Materials Express最新文献

{"title":"Ochratoxin A oral mycotoxin and honey dietary intake effects on TNF-α immunology response, lactic acid bacteria microbial louds, β-glucuronidase enzyme activity, some hematological and biochemical parameters on mice","authors":"Rasha A. Al-Eisa, M. Helal, Amani H. Aljahani, R. Sami, H. Banjer, Naseh A. Algehainy, Mohammad Y. Alshahrani, A. Ashour, Ali Alqarni","doi":"10.1166/mex.2023.2462","DOIUrl":"https://doi.org/10.1166/mex.2023.2462","url":null,"abstract":"The current study aimed to evaluate ochratoxin A oral mycotoxin and the dietary intake effects of four honey varieties (Nigella sativa, moringa, sidr, and pumpkin–coded as NS, MO, SI, and PU respectively), on the TNF-α immunology response, lactic acid bacteria\u0000 microbial louds (Lactobacilli and Bifidobacteria), β-glucuronidase enzyme activity, some hematological and biochemical parameters of mice. MO Honey Group + OTA Infection had the highest value of TNF-α immunology response at 445.17 pg/mL. It was followed\u0000 by PU Honey Group + OTA Infection at 360.88 pg/mL, while NS Honey Group + OTA Infection reported the lowest at 210.03 pg/mL. Honey dietary intake efficiently increased the colonic probiotic bacteria counts Lactobacilli and Bifidobacteria, in the animal’s cecum from 0.93\u0000 in SI Honey Group + OTA Infection to 2.59 in MO Honey Group + OTA Infection and from 1.78 in PU Honey Group + OTA Infection to 3.22 in NS Honey Group + OTA Infection Log 10 CFU/g, respectively. The β-glucuronidases enzyme activity in the caecum contents of mice groups ranged from\u0000 0.31 μmol/g in PU Honey Group + OTA Infection to 0.36 μmol/g in SI Honey Group + OTA Infection. Positive and negative control mice groups reported 7.22 and 6.98 × 109 L−1; 8.09 and 8.44 × 1012 L−1 for white\u0000 blood cell and red blood cell counts, respectively. The mean glutathione concentrations were from 3.17 ng/g in MO Honey Group + OTA Infection, to 4.32 ng/g in SI Honey Group + OTA Infection. Catalase activities ranged from 0.99 u/gin MO Honey Group + OTA Infection to 1.08 u/g in the PU Honey\u0000 Group + OTA Infection. Honey dietary intake decreased malondialdehyde concentrations in infected mice groups and ranged from 3.84 nmol/g in NS Honey Group + OTA Infection to 5.47 nmol/g in MO Honey Group + OTA Infection. NS Honey Group + OTA Infection reported the lowest values for alkaline\u0000 phosphatase as 70.15 U L−1, glucose as 6.12 mmol L−1, and urea as 4.89 mmol L−1. SI Honey Group + OTA Infection reported the highest values for AP as 75.52 U L−1 and urea as 5.78 mmol L−1. PU Honey Group +\u0000 OTA Infection reported the lowest value for ALT as 55.47 U L−1 and the highest value for glucose as 7.88 mmol L−1.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49484602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon-based solid acids catalyze the synthesis of ethylene glycol monoacetate from ethylene glycol and acetic acid","authors":"Z. Tian, Jidong Liu, Yida Liu, Wensong Li, Ridong Zhang, J. Lv","doi":"10.1166/mex.2023.2463","DOIUrl":"https://doi.org/10.1166/mex.2023.2463","url":null,"abstract":"Activation is essential for improving the structure and surface functional groups of carbon-based solid acids (CSA) during the preparation of carbon materials. This paper compared the catalytic activity of CSA treated non-, KOH-, H3PO4-, and ZnCl2-activation\u0000 in esterification of ethylene glycol (EG) and acetic acid (HAc) to synthesize ethylene glycol monoacetate (EGMA). The catalysts were characterized using N2 isothermal adsorption–desorption, acid-base titration, Fourier transform infrared (FT-IR) spectroscopy, scanning electron\u0000 microscopy (SEM), Raman spectrometer, X-ray photoelectron spectroscopy (XPS), and X-ray diffractometer analysis (XRD). The results showed that activation treatment clearly enhanced the CSA’s specific surface area and significantly influenced the distribution of surface functional groups.