Materials Express最新文献_第3页

Application value of a nano-siRNA delivery system in treatment against senile cataracts by modulating apoptosis in lens epithelial cells 纳米 siRNA 递送系统通过调节晶状体上皮细胞凋亡防治老年性白内障的应用价值

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-06-01 DOI: 10.1166/mex.2024.2677

Xiaoqing Wei, Xiaoxing Wang, Ping Wang

引用次数: 0

Experimental study on properties of cinder aggregate lightweight concrete with fibre reinforcement 带纤维加固的煤渣骨料轻质混凝土性能实验研究

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-06-01 DOI: 10.1166/mex.2024.2701

K. Sadhana, K. Suguna, P. Raghunath

引用次数: 0

BMSC-derived exosomes attenuate persistent corneal epithelial injury by affecting retinal neural-like cells 源自 BMSC 的外泌体通过影响视网膜神经样细胞减轻持续性角膜上皮损伤

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-06-01 DOI: 10.1166/mex.2024.2694

Dengting Wang, Jianyun Wang, Yan Sun

{"title":"BMSC-derived exosomes attenuate persistent corneal epithelial injury by affecting retinal neural-like cells","authors":"Dengting Wang, Jianyun Wang, Yan Sun","doi":"10.1166/mex.2024.2694","DOIUrl":"https://doi.org/10.1166/mex.2024.2694","url":null,"abstract":"Persistent corneal epithelial defect (PED) is a challenge to human which is difficultly cured, normally requiring long-term follow-up. Herein, this study explored the potential role of bone marrow mesenchymal stem cell-derived exosomes (BMSC-exos) in persistent corneal epithelial injury\u0000 and the underlying mechanism. After characterization of BMSC-exos, RGC-5 cell viability was determined and surface markers of BMSCs were analyzed. Additionally, RT-qPCR and Western blot measured miR-150-5p, Brn3, Islet-1, and PCNA expression. Dual luciferase assays were conducted to evaluate\u0000 the targeting relationship between long non-coding Ribonucleic Acid (lncRNA) MIAT and miR-150-5p. Presented in ellipsoidal or cup shape, BMSC-exos were positive to BMSC-specific markers CD29 and CD90, and cell surface markers CD9 and CD63 were detected on exosomes. Importantly, treatment with\u0000 BMSC-exos significantly promoted proliferation of retinal ganglion cells (RGCs) and hindered cell differentiation. Interestingly, down-regulating lncRNA MIAT exerted the same effect as BMSC-exos, increasing cell viability and decreasing the expression of differentiation-related proteins Brn3\u0000 and ISL1. Bioinformatics software predicted miR-150-5P as target of lncRNA MIAT, and the relative luciferase activity of miR-150-5P+MIAT-WT co-transfection group was lower. Conclusively, BMSC-exos can improve PED by targeting and regulating miR-150-5p expression through lncRNA MIAT, which\u0000 can up-regulate PCNA in RGC-5 cells and down-regulate Brn3 and ISL1.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141231177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality assessment standards and production technology of artificial sand based on hydraulic concrete construction specifications 基于水工混凝土施工规范的人工砂质量评估标准和生产技术

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-06-01 DOI: 10.1166/mex.2024.2709

