变化及车前草内生真菌镰刀菌提取物的抗真菌活性研究
IF 3.4 3区 生物学
Metabolites Pub Date : 2025-07-04 DOI: 10.3390/metabo15070451
Hilzimar de Jesus Freitas Sá, Anne Karoline Maiorana Santos, Adriano Souza Fonseca, Lourivaldo da Silva Santos, Josivan Regis Farias, Rosane Nassar Meireles Guerra, Edson Rodrigues-Filho, Gilmar Silverio da Silva, Cleydlenne Costa Vasconcelos, Alberto Jorge Oliveira Lopes, Antônio José Cantanhede Filho
{"title":"Assessment of Metabolic Alterations Induced by Halogenated Additives and Antifungal Activity of Extracts from the Endophytic Fungus <i>Fusarium</i> sp. Associated with <i>Dizygostemon riparius</i> (Plantaginaceae).","authors":"Hilzimar de Jesus Freitas Sá, Anne Karoline Maiorana Santos, Adriano Souza Fonseca, Lourivaldo da Silva Santos, Josivan Regis Farias, Rosane Nassar Meireles Guerra, Edson Rodrigues-Filho, Gilmar Silverio da Silva, Cleydlenne Costa Vasconcelos, Alberto Jorge Oliveira Lopes, Antônio José Cantanhede Filho","doi":"10.3390/metabo15070451","DOIUrl":"https://doi.org/10.3390/metabo15070451","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Endophytic fungi are valuable sources of bioactive compounds with potential therapeutic applications. This study aimed to evaluate the antifungal activity of secondary metabolites produced by <i>Fusarium</i> sp. isolated from <i>Dizygostemon riparius</i>, with particular focus on the impact of culture medium supplementation with halogenated and metallic additives on metabolite production. <b>Methods</b>: The fungus was cultivated in standard Czapek medium and media supplemented with NH<sub>4</sub>Br or MnCl<sub>2</sub>. Methanolic extracts were obtained, fractionated, and chemically characterised via LC-ESI-HRMS. In vitro antifungal assays, including MIC and MFC determinations and biofilm inhibition tests, were performed against <i>Candida albicans</i> strains. In vivo toxicity and efficacy were assessed using <i>Tenebrio molitor</i> larvae. <b>Results</b>: Fifteen metabolites were annotated, including known antifungals such as fusaric acid and cyclosporin A. Fractions EMBr4 and EMC5 demonstrated fungicidal activity with MIC values close to fluconazole and significantly inhibited biofilm formation and maturation. In vivo, these fractions displayed low acute toxicity and improved survival in infected larvae, comparable to fluconazole treatment. <b>Conclusions</b>: The results indicate that culture medium modulation enhances the production of bioactive metabolites by <i>Fusarium</i> sp., leading to extracts with notable antifungal efficacy and safety. EMBr4 and EMC5 are promising candidates for further development as antifungal agents, particularly for targeting biofilm-associated <i>Candida</i> infections. These findings support the potential of endophytic fungi as sources of novel therapeutics and warrant further mechanistic and pharmacological investigations.</p>","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolomic Prediction of Naphthalene Pneumo-Toxicity in the Snail Helix aspersa maxima. 最大螺旋螺的萘肺毒性代谢组学预测。
IF 3.4 3区 生物学
Metabolites Pub Date : 2025-07-03 DOI: 10.3390/metabo15070448
Aude Devalckeneer, Marion Bouviez, Jean-Marie Colet
{"title":"Metabolomic Prediction of Naphthalene Pneumo-Toxicity in the Snail <i>Helix aspersa maxima</i>.","authors":"Aude Devalckeneer, Marion Bouviez, Jean-Marie Colet","doi":"10.3390/metabo15070448","DOIUrl":"https://doi.org/10.3390/metabo15070448","url":null,"abstract":"<p><p><b>Background:</b> Polluted soils represent a major problem in many industrialized countries that urgently requires appropriate health risk assessment. The One Health concept that considers a close relationship between human and animal health and ecosystems relies, among other techniques, on continuous monitoring through the use of animal species as bioindicators. In this context, terrestrial gastropods, already recognized as relevant indicators due to their anatomo-physiology, provide a reliable model to study the