{"title":"Nanoparticle contrast technology-based protective effects of amiodarone catheter perfusion on cardiac injury caused by radiofrequency ablation","authors":"Mingwei Huang, Weiwei Li, Yaoguo Wang, Chaoxiang Xu","doi":"10.1166/mex.2023.2504","DOIUrl":"https://doi.org/10.1166/mex.2023.2504","url":null,"abstract":"Radiofrequency ablation can damage the cardiac tissues and affect their functions. Amiodarone is a commonly used antiarrhythmic drug that protects the heart tissues. This study used nanoparticle contrast technology to explore the protective effects of amiodarone catheter perfusion on cardiac injury caused by radiofrequency ablation. The model of atrial fibrillation (AF) was established in healthy piglets. All piglets were subjected to three-dimensional heart reconstruction with nano-computed tomography (CT) before surgery, followed by radiofrequency ablation. Subsequently, the random number table method divided them into experimental (four piglets) and control groups (four piglets). The experimental group was treated with amiodarone catheter infusion, and the control group was the amiodarone non-intervention group. The changes in serum myoglobin (Mb), troponin I (cTnI), and creatine kinase isoenzyme (CK-MB) in the two groups before an operation, 6 h, 12 h, and 48 h after the operation, were analyzed. The degree of injury of right atrial radiofrequency ablation was analyzed and compared between the two groups. The total time and the number of radiofrequency ablation discharges were recorded. After 12 h of radiofrequency ablation, the levels of Mb and CK-MB in the pigs’ serum increased ( P <0.05). The levels of cTnI increased 12 h after surgery ( P <0.01) and became normal 48 h after surgery. The depth and width of right atrial heart tissue injury, Mb, CK-MB, and cTnI in the experimental group were significantly lower than in the control group. After treatment, the left ventricular ejection fraction (LVEF) and cardiac index (CI) in the two groups were higher, while the left ventricular end-systolic volume (LVESV) was lower than those before treatment. The LVEF and CI in the experimental group were higher, and LVESV was lower than those in the control group. The myocardial injury caused by radiofrequency ablation is a minor myocardial injury, which can increase the serum myocardial damage markers to varying degrees; CK-MB, cTnI, and Mb can be used for radiofrequency catheter ablation monitoring of myocardial injury. Amiodarone catheter perfusion produces protective effects on cardiac injury caused by radiofrequency ablation. This study provides a new therapeutic method for cardiac injury caused by radiofrequency ablation.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135349274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study on marine microplastics monitoring based on infrared spectroscopy technology","authors":"Shengmei Shang, Yanwei Guo, Jing Song, Liping Liu","doi":"10.1166/mex.2023.2506","DOIUrl":"https://doi.org/10.1166/mex.2023.2506","url":null,"abstract":"In recent years, microplastics particles have been detected in many sea areas around the world. Microplastics has done great harm to marine and terrestrial seawater ecosystems, so it is necessary to obtain the effective statistical data of microplastics in the environment accurately and quickly for the further study of pollution in microplastics. In this paper, based on IR (Infrared Spectroscopy) technology, hyperspectral images of marine microplastics samples containing different materials were obtained. SVM (Support Vector Machine) algorithm is used to identify microplastics in hyperspectral images. The results show that the microplastics abundance ranges from 5.193 to 20.281 N/L, 6.087 to 38.679 N/L and 7.498 to 11.084 N/L, respectively, and the average abundance is 11.83 N/L, 24.84 N/L and 19.27 N/L, respectively. The types of microplastics in the bottom water of the bay in the study area are mainly fibers (53–68%) and debris (23–34%). NIR (Near Infrared) analysis shows that the characteristic curves of microplastics spectra of the same species with different particle sizes are different. IR technology combined with chemometrics algorithm has great potential for the detection of microplastics in seawater surface and seawater. This method is simple and feasible, and has the feasibility of popularization.