Pei Yu, Suqin Gao, Jun Peng

{"title":"Quality assessment standards and production technology of artificial sand based on hydraulic concrete construction specifications","authors":"Pei Yu, Suqin Gao, Jun Peng","doi":"10.1166/mex.2024.2709","DOIUrl":"https://doi.org/10.1166/mex.2024.2709","url":null,"abstract":"Natural sand and gravel resources are a local resource. Natural sand and gravel are non-renewable in a short time and are not suitable for long-distance transportation. After decades of mining, sand and gravel resources in some areas have been exhausted. The transportation distance\u0000 of natural sand and gravel is getting farther and farther, and accordingly, the price of natural sand and gravel continues to rise. At the same time, continuous and disorderly mining has caused serious damage to the environment and resources. During the construction of large and medium-sized\u0000 water conservancy and hydropower projects in China, due to the lack of surrounding natural aggregates, most projects use artificial aggregates. In the current national standards for water conservancy projects, the content of artificial sand and gravel powder is clearly defined. Based on the\u0000 “Hydraulic Concrete Construction Specifications” (SL677-2014), this article summarizes the particle shape, gradation and surface structure of artificial sand, and also calculates the theoretical gradation of artificial sand. To find out the impact of stone powder content on the\u0000 performance of artificial sand, different levels of stone powder content need to be selected for research and analysis to clarify the impact of artificial sand powder content on concrete properties. Research shows that for concrete made from artificial sand, increasing the aggregate content\u0000 with a particle size less than 0.075 mm can significantly increase the compressive strength of the concrete. In artificial sand, the content of stone powder will affect the workability, polishability, durability, permeability and water release of concrete. In the artificial sand and gravel\u0000 production process system, crushing and sand making equipment are the most important sand and gravel production equipment. The research results provide theoretical reference for the application of artificial sand in concrete and the update of artificial sand production technology and equipment.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141231524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation method and industrialization of Ta-based ultra high temperature ceramic Tujia jar tea baking jar materials Ta 基超高温陶瓷土家族罐茶烘焙罐材料的制备方法及产业化

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-06-01 DOI: 10.1166/mex.2024.2700

Wenwen Shi, Zhangli Jin, Meng Li, Dongya Hu, Fangyu Liu, Yu’e Chen, Wencheng Zhang

{"title":"Preparation method and industrialization of Ta-based ultra high temperature ceramic Tujia jar tea baking jar materials","authors":"Wenwen Shi, Zhangli Jin, Meng Li, Dongya Hu, Fangyu Liu, Yu’e Chen, Wencheng Zhang","doi":"10.1166/mex.2024.2700","DOIUrl":"https://doi.org/10.1166/mex.2024.2700","url":null,"abstract":"The production materials of traditional Tujia jar tea often face problems such as poor high-temperature performance and poor durability. To improve the temperature resistance and durability of tea baking utensils, this study proposes a new type of TaC ultra-high temperature ceramic.\u0000 TaC ceramics with excellent performance were prepared through powder metallurgy technology, including high-energy ball milling to ensure uniform mixing, followed by compression molding and high-temperature sintering. The test results demonstrated excellent mechanical properties, with a maximum\u0000 depth of 948.67 nm and a contact depth of 954.45 nm, proving outstanding compressive and wear resistance. The hardness reached 21.4±0.5 Gpa, and the elastic modulus was 397.2±8.7 Gpa, both of which indicate its stability under high loads. In addition, the fracture toughness was\u0000 2.8±0.2 Mpa*m1/2. At a high temperature environment of 1000 °C, the oxidation rate constant of TaC ceramics was only 0.183 mg2 *cm−4 *h, which demonstrates its excellent high-temperature stability. The development of this TaC ceramic not only\u0000 strengthened the traditional production process of Tujia teapots and tea roasting teapots, thereby improving the product’s service life, but also holds potential for other industrial applications that demand ultra-high temperature stability. These contributions provide new directions\u0000 for the high-temperature application of ceramic materials and bring tangible economic and technological value to related industries.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of miR-203 expression using a nanofluorescent probe to study the neuroprotective effect of sevoflurane in a neuroinflammatory injury rat model 利用纳米荧光探针检测 miR-203 的表达，研究七氟醚对神经炎症损伤大鼠模型的神经保护作用

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-06-01 DOI: 10.1166/mex.2024.2676

