Materials Express最新文献

{"title":"Effect of different initial tempers on creep aging behavior of 2195 aluminum-lithium alloy","authors":"Liwen Zhang, Tianjun Bian, Jiping Song","doi":"10.1166/mex.2024.2627","DOIUrl":"https://doi.org/10.1166/mex.2024.2627","url":null,"abstract":"Five kinds of 2195 aluminum-lithium alloys with different initial tempers were obtained through different heat treatment methods. The creep aging test with a constant stress of 140 MPa, at 180 °C, mechanical tensile test at room temperature and the scanning electron microscope (SEM)\u0000 observation were used to study the dependence of microstructure and properties on the initial tempers of 2195 aluminum-lithium alloy under creep aging forming conditions. The results show that the creep deformation of the alloy with re-solution initial temper is the largest, followed by the\u0000 solid solution, over-aging and peak aging tempers, while the aged alloy with the regression temper has the smallest creep deformation. The order of yield and tensile strength from high to low is re-solution > solid solution > peak aging > over-aging > regression treatment. The\u0000 order of elongation to fraction from large to small is solid solution > re-solution > peak aging > over aging > regression treatment. Finally, the high-strength and ductility mechanism of the creep-aged alloy with the re-solution temper was revealed: uniformly distributed fine\u0000 strengthening phase (T1 phase) within the grain and narrowed precipitation-free zone at grain boundaries.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140089061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the pancreatic regenerative potential of Nigella sativa in diabetic rats: Evaluation of histological changes and transcription factors pdx-1 and neurog-3 levels","authors":"Fatima S. Alaryani","doi":"10.1166/mex.2024.2685","DOIUrl":"https://doi.org/10.1166/mex.2024.2685","url":null,"abstract":"Pancreatic β cell neogenesis and proliferation represent promising avenues for diabetes management. Nigella sativa, known for its potent anti-inflammatory and antioxidant properties, has demonstrated efficacy in promoting regeneration across various organ systems.\u0000 This study investigates the potential of Nigella sativa in pancreatic regeneration by examining pancreatic histology in addition, the expression levels of the key transcription factors, comprising NEUROG-3, PDX-1, INS-1, and INS-2. Twenty-four rats were categorized in 4sets that is\u0000 negative control, positive control, normal, and treatment. Diabetes was prompted through intraperitoneal administration of alloxan hydrate. After 21 days of diabetes induction, the treatment set was applied with N. sativa extract, the positive control set was administered Glibenclamide,\u0000 while the negative control group received no treatment. Parameters such as biochemical markers, oxidative stress markers, pancreatic islet architecture changes, and the expression levels of the NEUROG-3, PDX-1, INS-1, and INS-2 were assessed. Data analysis, conducted through DMR Test and ANOVA\u0000 with a 5% threshold of significance, revealed significant insights into the consequence of N. sativa on the parameters under investigation. The results propose a possible part for N. sativa in promoting pancreatic regeneration and warrant further exploration for its application\u0000 in diabetes management.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140090014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The performance improvement of basketball shell prepared with nanomaterials modified rubber supported by wet mixing method","authors":"Hui Wang, Ling Cao, Hejun Shao, Chen Xue","doi":"10.1166/mex.2024.2653","DOIUrl":"https://doi.org/10.1166/mex.2024.2653","url":null,"abstract":"This study investigates the performance of rubber composite combined with carbon nanotubes to improve its physicochemical properties during the vulcanization process, thereby improving the quality of basketballs. Natural rubber and butyl rubber were mixed in a 7:3 ratio to prepare a\u0000 rubber composite. Subsequently, the rubber composite was mixed with carbon nanotubes. The results demonstrate that the rubber nanocomposite prepared using wet mixing exhibits thermal aging resistance. Furthermore, the rubber nanocomposite demonstrates excellent vulcanization characteristics,\u0000 which can achieve a reduction in the cure time of the rubber nanocomposite exceeding 10%. Additionally, the rubber nanocomposite shows good compatibility and mechanical properties, such as elongation at break, hardness, swelling coefficient, and cross-linking density. Notably, under high sulfur\u0000 and low sulfur conditions, the decrease in tensile strength of the rubber nanocomposite is significantly smaller compared to that under the normal conditions, indicating a substantial enhancement in flexural resistance for this rubber nanocomposite. In conclusion, the prepared rubber nanocomposite\u0000 shows an improvement in mechanical properties, which holds valuable implications for enhancing the quality of rubber basketballs and promoting applications of rubber products.