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135349105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Curcumin-Loaded nano-phospholipid complex maintains mitochondrial homeostasis through regulation of parkin in Parkinson’s disease","authors":"Hejie Xie, Dajin Zhou, Tielun Yan, Xiumei Yan, Qiulin Wu, Weifeng Chen","doi":"10.1166/mex.2023.2495","DOIUrl":"https://doi.org/10.1166/mex.2023.2495","url":null,"abstract":"Curcumin (Cur) can modulate multiple signal transductions and play a protective role in Parkinson’s disease (PD). Nano-phospholipid composite carriers were prepared to observe the nano-phospholipid complex EM maps, and then evaluated the size and surface potential of the composites using a Zetasizer IV analyzer. Microglial cells (BV2) were divided into control group, empty vector group, Cur group and drug-loaded group and administered treatment, respectively. The levels of Parkin, BAG5 and PINK1 were detected. With encapsulation efficiency of 26.0% and drug loading of 52.0%, respectively, the average particle size of the Cur-loaded nano-phospholipid was (197.15±4.42) nm, with a potential of (−18.2±2.0) mV. The difference between empty vector group and control group in the level of BAG5, Parkin and PINK1 was not significant ( P >0.05). BAG5 level increased significantly upon treatment with Cur or Cur-loaded nano-phospholipid complex, with highest level in the drug-loaded group ( P <0.05). As such, Parkin and PINK1 expression increased greatly in the presence of Cur or Cur-loaded nano-phospholipid complex, while the drug-loaded group had the highest level ( P <0.05). Collectively, the curcumin/nano-phospholipid complexes upregulated Parkin, PINK1 and BAG5 expression, thereby maintaining mitochondria and potentiating the efficacy of Cur on PD. The Cur-loaded nano-phospholipid complexes show promising potential for PD prevention and treatment.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135349454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhe Ye, Lingling Long, Sizhu Long, Min Yang, Ming Tan
{"title":"Liensinine improves cognitive function of gastric cancer under dexmedetomidine anesthesia by inhibiting neuron apoptosis through synuclein","authors":"Zhe Ye, Lingling Long, Sizhu Long, Min Yang, Ming Tan","doi":"10.1166/mex.2023.2502","DOIUrl":"https://doi.org/10.1166/mex.2023.2502","url":null,"abstract":"Surgical resection is the main treatment approach for gastric cancer (GC), but surgical anesthetics may have an impact on postoperative cognitive function. Therefore, this study investigated the effect of liensinine on neuronal apoptosis and cognitive function in mice with GC induced by dexmedetomidine anesthesia. Firstly, a GC mouse model was established and divided into the following groups; blank control group, GC model group, low-dose (4 μ mol/L) and high-dose (8 μ mol/L) groups of liensinine ( n = 6), to detect apoptosis of neurons. In addition, the GC model group, Synuclein (SYN) mimic group, SYN inhibitor group, high-dose neusinine group, and high-dose liensinine+SYN inhibitor group were set up with 6 rats in each group. The cognitive function of mice after treatment was observed by Morris water maze experiment, and neuronal cell apoptosis and expressions of SYN, brain-derived neurotrophic facto (BDNF) and Caspase-3 were explored. Liensinine significantly improved the cognitive function of GC mice after dexmedetomidine anesthesia, and this process is related to decreased SYN expression. Liensinine can inhibit increased SYN expression, so apoptosis of neurons in the hippocampus of mice was controlled after the use of SYN inhibitors, especially in the high-dose liensinine+SYN inhibitor group. Liensinine down-regulated the expression of SYN and inhibited the Caspase-3 to reduce neuronal cell apoptosis, promoting recovery of BDNF level, and then playing role in improving the cognitive function of GC mice after dexmedetomidine anesthesia.