Journal of Blood Disorders and Transfusion最新文献

Thalassemia Carriers among Healthy Blood Donors 健康献血者中的地中海贫血携带者

Journal of Blood Disorders and Transfusion Pub Date : 2019-04-10 DOI: 10.4172/2155-9864.1000421

E. Ezalia, A. SharifahZahra, Elfina Ir, G. Elizabeth, Hayati Wmy, A. Norhanim, A. Wahidah, Chin Ym, A. Rahimah, Z. Zubaidah

{"title":"Thalassemia Carriers among Healthy Blood Donors","authors":"E. Ezalia, A. SharifahZahra, Elfina Ir, G. Elizabeth, Hayati Wmy, A. Norhanim, A. Wahidah, Chin Ym, A. Rahimah, Z. Zubaidah","doi":"10.4172/2155-9864.1000421","DOIUrl":"https://doi.org/10.4172/2155-9864.1000421","url":null,"abstract":"Thalassemia is a common hereditary anaemia in Southeast Asia which may also be found among healthy blood donors. The established screening method is less sensitive and can miss donors with clinically silent Thalassemia. The Thalassemia screening tests may help in selection of truly healthy blood donors, hence providing the most functional red cell concentrates for blood transfusion. This is an extension study from our previous work, aiming to detect thalassemia trait among clinically asymptomatic blood donors. We performed Thalassemia screening in 738 healthy blood donors who were allowed for blood donation using full blood count and haemoglobin (Hb) analysis. After screening analyses using high performance liquid chromatography, capillary zone electrophoresis and agarose gel electrophoresis, 85 samples were excluded from the study due to inadequate volume for DNA analysis. Five hundred twelve (512/653; 78.4%) samples were within normal limit and 74 (74/653; 11.3%) samples with Hb less than 12.5 g/dl. Thirty eight donors were found to have Thalassemia and/or haemoglobinopathies by Hb analysis. The remaining 105 blood donors samples with value of MCV less than 80 fl and/or MCH lower than 27 pg with no detectable abnormal pattern from Hb analysis subjected to multiplex PCR that was capable of detecting deletional and nondeletional of the α-globin gene. Majority (79/653; 2.1%) of them had no identified mutation while 23 (23/653; 3.5%) of them had heterozygous α-3.7 deletion, 2 (2/653; 0.3%) had heterozygous α--SEA deletion and only one (1/653; 0.1%) had heterozygous α-4.2 deletion. This data indicates that 74 (74/653; 11.3%) of our blood donors were anaemic, 64 (64/65; 39.8%) had haemoglobinopathies and 79 (79/653; 12.1%) were presumptively had iron deficiency anaemia based on red blood cell indices. Provision of best quality pack red cells should be selected for patients who require regular blood transfusion in order to maintain appropriate Hb level.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115776809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The potentials of natural compounds in treating human retinal diseases 天然化合物治疗人类视网膜疾病的潜力

Journal of Blood Disorders and Transfusion Pub Date : 2018-12-28 DOI: 10.4172/2155-9864-C3-036

pFanfan Zhoup

引用次数: 1

Obstructive jaundice: A rare presentation of childhood acute lymphoblastic leukemia 梗阻性黄疸:儿童急性淋巴细胞白血病的罕见表现

Journal of Blood Disorders and Transfusion Pub Date : 2018-08-01 DOI: 10.4172/2155-9864-C2-033

Pham Thi Thu Huong

引用次数: 0

Myocardial Infarction caused by Triple-Hit Lymphoma 三击淋巴瘤引起的心肌梗死

Journal of Blood Disorders and Transfusion Pub Date : 2018-05-25 DOI: 10.4172/2155-9864.1000399

H. Amanuel, J. Schofield, Kotoucek Pp

引用次数: 0

Thalassemia Distribution Based on Screening Programs in the Population of the East Malaysian State of Sabah 基于筛查方案的地中海贫血分布在马来西亚东部沙巴州的人口

Journal of Blood Disorders and Transfusion Pub Date : 2018-01-31 DOI: 10.4172/2155-9864.1000395

Lailatul Hadziyah Mohd Pauzy, E. Esa, Nizmah Mahani Mokhri, Y. Yusoff, Nurul Amira Jamaludin, Z. Zakaria

