Materials Express最新文献_第9页

Behaviour of hybrid fibre reinforced polymer (HyFRP) laminates on high strength concrete (HSC) beams under flexural loading 混合纤维增强聚合物(HyFRP)层合板在高强混凝土(HSC)梁上受弯荷载的性能

4区材料科学

Materials Express Pub Date : 2023-10-01 DOI: 10.1166/mex.2023.2516

P. Somiyadevi, V. Ramasamy

{"title":"Behaviour of hybrid fibre reinforced polymer (HyFRP) laminates on high strength concrete (HSC) beams under flexural loading","authors":"P. Somiyadevi, V. Ramasamy","doi":"10.1166/mex.2023.2516","DOIUrl":"https://doi.org/10.1166/mex.2023.2516","url":null,"abstract":"In this paper, experimental studies of hybrid fibre reinforced polymer (HyFRP) laminates consisting of carbon ply fibre reinforced polymer (CFRP) and glass ply fibre reinforced polymer (GFRP) are reported on in conjunction with studies of concrete beams with high strength (HSC) under the category of with and without HyFRP laminates. The aim of this experimental work is to examine how alternative sequences of CFRP and GFRP ply of hybrid FRPs effect the enhancement of the high strength concrete beams. For the purpose of this study, there are a total of seventeen HSC beams cast. One of the beams was cast without HyFRP to act as a guiding beam, and the residual sixteen beams were cast with HyFRP using reinforced concrete and various combinations of carbon ply fibre reinforced polymer (CFRP) and glass ply fibre reinforced polymer (GFRP). The sequences in which hybrid FRP layers are attached serve as the primary variables in this test. Concrete with reinforcements after laminating beams with two, three, and even four layers of HyFRP, a load was applied in the form of static to the beams until they failed. The findings of the tests lead one to the conclusion that the repercussions of hybrid FRPs on the ductility of HSC beams are strengthened differently depending the order of the FRP layers.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135324741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sinomenine promotes ferroptosis in lung cancer cells by driving P53 gene 青藤碱通过驱动P53基因促进肺癌细胞铁下垂

4区材料科学

Materials Express Pub Date : 2023-10-01 DOI: 10.1166/mex.2023.2514

Zhengkai Xiang, Xiang Wang, Bingfeng Li, Xiaochuan Dong

{"title":"Sinomenine promotes ferroptosis in lung cancer cells by driving P53 gene","authors":"Zhengkai Xiang, Xiang Wang, Bingfeng Li, Xiaochuan Dong","doi":"10.1166/mex.2023.2514","DOIUrl":"https://doi.org/10.1166/mex.2023.2514","url":null,"abstract":"Research reports have found that sinomenine has a potentially inhibitory effect on lung cancer. At the same time, sinomenine and P53 gene show a close relationship with ferroptosis. In order to further discover the mechanism of action, this research intends to evaluate whether sinomenine can drive P53 gene through DKN2A to promote the growth of iron in lung cancer. Lung cancer cells were transfected with DKN2A overexpression plasmid followed by analysis of cell proliferation, expression of DKN2A and P53. Protein expression and cell viability were observed after P53 was inhibited by the chemical inhibitor PFT- α . To further verify histological expression, epithelial injury and apoptosis expression were detected by hematoxylin and eosin stain (H&E) and immunofluorescence. Sinomenine affects activities of lung cancer cells. After sinomenine treatment, cell shape became round, with increased cell shrinkage and death. Overexpression of DKN2A inhibited sinomenine-induced ferroptosis. P53 negatively modulated DKN2A. STAT3 was upregulated with induction of ferroptosis during lung injury. In conclusion, Sinomenine promotes ferroptosis of lung cancer cells by regulating DKN2A and P53, thereby affecting the proliferation of lung cancer cell proliferation.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135324743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the protective mechanism of neuropeptide S in neonates with hypoxic ischemic encephalopathy 神经肽S对新生儿缺氧缺血性脑病的保护机制研究