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135349463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nanomagnetic bead-based nucleic acid isolation to examine the correlation of serum TRAP1 and MDSC levels with clinical treatment efficacy and prognosis in nonsmall cell lung cancer","authors":"Shan Dai, Nan Dai, Jie Zhang","doi":"10.1166/mex.2023.2501","DOIUrl":"https://doi.org/10.1166/mex.2023.2501","url":null,"abstract":"To explore the correlation of tumor necrosis factor receptor-associated protein (TRAP1) and myeloid-derived suppressor cells (MDSCs) in peripheral blood with clinical treatment efficacy and prognosis in nonsmall-cell lung cancer (NSCLC). The study cohort comprised 112 patients with NSCLC who were treated between March 2020 to December 2022, including 45 and 67 patients with stage I–II and III–VI NSCLC, respectively, and 90 healthy individuals as controls. Peripheral blood samples of study participants before and after chemotherapy were collected. Serum MDSC and TRAP1 levels were compared in patients categorized according to the NSCLC stage by nanomagnetic bead-based separation method. Flow cytometry was used to further analyze the expression levels of MDSCs and TRAP1 in cells before and after chemotherapy in patients with NSCLC. Chemotherapy efficacy was evaluated according to the World Health Organization objective evaluation criteria for tumor efficacy, and the relationship of chemotherapy efficacy with serum MDSC and TRAP1 levels was analyzed. Multivariate Cox regression analysis was conducted to evaluate factors associated with prognosis. The serum levels of TRAP1 and MDSCs were significantly higher in patients with NSCLC than in healthy controls ( P <0.05). Serum TRAP1 and MDSC levels were positively correlated with TNM stage. Serum levels of TRAP1 and MDSCs after chemotherapy were significantly lower than those before chemotherapy in the overall cohort, serum levels of TRAP1 after chemotherapy were significantly lower than those before chemotherapy in patients with partial response, and serum levels of MDSCs after chemotherapy were significantly higher than those before chemotherapy in patients with progressive disease ( P < 0.05). Multivariate Cox regression analysis revealed that high serum levels of TRAP1 and MDSCs were associated with poor prognosis. Serum levels of TRAP1 and MDSCs should be considered as potential predictive biomarkers for chemotherapy efficacy and prognosis in NSCLC.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135349102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yingjun Wu, Xiaoyuan Bu, Xinyu Zhou, Zhilin Sha, Xintong Shi
{"title":"Polyethylenimine 2k (PEI2k)/superparamagnetic iron oxide (SPIO) nanoparticle inhibits development of hepatocellular carcinoma through targeting of c-MET and Ets-1","authors":"Yingjun Wu, Xiaoyuan Bu, Xinyu Zhou, Zhilin Sha, Xintong Shi","doi":"10.1166/mex.2023.2490","DOIUrl":"https://doi.org/10.1166/mex.2023.2490","url":null,"abstract":"This study investigates the efficacy of N-Alkyl-polyethylenimine 2 kDa–stabilized superparamagnetic iron oxide ((PEI2k/SPIO) nanoparticles on hepatocellular carcinoma (HCC) in mice and explored the underlying mechanism. Highly metastatic HCC cells were cultured and mRNA expressions of c-MET and Ets-1 were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Cell viability was detected by CCK-8 and apoptosis was assessed by flow cytometry. After establishment of animal model for HCC, the rats were administered PEI2k/SPIO nanoparticles and/or Ets-1 inhibitor through tail vein. Cell apoptosis and proliferation were then assessed by EdU experiment and flow cytometry, and the levels of c-MET, Ets-1, MMP-2 were measured as well. HCC cells presented up-regulated c-MET and down-regulated Ets-1. Treatment with PEI2k/SPIO nanoparticles resulted in decreased in c-MET expression and increased Ets-1 in both cells and animals. The PEI2k/SPIO nanoparticles significantly decreased cell proliferation and suppressed tumor growth, and induced apoptosis. Besides, additional injection of Ets-1 enhanced phosphorylation activity of MMP-2 and alleviated PEI2k/SPIO’s effect on MMP-2 expression. Nanotechnology is known to improve delivery efficiency and hence affect prognosis. This study elucidated that, PEI2k/SPIO nanoparticles suppressed malignant characteristics of HCC cells and tumor growth through down-regulation of c-MET and growth factors and up-regulation of MMP-2 and Ets-1.