新型负载抗esr1 siRNA的纳米siRNA递送系统用于卵巢癌临床及护理价值评估

IF 0.7 4区材料科学 Q3 Materials Science

Materials Express Pub Date : 2023-10-01 DOI:10.1166/mex.2023.2520

Jin Zhang, Wenhui Fan

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引用次数: 0

摘要

在全球范围内，卵巢癌是妇女最常见的癌症之一，也是癌症死亡的最常见原因之一。研究人员一直致力于研究卵巢癌的新治疗方法。本研究设计并合成了一种负载抗esr1 siRNA的新型纳米siRNA递送系统。评价其在卵巢癌中的临床及护理价值，并探讨其作用机制。首先，通过CCK-8法测定新化合物对卵巢癌细胞活力的抑制活性。其次，通过实时RT-PCR检测卵巢癌细胞中雌激素受体的相对表达量。结果表明，负载抗ER α siRNA的新型纳米siRNA递送系统可以负向调节ER α的表达，抑制卵巢癌的进展。

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Novel nano-siRNA delivery system loaded with anti-ESR1 siRNA for ovarian cancer clinical and nursing value assessment

Globally, ovarian cancer is one of the most common cancers in women and one of the most common causes of cancer death. Researchers have been committed to investigating new treatment methods for ovarian cancer. In the present study, a new nano-siRNA delivery system loaded with anti-ESR1 siRNA was designed and synthesized. Its clinical and nursing value for ovarian cancer was evaluated, and the related mechanism was explored. First, the inhibitory activity of the new compound on the viability of ovarian cancer was measured via CCK-8 assay. Second, the relative expression of the estrogen receptor in the ovarian cancer cells was determined through real-time RT-PCR detection. Results revealed that the novel nano-siRNA delivery system loaded with anti-ER α siRNA could negatively regulate the expression of ER α and suppress the progression of ovarian cancer.

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来源期刊

Materials Express NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

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0.00%

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审稿时长

>12 weeks

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