pneumotoxic effects of pollutants. On the other hand, risk assessment is based on multi-biomarker studies. Therefore, omic approaches seem particularly useful since they can simultaneously detect numerous early biological changes. <b>Methods:</b> In this study, <i>Helix aspersa maxima</i> was exposed to naphthalene, a highly volatile aromatic hydrocarbon responsible for numerous respiratory disorders. Pulmonary membrane extracts and hemolymph samples were analyzed by <sup>1</sup>H-NMR spectroscopy after single or repeated exposures to naphthalene. <b>Results:</b> Numerous metabolic changes were observed, which could be related to membrane lesions, energy, anti-inflammatory, and tumorigenesis pathways. <b>Conclusions:</b> Our findings highlight the potential of combining animal indicator and omics techniques to predict respiratory health risks in cases of exposure to polluted soils.</p>","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impacts of Protease Sources on Growth and Carcass Response, Gut Health, Nutrient Digestibility, and Cecal Microbiota Profiles in Broilers Fed Poultry-by-Product-Meal-Based Diets. 蛋白酶源对饲粮中肉鸡生长和胴体反应、肠道健康、营养物质消化率和盲肠微生物群的影响
IF 3.4 3区 生物学
Metabolites Pub Date : 2025-07-02 DOI: 10.3390/metabo15070445
Muhammad Shahbaz Zafar, Shafqat Nawaz Qaisrani, Saima, Zafar Hayat, Kashif Nauman
{"title":"Impacts of Protease Sources on Growth and Carcass Response, Gut Health, Nutrient Digestibility, and Cecal Microbiota Profiles in Broilers Fed Poultry-by-Product-Meal-Based Diets.","authors":"Muhammad Shahbaz Zafar, Shafqat Nawaz Qaisrani, Saima, Zafar Hayat, Kashif Nauman","doi":"10.3390/metabo15070445","DOIUrl":"https://doi.org/10.3390/metabo15070445","url":null,"abstract":"<p><strong>Background: </strong>The current study aimed to evaluate the effects of the supplementation of protease sources on growth and carcass response, gut health, nutrient digestibility, and cecal microbiota profiles in broilers fed poultry-by-product-meal (PBM)-containing diets.</p><p><strong>Methods: </strong>In total, 800 one-day-old mixed-sex broilers (Arbor Acres) were weighed and allocated to one of the four dietary treatments in a completely randomized design, with eight replicates and 25 birds each per replicate. The treatments were as follows: (1) T<sub>0</sub>, control diet (without protease supplementation and 3% PBM); (2) T<sub>1</sub>, control diet supplemented with acidic protease at 100 g/ton (50,000 U/g); (3) T<sub>2</sub>, control diet supplemented with alkaline protease at 200 g/ton (25,000 U/g); (4) T<sub>3</sub>, control diet supplemented with neutral protease at 200 g/ton (25,000 U/g).</p><p><strong>Results: </strong>Protease supplementation enhanced (<i>p</i> < 0.05) body weight gain and the feed conversion ratio, predominantly in broilers fed PBM-based diets containing alkaline protease. Alkaline protease supplementation increased (<i>p</i> < 0.05) the apparent ileal digestibility of proteins (AIDP) by 4.3% and the apparent ileal digestibility of amino acids (AIDAA) by up to 5.8%, except for ornithine. Increments (<i>p</i> < 0.05) in carcass, breast, and leg quarter yields due to protease supplementation were evident, particularly in broilers fed diets containing alkaline protease. Alkaline protease improved (<i>p</i> < 0.05) the duodenal villus height (VH), reduced the crypt depth (CD), and increased the villus height to crypt depth ratio (VCR). Alkaline protease supplementation reduced (<i>p</i> < 0.05) cecal counts of <i>Salmonella</i>, <i>Escherichia coli</i>, and <i>Clostridium</i> in the broilers, whereas it increased (<i>p</i> < 0.05) the <i>Lactobacillus</i> counts.</p><p><strong>Conclusions: </strong>the supplemented alkaline protease resulted in improved growth performance and carcass traits, better gut health, as well as improved ileal digestibility of nutrients, including crude protein (CP) and acid insoluble ash (AIA), with a more balanced cecal microbial composition in broilers.</p>","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-Omics Analysis of Gut Microbiota and Sperm Quality in Tibetan Breeding Boars. 藏种公猪肠道微生物群与精子质量的多组学分析。