4区材料科学

Materials Express Pub Date : 2023-10-01 DOI: 10.1166/mex.2023.2525

Jun Wang, Qiong Yan

{"title":"Study on the protective mechanism of neuropeptide S in neonates with hypoxic ischemic encephalopathy","authors":"Jun Wang, Qiong Yan","doi":"10.1166/mex.2023.2525","DOIUrl":"https://doi.org/10.1166/mex.2023.2525","url":null,"abstract":"Hypoxic-ischemic brain damage (HIBD) is a severe complication of neonatal asphyxia that contributes significantly to neonatal mortality, cerebral palsy, and delays in intellectual and motor development. Neuropeptide S (NPS) plays a role in the regulation of various physiological processes. This study aimed to determine the morphological localization of NPS in hypothalamic target neurons during HIBD, providing a basis for further investigation of HIBD. Seven-day-old SD neonatal male rats were assigned to a sham group and a model group to establish the HIBD model. Then, the rats in the model group were further averagely divided into the NPS group and the normal saline group. Immunohistochemical staining of Fos immunoreactivity (Fos-IR) found that NPS administration resulted in a significant increase in the count of Fos-IR neurons in the suprachiasmatic nucleus (122%), paraventricular nucleus (108%), dorsal tuberomammillary nucleus (174% and 386%), ventromedial hypothalamic nucleus (116%), arcuate nucleus (167%), perifornical nucleus (320%), ventral tuberomammillary nucleus (441%), and lateral hypothalamic area (278%) ( P < 0.0001), compared to the normal saline group. During HIBD, NPS can protect the above neurons and activate the above target neurons in the hypothalamus to participate in the sleep and wake cycle, mood, diet, circadian rhythm, temperature and neuroendocrine regulation.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135324748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on the treatment of black and odorous water bodies in rural areas under the background of rural revitalization 乡村振兴背景下乡村黑臭水体治理研究

4区材料科学

Materials Express Pub Date : 2023-10-01 DOI: 10.1166/mex.2023.2537

Mi Duan, Hongjun Chen

{"title":"Research on the treatment of black and odorous water bodies in rural areas under the background of rural revitalization","authors":"Mi Duan, Hongjun Chen","doi":"10.1166/mex.2023.2537","DOIUrl":"https://doi.org/10.1166/mex.2023.2537","url":null,"abstract":"This research addresses the excessive presence of pollutants, such as total nitrogen (TN), total phosphorus (TP), ammonia nitrogen (NH 3 -N), and chemical oxygen demand (COD), among others, in rural water bodies that are heavily contaminated and emit a foul odor. The base substrate used in this research consists of nano-particles of ferric chloride. Subsequently, these particles undergo chemical modifications using various agents, such as hydroxybenzoic acid, sodium hydroxide, chitosan, acrylamide, sodium polyacrylate, and zinc sulfate. To alleviate the contamination and foul odor in rural water bodies, the resulting composite material was combined with microbial effective microorganisms (EM) agents and subjected to an aeration process. The findings of this study indicate a significant reduction in the chemical oxygen demand (COD) value over a 70-day experimental period. The COD concentration in the water decreased significantly from 80 mg/L to a mere 15 mg/L, resulting in a reduction percentage of approximately 68.56%. Additionally, the water quality improved from a fifth-class rating, indicating inferior quality, to a third-class rating, denoting a higher quality. The oxidation-reduction potential (ORP) value remained stable at levels below 50 mV, while the redox potential increased fivefold, effectively eliminating black and smelly water. Moreover, the levels of TN and TP also improved from inferior fifth-class to third-class water quality. This research highlights the capacity of using a combination of flocculants and microbial treatments, in aerated environments, to significantly enhance the water quality in heavily contaminated and foul-smelling rural water bodies. The proposed method exhibits the potential to efficiently remediate heavily contaminated and foul-smelling water bodies in small-scale rural regions, indicating its robust scope for future application.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135323178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total alkaloids of Sophora alopecuroides alleviate atherosclerosis by regulating macrophage pyroptosis induced by reactive oxygen species-NLRP3 signaling axis 苦参总生物碱通过调节活性氧- nlrp3信号轴诱导的巨噬细胞热亡来缓解动脉粥样硬化

