E. Okocha, E. Onwubuya, C. Osuji, G. Ahaneku, U. Okonkwo, N. Ibeh, J. Aneke, Ebele Nwachukwu, C. Onah
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Statistical analysis of data was done using Statistical Package for Social Sciences software, version 20 (SPSS Inc., IL, Chicago, USA), with significance assigned to p values less than 0.05. \nResult: Of the 60 subjects assessed, severity scores were calculated for 49: 11 (22.4%), 31 (63.3%) and 7 (14.3%) met the criteria for mild, moderate and severe disease respectively. The haemogram parameters that were significantly correlated with disease severity were mean corpuscular haemoglobin concentration (MCHC), and white blood cell count (WBC), p=0.014, and 0.001 respectively. Haemoglobin concentration (Hb) and packed cell volume (PCV) were negatively correlated with disease severity (p=0.001). \nConclusion: In addition to already known haemogram parameters that affect SCD severity (such as WBC, Hb concentration, and PCV) MCHC also does same and can be manipulated by drugs and other kinds of therapy to ameliorate severity in patients.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"126 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2015-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Disease Severity Scores and Haemogram Parameters in Nigerian Sickle Cell Disease Patients\",\"authors\":\"E. Okocha, E. Onwubuya, C. Osuji, G. Ahaneku, U. Okonkwo, N. Ibeh, J. Aneke, Ebele Nwachukwu, C. 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Statistical analysis of data was done using Statistical Package for Social Sciences software, version 20 (SPSS Inc., IL, Chicago, USA), with significance assigned to p values less than 0.05. \\nResult: Of the 60 subjects assessed, severity scores were calculated for 49: 11 (22.4%), 31 (63.3%) and 7 (14.3%) met the criteria for mild, moderate and severe disease respectively. The haemogram parameters that were significantly correlated with disease severity were mean corpuscular haemoglobin concentration (MCHC), and white blood cell count (WBC), p=0.014, and 0.001 respectively. 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引用次数: 7
摘要
背景:镰状细胞病(SCD)与尼日利亚和撒哈拉以南非洲其他地区的高死亡率有关;有必要找到容易获得的参数,可以预测疾病的严重程度和影响治疗。目的:评估SCD患者人群的血象,并将其与疾病严重程度的客观评分相关联。方法:随机选取我院无症状稳态(ASS) SCD患者60例,进行问卷调查。他们的血象图使用17个参数,3部分的白细胞鉴别自动分析仪(KX 21N, Sysmex公司,中央ku,神户,日本)完成,并使用Anyeagbu等人提出的方法的修改计算客观严重程度评分。数据采用Statistical Package for Social Sciences软件,version 20 (SPSS Inc., IL, Chicago, USA)进行统计分析,p值< 0.05为显著性。结果:60例受试者中,49例患者的严重程度评分达到轻度、中度和重度标准,分别为11例(22.4%)、31例(63.3%)和7例(14.3%)。与疾病严重程度显著相关的血象参数为平均红细胞血红蛋白浓度(MCHC)和白细胞计数(WBC), p值分别为0.014和0.001。血红蛋白浓度(Hb)和堆积细胞体积(PCV)与疾病严重程度呈负相关(p=0.001)。结论:除了已知的影响SCD严重程度的血象参数(如WBC、Hb浓度和PCV)外,MCHC也有同样的影响,可以通过药物和其他治疗方法来控制,以改善患者的严重程度。
Disease Severity Scores and Haemogram Parameters in Nigerian Sickle Cell Disease Patients
Background: Sickle cell disease (SCD) is associated with high mortality in Nigeria and the rest of sub-Saharan Africa; there is need to find easily available parameters that could predict disease severity and influence therapy.
Objective: To evaluate the haemogram of a population of SCD patients and correlate these with objective scores of disease severity.
Methods: Sixty (60) asymptomatic steady state (ASS) SCD patients in our clinic were randomly selected and interviewed with a questionnaire. Their haemogram was done using a 17 parameter, 3-part white cell differential, auto-analyser (KX 21N, Sysmex corporation, Chuo ku, Kobe, Japan) and objective severity scores calculated using a modification of the method proposed by Anyeagbu et al. Statistical analysis of data was done using Statistical Package for Social Sciences software, version 20 (SPSS Inc., IL, Chicago, USA), with significance assigned to p values less than 0.05.
Result: Of the 60 subjects assessed, severity scores were calculated for 49: 11 (22.4%), 31 (63.3%) and 7 (14.3%) met the criteria for mild, moderate and severe disease respectively. The haemogram parameters that were significantly correlated with disease severity were mean corpuscular haemoglobin concentration (MCHC), and white blood cell count (WBC), p=0.014, and 0.001 respectively. Haemoglobin concentration (Hb) and packed cell volume (PCV) were negatively correlated with disease severity (p=0.001).
Conclusion: In addition to already known haemogram parameters that affect SCD severity (such as WBC, Hb concentration, and PCV) MCHC also does same and can be manipulated by drugs and other kinds of therapy to ameliorate severity in patients.