Materials Express最新文献

Highly temperature-sensitive, photothermal, and robust intelligent hydrogels tailored for the NIR-II biological window 为NIR-II生物窗口量身定制的高度温度敏感，光热和坚固的智能水凝胶

4区材料科学

Materials Express Pub Date : 2024-08-01 DOI: 10.1166/mex.2024.2722

Guanghui Yang, Shao-Zhen Yi, Shurong Du, Jialin Gao, Xuejuan Wan

{"title":"Highly temperature-sensitive, photothermal, and robust intelligent hydrogels tailored for the NIR-II biological window","authors":"Guanghui Yang, Shao-Zhen Yi, Shurong Du, Jialin Gao, Xuejuan Wan","doi":"10.1166/mex.2024.2722","DOIUrl":"https://doi.org/10.1166/mex.2024.2722","url":null,"abstract":"Combining PNIPAM with a biocompatible NIR-II photothermal agent to prepare near-infrared-responsive hydrogels holds significant importance in the field of biomedical applications. In this study, PNIPAM/Bacterial cellulose (BC)/MXene composite hydrogels were prepared by in-situ polymerization, where Nb 2 C MXene serving as a near-infrared photothermal agent and BC acting as enhancing filler. The composite hydrogels possess a semi-interpenetrating network structure, where PNIPAM serves as the crosslinking network backbone, and BC act as a semi-interpenetrating network, which significantly enhances the mechanical strength of the composite hydrogels. The tensile strength and compressive strength reach 35 KPa and 500 KPa, respectively, which is an order of magnitude higher than that of pure PNIPAM hydrogel. The introduction of BC and MXene did not significantly affect the thermo-sensitivity of the composite hydrogel which can rapidly undergo a phase transition and release internal moisture above LCST. Morover, the composite hydrogel exhibits excellent photothermal performance, with its temperature rapidly increasing to around 70 °C under the irradiation of 1064 nm laser. The degree of temperature fluctuations can be accurately regulated by modifying the laser intensity and exposure time. Additionally, it demonstrates good photothermal cycling stability and significant potential for photothermal therapy.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"14 8","pages":"1113-1125"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antitumor activity of DABA-containing carboxylate Zn complexes on breast cancer cell line MCF-7 含daba羧酸锌配合物对乳腺癌细胞系MCF-7的抗肿瘤活性

4区材料科学

Materials Express Pub Date : 2024-08-01 DOI: 10.1166/mex.2024.2721

Xiaoliu Liu, Wenyan Wu, Xiaojun Tan, Weizhao Lu, Dudu Wu, Yongdui Ruan, Zhi Chen, Hongmei Mo

{"title":"Antitumor activity of DABA-containing carboxylate Zn complexes on breast cancer cell line MCF-7","authors":"Xiaoliu Liu, Wenyan Wu, Xiaojun Tan, Weizhao Lu, Dudu Wu, Yongdui Ruan, Zhi Chen, Hongmei Mo","doi":"10.1166/mex.2024.2721","DOIUrl":"https://doi.org/10.1166/mex.2024.2721","url":null,"abstract":"The coordination polymer [Zn 2 (DABA) 3 (CH 3 OH)] (DABA = 4-dimethylaminobenzoic acid) (ZP) was synthesized via hydrothermal method using DABA and Zn(NO 3 ) 2 · 6H 2 O as precursors. The structure of ZP was elucidated through thermogravimetric analysis (TGA), Fourier-transforms infrared spectroscopy (FTIR), and single-crystal X-ray diffraction. The cytotoxic effects of ZP on various cell lines (A549, HepG2, Huh-7, MCF-7, LO2) were assessed using the Cell Counting Kit-8 (CCK-8) assay, revealing significant toxicity towards the MCF-7 cell line and minimal toxicity towards normal hepatocytes (LO2). Further analysis on the MCF-7 cell line using flow cytometry showed that ZP induced cell cycle arrest at the S phase and markedly decreased mitochondrial membrane potential. Western blot analysis demonstrated that ZP could increase the expression levels of cleaved poly(ADP-ribose) polymerase (PARP), cleaved caspase, and Bax proteins, while decreasing the expression of Bcl-2. These findings indicate that ZP promotes apoptosis in tumor cells through a mitochondria-mediated pathway, involving the modulation of Bcl-2 family proteins and caspases.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"14 8","pages":"1147-1154"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147904633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable hydrogels containing heparin and sodium alginate: Preparation, biocompatibility, and potential applications 含有肝素和海藻酸钠的可注射水凝胶：制备、生物相容性和潜在应用