4区材料科学

Materials Express Pub Date : 2023-10-01 DOI: 10.1166/mex.2023.2526

Yu Shi, Bing Han, Xianchi Li, Xiaojing Yuan

{"title":"Total alkaloids of <i>Sophora alopecuroides</i> alleviate atherosclerosis by regulating macrophage pyroptosis induced by reactive oxygen species-NLRP3 signaling axis","authors":"Yu Shi, Bing Han, Xianchi Li, Xiaojing Yuan","doi":"10.1166/mex.2023.2526","DOIUrl":"https://doi.org/10.1166/mex.2023.2526","url":null,"abstract":"Cardiovascular and cerebrovascular diseases are common diseases. This study aimed to investigate the role of total alkaloids of Sophora alopecuroides (TASA) in atherosclerosis and exploring the underlying mechanism. Mice were given normal diet (ND), high-fat diet (HFD), and TASA plus ND or HFD. The mice were further administered with NLRP3 shRNA and shControl. After treatment, Hematoxylin and Eosin and Oil Red O staining assessed histological changes. CD31/caspase-1 double staining was detected by fluorescent staining and pyroptosis expression assessed by CD31/TUNEL double staining. Western blot results determined caspase-1 expression in HFD mice. TASA treatment suppressed plaque formation in HFD-fed ApoE-/- mice but insignificantly altered the lesion area in ND-fed ApoE-/- mice. Caspase-1 content and TUNEL positive cells were significantly elevated in mice fed with HFD or ND, whilst advent of TASA further enhanced the activation of caspase-1 in HFD mice. TASA treatment reduced activity of ROS, inhibited NLRP3 inflammasome and regulated macrophage pyroptosis. Inhibition of NLRP3 decreased the lesion area of atherosclerosis and lipid deposition. TASA inhibited the expression of ROS to reduce macrophages necrosis and secretion of inflammatory mediators, thereby alleviating inflammation, delaying plaque formation and stabilizing plaques in atherosclerosis.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135323183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of nanomaterials in the treatment of medical waste in hospitals 纳米材料在医院医疗废物处理中的效果

4区材料科学

Materials Express Pub Date : 2023-10-01 DOI: 10.1166/mex.2023.2521

Xuefeng Su, Mengni Zhu, Hui Li, Yilin Li, Cheng Sun

{"title":"The effect of nanomaterials in the treatment of medical waste in hospitals","authors":"Xuefeng Su, Mengni Zhu, Hui Li, Yilin Li, Cheng Sun","doi":"10.1166/mex.2023.2521","DOIUrl":"https://doi.org/10.1166/mex.2023.2521","url":null,"abstract":"In recent years, there has been a significant increase in the amount of medical waste produced, which poses a serious threat to the environment. Within such waste, the presence of antibiotics, which are now widely used, poses a potential threat to human health. This paper investigates the ability of Fe–Mn-NAM adsorbent material made from water hyacinth extract, iron chloride, and manganese sulfate, to adsorb the antibiotics norfloxacin (NOR) and ofloxacin (OFLX) in medical solid waste. Experimental results indicated that the specific surface area of the Fe–Mn-NAM nanosorbent material was 32.56 m 2 /g, with an average pore volume of 0.083 cm 3 /g and an average pore size of 3.21 nm. The amount of antibiotics adsorbed by Fe–Mn-NAM peaked under weakly alkaline conditions, and the capacity of the material to adsorb NOR significantly exceeded that for OFLX. There was a negative correlation between the amount of Fe–Mn-NAM adsorbent material added and the adsorption of NOR and OFLX, and a positive correlation with the antibiotic removal rate. At the same adsorbent dosage, the amount of adsorption and the removal rate of NOR by the Fe–Mn-NAM adsorbent material were significantly higher than for OFLX. Through electrostatic attraction, hydrogen bonding, surface complexation, and surface hydrophobicity, the Fe–Mn-NAM adsorbent material demonstrated a certain capacity to treat and eliminate NOR and OFLX in medical solid waste.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135324745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress of nano-drug delivery systems in gastrointestinal cancer 纳米给药系统在胃肠道肿瘤中的研究进展

4区材料科学

Materials Express Pub Date : 2023-10-01 DOI: 10.1166/mex.2023.2519

Xiaoqi Guan, Ke Zhang, Xianghuang Mei, Zhipeng He, Shi Su, Jingcheng Yang, Jiake Lv, Li Yuan, Xiao Duan, Wei Guo

引用次数: 0

Differential genomic effects of four nano-sized and one micro-sized CeO₂ particles on HepG2 cells 四种纳米级和一种微型CeO2颗粒对HepG2细胞的差异基因组效应

4区材料科学

Materials Express Pub Date : 2023-10-01 DOI: 10.1166/mex.2023.2527

Sheau-Fung Thai, Carlton P. Jones, Brian L. Robinette, Hongzu Ren, Beena Vallanat, Anna Fisher, Kirk T. Kitchin