IF 3.4 3区 生物学
Metabolites Pub Date : 2025-07-02 DOI: 10.3390/metabo15070447
Mingxuan Zhao, Mengjia Han, Hongliang Zhang, Xiangdong Wang, Yikai Yin, Jian Zhang, Peng Shang
{"title":"Multi-Omics Analysis of Gut Microbiota and Sperm Quality in Tibetan Breeding Boars.","authors":"Mingxuan Zhao, Mengjia Han, Hongliang Zhang, Xiangdong Wang, Yikai Yin, Jian Zhang, Peng Shang","doi":"10.3390/metabo15070447","DOIUrl":"https://doi.org/10.3390/metabo15070447","url":null,"abstract":"<p><strong>Background/objectives: </strong>Reproductive efficiency in breeding boars critically impacts swine industry productivity, with sperm quality being multifactorially regulated by gut microbiota. This study aimed to elucidate the microbiota-metabolite interactions underlying sperm quality differences in Tibetan boars.</p><p><strong>Methods: </strong>Integrated 16S rRNA sequencing and untargeted metabolomics were performed on fecal and semen samples from eight healthy Tibetan boars (31-33 months old), stratified into low-semen (CJ) and high-semen utilization (HJ) groups. Analyses included sperm quality assessment, microbial profiling, and metabolic pathway enrichment.</p><p><strong>Results: </strong>The HJ group exhibited significantly enhanced sperm motility and semen utilization rates (<i>p</i> < 0.05). Gut microbiota composition differed markedly, with Firmicutes and Proteobacteria enriched in HJ boars. Metabolomics identified key metabolites positively correlated with sperm quality (e.g., butyrate, phenyllactic acid), while lithocholic acid showed negative associations. KEGG analysis revealed predominant involvement in butanoate metabolism and bile acid biosynthesis. Core microbiota (e.g., Ruminococcus) modulated sperm quality through short-chain fatty acid networks and bile acid homeostasis.</p><p><strong>Conclusions: </strong>Gut microbiota regulated the sperm microenvironment via a \"metabolic-immune\" dual pathway mediated by the gut-testis axis. These findings establish a theoretical basis for probiotic or metabolite-targeted strategies to improve boar reproductive performance.</p>","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amino Acid Metabolism in Liver Mitochondria: From Homeostasis to Disease. 肝脏线粒体中的氨基酸代谢:从稳态到疾病。
IF 3.4 3区 生物学
Metabolites Pub Date : 2025-07-02 DOI: 10.3390/metabo15070446
Ranya Erdal, Kıvanç Birsoy, Gokhan Unlu
{"title":"Amino Acid Metabolism in Liver Mitochondria: From Homeostasis to Disease.","authors":"Ranya Erdal, Kıvanç Birsoy, Gokhan Unlu","doi":"10.3390/metabo15070446","DOIUrl":"https://doi.org/10.3390/metabo15070446","url":null,"abstract":"<p><p>Hepatic mitochondria play critical roles in sustaining systemic nutrient balance, nitrogen detoxification, and cellular bioenergetics. These functions depend on tightly regulated mitochondrial processes, including amino acid catabolism, ammonia clearance via the urea cycle, and transport through specialized solute carriers. Genetic disruptions in these pathways underlie a range of inborn errors of metabolism, often resulting in systemic toxicity and neurological dysfunction. Here, we review the physiological functions of hepatic mitochondrial amino acid metabolism, with a focus on subcellular compartmentalization, disease mechanisms, and therapeutic strategies. We discuss how emerging genetic and metabolic interventions-including dietary modulation, cofactor replacement, and gene therapy-are reshaping treatment of liver-based metabolic disorders. Understanding these pathways offers mechanistic insights into metabolic homeostasis and reveals actionable vulnerabilities in metabolic disease and cancer.</p>","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uric Acid in Primary Hyperparathyroidism: Marker, Consequence, or Bystander? 原发性甲状旁腺功能亢进的尿酸:标志、后果还是旁观者?