4区材料科学

Materials Express Pub Date : 2024-08-01 DOI: 10.1166/mex.2024.2727

Li-Peng Wan, Chang-yuan Nie, Yuqing Wang, Yijie Zhang, Xiaoya Zhang, Yi-min Liao, Hong Zhang

引用次数: 0

The protective role of chemokines 12 and chemokines 4 by mediating interleukin-6 in delayed diabetic foot wound healing 趋化因子 12 和趋化因子 4 通过介导白细胞介素-6 在糖尿病足伤口延迟愈合中的保护作用

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-01-01 DOI: 10.1166/mex.2024.2575

Chaoyan Yin, Yuan Lin, Fan Zhang, Xiaofen Lian

{"title":"The protective role of chemokines 12 and chemokines 4 by mediating interleukin-6 in delayed diabetic foot wound healing","authors":"Chaoyan Yin, Yuan Lin, Fan Zhang, Xiaofen Lian","doi":"10.1166/mex.2024.2575","DOIUrl":"https://doi.org/10.1166/mex.2024.2575","url":null,"abstract":"Refractory diabetic foot ulcer is commonly encountered in clinical practice and it is hardly cured with a long duration of treatment and a high expense, as such problem involves multiple disciplines. Therefore, in case of refractory wounds, it is necessary to first analyze the causes, general or local. Immunohistochemistry (IHC) was conducted to determine α-SMA, chemokines 12 (CXCL12) and chemokines 4 (CXCR4) levels in pancreatic tissues and distant normal pancreatic tissues. Cells were treated with recombinant human CXCL12 (rhCXCL12) or the CXCR4 antagonist AMD3100. After treatment, Western blot determined FAK-AKT and ERK1/2 expression in islet cells, whilst ELISA detected the content of IL-6 and IL-8. rhCXCL12 increased the expression and secretion of Interleukin-6 (IL-6) time- and dose-dependently. But the advent of CXCR4 antagonist abrogated the protective effect of rhCXCL12. rhCXCL12 exhibited a protective effect on apoptosis, but this effect was abrogated by down-regulation of IL-6 with AMD3100. In addition, rhCXCL12 increased the phosphorylation of FAK, ERK1/2, AKT, and P38 and inhibition of FAK inhibited IL-6 expression. FAK inhibition almost completely blocked CXCL12-induced activation. This study demonstrates that CXCL12/CXCR4 pathway mediates the expression of IL-6 to enhance healing of refractory diabetic foot wounds by down-regulating the FAK pathway.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"4 9","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139124940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Settlement rule of underpass railway model in shield tunnel and influence of nanomaterials on slurry performance during construction 盾构隧道下穿铁路模型的沉降规律及施工过程中纳米材料对泥浆性能的影响

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-01-01 DOI: 10.1166/mex.2024.2582