{"title":"Thalassemia Distribution Based on Screening Programs in the Population of the East Malaysian State of Sabah","authors":"Lailatul Hadziyah Mohd Pauzy, E. Esa, Nizmah Mahani Mokhri, Y. Yusoff, Nurul Amira Jamaludin, Z. Zakaria","doi":"10.4172/2155-9864.1000395","DOIUrl":"https://doi.org/10.4172/2155-9864.1000395","url":null,"abstract":"Objective: The aim of the study is to examine the distribution of thalassemia in the indigenous population of Sabah where thalassemia is most prevalent in Malaysia based on screening programs carried out at the public health centers. \u0000Method: A total of 645 blood samples were obtained from all over Sabah for thalassemia screening in the month of May 2013. High performance Liquid Chromatography and Capillary Electrophoresis were used for analyzing the hemoglobin subtypes. \u0000Result: 94% of the total sample came from voluntary screening offered at primary care level and various government-promoted programs while the other 6% were cascade screening. The study included patients from the age of 1 to 73 years old. The majority (97%; 624/645) were indigenous people and 94% of the total sample came from voluntary screening offered at primary care level via various government promoted programs. 82% were female, mostly screened during their antenatal visit. 30% (193/645) of the sample were tested positive for; β-Thalassemia trait (78%; 151/193), HbE trait (10%; 20/193), Homozygous HbE (2%; 4/193) and other haemoglobinopathies (7%; 13/193). The other 3% (5/193) of the abnormal results were inconclusive hence would require further molecular analysis. Among all the indigenous people screened, the Kadazandusuns had the highest occurrence of haemoglobinopathies (35%; 87/250), followed by the Muruts (33%; 15/45), Malays (29%; 19/65), other races (26%; 46/180) and the Bajau people (23%; 19/84). \u0000Conclusion: Thalassemia is prevalent in the indigenous population of Sabah and most people are asymptomatic. Government health clinics play a crucial role in promoting greater awareness of the disease via campaigns and screening programs as they are easily accessible and oftentimes are the first point of contact with the community.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127237125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Cytogenetics-based risk prediction of blastic transformation of chronic myeloid leukemia treated with tyrosine kinase inhibitors 基于细胞遗传学的酪氨酸激酶抑制剂治疗慢性髓系白血病成母细胞转化的风险预测

Journal of Blood Disorders and Transfusion Pub Date : 2017-11-27 DOI: 10.4172/2155-9864-C1-027

Shimin Hu

引用次数: 0

Successful Treatment of Immunosuppressant-resistant Thrombocytopenia with Eltrombopag in a Patient with TAFRO Syndrome(Retracted) Eltrombopag成功治疗TAFRO综合征患者的免疫抑制剂抵抗性血小板减少症(缩回)

Journal of Blood Disorders and Transfusion Pub Date : 2017-11-04 DOI: 10.4172/2155-9864.1000393

K. Okazuka, N. Tsukada, Yoshitaka Isotani, Kota Sato, Kanji Miyazaki, Y. Abe, Y. Yoshiki, T. Ishida, Kenshi Suzuki

{"title":"Successful Treatment of Immunosuppressant-resistant Thrombocytopenia with Eltrombopag in a Patient with TAFRO Syndrome(Retracted)","authors":"K. Okazuka, N. Tsukada, Yoshitaka Isotani, Kota Sato, Kanji Miyazaki, Y. Abe, Y. Yoshiki, T. Ishida, Kenshi Suzuki","doi":"10.4172/2155-9864.1000393","DOIUrl":"https://doi.org/10.4172/2155-9864.1000393","url":null,"abstract":"TAFRO syndrome has been proposed to be a systemic inflammatory disorder that causes thrombocytopenia; anasarca; fever; renal insufficiency; and organomegaly, including hepatosplenomegaly and lymphadenopathy. It could be a variant of multicentric Castleman disease (MCD). Although the pathological findings of the lymph nodes in TARFO syndrome resemble those seen in MCD, the clinical findings of TAFRO syndrome differ from those of MCD; i.e., TAFRO syndrome causes severe thrombocytopenia and systemic edema, but not polyclonal gammopathy and no positivity of HHV-8. The etiology of TAFRO syndrome has not been elucidated. In our case, several symptoms were resolved with tocilizumab, but the patient’s severe thrombocytopenia was resistant to various treatments. Although the pathogenesis of thrombocytopenia in TAFRO syndrome remains unclear, in our case eltrombopag, which is a thrombopoietin receptor agonist, improved tocilizumab-resistant thrombocytopenia. Eltrombopag could be an effective treatment for persistent thrombocytopenia in TAFRO syndrome.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130029593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative Stress and Antioxidant Status in Immune Thrombocytopenia 免疫性血小板减少症的氧化应激和抗氧化状态

Journal of Blood Disorders and Transfusion Pub Date : 2017-10-07 DOI: 10.4172/2155-9864.1000392

