硝酸甘油或皮质扩张抑制诱导的偏头痛大鼠模型的脑组织代谢组学研究

IF 0.7 4区材料科学 Q3 Materials Science

Materials Express Pub Date : 2024-01-01 DOI:10.1166/mex.2024.2579

Jiansheng Yang, Di Wu, Liling Zeng, Minzhi Zhong, Tianshan Liang, Honghong Jiang, Qiang Liu, Yanhua Wu, Hui Li

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引用次数: 0

摘要

本研究通过代谢组学研究分析了两种常用建模方法构建的偏头痛模型在潜在生物标志物方面的差异。偏头痛模型是通过硝酸甘油（NTG）诱导或机械刺激诱导大鼠皮层展延抑制（CSD）构建的。代谢组学分析采用了多变量分析方法。与对照组相比，NTG偏头痛组有1种不同的代谢物上调，14种下调。与NTG偏头痛组相比，CSD偏头痛模型组有13种不同代谢物上调，12种下调。硝酸甘油诱导和机械刺激诱导的CSD都可以构建偏头痛大鼠模型，而两种模型的生物标志物是不同的。

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Metabonomics of brain tissue in migraine rat model induced by nitroglycerin or cortical spreading depression

This study analyzes the differences in potential biomarkers of migraine models constructed by two commonly used modeling methods through metabolomics research. Migraine models were constructed by nitroglycerin (NTG) induction or mechanical stimulus-induced cortical spreading depression (CSD) in rats. Multivariate analysis was used for metabolomic analysis. Compared with control group, NTG migraine group had 1 different metabolite up-regulated and 14 down-regulated. Compared with NTG migraine group, 13 differential metabolites in the CSD migraine model group were up-regulated and 12 were down-regulated. Both nitroglycerin-induced and mechanical stimulation-induced CSD can construct migraine rat models, and the biomarkers of the two models are different.

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来源期刊

Materials Express NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

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0.00%

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审稿时长

>12 weeks

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