Ying Li, Minji Wang, Yawen Yang, Haoran Guo, Yilin Zhou

{"title":"Settlement rule of underpass railway model in shield tunnel and influence of nanomaterials on slurry performance during construction","authors":"Ying Li, Minji Wang, Yawen Yang, Haoran Guo, Yilin Zhou","doi":"10.1166/mex.2024.2582","DOIUrl":"https://doi.org/10.1166/mex.2024.2582","url":null,"abstract":"In the shield tunnel, the phenomenon of structure penetration occurs frequently. Therefore, strict control of ground subsidence is imperative during the construction phase. In addition, other variables may be influence the performance of the slurry during the grouting procedure. This study aims to investigate and analyze the impact of nanomaterials on the properties of slurry used in construction, with the goal of determining the optimal construction route for the shield, ensuring quality construction of a U-shaped section, and meeting settlement control requirements. Firstly, the impact of double line spacing on the subsidence of U-shaped grooves is analyzed. Subsequently, the influence of common nanomaterials on slurry properties is examined through compressive strength testing. Among these nanomaterials, micro-silica powder exhibits the most significant enhancement effect on construction slurry performance with an optimal content of 5%. If the content of silica powder reaches 5%, the initial strength and later strength of the cement slurry will increase by 35% and 25% respectively, thereby promoting the enhanced performance of the slurry. In this study, the settlement of a U-shaped groove on the surface and subgrade is controlled by the settlement of a shield tunnel underpass railway model based on the distance between shield construction lines, providing valuable insights for future constructions with similar characteristics.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"26 21","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139126295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The inhibitory effect of cisplatin combined with pemetrexed on lung cancer cells via targeting miR-135 and ATG7 顺铂联合培美曲塞通过靶向 miR-135 和 ATG7 对肺癌细胞的抑制作用

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-01-01 DOI: 10.1166/mex.2024.2588

Dong Xie, Gang Zhou, Wei Zhang, Y. Gao, Xing Cai, Yang Cai, Zhiyun Liu, Weijun Zhao

引用次数: 0

Effects of surface scratches on thermal damage characteristics of SiO2 表面划痕对二氧化硅热损伤特性的影响

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-01-01 DOI: 10.1166/mex.2024.2598

Sisi Xie, Wenze Dong, Wenming Wu, Yanxin Xie, Fangfang Du

引用次数: 0

Regulatory mechanism of LINC00657/MiR-26b in the TNF-α/NF-κB pathway for the progression of colorectal cancer LINC00657/MiR-26b在TNF-α/NF-κB通路中对结直肠癌进展的调控机制

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-01-01 DOI: 10.1166/mex.2024.2592

Shengjun Zhang, Minli Liu, Ajing Zhao, Anrui Zhang, Yawei Li, Xiaobao Li

{"title":"Regulatory mechanism of LINC00657/MiR-26b in the TNF-α/NF-κB pathway for the progression of colorectal cancer","authors":"Shengjun Zhang, Minli Liu, Ajing Zhao, Anrui Zhang, Yawei Li, Xiaobao Li","doi":"10.1166/mex.2024.2592","DOIUrl":"https://doi.org/10.1166/mex.2024.2592","url":null,"abstract":"This study investigates the effect of long-chain non-coding LINC00657 on cell proliferation and apoptosis in colorectal cancer and its molecular mechanism based on magnetic nanocarriers for gene delivery. Tumor tissues were collected from patients with colorectal cancer (CRC) to examine the expression of LINC00657. Magnetic nano microspheres were prepared and CRC cells were transfected with short hairpin RNA (shRNA) targeting LINC00657 to establish a stably transfected cell line. The binding relationship between LINC00657 and MicroRNA-26b (MiR-26b) was also verified using a dual-luciferase gene reporter assay. The expression of LINC00657 and MiR-26b were determined by qRT-PCR and Western blot. Cell proliferation, migration, and apoptosis were assessed. Our findings reveal that LINC00657 is highly expressed in CRC tissues and cells, significantly promoting hepatoma carcinoma cell proliferation and migration. Furthermore, we demonstrate that MiR-26b can target and bind to LINC00657, while its expression decreases in CRC cells. Knockdown of LINC00657 resulted in significant downregulation of both MiR-26b expression levels and tumor necrosis factor-α (TNF-α)/nuclear factor-kappa B (NF-κB) pathway activity. However, co-transfection of a MiR-26b inhibitor into sh-LINC00657-transfected cells attenuated the effects on malignant phenotypes while activating TNF-α/NF-kB pathway activity. Conversely, transfection of an NF-kB activator exerted similar effects as the MiR-26b inhibitor by enhancing malignant proliferation ability in CRC cells. Overall, the upregulation of LINC00657 potentially modulates the proliferation and apoptosis of colorectal cancer cells through its interaction with MiR-26b, leading to the activation of the TNF-α/NF-κB signaling pathway.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"3 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139125954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy and short-term prognosis of butylphthalide sodium chloride injection combined with edaravone dextroborneol in acute stroke 丁苯酞氯化钠注射液联合依达拉奉-右旋糖酐治疗急性脑卒中的临床疗效和短期预后