Xuewei Li, Zhaoyue Wang, X. Qi, Dongjie Zhang

引用次数: 3

Seroprevalence of Hepatitis B, Hepatits C, Human Immunodeficiency Virus and Syphilis in Donated Blood in Kenya, 2016: Situation Analysis 2016年肯尼亚捐献血液中乙型肝炎、丙型肝炎、人类免疫缺陷病毒和梅毒的血清阳性率:情况分析

Journal of Blood Disorders and Transfusion Pub Date : 2017-09-27 DOI: 10.4172/2155-9864.1000390

Mahuro Gm, Gichangi Pb, M. Cw, N. Kipkorir

{"title":"Seroprevalence of Hepatitis B, Hepatits C, Human Immunodeficiency Virus and Syphilis in Donated Blood in Kenya, 2016: Situation Analysis","authors":"Mahuro Gm, Gichangi Pb, M. Cw, N. Kipkorir","doi":"10.4172/2155-9864.1000390","DOIUrl":"https://doi.org/10.4172/2155-9864.1000390","url":null,"abstract":"Background and Objective: Blood transfusion is a prevalent life-saving intervention that replaces blood or blood-products lost in severe malnutrition, infections, during surgical procedures, obstetrical emergencies and blood disorders or trauma. Transfusion of infected blood remains a public health concern. With all interventions aimed at reducing transfusion transmissible infections (TTIs), it’s imperative to review the Kenyan current situation. This presents TTIs prevalence among volunteer blood donors in Kenya 2016, and, relationship between volunteer blood donors’ health and risk characteristics and TTIs in donated blood. \u0000Materials and Methods: This adopts cross-sectional design for data collected for ten months in 2016. Only 17.8% of 20,230 volunteer blood donors recruited through mobile phone application, text for life (T4L), whose blood test results were uploaded into T4L and had complete data on TTI tests was included. Kenya National Blood Transfusion Services pre-screening assessment used prior to voluntary blood donation provided variables of interest for analysis. Descriptive frequencies, association test and odds ratio was performed using Stata V14.2. \u0000Result: Four in every five voluntary blood donors were male, and, had no or primary education. Hepatitis B, Hepatitis C, Human immunodeficiency viruses and Syphilis prevalence was 0.7%, 1.2%, 6.2% and 1.0% respectively. Having “disease\" or “sexual” does not infer having any TTI but “stab” increases odds of having syphilis two fold (AOR=2.03, 95%CI=0.27-15.15, p=0.000). \u0000Conclusion: Excluding individuals who self-report as having had stab wounds could reduce the chances of having TTIs. Individuals found to be having TTIs should receive appropriate referrals for care and support.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131118309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Frequency of Anemia and Blood Transfusion in Critically Ill Patients 危重病人贫血及输血频率

Journal of Blood Disorders and Transfusion Pub Date : 2017-09-18 DOI: 10.4172/2155-9864.1000391

H. Mushtaq, Zunairah Raees, K. Zaidi, K. Makki

{"title":"Frequency of Anemia and Blood Transfusion in Critically Ill Patients","authors":"H. Mushtaq, Zunairah Raees, K. Zaidi, K. Makki","doi":"10.4172/2155-9864.1000391","DOIUrl":"https://doi.org/10.4172/2155-9864.1000391","url":null,"abstract":"Background: Anemia in adults is defined as, hemoglobin of patients admitted to critical care units become anemic within the first 3 days of ICU stay due to a number of reasons, and almost half of the patients receive blood transfusion and the number of transfusion increases proportionately with the duration of stay of patient in critical care unit. \u0000Objective: To determine the frequency of blood transfusion due to anemia in critically ill patients. \u0000Subject and Method: This cross-sectional study was conducted at Medical ICU of Liaquat National hospital Karachi from 26th July 2016 to 25th January 2017. Total 196 patients from critical care unit were included. The data collection technique applied is non-probability consecutive sampling. Demographic data along with co morbidities recorded and value of hemoglobin is recorded on daily basis. \u0000Results: Out of 196 patients 65.8% were anemic at the time of admission in ICU with mean hemoglobin of 10.85 ± 1.14 mg/dl. 84.7% of patients developed anemia during their ICU stay and their mean hemoglobin was 9.51±1.65 mg/dl. 13.8% patients were transfused Packed red blood cells, 9.7% were transfused once, while only single patient was given 4PRBCs. The mean pre-transfusion hemoglobin was 7.57 ± 0.60 mg/dl. \u0000Conclusion: Anemia is very frequent and multifactorial in critically ill patients. The study has helped to gauge the burden of blood transfusion in critically ill patients. It has highlightened the fact that blood transfusion has become an important component in the critical care units for the management of worsening anemia during ICU stay.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126146538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1