IF 3.4 3区 生物学
Metabolites Pub Date : 2025-07-02 DOI: 10.3390/metabo15070444
Matteo Malagrinò, Guido Zavatta
{"title":"Uric Acid in Primary Hyperparathyroidism: Marker, Consequence, or Bystander?","authors":"Matteo Malagrinò, Guido Zavatta","doi":"10.3390/metabo15070444","DOIUrl":"https://doi.org/10.3390/metabo15070444","url":null,"abstract":"<p><p><b>Background:</b> Several recent studies have documented an increased cardiovascular risk in patients with primary hyperparathyroidism (PHPT), thereby stimulating interest in the association with uric acid (UA), a metabolite linked to cardiovascular disease and chronic kidney disease (CKD) progression, whose role in these conditions is still the subject of study. The aim of this review is to summarize the underlying pathophysiological mechanisms of the PHPT-UA relation and discuss their potential clinical implications. <b>Methods:</b> We conducted a comprehensive literature review, with a focus on the physiological and clinical aspects of the relationship between PHPT and UA. <b>Results:</b> The evidence in the literature supports the association between PHPT and elevated UA levels, although the underlying mechanisms still need to be elucidated. Key mechanisms seem to involve tubular and intestinal transporters, particularly the ABCG2 transporter, as well as indirect effects mediated by hypercalcemia and inflammatory processes. <b>Conclusions:</b> The association between PHPT and UA, though recognized for years, highlights the existence of linked pathophysiological mechanisms between mineral and purine metabolism. However, the current knowledge does not clarify whether uric acid plays an active role in the development of complications related to hyperparathyroidism or if it just represents an indirect marker of metabolic dysfunction. In the absence of specific guidelines, measuring UA levels to screen for hyperuricemia, especially in patients with additional risk factors, should be considered to prevent related complications. Future studies could clarify the role of UA in PHPT, improving our understanding of the disease and potentially leading to new therapeutic strategies to prevent cardiovascular, renal and joint manifestations.</p>","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory Mechanisms in the Management and Treatment of Retinal Detachment. 视网膜脱离的管理和治疗中的炎症机制。
IF 3.4 3区 生物学
Metabolites Pub Date : 2025-07-01 DOI: 10.3390/metabo15070442
Pablo Redruello-Guerrero, María Gómez-Tomás, Tomás Rechi-Sierra, Laura Molinero-Sicilia, Nadia Galindo-Cabello, Ricardo Usategui-Martín, Salvador Pastor-Idoate
{"title":"Inflammatory Mechanisms in the Management and Treatment of Retinal Detachment.","authors":"Pablo Redruello-Guerrero, María Gómez-Tomás, Tomás Rechi-Sierra, Laura Molinero-Sicilia, Nadia Galindo-Cabello, Ricardo Usategui-Martín, Salvador Pastor-Idoate","doi":"10.3390/metabo15070442","DOIUrl":"https://doi.org/10.3390/metabo15070442","url":null,"abstract":"<p><p>Retinal detachment (RD) is a serious clinical condition that significantly impacts patients' quality of life. Its management involves considering several clinical factors that may affect the therapeutic approach. Inflammatory complications can affect visual recovery, long-term outcomes, and prognosis. Understanding the underlying inflammatory mechanisms is key to improving personalized medicine and optimizing therapeutic approaches to management. This review comprehensively searched scientific databases (Medline, Web of Science, and Scopus), considering clinical and experimental studies published between 1999 and 2025. Specific MeSH terms and predefined inclusion and exclusion criteria were used to select the most relevant papers. A total of 140 studies were analyzed. The findings were analyzed qualitatively and illustrated with images from clinical practice. Several studies have demonstrated the critical role of cytokines in retinal inflammation, highlighting their importance in regulating