Journal of Blood Disorders and Transfusion最新文献

{"title":"Effect of Blood Storage on Complete Biochemistry","authors":"M. Verma, K. Dahiya, Deepika Malik, Sehgal Pk, R. Devi, A. Soni, V. Ghalaut","doi":"10.4172/2155-9864.1000329","DOIUrl":"https://doi.org/10.4172/2155-9864.1000329","url":null,"abstract":"Background: Prolonged storage of blood leads to alteration in RBCs biochemistry which may lose viability with time. \u0000Aim: This study was planned to observe biochemical changes on stored blood on 19 different analytes. \u0000Material and Methods: The study was conducted on blood donated by 30 healthy volunteer donors. Effect of storage was analyzed at 0, 3, 7, 14 and 21 days interval. Biochemical parameters were measured using Randox suzuka autoanalyzer and Combiline ISE analyzer. \u0000Results: Significant changes were observed in serum phosphorus, SGOT, serum protein, LDH, pH, serum chloride, ionized calcium, serum sodium, potassium and bicarbonate levels (p<0.05 for ionized calcium, serum protein and p<0.001for rest of the parameters). On the other hand there was no impact of storage time on rest of the parameters. \u0000Conclusion: Prolonged contact of plasma with RBCs results in exchange of contents between plasma and red cells which leads to changes in analyte concentrations as well as dilution. RBC stored for a period of time at 4°C loose viability. Some may undergo spontaneous hemolysis while in storage; others lose the ability to survive in the recipient’s circulation following transfusion. Inspite of storing blood with CPDA, the storage time has a negative impact on the biochemical composition of RBCs. Therefore, it is better to give patients fresh blood with less than 7 days of storage in order to decrease the levels of non-viable red blood cells.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128164217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemostatic Profile and Associated Factors of Hemostatic Abnormality in Human Immunodeficiency Virus Infected Adults Attending Jimma University Specialized Hospital, Southwest Ethiopia: A Case-Control Study","authors":"Girum Tesfaye, T. Yemane, Lealem Gedefaw","doi":"10.4172/2155-9864.1000330","DOIUrl":"https://doi.org/10.4172/2155-9864.1000330","url":null,"abstract":"Background: Human immunodeficiency virus infection has been proposed to inflict an insult on hemostatic system which involves endothelium, platelet and coagulation proteins. Information regarding hemostatic profile in human immunodeficiency virus infected patients is limited and contradicting too. \u0000Method: A case control study was conducted from April to May 2014 in Jimma University specialized hospital, involving 96 HIV infected patients and 96 healthy controls that came consecutively to comprehensive chronic care center and voluntary counseling and testing (VCT) center respectively. Socio demographic and clinical data were obtained using structured questionnaire. For the purpose of hemostasis tests, 2.7ml of venous blood sample was collected in a 3ml citrated (3.2%) vacuum tube. Platelet count and CD4 count was determined from a 3ml EDTA sample. Mixing study was undertaken for prolonged coagulation tests. Data were analyzed using SPSS, version 20. \u0000Result: The mean value of prothrombin time (PT), international normalized ratio(INR), activated partial thromboplastin time(APTT) and fibrinogen level was significantly higher in case group than control (p< 0.001, 0.01, <0.001 and <0.001) while mean platelet count was significantly lower in case group (p<0.0001). Mixing study showed correction of 35(87.5%) of 40 prolonged PT both in immediate and delayed test while 58(95.1%) of 60 prolonged activated APTT fail to correct in both situations. A CD4 count of less than 200cells/mm 3(AOR=8.8, 95% CI (1.8-42.4)) and HAART (AOR=3.4, 95%CI (1.2-10.1)) use were significantly associated with prolonged PT while a CD4 count of less than 200cells/mm3 (AOR=11.55, 95% CI (1.25-106)) was significantly associated with prolonged APTT. \u0000Conclusion: There was a significant mean difference between case and control groups with respect to PT, APTT, platelet count and fibrinogen level. Direction of the finding points towards presence of inhibitors and factor deficiency which demands in depth investigation and corresponding intervention.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130107740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cimetidine in the Treatment of Acute Intermittent Porphyria from Onset to Death","authors":"Yanyan Xie, Zhenyu Yan, Linhong Wang, B. Yan, Z. Deng, Naiyao Chen","doi":"10.4172/2155-9864.1000331","DOIUrl":"https://doi.org/10.4172/2155-9864.1000331","url":null,"abstract":"Acute intermittent porphyria (AIP) is a rare, frequently misdiagnosed disease characterized by abdominal pain and psychiatric symptoms. Abdominal pain is the most common. At present, there is no radical cure for AIP. Hematin is considering the effective treatment to relieve the symptom. However, it is not available in china. A 25-year-old Chinese woman complained about intermittent abdominal pain for 2 years. He was misdiagnosed as acute abdominal disease many times. During attacks, abdominal pain relief always took more than 1 week without effective treatment. In our hospital, the patient was diagnosed AIP definitely and treated with intravenous cimetidine 400mg Q6h, symptoms especially abdomen pain relieved within 48-72 hours completely in each acute attack. Few cases of cimetidine to treat AIP have been reported. More clinical date is required in order to verify whether the routine treatment of cimetidine can replace hematin or be used as a preventive treatment. This is the first case to report that cimetidine has obvious effect during AIP acute attacks.