{"title":"Differential genomic effects of four nano-sized and one micro-sized CeO<sub>2</sub> particles on HepG2 cells","authors":"Sheau-Fung Thai, Carlton P. Jones, Brian L. Robinette, Hongzu Ren, Beena Vallanat, Anna Fisher, Kirk T. Kitchin","doi":"10.1166/mex.2023.2527","DOIUrl":"https://doi.org/10.1166/mex.2023.2527","url":null,"abstract":"The objective of this research was to perform a genomics study of five cerium oxide particles, 4 nano and one micrometer-sized particles which have been studied previously by our group with respect to cytotoxicity, biochemistry and metabolomics. Human liver carcinoma HepG2 cells were exposed to between 0.3 to 300 ug/ml of CeO 2 particles for 72 hours and then total RNA was harvested. Fatty acid accumulation was observed with W4, X5, Z7 and less with Q but not Y6.The gene expression changes in the fatty acid metabolism genes correlated the fatty acid accumulation we detected in the prior metabolomics study for the CeO 2 particles named W4, Y6, Z7 and Q, but not for X5. In particular, the observed genomics effects on fatty acid uptake and fatty acid oxidation offer a possible explanation of why many CeO 2 particles increase cellular free fatty acid concentrations in HepG2 cells. The major genomic changes observed in this study were sirtuin, ubiquitination signaling pathways, NRF2-mediated stress response and mitochondrial dysfunction. The sirtuin pathway was affected by many CeO 2 particle treatments. Sirtuin signaling itself is sensitive to oxidative stress state of the cells and may be an important contributor in CeO 2 particle induced fatty acid accumulation. Ubiquitination pathway regulates many protein functions in the cells, including sirtuin signaling, NRF2 mediated stress, and mitochondrial dysfunction pathways. NRF2-mediated stress response and mitochondrial were reported to be altered in many nanoparticles treated cells. All these pathways may contribute to the fatty acid accumulation in the CeO 2 particle treated cells.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135324551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel nano-siRNA delivery system loaded with anti-ESR1 siRNA for ovarian cancer clinical and nursing value assessment 新型负载抗esr1 siRNA的纳米siRNA递送系统用于卵巢癌临床及护理价值评估

4区材料科学

Materials Express Pub Date : 2023-10-01 DOI: 10.1166/mex.2023.2520

Jin Zhang, Wenhui Fan

引用次数: 0

Insulation aging diagnosis and defect location of crosslinked polyethylene cable in the distribution network based on radio frequency identification 基于射频识别的配电网交联聚乙烯电缆绝缘老化诊断与缺陷定位

4区材料科学

Materials Express Pub Date : 2023-10-01 DOI: 10.1166/mex.2023.2513

Chenggang Li, Zhaojie Chu, Liang Zhang, Jianguo Zhang, Jiagui Tao

{"title":"Insulation aging diagnosis and defect location of crosslinked polyethylene cable in the distribution network based on radio frequency identification","authors":"Chenggang Li, Zhaojie Chu, Liang Zhang, Jianguo Zhang, Jiagui Tao","doi":"10.1166/mex.2023.2513","DOIUrl":"https://doi.org/10.1166/mex.2023.2513","url":null,"abstract":"With the expansion of power grid construction, the regulatory requirements of various equipment are increasing. Further, the safe and stable operation of the distribution network plays a crucial role in the entire power system. In particular, the cables in DNs are prone to aging during long-term operation due to various factors, such as electricity and heat. Therefore, the effective diagnosis of their operating status is necessary. Crosslinked polyethylene (XLPE) is widely used as the main insulation material for cables in power systems. In this study, the microscale and macroscale performance of the molding process of XLPE cables were compared. Wireless radio frequency identification (RFID) technology was used to diagnose the aging and locate the defects of XLPE cables in the DN. The experiment noted the average insulation crosslinking degree of 88.93% and 87.98% for the suspension chain- and tower-type XLPE cables, respectively. The insulation-melting and crystallization temperatures of the suspension chain-type XLPE cable were approximately 110 °C and 92 °C, respectively, and the crystallinity was approximately 36.5%. The insulation-melting and crystallization temperatures of the tower-type XLPE cable were approximately 105 °C and 88 °C, respectively, and the crystallinity was approximately 34%. Using the wireless RFID technology, the precise positioning of the local aging and insulation damage defects in XLPE cables can be achieved. The error in locating the cable defects using the high-frequency phase spectrum of the cable was less than 0.5 m. Therefore, the study on the manufacture of XLPE cables has significant impact on the physical and chemical properties of their insulation layer. Further, the cable inspection using the wireless RFID technology provides a guarantee on the safe operation of the power system.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135323185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0