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140090056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-microcapsules loaded with nano-antibacterial agents for long-term inhibition of drug-resistant strains","authors":"Ke He, Fu Pengjiazi, Yanqi Wu, Yanting He, Qing Hu, Jia Wu, Guangxun Cui, Jun Zhang, Jun Jin","doi":"10.1166/mex.2024.2570","DOIUrl":"https://doi.org/10.1166/mex.2024.2570","url":null,"abstract":"There are growing concerns and worries about the safety of public facilities and equipment. Therefore, coating products with antibacterial properties have become the key to solve this problem, and there is an urgent need to develop new antibacterial architectural coatings. In this study,\u0000 polystyrene nano-microspheres (PS NMS) were prepared from styrene as raw material. PS nano-microcapsules (PS NMC) were prepared by solute co-diffusion method (SCM) using PS NMS as a template, which were modified to obtain PS-OH NMC. CuS nanoparticles (CuS NPs) with antibacterial activity were\u0000 further loaded to prepare CuS@PS-OH NMC with long-term antibacterial activity. The SEM results showed that the particle size of CuS@PS-OH NMC was about 410 nm, which was larger than that of PS-OH NMC. The characterization of UV and IR spectra confirmed that CuS NPs were not only encapsulated\u0000 into PS NMC in large quantities, but also adhered to its surface in a small amount. CuS@PS-OH NMC has good water solubility and can slowly release Cu2+, showing good long-term antibacterial properties against Methicillin-resistant Staphylococcus aureus (MRSA). The CuS@PS-OH\u0000 NMC developed in this study has excellent performance, good antibacterial effect, environmental friendliness, low price, etc. More importantly, it can efficiently and long-term inhibit MRSA, and can be used as a potential antibacterial architectural coating for special scenarios such as hospitals,\u0000 schools and densely populated places, which has excellent social and economic value.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140086294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanism of intravenous immunoglobulin (IVIG) in vascular endothelial injury in kawasaki disease based on neutrophil extracellular traps","authors":"Fengzhi Wu, Wei Zhang, Gaoyang Duan, Yao Guo, Mingsheng Tang, Fengzhi Jiang, Haiqiao Zhang","doi":"10.1166/mex.2024.2690","DOIUrl":"https://doi.org/10.1166/mex.2024.2690","url":null,"abstract":"This study explores the role of Neutrophil extracellular traps (NETs) in kawasaki disease (KD)-induced vascular inflammatory injury and the protective effect and mechanism of IVIG on vascular endothelial damage. A total of 37 children diagnosed with KD and admitted to Dongguan maternal\u0000 and Child Health Care Hospital between March 2020 and June 2022 were included in the study. The children were divided into different groups based on their treatment and the presence or absence of coronary artery damage: IVIG treatment group (KDIVIG group), subgroup with coronary\u0000 artery damage (KDCAL group), and subgroup without coronary artery damage (KDNCAL group), and a Control group consisting of 9 children who underwent surgical treatment. Flow cytometry was used to detect the proportion of neutrophils and the number of NETs in peripheral\u0000 blood. It was found that the proportion of neutrophils in the peripheral blood of the acute KD group significantly increased with the presence of NETs. RT-PCR and ELISA detection showed that the levels of inflammatory factors TNF-α, IL-6 and CitH3 were abnormally elevated in this\u0000 acute KD group, and the CAL group exhibited higher proportions of neutrophils and NETs-related markers compared to the NCAL group, while the IVIG group had significantly decreased proportions of neutrophils. PMA culture of neutrophils induced an increase expression of NETs marker protein,\u0000 the content of NETs cfDNA increased. NETs culture could promote the secretion of TNF-α, whereas IVIG cultured cells inhibited the secretion of TNF-α. Finally, HCAEC cells were cultured with different levels of TNF-α, and the function of HCAEC cells was\u0000 assessed using CCK8, scratch assay and flow cytometry. The high expression of TNF-α in the NETs group inhibited the proliferation and migration of HUVEC cells and enhanced their apoptosis. In contrast, the IVIG culture group exhibited similar effects to the TNF-α\u0000 monoclonal antibody, as it inhibited HUVEC cell apoptosis and improved their viability by reducing TNF-α expression. Total protein was extracted from the cells using nano-magnetic beads, and RT-PCR and western blot detection indicated that the increase of TNF-α expression\u0000 could increase the phosphorylation of NF-κB and and the expression of MMP-9. However, when TNF-α was inhibited by IVIG and TNF-α monoclonal antibody culture, the activity of NF-κB/MMP-9 athway was decreased. Therefore, IVIG may inhibit the\u0000 production of NETs in KD children, thereby reducing TNF-α/NF-NF-κB/MMP-9 mediated inflammatory response process and protecting the function of vascular endothelial cells.