西咪替丁治疗急性间歇性卟啉症从发病到死亡

Yanyan Xie, Zhenyu Yan, Linhong Wang, B. Yan, Z. Deng, Naiyao Chen
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摘要

急性间歇性卟啉症(AIP)是一种罕见的,经常误诊的疾病,其特征是腹痛和精神症状。腹痛是最常见的。目前,尚无根治AIP的方法。目前正在考虑有效的治疗方法来缓解症状。然而,它在中国是不可用的。一名25岁的中国女性主诉间歇性腹痛2年。他多次被误诊为急腹症。发作时腹痛缓解总需1周以上,无有效治疗。患者在我院确诊为AIP,经静脉注射西咪替丁400mg Q6h治疗,每次急性发作48 ~ 72小时症状尤其是腹痛完全缓解。西咪替丁治疗AIP的病例报道较少。为了验证西咪替丁常规治疗是否可以替代血素或作为预防性治疗,需要更多的临床数据。这是第一例报道西咪替丁对AIP急性发作有明显疗效的病例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cimetidine in the Treatment of Acute Intermittent Porphyria from Onset to Death
Acute intermittent porphyria (AIP) is a rare, frequently misdiagnosed disease characterized by abdominal pain and psychiatric symptoms. Abdominal pain is the most common. At present, there is no radical cure for AIP. Hematin is considering the effective treatment to relieve the symptom. However, it is not available in china. A 25-year-old Chinese woman complained about intermittent abdominal pain for 2 years. He was misdiagnosed as acute abdominal disease many times. During attacks, abdominal pain relief always took more than 1 week without effective treatment. In our hospital, the patient was diagnosed AIP definitely and treated with intravenous cimetidine 400mg Q6h, symptoms especially abdomen pain relieved within 48-72 hours completely in each acute attack. Few cases of cimetidine to treat AIP have been reported. More clinical date is required in order to verify whether the routine treatment of cimetidine can replace hematin or be used as a preventive treatment. This is the first case to report that cimetidine has obvious effect during AIP acute attacks.
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