装载抗ESR1 siRNA的新型纳米SiRNA递送系统及其作为环孢素药物载体在糖尿病所致干眼症中的应用

IF 0.7 4区材料科学 Q3 Materials Science

Materials Express Pub Date : 2023-12-01 DOI:10.1166/mex.2023.2561

Jing He, Yunzhi Lin, Fen Ye, Ying Gao, Ting Yu, Bilian Ke, Weihong Zhou

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引用次数: 0

摘要

干眼症是一种较为常见的临床疾病，由异常的流体动力学和泪液质量引起，缺乏有效的药物治疗。本研究设计并合成了一种新型的纳米siRNA递送系统，负载抗esr1 siRNA，并对其治疗干眼症的效果进行了评价。该系统显著抑制了nacl诱导的炎症因子的增加，从而抑制了炎症反应。此外，该系统下调了MMP-9和STRA6的表达水平。该系统可开发为治疗糖尿病性干眼症的药物。

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Novel nano-SiRNA delivery system loaded with anti-ESR1 siRNA and its application as a cyclosporine drug carrier in dry eye caused by diabetes

Dry eye is a relatively common clinical condition caused by abnormal fluid dynamics and tear quality, for which effective pharmacological treatment is lacking. In this study, a new nano-siRNA delivery system loaded with anti-ESR1 siRNA was designed and synthesized, and its effect in the treatment of dry eye was evaluated. The system significantly inhibited the NaCl-induced increase in inflammatory factors, thereby suppressing the inflammatory response. In addition, the system downregulated the expression level of MMP-9 and STRA6. This system could be developed as a drug for the treatment of diabetes-induced dry eye.

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来源期刊

Materials Express NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

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0.00%

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审稿时长

>12 weeks

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