\u0000 Notably, the CSA activated with H3PO4 had a markedly higher density of –SO3H groups than the non- activated, KOH- activated, and ZnCl2-activated CSA. The high density of –SO3H on the catalyst surface is advantageous for the\u0000 synthesis of EGMA from EG and HAc, making the H3PO4-activated CSA the best performer. The reaction conditions were optimized on H3PO4-activated CSA, resulting in a 74.1% conversion of EG and an 81.8% selectivity of EGMA at 100 °C for 30 min,\u0000 and the EG/HAc molar ratio of 1:2. H3PO4-activated CSA was not obviously deactivated even after five cycles, and the decrease of its catalytic performance was related to the leaching of –SO3H on the catalyst surface. Overall, these findings suggest that\u0000 H3PO4-activated CSA offers the benefits of less cost, a simpler preparation method, and greater catalytic activity compared to other catalysts, making it a desirable option for the synthesis of EGMA.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47057512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofrequency ablation in breast-conserving surgery after neo-adjuvant chemotherapy and analysis of antibacterial effect of Ag nanogel","authors":"Hui-ming Zhang, Zihan Wang, Z. Ge, Xue Wei, X. Guan, Yinguang Gao, G. Gao, Zhongtao Zhang, X. Qu","doi":"10.1166/mex.2023.2454","DOIUrl":"https://doi.org/10.1166/mex.2023.2454","url":null,"abstract":"Radiofrequency ablation (RFA) has emerged as a treatment modality for solid tumors. However, the feasibility of RFA in treating the tumor bed in breast surgery remains investigational. Herein, we have reported the preliminary results evaluating the effect of RFA in breast-conserving\u0000 surgery (BCS), followed by neo-adjuvant chemotherapy (NAC), and the antibacterial effect of nanomaterials. From April 1, 2015 to March 31, 2017, 22 patients received NAC followed by BCS. After the lumpectomy was complete, suspicious tumor margins were ablated with radiofrequency electrodes.\u0000 The clinicopathological features and follow-up results of these patients were collected. Furthermore, the Ag nanogel was prepared for the evaluation of antibacterial activity. RFA was successful in all 22 patients during BCS. Two patients (4.5%) got skin burns and six patients (27.3%) had\u0000 solid nodules formed in situ. The median follow-up time was 22.5 months (range, 11–34 months). No patients presented local recurrences or metastasis. Moreover, 18 patients (81.8%) were satisfied with the cosmetic outcomes. The Ag nanogel has stable morphology and good bacteriostatic\u0000 effect in Escherichia coli and Bovis aureus. The RFA techniques applied in BCS after NAC have high success rates with relatively low complication rates. RFA may improve cosmetic results after BCS and enhance local tumor control. Further applications of RFA in patients treated\u0000 with BCS after NAC must be assessed in long-term studies. Nanomaterials have good antibacterial effect and can be used on the surface of medical instruments.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42308109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TiW/SiOX:Al/TiW memristor with negative differential resistance effect for neuromorphic computing","authors":"Facai Wu, T. Tseng","doi":"10.1166/mex.2023.2457","DOIUrl":"https://doi.org/10.1166/mex.2023.2457","url":null,"abstract":"Memristors, acting as artificial synapses, are proposed to be a promising candidate for neuromorphic computing applications. In this work, the CMOS process-compatible TiW/SiOX:Al/TiW memristor with negative differential resistance (NDR) effect is explored for this application.\u0000 Nonpolar switching with a 340 on/off ratio, data retention beyond 106 s, and endurance of 106 cycles are realized. The device shows excellent analog behavior with nonlinearities of 1.69 and 0.65 of long-term potentiation and depression, respectively, under identical pulse\u0000 stimuli. The synaptic features such as long-term potentiation (LTP), long-term depression (LTD), spike-timing-dependent plasticity (STDP), and paired-pulse facilitation (PPF) are mimicked. Moreover, on the basis of the symmetry and linearity of the conductance of TiW/SiOX:Al/TiW\u0000 memristor, the neural network simulation for supervised learning presents successful pattern recognition, with an accuracy of 93.11% achieved after 20 iterations. It is proposed that the nonpolar NDR switching originates from the discontinuous Al metal nanoparticles that form deeply localized\u0000 states in the energy band and result in the trap/de-trap of electronic carriers. Overall, this memristor with the NDR effect presents a unique way to simulate artificial synapse behavior for neuromorphic computing.