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126818345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged Severe Anemia and Transfusion Refusal Following Abdominal Surgery. A Case Report and Short Literature Review","authors":"P. Mura, M. Deiana, E. d’Aloja, F. Paribello, M. Musu, G. Finco","doi":"10.4172/2155-9864.1000328","DOIUrl":"https://doi.org/10.4172/2155-9864.1000328","url":null,"abstract":"Mura P1*, Deiana M1, D'Aloja E2, Paribello F2, Musu M1 and Finco G1 1Department of Medical Sciences “M. Aresu”, University of Cagliari, Cagliari, Policlinico “Duilio Casula”, SS554 Bivio per Sestu, 09042 Monserrato (CA), Italy 2Department of Public Health, Clinical and Molecular Medicine, Cagliari University, Italy *Corresponding author: Paolo Mura, Department of Medical Sciences “M. Aresu”, Anesthesia and Intensive Care Unit, University of Cagliari, Cagliari, Policlinico “Duilio Casula”, SS554 Bivio per Sestu, 09042-Monserrato (CA), Italy, Tel: +39 07051096543; E-mail: mura_paolo@hotmail.com","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130415240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Dose Aspirin-Induced Upper Gastrointestinal Injury-Epidemiology, Management and Prevention","authors":"T. Tsai, P. Hsu","doi":"10.4172/2155-9864.1000327","DOIUrl":"https://doi.org/10.4172/2155-9864.1000327","url":null,"abstract":"Tzung-Jiun Tsai1,2 and Ping-I Hsu1,2* 1Department of Internal Medicine, Division of Gastroenterology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan 2National Yang-Ming University, Taipei, Taiwan *Corresponding author: Ping-I Hsu, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan, Tel: +886-7-3468233; Fax: +886-7-3468237; E-mail: williamhsup@yahoo.com.tw","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130334335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing Scenario of Prevalence of Hepatitis B and C Among Blood Donors","authors":"S. Mehdi","doi":"10.4172/2155-9864.1000326","DOIUrl":"https://doi.org/10.4172/2155-9864.1000326","url":null,"abstract":"","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115356988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease Severity Scores and Haemogram Parameters in Nigerian Sickle Cell Disease Patients","authors":"E. Okocha, E. Onwubuya, C. Osuji, G. Ahaneku, U. Okonkwo, N. Ibeh, J. Aneke, Ebele Nwachukwu, C. Onah","doi":"10.4172/2155-9864.1000324","DOIUrl":"https://doi.org/10.4172/2155-9864.1000324","url":null,"abstract":"Background: Sickle cell disease (SCD) is associated with high mortality in Nigeria and the rest of sub-Saharan Africa; there is need to find easily available parameters that could predict disease severity and influence therapy. \u0000Objective: To evaluate the haemogram of a population of SCD patients and correlate these with objective scores of disease severity. \u0000Methods: Sixty (60) asymptomatic steady state (ASS) SCD patients in our clinic were randomly selected and interviewed with a questionnaire. Their haemogram was done using a 17 parameter, 3-part white cell differential, auto-analyser (KX 21N, Sysmex corporation, Chuo ku, Kobe, Japan) and objective severity scores calculated using a modification of the method proposed by Anyeagbu et al. Statistical analysis of data was done using Statistical Package for Social Sciences software, version 20 (SPSS Inc., IL, Chicago, USA), with significance assigned to p values less than 0.05. \u0000Result: Of the 60 subjects assessed, severity scores were calculated for 49: 11 (22.4%), 31 (63.3%) and 7 (14.3%) met the criteria for mild, moderate and severe disease respectively. The haemogram parameters that were significantly correlated with disease severity were mean corpuscular haemoglobin concentration (MCHC), and white blood cell count (WBC), p=0.014, and 0.001 respectively. Haemoglobin concentration (Hb) and packed cell volume (PCV) were negatively correlated with disease severity (p=0.001). \u0000Conclusion: In addition to already known haemogram parameters that affect SCD severity (such as WBC, Hb concentration, and PCV) MCHC also does same and can be manipulated by drugs and other kinds of therapy to ameliorate severity in patients.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132653588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compartment syndrome as a complication of femoral deep vein thrombosis","authors":"Asija Ankush Kaur Sayanika Sapkota Smarika, Aasim Mohammed","doi":"10.4172/2155-9864.C1.011","DOIUrl":"https://doi.org/10.4172/2155-9864.C1.011","url":null,"abstract":"This case report demonstrates that measurement of the activity of technetium-99m-methylene diphosphonate in bone can play an important role in the diagnosis and fol- low-up of bone lesions in sickle-cell anaemia. In this case, the whole-body scan revealed remarkably increased activity in the spleen region, in the right ulna and in the left femoral head, consistent with bone infarcts. Bone scanning is a reli- able imaging method for early detection and diagnosis of osseous and extraosseous crises in sickle-cell anaemia.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122203443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6-thioguanine in vivo selection for hematopoietic stem cell transplantation (HSCT)","authors":"R. Schiestl","doi":"10.4172/2155-9864.C1.009","DOIUrl":"https://doi.org/10.4172/2155-9864.C1.009","url":null,"abstract":"","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115817841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOACs; Friend or Foe?","authors":"L. Rasmussen","doi":"10.4172/2155-9864.1000323","DOIUrl":"https://doi.org/10.4172/2155-9864.1000323","url":null,"abstract":"New oral anticoagulants (NOAC’s) are becoming more popular as antithrombotic agents for the prevention of venous thromboembolism in atrial fibrillation and as prophylaxis in hip and knee surgery. With simple administration, rapid onset, few drug interactions and the absence of coagulation monitoring, NOAC’s appear as a friend in the prevention of thromboembolic events. Undoubtedly patients would prefer treatment with a simple pill over injections and intensive monitoring implied that the treatment is efficient and without adverse effects.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124430342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}