Journal of Blood Disorders and Transfusion最新文献_第9页

Donor Hemovigilance: Need of the Hour 献血者血液警戒:时刻的需要

Journal of Blood Disorders and Transfusion Pub Date : 2015-11-12 DOI: 10.4172/2155-9864.1000321

Rajeswari Subramaniyan

引用次数: 1

Intractable Hemolytic Anemia after Heart Valve Surgery 心脏瓣膜手术后顽固性溶血性贫血

Journal of Blood Disorders and Transfusion Pub Date : 2015-11-11 DOI: 10.4172/2155-9864.1000322

A. Muraoka, K. Aizawa, Y. Misawa

引用次数: 0

Successful Identification of Anti-f Alloantibody in a Non-transfused Male Patient Employing ID-Micro Typing System Gel CardsÃÂ® 使用ID-Micro分型系统凝胶CardsÃÂ®成功鉴定非输血男性患者的抗f同种抗体

Journal of Blood Disorders and Transfusion Pub Date : 2015-11-09 DOI: 10.4172/2155-9864.1000320

Y. Nakamura, T. Ohsawa, Y. Furuta, Miho Tokida, K. Ichikawa, A. Ohsaka

引用次数: 1

A Prospective Study of Blood Usage Pattern and Demand Supply Assessment in a Tertiary Care Hospital in India 印度一家三级医院血液使用模式和需求供应评估的前瞻性研究

Journal of Blood Disorders and Transfusion Pub Date : 2015-11-04 DOI: 10.4172/2155-9864.1000317

S. Singh, Heena Nazreen

{"title":"A Prospective Study of Blood Usage Pattern and Demand Supply Assessment in a Tertiary Care Hospital in India","authors":"S. Singh, Heena Nazreen","doi":"10.4172/2155-9864.1000317","DOIUrl":"https://doi.org/10.4172/2155-9864.1000317","url":null,"abstract":"Background: Most patients of Mahatma Gandhi Memorial (MGM) Hospital receive blood transfusion from MGM Blood Bank, but representative data are lacking to substantiate this claim, and the characteristics of individuals who receive the transfusion have not been well described. \u0000Aim and Objective: The main objective of the study was to assess the utilization pattern of blood and blood components and to assess their demand and supply in blood bank of MGM hospital, Warangal. \u0000Material and Methodology: The data collection form was exclusively designed for data collection and entry. The analysis was done using MS-Access 2010 and Microsoft excel 2010. The statistical analysis was performed using SPSS22.0 P ≤ 0.05 as level of significance. \u0000Results and Discussion: Most of the donors were found to be males (95%) of which O positive 1077(40%) were high in number. 23 infected donations were found in 2684 donations and were excluded from out study population. Age group of 20-29 were the highest donors and also the receptors. 2661 donations were supplied as 3225 units to 2223 patients, 2 unit transfusions was done in 481(21.6%) patients >2 transfusions was found in 197(8.85) patients. Highest number of requisitions were from general medicine ward and most indication was anemia (Includes various causes that may result in anemia, major being nutritional anemia) among which Females were most suffering group with anemia. There was no significant difference found between the average mean of donations per day (32.91 ± 11.65) and average issues per day (28.92 ± 60.19) at p<0.5333. When the replacements and unsupplied units were considered the blood bank was able to supply only 85% of the requests and was falling short of supplies. \u0000Conclusion: Periodic review of blood usage pattern is very essential in MGM hospital. Implementing a transfusion committee is essential for checking the appropriateness of transfusion.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114965193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Identification of Children with Acute Lymphoblastic Leukemia at Low Risk for Tumor Lysis Syndrome 低风险急性淋巴细胞白血病患儿肿瘤溶解综合征的鉴定

Journal of Blood Disorders and Transfusion Pub Date : 2015-11-03 DOI: 10.4172/2155-9864.1000318

G. Bahoush, E. Yazdi, S. Ansari, Arjm, P. Vossough

引用次数: 8

Prognostic Value of Hematogones in Patients with Acute Myeloid Leukemia in First Complete Remission 红细胞在急性髓系白血病首次完全缓解患者中的预后价值

Journal of Blood Disorders and Transfusion Pub Date : 2015-11-03 DOI: 10.4172/2155-9864.1000319