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42767921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asiaticoside promotes heart autonomic nerve repair through receptor activator of nuclear factor kappa-B ligand pathway in coronary heart disease","authors":"Ya Li, Xiaolei Zhang, Hong Liu, Ansheng Cai, Danhua Zhao, Liming Fan, Hai-ling Ma","doi":"10.1166/mex.2023.2470","DOIUrl":"https://doi.org/10.1166/mex.2023.2470","url":null,"abstract":"This experiment intends to observe the effects of Asiaticoside on angiotensin II (AngII)-induced coronary heart disease (CHD) by regulating nuclear factor κ-B ligand receptor activator and RANK pathway (RANKL/RANK). Cardiomyocytes of rats with CHD were divided into AngII\u0000 group (2 μmol/L), blank control group, and asiaticoside group (2 μmol/L and 10 μmol/L). After 24 hours of intervention, proliferation and apoptosis was assessed. At the same time, the expressions of RANKL, RANK and α-smooth muscle actin (α-SMA)\u0000 were measured. Compared with blank group, the proliferation ability of cardiomyocytes with CHD in AngII group was significantly decreased and it increased after asiaticoside treatment (P <0.05). The apoptosis of cardiomyocytes in AngII group was higher than blank group and asiaticoside\u0000 group. Cardiomyocytes proliferation in asiaticoside group was the most obvious (P <0.05). α-SMA expression decreased in AngII group and increased after asiaticoside treatment (P <0.05). RANKL and RANK mRNA in CHD were significantly upregulated after administration\u0000 of asiaticoside (P <0.05). RANKL/RANK expression was high in normal CHD cardiomyocytes and reduced after Ang II stimulation. Asiaticoside promotes cardiomyocyte proliferation in CHD by promoting RANKL/RANK signaling, thereby reducing the possibility of heart failure in CHD.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"45 8","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41247312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the mechanism of liquiritigenin in promoting cardiomyocyte regeneration based on miRNA-34b-TIA-1-SG molecular network-mediated autophagy","authors":"Jiadi Zheng, Naiyu Zheng, Meise Lin","doi":"10.1166/mex.2023.2472","DOIUrl":"https://doi.org/10.1166/mex.2023.2472","url":null,"abstract":"This study aims to clarify that miRNA-34b affects the autophagy through regulating TIA-1-SG and explore the role of miRNA-34b-TIA-1-SG molecular network-mediated autophagy in cardiomyocyte regeneration. 32 patients with autophagy injury caused by myocardial ischemia perfusion admitted\u0000 to the hospital were included and 32 healthy controls were enrolled at the same time. ELISA was used to detect miRNA-34b level. Cardiomyocytes were isolated and cultured by adherence method and the relationship between miRNA-34b and TIA-1-SG was analyzed by dual-luciferase gene reporter assay.\u0000 The correlation between myocardial autophagy and liquiritigenin treatment was assessed along with qRT-PCR analysis of the changes of genes (TIA-1, SG, ULK1, OsATG7, FAM176A, Beclin 1). miRNA-34b expression in 32 patients with myocardial autophagy injury was higher than normal group. miRNA-34b\u0000 binds to the 3′-UTR of TIA-1 and transfection of miRNA-34b inhibitor increased the luciferase activity, which was not affected in pMIR-TIA-1-mut group, confirming the relationship between miRNA-34b and TIA-1. The addition of liquiritigenin can promote the reduction of expression of myocardial\u0000 autophagy injury-related genes. In the absence of liquiritigenin, the expression of genes related to myocardial autophagy injury increased significantly. Autophagy imbalance plays an important role in myocardial infarction, which participates in myocardial infarction. miRNA-34b can target\u0000 and regulate TIA-1 gene, promote myocardial infarction repair, and inhibit the state of autophagy by regulating autophagy-related gene TIA-1. Liquiritigenin regulates autophagy imbalance in myocardial infarction to delay myocardial remodeling and improve prognosis.