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140087001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effect of saikosaponin-d on airway allergy in asthma","authors":"Yandan Yin, Guiying Ruan, Qunyan Su, Lingfei Li, Nan Zheng, Yan Hong","doi":"10.1166/mex.2024.2679","DOIUrl":"https://doi.org/10.1166/mex.2024.2679","url":null,"abstract":"Saikosaponin-d (SSd) is a compound extracted from Bupleurum chinense, a traditional ethnic medicine known for its antipyretic and analgesic properties. In this study, our research group established a mouse allergic asthma model with ovalbumin (OVA) as the inducer, and evaluated\u0000 the therapeutic effects of different SSd groups. We measured lgE levels, cytokine levels, and the number of innate lymphocytes 2 (ILC2) to assess the effect of SSd on allergic asthma, and detected miR-155 expression. The results show that SSd reduces the levels of inflammatory factor in asthmatic\u0000 mouse models, alleviating airway inflammation by inhibiting the regulation of lung ILC2. At the same time, it can reduce the downstream inflammatory level factors. In addition, SSd reduced the expression of miR-155 in the lung. These results suggest that SSd plays an important role in the\u0000 treatment of airway inflammation, and its mechanism may be related to the regulation of miR-155.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140086909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on aluminum matrix composites reinforced by medium and high volume fraction hybrid particles","authors":"Zeyi Hu, Puyu Li, Caihe Fan, Yinchun Xiao, Jingyue Huang, Wudan Ma","doi":"10.1166/mex.2024.2673","DOIUrl":"https://doi.org/10.1166/mex.2024.2673","url":null,"abstract":"Aluminum matrix composites reinforced with particles offer many advantages, including high specific strength, elevated specific stiffness, reduced thermal expansion coefficient, enhanced thermal conductivity, abrasion resistance, and dimensional stability. These composites find extensive\u0000 application in aerospace, electronic packaging, and weaponry. The concept of hybrid particle reinforcement, involving multiple reinforcing particles, optimizes the performance attributes of each phase and the synergistic reinforcement effect, leading to potentially superior hybrid particle-reinforced\u0000 aluminum matrix composites. This paper presents a comprehensive overview of the methods for preparing particle-reinforced aluminum matrix composites. It examines the toughening mechanisms in aluminum matrix composites reinforced with hybrid particles at medium and high volume fractions. These\u0000 mechanisms include fine grain reinforcement, Orowan reinforcement, and heterogeneous deformation-induced reinforcement, including geometrically necessary dislocation reinforcement. This paper elucidates the role of micronano organizational structures-such as the morphology, size, distribution,\u0000 and interfacial bonding state of hybrid particles and matrix-in determining the comprehensive performance of aluminum matrix composites. Additionally, it explores the effect of hybrid particle morphology, size, distribution, and micronano structure on the composite’s overall performance.\u0000 Finally, future research directions and trends in the development of high-performance hybrid particle-reinforced aluminum matrix composites are discussed.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140092014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platinum nanozyme co-loaded reactive oxygen species-responsive prodrug integrated with dissolvable microneedle for chemotherapy and photodynamic therapy of melanoma","authors":"Yuwen Chen, Shiqin Peng, Hao Zhou, Ying Hao","doi":"10.1166/mex.2024.2638","DOIUrl":"https://doi.org/10.1166/mex.2024.2638","url":null,"abstract":"Melanoma, the most aggressive form of skin cancer, is characterized by an increasing incidence rate. However, conventional treatment methods such as surgery, chemotherapy, radiotherapy, and immunotherapy have limitations that hinder their widespread application. In this study, we aim\u0000 to develop a platinum nanozyme (PtNP) co-loaded reactive oxygen species (ROS)-responsive prodrug integrated with dissolvable microneedle for chemotherapy and photodynamic therapy of melanoma. The utilization of microneedle can significantly enhance the efficiency of transdermal drug delivery\u0000 while improving treatment efficacy and minimizing