Journal of Blood Disorders and Transfusion最新文献

{"title":"Coronarography in Patients with Factor XI deficiency: A Literature Review","authors":"Mokhtar Abdallah, Georges Khoueiry, Tarek Abdallah","doi":"10.4172/2155-9864.1000341","DOIUrl":"https://doi.org/10.4172/2155-9864.1000341","url":null,"abstract":"Hemophilia C or Factor XI deficiency is a hypocoagulable state leading to increased bleeding diathesis. Acute coronary syndrome can be manifested with chest pain and require a coronography to investigate the reason of the symptoms. This type of procedure requires the use of heparin and the possible need for oral antiplatelets especially if a stent was deployed. The use of anticoagulants or antiplatelets to prevent stent clotting becomes a challenge in patients with hypocoagulable state including patients with Hemophilia C. We will summarize in our review the approach taken in similar cases described in literature.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"130 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124957356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Low Level Mixed Chimerism Using High Throughput SNP Genotyping","authors":"A. Nakorchevsky, E. Flores, Li Xiangyang, Tao Hong, A. Nygren","doi":"10.4172/2155-9864.1000340","DOIUrl":"https://doi.org/10.4172/2155-9864.1000340","url":null,"abstract":"Recipients of allogeneic bone marrow transplants (BMT) or stem cell transplants (SCT) require clinical monitoring to allow for early diagnosis of such post-transplant adverse effects as rejection, graft vs. host disease (GVHD), or a malignancy relapse. Triaging of the transplant recipients in clinical settings is achieved by monitoring the Minimal Residual Disease (MRD) and measuring the amount of mixed chimerism in peripheral blood lymphocytes (PBL). While MRD monitoring involves detection of the malignancy-specific markers, measuring the extent of mixed chimerism can be achieved via general PCR-based methods. We have developed a SNP genotyping method to detect low levels of mixed chimerism in PBL and genomic DNA. Sensitivity is achieved by measuring a cumulative skew in genotyping data across a cohort of 92 independent SNP markers. This method showed a sensitivity of 0.98 and a specificity of 0.90 for 10%, 5%, and 2% mixed chimerism samples. The overall specificity of the method is 0.98 and the accuracy is 0.95. The results show 100% concordance with the STR data for a set of clinical samples. The advantage of this method compared to already established methodologies is that it does not require disease-specific markers and can be multiplexed. The method and the analysis software can also be used with other genotyping and sequencing technologies.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127607572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Ferrous Bisglycinate Chelate for the Management of Preoperative Anaemia in Orthopaedic Surgical Patients: A Prospective Study","authors":"M. Rondinelli, G. Inghilleri, M. Pavesi, A. Bartolomei, R. Pagnotta, D. Fioravanti, P. Iudicone, Roberto Rossetti, F. Pallotta, M. Bertini, L. Pierelli","doi":"10.4172/2155-9864.1000339","DOIUrl":"https://doi.org/10.4172/2155-9864.1000339","url":null,"abstract":"Background: Oral iron support in patients (pts) undergoing preoperative autologous blood donation (PABD) programs has been suggested by different authors to improve red blood cell (RBC) production and limit iron depletion. Oral iron therapy, however, is frequently associated with side effects and poor pts compliance. The aim of this study was to evaluate the effectiveness of low doses of ferrous bisglycinate chelate (Tecnofer, Baldacci) a new oral iron preparation characterized by high gastrointestinal absorption and tolerability in the management of preoperative anemia. \u0000Material and methods: In our hospital we used a multimodal approach of integrated alternatives strategies after a preliminary clinical evaluation (CE) that provides a supportive iron therapy. We enrolled 60 pts candidate for orthopedic surgery presenting hemoglobin (Hb) levels between 11.5 and 12.5 g/dL in order to evaluate the effectiveness of ferrous bisglycinate chelate for these pts who presented gastrointestinal side effects related to previous oral iron treatment. All pts pre-deposited 1 unit of PABD (400 mL) at day 0. Forty pts (Group A) received 1 tablet/day of ferrous bisglicinate (14 mg/day) for 10 days. No iron was given to 20 pts (Group B). The variation in Hb concentration, percentage of reticulocytes (% RET), serum ferritin (FER) and percentage of transferrin saturation (%SAT) from the day of pre-deposit to ten days after donation were compared between the two groups. \u0000Results: The study lasted From October 2014 to December 2014 baseline Hb, RET count, serum FER and transferrin saturation were similar in the 2 groups. Pts receiving iron therapy had a lesser iron depletion, an increased erythropoiesis which in turn limited Hb reduction due to PABD, without showing any side effects. \u0000Discussion: Preliminary data of our study seem to indicate that oral administration of low doses of ferrous bisglycinate chelate is an effective and safe therapy to support PABD and to treat iron deficiency in patient’s candidate for major surgery. The high patient’s compliance to this new oral iron therapy seems to be a “Key Factor” in the treatment success.