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48801407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of prenatal nicotine exposure on vascular endothelial function and structure in offspring rats","authors":"Mianmian Wang, Er'mei Yu, Kunlin Zhou, Qingquan Liu, Weiwei Li, Zhenhua Wang","doi":"10.1166/mex.2023.2465","DOIUrl":"https://doi.org/10.1166/mex.2023.2465","url":null,"abstract":"To clarify the effect of prenatal nicotine exposure (PNE) on vascular endothelial function (VEF) in offspring rats, and to explore whether these effects are long-lasting and sex-dependent. Pregnant Sprague-Dawley rats were randomized into two groups and exposed to either 102\u0000 mg/mL nicotine (experimental group) or normal saline (control group) through a subcutaneously implanted osmotic micropump. Vascular rings from the thoracic aorta were collected from offspring rats at 1, 4, and 12 months of age. The specimens were used to determine VEF using functional tests\u0000 and to observe morphologic and pathologic changes of blood vessels in hematoxylin and eosin-stained samples with light microscopy. The percentage of acetylcholine-induced endothelium-dependent vasorelaxation (EDV) of the thoracic aorta was significantly higher in the experimental group than\u0000 in the control group in 1-, 4-, and 12-month-old female offspring rats (18.68±2.32 vs. 13.85±6.10, 17.44±3.91 vs. 10.77±5.77, and 30.96±22.26 vs. 18.94±13.61, respectively; P <0.05). The percentage of acetylcholine-induced EDV was significantly\u0000 lower in the experimental group than in the control group in 1-, 4-, and 12-month-old male offspring rats (10.31±4.05 vs. 16.05±14.80, 5.57±2.81 vs. 12.12±5.62, and 11.98±7.24 vs. 58.87±32.43, respectively; P <0.05). The hematoxylin &\u0000 eosin-stained vascular rings of the offspring rats displayed an uneven lumen, scattered intimal thickening, partial shedding and vacuolar degeneration of endothelial cells, and inflammatory cell infiltration and phagocytosis in the experimental group. In addition, overt smooth muscle atrophy\u0000 in tunica media, disordered cell arrangement, and unclear structure of the elastic fiber layer was observed. None of these histopathologic changes were found in the control group. In adult offspring rats, PNE not only affected the VEF of the thoracic aorta but also led to pathologic changes\u0000 in the vascular structure. Additionally, the effects of PNE on VEF were sex-specific, manifesting primarily as significantly improved VEF in female offspring rats and significantly impaired VEF in male offspring rats, lasting into adulthood.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47828111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ice treatment combined with nano-silver hydrogel nursing in operative area after microwave ablation of benign thyroid nodule","authors":"Jing Shi, Xuguang Wang","doi":"10.1166/mex.2023.2437","DOIUrl":"https://doi.org/10.1166/mex.2023.2437","url":null,"abstract":"This study aims to evaluate the effect of microwave ablation (MWA) and the effect of ice nursing combined with nano-silver hydrogel nursing on postoperative recovery. The clinical data of 120 patients with benign thyroid nodules who received MWA from January 2019 to December 2021 were\u0000 retrospectively analyzed. The patients were randomly divided into the control (60 cases) and observation (60 cases) groups. The control group received routine nursing, and the observation group received postoperative ice nursing and nano-silver hydrogel nursing on the basis of routine nursing.\u0000 Postoperative skin temperature, SF-MPQ pain scale scores, state anxiety inventory (S-AI) scores, general comfort questionnaire scores for each dimension, and incidence of postoperative adverse reactions were compared between the two groups. At admission, differences in basic data between the\u0000 two groups were statistically insignificant (P >0.05). After ice nursing and nano-silver hydrogel nursing was complete, skin temperature of the participants decreased with the extension of cold treatment time; moreover, compared to the control group, the observation group had lower\u0000 skin temperature and a lower incidence of hematoma after nursing (P <0.05). Postoperative SF-MPQ pain scores of patients decreased gradually; SF-MPQ pain scores and corresponding