the immune response following RD. In addition, oxidative stress, apoptotic mechanisms, and glia activation, particularly Müller cells and microglia, have been identified as crucial elements in the progression of retinal damage. In this sense, inflammation poses significant clinical challenges that require more effective therapeutic strategies. In conclusion, this review differs from previous literature by emphasizing the translational implications of inflammatory mechanisms in RD and by comparing experimental and clinical data. The management of RD should consider not only surgical aspects, but also modulation of the inflammatory response to improve visual outcomes and prevent long-term complications.</p>","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin B12 and Folate in Adherent and Non-Adherent Individuals with Phenylketonuria: A Cross-Sectional Study, Systematic Review, and Meta-Analysis. 苯丙酮尿患者黏附和非黏附的维生素B12和叶酸:横断面研究、系统评价和荟萃分析
IF 3.4 3区 生物学
Metabolites Pub Date : 2025-07-01 DOI: 10.3390/metabo15070438
Kamila Bokayeva, Małgorzata Jamka, Dariusz Walkowiak, Monika Duś-Żuchowska, Łukasz Kałużny, Natalia Wichłacz-Trojanowska, Agnieszka Chrobot, Renata Mozrzymas, Gulnara Sultanova, Karl-Heinz Herzig, Jarosław Walkowiak
{"title":"Vitamin B12 and Folate in Adherent and Non-Adherent Individuals with Phenylketonuria: A Cross-Sectional Study, Systematic Review, and Meta-Analysis.","authors":"Kamila Bokayeva, Małgorzata Jamka, Dariusz Walkowiak, Monika Duś-Żuchowska, Łukasz Kałużny, Natalia Wichłacz-Trojanowska, Agnieszka Chrobot, Renata Mozrzymas, Gulnara Sultanova, Karl-Heinz Herzig, Jarosław Walkowiak","doi":"10.3390/metabo15070438","DOIUrl":"https://doi.org/10.3390/metabo15070438","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The impact of dietary adherence and regular formula intake on the vitamin levels in individuals with phenylketonuria (PKU) remains unclear. This study aimed to assess the influence of both adherence to dietary management and regular formula intake on the vitamin B12 and folate levels in individuals with PKU. <b>Methods:</b> This cross-sectional multicentre study included 63 patients with PKU aged 12-41 years. The participants were classified as adherent or non-adherent based on their mean plasma phenylalanine levels or as regular or irregular formula consumers. The participants' vitamin B12 and folate levels were compared across these groups. In addition, a systematic search of PubMed, Web of Science, Scopus, and Cochrane Library identified 11,631 studies comparing vitamin B12 and folate levels between adherent vs. non-adherent patients and regular vs. irregular formula intake groups, of which eight met the inclusion criteria. Analyses were conducted using random-effects and fixed-effects models and effect sizes were expressed as standardised mean differences (SMDs). <b>Results:</b> This cross-sectional study showed significantly higher vitamin B12 and folate levels in adherent vs. non-adherent individuals (767.6 ± 264.5 vs. 524.7 ± 216.4 pg/mL; 13.44 ± 1.96 vs. 10.62 ± 3.36 ng/mL, both <i>p</i> < 0.001) and in regular vs. irregular formula consumers (746.7 ± 228.4 vs. 527.4 ± 281.9 pg/mL; 13.32 ± 2.25 vs. 10.48 ± 3.23 ng/mL, <i>p</i> < 0.0001 and <i>p</i> < 0.001 respectively). The meta-analysis found no significant differences between the adherent and non-adherent groups, which were defined based on their phenylalanine levels, but showed higher vitamin B12 levels (fixed-effects model, SMD: 1.080, 95% CI: 0.754, 1.405, <i>p</i> < 0.0001) and a near-significant trend toward higher folate levels (random-effects model, SMD: 0.729, 95% CI: -0.032, 1.490, <i>p</i> = 0.061) in regular formula consumers. <b>Conclusions:</b> Regular formula intake is a key determinant of vitamin B12 in patients with PKU. These findings highlight the importance of consistent formula use in dietary management and warrant further research.</p>","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信