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133293308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posttraumatic Intracerebral Haemorrhage of a Patient with Inhibitor Positive Hemophilia A: A Case Report","authors":"P. Patir, Osman Butun, M. Duran, F. Koseoglu, N. Soyer, F. Şahin, G. Saydam","doi":"10.4172/2155-9864.1000338","DOIUrl":"https://doi.org/10.4172/2155-9864.1000338","url":null,"abstract":"Treatment of hemaophilia patients with inhibitor has been difficult situation especially in emergency rooms. Here, we report the successful treatment of a patient with inhibitor positive severe hemophilia A hospitalized due to intracerebral haemorrhage after traffic accident.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127276446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothyroidism-Associated Autoimmune Thyroiditis and Papillary Thyroid Cancer","authors":"A. Gheorghisan-Galateanu, M. Carsote, D. Terzea, A. Valea, D. Pereţianu, Alin Horatiu Muresean, A. Ghemigian","doi":"10.4172/2155-9864.1000337","DOIUrl":"https://doi.org/10.4172/2155-9864.1000337","url":null,"abstract":"Autoimmune thyroiditis (AI) and differentiated thyroid cancer as papillary type (PTC) are sometimes associated and several common pathogenic mechanisms have been described: BRAF mutations, hOGG1 loss of heterozygosity, interleukin-10 activation, selenoproteomas disturbances. Controversies are related to a more aggressive profile of PTC if AI is presented by interferences with oxidative stress and secondary carcinogenesis. This is a case report of a 37-year old female diagnosed a decade ago with multi-nodular goiter and hypothyroidism. She was treated in different endocrine centers. She started to accuse intermittent breathing difficulties which were not related to her previous diagnosis of asthma. On admission, the thyroid function was normal under levothyroxine (LT4) therapy with high anti-thyreoperoxidase antibodies levels of 1000 UI/mL (Normal<35) confirming AI. Thyroid ultrasound showed multiple nodules of 10 millimetres (mm), and a dominant one on the right lobe of 20 mm. Total thyroidectomy and lymph nodes dissection was performed. Pathological report confirmed AI and micro-PTC was identified (of 3 by 2 mm; T1N0M0). The thyroid scintigrame was negative when LT4 substitution was stopped and the blood thyroglobuline (TG) was very low (of 0.2 ng/mL) with negative anti-TG antibodies. A good outcome is estimated and no radioiodine ablative therapy was added only TSH suppressive doses of LT4. This case confirms that long standing autoimmune hypothyroidism might not protect of differentiated thyroid cancer but the papillary microcarcinoma display a good prognosis, in this particular situation based on small dimensions of the lesion and low levels of TG after surgery.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116552984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune Hemolytic Anemia in a Patient with Acute Myelomonocytic Leukemia","authors":"Oha Essa, S. El-Ashwah, M. Denewer, Y. Essam, M. Mabed","doi":"10.4172/2155-9864.1000336","DOIUrl":"https://doi.org/10.4172/2155-9864.1000336","url":null,"abstract":"Autoimmune hemolytic anemia (AIHA) has been described in patients with lymphoid neoplasm with an etiologic relationship between the emergence of autoantibodies and lymphocyte dysfunction. Autoimmune disorders are less to develop in patients with other neoplasm like chronic myeloid leukemia, myelodysplastic syndrome or acute myeloid leukemia. Few reports have been documented the development of immune hemolytic anemia in patients with acute myeloid leukemia. We herein, present the case of de novo acute myelomonocytic leukemia associated with autoimmune hemolytic anemia. The patient has no previous medical history of anemia and Hb level at presentation was normal. She received chemotherapy containing Adriamycin plus Cytarabine. She showed marked improvement of anemia after steroid therapy with subsidence of all the clinical and laboratory manifestations of hemolysis when the patient went into remission. AIHA should be considered as one cause of anemia in","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116277726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Genotypic