S-AI scores of patients in the observation group were lower than those in the control group. Compared\u0000 to that before nursing, the comfort level of patients after postoperative care significantly improved. Compared to that in the control group, the comfort score of physiological and psychological dimensions in the General Comfort Questionnaire score of the observation group was higher after\u0000 nursing, and the overall comfort score of the observation group was higher (P <0.05). There was no significant difference in the incidence of postoperative adverse reactions between the two groups. Nursing satisfaction was higher in the observation group than the control group. The\u0000 use of MWA in the treatment of benign thyroid nodule has a good effect and the incidence of postoperative adverse reactions is low. Postoperative ice nursing can reduce skin temperature in the operative area, relieve pain, and reduce psychological and physiological pressure of patients, as\u0000 well as improve nursing satisfaction. Thus, postoperative ice nursing and nano-silver hydrogel nursing has great potential in promoting postoperative recovery after MWA.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43423338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of visual perceptual training-assisted far-infrared nanomaterial-based eye relaxation system combined with chinese medicine therapy to control myopia in adolescents","authors":"Fei Liu, Bo Zhao, Mi Tian","doi":"10.1166/mex.2023.2486","DOIUrl":"https://doi.org/10.1166/mex.2023.2486","url":null,"abstract":"This study investigated the efficacy of the far-infrared eye relaxation system assisted visual perceptual training (VPT) combined with auricular point sticking (APS) in myopia. Fifty-two adolescent myopic patients were randomly divided into the comprehensive intervention and control\u0000 groups. The control group received optometry therapy, whereas the comprehensive treatment group received VPT combined with APS and supplemented with an eye relaxation system. The zinc oxide and silica nanoparticles used in the eye relaxation system could maintain good stability in acid and\u0000 alkali, and had a considerable bactericidal effect. After treatment, patients in the comprehensive intervention group showed significant improvements in ocular accommodation, visual acuity, and diopter. Furthermore, the growth rate of the axial length and intraocular pressure were significantly\u0000 controlled, while lens thickness decreased and eye fatigue improved. Thus, the combination of VPT and APS shows great potential in the myopia therapy.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43108359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on biological activity and p38 mitogen-activated protein kinases of magnetic nanoparticles on hepatoma cells","authors":"Wenyuan Zhang, Chongling Zhang, Shixin Liu, Yong-jing Yang","doi":"10.1166/mex.2023.2428","DOIUrl":"https://doi.org/10.1166/mex.2023.2428","url":null,"abstract":"This study assessed effects of magnetic nanoparticles (MNPs) on biological activity of hepatoma cells. HepG2 cells were cultured with MNPs, then morphological changes, cell proliferation, number of cell clones, apoptosis, and expressions of p38MAPK and p53 were analyzed. Hepatoma cells\u0000 in the group grew fusiform and were connected with each other, while cell density and growth connection in the group B decreased, while cell number in group C decreased with changed cell morphology changed, while the number of cells in group D was least. The number of round suspension cells,\u0000 volume, and nucleus increased, and apoptotic bodies gradually appeared. Compared with group A, groups B, C and D had lower cell proliferation rate, clone number and higher apoptosis rate (P < 0.05). The expressions of p38 MAPK and p53 in groups B, C and D was decreased (P\u0000 < 0.05). The expression of p38MAPK and p53 in other groups was different (P < 0.05). MNPs changed cell morphology, reduced proliferation and clonal ability of HepG2 cells, and accelerated apoptosis, which is related to activation of p38MAPK and p53 expression.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44628208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}