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135349283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Performance study and tunnel waterproofing application of polyurethane prepolymer prepared by prepolymer and acetone combination","authors":"Hui Yang, Qiao He, Dongdong Zhang","doi":"10.1166/mex.2023.2500","DOIUrl":"https://doi.org/10.1166/mex.2023.2500","url":null,"abstract":"Waterproof measures are an important guarantee to protect the tunnel structure and maintain its safe and reliable operation. With the continuous progress of science and technology, waterborne polyurethane (WPU) is widely used in various applications such as coatings and adhesives due to its excellent mechanical properties. With the presence of hydrophilic groups, it is necessary to chemically modify PU due to its reduced performance. The PU prepolymer was prepared using the prepolymer acetone combination method and was emulsified by the high gravity strengthening technology for a better synthetic process. The modified PU composite lotion (CL) was then prepared. When the acrylate content increased, the two parameters, i.e., the size and particle size distribution of PU CL, showed opposite trends. For instance, the size changed from 61.45 nm to 106.5 nm, and the particle size distribution index changed from 0.255 to 0.11. Furthermore, the compressive strength of the material is 13.7 Mpa. When the acrylate content gradually increases, the material tensile strength changes from 11.9 MPa to about 6.5 MPa, and the overall elongation at break remains within 200%–250%. In the actual test of tunnel waterproofing (TW), the water absorption rate of the modified polyurethane changes slightly and is generally kept in the range of 4%–4.5%. It has a good waterproof effect, providing a new method reference for PU CL modification and TW.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135348043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Astragaloside improves asthmatic airway inflammation mediated by inhibition of early growth response-1 through S14G-humanin","authors":"Shengnan Zhou, Youlun Li","doi":"10.1166/mex.2023.2492","DOIUrl":"https://doi.org/10.1166/mex.2023.2492","url":null,"abstract":"In this experiment, we explored the role of astragaloside in regulating Egr-1 through S14G-humanin on asthmatic airway inflammation. 64 juvenile Sprague Dawley (SD) rats were selected. After establishing rat asthma model, they were assigned into blank control group, astragaloside group, S14G-Humanin group and astragaloside+S14G-Humanin group (combined group). Astragaloside group was intervened with astragaloside II 0.6 mg/kg, S14G-Humanin group was intervened with 50 μ m S14G-Humanin, combined group RBSMCs were treated with astragaloside II 0.6 mg/kg and 50 μ M S14G-Humaninn. Airway responsiveness was assessed and pathological damage of lung tissue was assessed by HE staining along with analysis of inflammatory cells in bronchoalveolar lavage fluid (BALF), inflammatory cytokines and bone-marrow derived mesenchymal stem cells (rBMSCs) behaviors. Compared to blank control, the Penh values of astragaloside group, S14G-Humanin group and combination group were increased ( P <0.05) and pathological scores were lower with the lowest score in combined group (all P <0.05). The number of white blood cells, neutrophils, eosinophils, macrophages and lymphocytes in BALF of rats in astragaloside group, S14G-Humanin group and combination group were decreased, with the lowest number in combination group ( P <0.05). In addition, IL-4, IL-6, and IL-21 in astragaloside group, S14G-Humanin group and combination group were reduced, with the lowest levels in combination group ( P <0.05). RBSMCs proliferation and migration ability in treatment group was reduced with the lowest in combination group ( P <0.05). After up-regulating S14G-Humanin, Egr-1 mRNA expression was elevated ( P <0.05). Astragaloside can reduce inflammatory cells and inflammatory cytokines and increase the expression of Egr-1 by regulating S14G-Humanin expression.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135349275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingjing Li, Danni Zhu, Weichen Zhang, Songmei Tao, Guanghui Fan