Correlation of Beta S-Globin Haplotypes in Sickle Cell Anemia","authors":"G. Damanhouri, J. Jarullah","doi":"10.4172/2155-9864.1000335","DOIUrl":"https://doi.org/10.4172/2155-9864.1000335","url":null,"abstract":"Sickle cell disease played a pioneering role in the establishment of the field of molecular medicine. Even though this disease was identified many years ago its clinical course is still not clear. Clinical severity ranges across individuals, even within the same ethnic group. Molecular studies have identified different haplotypes across the globin gene cluster. Correlating individual haplotypes with clinical severity has become the primary focus in the endeavour to establish a successful treatment. Even though numerous studies have been performed, most have shown a negative correlation between beta S-globin haplotypes and clinical phenotype. After a review of recent medical literature, the authors conclude that further research translating genetic analysis to positive therapeutic response for sickle cell disease patients is needed.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121204133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacogenetic of Clopidogrel and Platelet Function Testing: The Clinical Impact","authors":"A. Almeman, H. Khalaf","doi":"10.4172/2155-9864.1000334","DOIUrl":"https://doi.org/10.4172/2155-9864.1000334","url":null,"abstract":"Cytochrome 450 (CYP 450) 2C19 is a well known polymorphic metabolising enzyme which is responsible for converting clopidogrel to its active form [1]. Measuring the resulting activity based on Platelet Reactivity Units (PRU) or inhibition rates of the platelet is well correlated with the genetic polymorphism in several studies worldwide [1-3]. However, the debate is whether the polymorphism or PRU may result in any significant clinical endpoint.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132117006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of a Child with Chronic Myeloid Leukemia Presenting with Vision and Hearing Loss","authors":"Mariam Ngaeje, Furahini Chinenere, Alex Magessa, J. Makani","doi":"10.4172/2155-9864.1000333","DOIUrl":"https://doi.org/10.4172/2155-9864.1000333","url":null,"abstract":"Chronic myeloid leukemia (CML) is a relatively rare malignancy of cells of the hematopoietic system. Loss of vision and hearing is a very rare presenting manifestation of CML especially at a young age. We are reporting a rare case of CML in 16 years old male presenting with loss of hearing and vision in Muhimbili National Hospital in Tanzania. This case shows how the non-communicable disease can cause morbidity in children in a developing world and the importance of early diagnosis and management of CML in prognosis. In addition the case shows how adequate investigations and documentation is important in follow up of the patient clinical conditions and treatment outcomes. The patient was put on Tabs Alluprinol 300mg once daily for one month and Tabs hydroxyl urea (HU) 3g once daily for one month. 2 weeks later the child was reported to have confusion, being overactive and over talkative for 3 days prior to attending the scheduled hematology clinic. Complete Blood Count showed a marked decrease in White blood cells. With the rapid patient’s clinical deterioration after initiation of HU, indicates that detailed medical investigations is crucial in disease management and the use of Tyrosine Kinase inhibitors should be encouraged as it has shown to be more tolerated and better survival outcomes in treatment of CML.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123819281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pentoxifylline Lifts the Burden of Preeclampsia","authors":"Arsalan Azimi","doi":"10.4172/2155-9864.1000332","DOIUrl":"https://doi.org/10.4172/2155-9864.1000332","url":null,"abstract":"Worldwide, Preeclampsia is the leading cause of maternal morbidity and perinatal mortality and it initiates as inappropriate immune response to trophoblastic invasion impairs placentation and placental circulation followed by generation of superoxide anions as well as anti-angiogenic factors and this series of events result in impairment of maternal/placental endothelial function, maternal hypertension, kidney injury, proteinuria and thromboembolic events. Renal loss of anti-coagulant proteins and subsequent hyper-coagulable state along with endothelial dysfunction accelerates progression of the disease toward eclampsia. Pentoxifylline, could hypothetically modify pathophysiological mechanisms of preeclampsia including impaired immune response, placentation, endothelial function and coagulation, so it could explore new horizons in treatment of preeclampsia.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126631278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}