toxic side effects. The nanodrug system incorporates a prodrug composed of chemotherapeutic agent, photosensitizer, and ROS-responsive chemical bond. Upon laser irradiation, it generates ROS for effective photodynamic therapy while precisely\u0000 controlling the release behavior of camptothecin (CPT) within the prodrug formulation. Furthermore, PtNP in the nanodrug exhibits nanozyme-like activity by catalyzing the decomposition of hydrogen peroxide into oxygen to overcome hypoxia-related challenges and enhance the effectiveness of\u0000 photodynamic therapy. The integration of the nanodrug complex with dissolvable microneedle presents a synergistic approach for the combined delivery of chemotherapy and photodynamic therapy to melanoma patients, offering novel strategies and avenues for clinical treatment.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140090312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based care combined with chlorhexidine gluconate antimicrobial dressing in the prevention of peritoneal dialysis catheter-associated infections","authors":"Zuping Wang, Zhang Lin, Fayiza Aikelamu, Gulixian Tuerhong","doi":"10.1166/mex.2024.2601","DOIUrl":"https://doi.org/10.1166/mex.2024.2601","url":null,"abstract":"To effectively prevent catheter-related infections during peritoneal dialysis (PD), we have applied evidence-based care (EBC) and chlorhexidine gluconate antimicrobial dressings (CHGAD) to the management of PD patients. CHGAD demonstrated good hygroscopic properties, effectively preventing\u0000 the pooling of blood and exudate at the catheter outlet. Additionally, CHGAD could effectively inhibit the activity of G+ and G− bacteria, providing effective antibacterial effect on the wound. Furthermore, we found that CHGAD also exhibited good biocompatibility without affecting the\u0000 activity of fibroblasts. Patients undergoing PD treatment were randomly assigned to either the control or EBC group. The control group received standard care while the EBC group received EBC along with CHGAD. Subsequently, we compared patient- and healthcare-related risk factors, treatment\u0000 adherence, self-care, catheter infection rates, and satisfaction between the two groups. The results demonstrated that EBC effectively reduced risk factors for catheter infections by improving compliance rate of patients’ Hb, HbA1c, and Alb level, as well as hand hygiene compliance,\u0000 dialysis water management, high-frequency contact table, disinfection and isolation, and catheter maintenance during dialysis. Furthermore, EBC improved patients’ treatment adherence, self-care ability, and participation in PD catheter management. The combination of EBC and CHGAD effectively\u0000 reduced the incidence of catheter infections and improved patient satisfaction with care. Consequently, EBC combined with CHGAD shows significant potential in the management of catheter infections in PD patients and should be advocated in clinical practice.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140085212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation of propofol-induced hippocampal neuron damage in developing rats by dexmedetomidine","authors":"Huamei Wang, Shenghua Li, Aifeng Tang","doi":"10.1166/mex.2024.2623","DOIUrl":"https://doi.org/10.1166/mex.2024.2623","url":null,"abstract":"This study explored the mechanism of dexmedetomidine attenuating propofol damage to hippocampal neurons in rats. By constructing rat hippocampal neuron model and carrying out targeted intervention; enzyme linked immunosorbent assay (ELISA) detected IL-1β and IL-18 levels;\u0000 while Nissl staining observed hippocampus Histopathology; flow cytometry quantitatively analyzed the number of hippocampal neuron cells and apoptosis rate. Moreover, levels of PKA, Caspase-1 and NOD-like receptor thermal protein domain associated protein 3(NLRP3) and corresponding proteins\u0000 were measured. Results showed that, there were more Nissl bodies in cytoplasm of hippocampal neurons in control group, and distribution in the cytoplasm was relatively uniform. Moreover, IL-1β and IL-18 in model group continued to increase; while dexmedetomidine effectively inhibited\u0000 apoptosis of hippocampal neurons, which may be related to decreased expression of protein kinase A (PKA). After using PKA inhibitors, apoptosis was significantly inhibited, and when the expression of PKA was reduced, Caspase-1 was down-regulated along with reduced NLRP3 level, which improved\u0000 the injury of hippocampal neurons. Dexmedetomidine can therefore down-regulate the level of Caspase-1 in hippocampal neurons by inhibiting the PKA signaling pathway, improving apoptosis, reducing the genetic and protein expressions of NLRP3, and slowing down the damage of hippocampal neurons.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140088302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}