{"title":"The mechanism of influence of kaempferol on proline-rich acidic protein 1 (PRAP1) expression after percutaneous coronary intervention (PCI) was investigated based on sini decoction and siwu decoction","authors":"Jingjing Li, Danni Zhu, Weichen Zhang, Songmei Tao, Guanghui Fan","doi":"10.1166/mex.2023.2493","DOIUrl":"https://doi.org/10.1166/mex.2023.2493","url":null,"abstract":"Coronary artery disease (CAD) is a common cardiovascular disease that is characterized by accumulation of fatty deposits. Recombinant Human Proline-Rich Acidic Protein 1 (PRAP1) expression is related to prognosis of patients after percutaneous coronary intervention (PCI). This study will be aimed at the treatment by the traditional chinese medicine Sini Decoction (SND) and Siwu Decoction (SWD), and investigate the influence of kaempferol in dried ginger on the postoperative coronary PCI, and further explore the mechanism of kaempferol on the expression of Proline-rich acidic protein 1 (PRAP1) after coronary PCI. Mesenchymal stem cells (MSCs) were isolated and induced to differentiate into endothelial progenitor cells (EPCs). After identification of EPCs by immunofluorescence and angiogenesis assay, cells were divided into high concentration of SND combined with SWD group, low concentration group, vehicle group, and negative control group. Immunofluorescence and Western blot were used to determine the expressions of β -catenin and GSK-3 β as well as PRAP1 in EPCs, whilst cell migration, proliferation and adhesion abilities were assessed. MSCs were positive for CD105 and negative for CD34 and CD45, followed by identification of EPCs with staining. Regardless of concentration, administration of SND plus SWD significantly increased EPC migration and proliferation, but decreased adhesion rate of EPCs ( P <0.05). Moreover, high concentration of SND and SWD significantly facilitated EPC growth and reduced cell adhesion ( P <0.05). Importantly, the levels of PRAP1 and GSK-3 β were elevated, and β -catenin decreased in the presence of SND and SWD, with high concentration achieving more significant alterations than low concentration. EPCs were fluorescently stained and showed proliferative properties and in vitro angiogenesis. Sini Decoction and Siwu Decoction can significantly increase β -catenin expression and decrease GSK-3 β and PRAP1 expression after PCI. Sini Decoction and Siwu Decoction can also promote cell migration and cell proliferation, and significantly reduce the adhesion ability of EPCs, so as to increase new blood vessels, improve cardiac function and protect the heart.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135349286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of nanomaterials in improving the nail-breaking performance of metal jets","authors":"Qingyu Meng, Feng Han, Bonan Jiang","doi":"10.1166/mex.2023.2498","DOIUrl":"https://doi.org/10.1166/mex.2023.2498","url":null,"abstract":"Modern science and technology development has put forward high requirements for armor performance. In this study, a coating based on nanocrystalline copper was proposed to further improve the mechanical properties of the coating and prolong the effective action time of the jet. Equal-diameter angular extrusion was adopted for the grain refinement of pure copper. Cold rolling was performed to strengthen the mechanical properties of nanocrystalline copper, laying a foundation for the follow-up work. The manufacturing process of the drug-type cover was then optimized and improved, and the two-phase theory of jet penetration was introduced to design and analyze the process in detail. Finally, simulation experiments were conducted to analyze the mechanical properties of nanocrystalline copper and the properties of the penetration process. Nanocrystalline copper had significantly improved tensile strength, yield strength, and other properties than the original material. In particular, the tensile strength increased to 195 and 208 MPa in two directions. In the penetration simulation experiment, the shaped charge performance of nanocrystalline copper increased by about 25% compared with that of the original material. Therefore, the nanocrystalline copper synthesized by equal-diameter angle extrusion can improve the jet armor-breaking performance.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135348040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}