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-01-01 DOI: 10.1166/mex.2024.2586

Guangyu Cao, Jianju Zhou, Guoqing Yu, Xiaohong Fu, Bo Xiong

{"title":"Clinical efficacy and short-term prognosis of butylphthalide sodium chloride injection combined with edaravone dextroborneol in acute stroke","authors":"Guangyu Cao, Jianju Zhou, Guoqing Yu, Xiaohong Fu, Bo Xiong","doi":"10.1166/mex.2024.2586","DOIUrl":"https://doi.org/10.1166/mex.2024.2586","url":null,"abstract":"Stroke is one of the important causes of death of patients. Both butylphthalide sodium chloride injection (BSCI) and edaravone dextroborneol (ED) show a curative effect. We intend to assess their effect on acute stroke. Patients with acute ischemic stroke diagnosed by our hospital in the past were included as research objects and different treatment methods were used to divide them into different groups. The research group was given combined treatment (BSCI and ED). The normal group chose one of the drugs as treatment. The curative effect was recorded. The neurological deficit score, the commonly used clinical infection markers mainly include IL-6, CRP and TNF-α, and the Barthel index widely used in the field of rehabilitation and elderly patients, hemorheology index and the expression of NSE were evaluated. The changes before and after medical level were compared with the adverse reaction group during the treatment. The analysis of Barthel index reflected that the effective rate was higher than normal group. Changes in neural functions were decreased than normal group (P <0.05) and the adverse reactions in the curing process were lower in both groups, but there was no statistical difference (P >0.05). Our research shows that combined therapy can improve drug efficacy by reducing the expression of cytokines and it does not bring about an increase in toxic and side effects. Combination therapy improves neurological function, reduces cytokine secretion, improves drug efficacy, and has a high drug safety.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"57 4","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139126202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-760 inhibits lung cancer cells through mitogen-activated protein kinase signaling pathway miR-760 通过丝裂原活化蛋白激酶信号通路抑制肺癌细胞

IF 0.7 4区材料科学

Materials Express Pub Date : 2024-01-01 DOI: 10.1166/mex.2024.2587

Jiao He, Yaolan Zhen, Lei Liu

{"title":"miR-760 inhibits lung cancer cells through mitogen-activated protein kinase signaling pathway","authors":"Jiao He, Yaolan Zhen, Lei Liu","doi":"10.1166/mex.2024.2587","DOIUrl":"https://doi.org/10.1166/mex.2024.2587","url":null,"abstract":"Our study assesses miR-760’s role in the proliferation, invasion and migration of non-small cell lung cancer (NSCLC) cells. Lung cancer A549 cells were assigned into BL group (no transfection), ZN group (transfection of NC), and ZM group (transfection of miR-760 mimics). The miR-760 level, cell viability, apoptosis, invasion, migration ability, ERK1, JNK, and p38MAPK protein expression were analyzed using Real Time Quantitative polymerase chain reaction (RT-qPCR), MTT, Hoechst33258 fluorescence staining, Transwell cell, cell scratch test, and Western blot. Compared with other groups, miR-760 expression in ZM group was the highest, indicating a successful transfection (P <0.05). 48, 72, and 96 hours later, A549 cell viability in ZM group was the lowest with a significant difference from other groups (P <0.05). The cell viability reached a peak after 96 hours of culture (P <0.05) with higher cell viability of BL group than ZN group (P >0.05). A549 cells in ZM group showed significantly higher cell apoptosis rate and lower cell invasion rate than ZN and BL group (P <0.05). The number of cell invasion (220.71±15.37) and migration in BL group (220.37±17.60) is similar to ZN group (215.32±15.62 and 217.26±15.94) (P >0.05). In addition, cell migration number in ZM group (99.62±12.01) was less than ZN and BL group (P <0.05). ERK1, JNK and p38MAPK protein expression in ZM group was the lowest (P <0.05) and those in BL group was close to ZN group (P >0.05). Upregulating miR-760 in A549 cancer cells can inhibit cell proliferation via regulation of MAPK signaling pathway.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"20 4","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139128189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0