Yun Shao, Yi Pu, Xiangrong Yu, Zhengxiang Yang

{"title":"Detection of miR-203 expression using a nanofluorescent probe to study the neuroprotective effect of sevoflurane in a neuroinflammatory injury rat model","authors":"Yun Shao, Yi Pu, Xiangrong Yu, Zhengxiang Yang","doi":"10.1166/mex.2024.2676","DOIUrl":"https://doi.org/10.1166/mex.2024.2676","url":null,"abstract":"Ischemic cerebrovascular disease has high disability and mortality rates that can result in related sequelae if not treated promptly and properly. Nanofluorescent probes are useful in the early diagnosis of the disease due to their high sensitivity and specificity, thus facilitating\u0000 early therapeutic measures and observation of disease progression. Here, a novel nanostructure probe was designed to detect the expression of miR-203 in a cerebral ischemia-reperfusion injury (CIRI) model after sevoflurane treatment, and the effects of sevoflurane and neuroinflammatory injury\u0000 were discussed. A CIRI rat model was established to study miR-203 expression, nerve injury, oxidative stress, and inflammatory factors in the brain tissue of rats treated with sevoflurane. The nanofluorescent probe showed high specificity and sensitivity for miR-203 detection. miR-203 was\u0000 over-expressed in CIRI rats, which was decreased by sevoflurane treatment. In addition, sevoflurane treatment significantly improved neurological function, learning, and memory in CIRI rats; decreased malondialdehyde, lactate dehydrogenase, and superoxide dismutase levels; and inhibited the\u0000 expression of tumor necrosis factor α and interleukins 1 and 6. Moreover, an inverse correlation was determined between miR-203 expression and the degree of neuroinflammation. This study demonstrated that miR-203 may be a useful diagnostic and prognostic index for neuroinflammatory\u0000 injury.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141229555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Titanium-coated high-density Fe2O3 single crystal nanowire array for solar water splitting 用于太阳能水分离的钛涂层高密度 Fe2O3 单晶纳米线阵列

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-06-01 DOI: 10.1166/mex.2024.2704

Md Sultan Mahmud, Shaojie Gu, S. Yoon, Yasuhiro Kimura, Yuhki Toku, Yang Ju

{"title":"Titanium-coated high-density Fe2O3 single crystal nanowire array for solar water splitting","authors":"Md Sultan Mahmud, Shaojie Gu, S. Yoon, Yasuhiro Kimura, Yuhki Toku, Yang Ju","doi":"10.1166/mex.2024.2704","DOIUrl":"https://doi.org/10.1166/mex.2024.2704","url":null,"abstract":"Fe2O3 holds promising n-type semiconductor material in the field of solar water splitting due to its excellent photocatalytic properties. However, the photoelectrochemical performance of Fe2O3 is limited by its inherent properties such\u0000 as poor conductivity, and charge separation efficiency owing to its recombination rate. Therefore, researchers are more focused on nanostructuring, doping, and surface coating to overcome these issues of Fe2O3. In this study, we have investigated a low-cost way to fabricate\u0000 a Ti coating layer on a high-density Fe2O3 single-crystal nanowire array for solar water splitting. Firstly, we have prepared a high-density single-crystal Fe2O3 nanowire array at lower temperatures by a new approach stress-induced atomic diffusion\u0000 method. Thereafter, the prepared nanowire array was coated by Ti film using RF sputtering. The optimal film thickness of 13 nm titanium coatings layer into Fe2O3 single crystal nanowire array exhibited a high photocurrent density of 1.36 mA/cm2 at 1.23 V versus\u0000 RHE and solar to hydrogen conversion efficiency (STH) of 1.67%, which could be resulting from adjusted optoelectronic properties of the nanowires.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141232316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of glass powder on compressive strengths and microstructure of ultra-high-performance concrete 玻璃粉对超高性能混凝土抗压强度和微观结构的影响

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-06-01 DOI: 10.1166/mex.2024.2707

Hongxin Liu, Jian Wang, Lijia Wang, Zhihui Yao, Zijun Li

{"title":"Effect of glass powder on compressive strengths and microstructure of ultra-high-performance concrete","authors":"Hongxin Liu, Jian Wang, Lijia Wang, Zhihui Yao, Zijun Li","doi":"10.1166/mex.2024.2707","DOIUrl":"https://doi.org/10.1166/mex.2024.2707","url":null,"abstract":"The most common methods for dealing with waste glass are landfilling or incineration, which cause wastage of resources. The method for preparing ultra-high-performance concrete (UHPC) by partially substituting cement with glass powder (GP) was herein studied in order to realize the\u0000 high value treatment of waste glass. The experimental results indicated that incorporation of 5% GP brought the highest compressive strengths for UHPC, which was increased by 5.11%, compared to the control UHPC in 28 days. Furthermore, the later-stage compressive strengths for UHPC at 60 days\u0000 increased continuously with incorporation of 10% and 15% GP, respectively, indicating that GP does not hinder the development of strengths. Using multiple micro testing techniques, it was indicated that, GP exhibited pozzolanic reaction and dilution effect, which can enhance cement hydration\u0000 and increased the amount of hydration products. Thus, the microstructure of UHPC with appropriate amount of GP was significantly improved. In addition, the CO2 emissions and production costs for UHPC decreased steadily with increased GP content. Compared to the control UHPC, UHPC\u0000 with 15% GP exhibited decreased by 1.47% in production costs and 7.39% in CO2 emissions.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy of ganciclovir combined with transfer factor oral solution for pediatric infectious mononucleosis 更昔洛韦联合转移因子口服溶液治疗小儿传染性单核细胞增多症的临床疗效

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-06-01 DOI: 10.1166/mex.2024.2691

Weiwei Qi, Ning Yang, Juan Lu, Ruiyu Chai, Hong Han, Meixu Hao

{"title":"Clinical efficacy of ganciclovir combined with transfer factor oral solution for pediatric infectious mononucleosis","authors":"Weiwei Qi, Ning Yang, Juan Lu, Ruiyu Chai, Hong Han, Meixu Hao","doi":"10.1166/mex.2024.2691","DOIUrl":"https://doi.org/10.1166/mex.2024.2691","url":null,"abstract":"This study investigates the clinical efficacy of ganciclovir combined with transfer factor oral solution in the treatment of patients with infectious mononucleosis (IM) to provide a reference for clinical application. A total of 150 children with IM who received treatment in our hospital\u0000 from 2020 to 2022 were randomly selected as the research subjects. They were randomly divided into a control group receiving intravenous administration of ganciclovir (n = 75) and an observation group receiving transfer factor oral liquid in combination with intravenous administration\u0000 of ganciclovir (n=75). The results showed that after treatment, the serum levels of CK-MB, CK, CRP, IL-6, and TNF-α were significantly reduced in both groups. The observation group showed lower levels than the control group. Additionally, peripheral blood CD4+\u0000 T cells, CD4+/CD8+ ratio, and Tfr expression were higher in the observation group compared to the control group, while the level of CD8+ T cells was lower than that of the control group. Furthermore, there were no significant changes in the levels of IgA, IgM,\u0000 and IgG antibodies in the two groups before and after treatment. In conclusion, the combination therapy of transfer factor oral solution and ganciclovir demonstrates favorable clinical efficacy and safety in the treatment of children with IM, as it effectively reduces inflammatory reactions,\u0000 regulates cellular immune function, promotes Tfr differentiation, and shortens recovery time.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ detection of miR-93/VEGFR2 by nanosensor and inhibition of trophoblast apoptosis 利用纳米传感器原位检测 miR-93/VEGFR2 并抑制滋养细胞凋亡

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-06-01 DOI: 10.1166/mex.2024.2678

Yanru Zhou, Yimei Ji, Yan Cheng

{"title":"In situ detection of miR-93/VEGFR2 by nanosensor and inhibition of trophoblast apoptosis","authors":"Yanru Zhou, Yimei Ji, Yan Cheng","doi":"10.1166/mex.2024.2678","DOIUrl":"https://doi.org/10.1166/mex.2024.2678","url":null,"abstract":"We investigated the pathogenesis of recurrent spontaneous abortion (RSA) and evaluated the therapeutic effect of Pill Nourishing Kidney and Fetus (PNKF). A sensitive DNA sensor was used to detect miR-93 expression and vascular endothelial growth factor receptor 2 (VEGFR2). We testing\u0000 the penetration capacity and physicochemical properties of the DNA sensor and found that the sensor had higher penetration and good stability and effectively detected miR-93 and VEGFR2 at different reaction temperatures and mediums with similar fluorescence signals. The sensor detected higher\u0000 miR-93 expression, increased apoptosis, and negative regulation of VEGFR2 in patients with RSA. Treatment with PNKF of cultured trophoblast cells collected from patients with RSA were treated with PNKF significantly inhibited trophoblast cell apoptosis and promoted trophoblast cell proliferation\u0000 by reducing miR-93 expression and promoting VEGFR2 expression. In conclusion, PNKF can improve the proliferation and inhibit apoptosis of trophoblast cells by suppressing miR-93 and promoting VEGFR2. Furthermore, the miR-93/VEGFR2 sensor demonstrated high sensitivity that has potential applications\u0000 in clinical practice.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141230070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0