Mona Hassanein, R. Haggag, S. Shorbagy, Hoda F. Ebian

{"title":"Prognostic Value of Hematogones in Patients with Acute Myeloid Leukemia in First Complete Remission","authors":"Mona Hassanein, R. Haggag, S. Shorbagy, Hoda F. Ebian","doi":"10.4172/2155-9864.1000319","DOIUrl":"https://doi.org/10.4172/2155-9864.1000319","url":null,"abstract":"Background: Hematogons (HGs) are normal bone marrow cells; that may reflect the quality of the bone marrow response to chemotherapy. Many studies have focused on the role of HGs in acute leukemia. \u0000Methods: A total of 65 patients with nonpromyelocytic AML, in first complete remission were enrolled in this study, and four color flow cytometry was used to quantify Hematogones. We identify the HGs detectable group as those who had more than or equal to 0.01% HGs in bone marrow aspirated sample. \u0000Results: HGs were detectable in 25 patients' marrow samples, and they were significantly associated with cytogenetic risk (p=0.01). After a median followup of 17.6 months, patients with detectable HGs had better DFS and OS than those with undetectable levels (p=0.013 and <0.001; respectively) and only 3 patients with detectable HGs in marrow remission samples experience relapse. On multivariate analysis, the HG ≥0.01% is an independent predictive value for DFS (p<0.0001), and OS (p<0.007), but number of chemotherapy cycles to achieve CR and poor cytogenetic had significant prognostic effect on DFS but not on OS, we can conclude that AML patients in first complete remission with HGs ≥0.01% have better DFS and OS. \u0000Conclusions: We can conclude that AML patients in first complete remission with HGs ≥0.01% have better DFS and OS.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132059272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Case of Anaplastic Large Cell Lymphoma Presenting in Leukemic Phase 以白血病期表现的间变性大细胞淋巴瘤1例

Journal of Blood Disorders and Transfusion Pub Date : 2015-10-31 DOI: 10.4172/2155-9864.1000316

Rahul Ravilla, A. Sasapu, J. Ramos, K. Arnaoutakis

{"title":"A Case of Anaplastic Large Cell Lymphoma Presenting in Leukemic Phase","authors":"Rahul Ravilla, A. Sasapu, J. Ramos, K. Arnaoutakis","doi":"10.4172/2155-9864.1000316","DOIUrl":"https://doi.org/10.4172/2155-9864.1000316","url":null,"abstract":"Anaplastic lymphoma kinase (ALK) with positive Anaplastic Large Cell Lymphoma (ALCL) is has a distinct entity among the peripheral T-cell lymphomas. With a 5-year survival rate of 70%, it carries one of the best prognoses among peripheral T cell lymphomas. In rare instances, ALK positive ALCL presents in leukemic phase and it has a very poor prognosis with negligible number of cases reporting a survival rate of beyond one year. Following Case study as a research technique, the researchers tried to discuss about a patient affected by ALK positive ALCL in leukemic phase, associated with t (2;5)(p23;q35). The patient reported the clinic with a three week history of breathlessness, fever, diarrhoea, and axillary lymphadenopathy. His condition deteriorated in spite of rapid initiation of chemotherapy, and he succumbed to the high tumor burden. The study concludes that early diagnosis and institution of treatment is important in this regard. As this is a rare medical condition, with negligible alternative solutions, the present study underlines the need for further research in this area, emphasizing the need for newer therapies. It particularly stresses the need to examine the association of EBV and ALCL, with a specific reference to ALK-negative ALCL.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125861987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluating Sensitivity of ipsogen BCR-ABL1 Mbcr IS-MMR DX Kit for Scoring Molecular Response 评估ipsogen BCR-ABL1 Mbcr IS-MMR DX试剂盒对分子反应评分的敏感性

Journal of Blood Disorders and Transfusion Pub Date : 2015-10-10 DOI: 10.4172/2155-9864.1000314

Akiko Mita, K. Miyamura, M. Hino, K. Watakabe, Keita Takahashi, Michiko Yoshimoto, N. Takahashi

{"title":"Evaluating Sensitivity of ipsogen BCR-ABL1 Mbcr IS-MMR DX Kit for Scoring Molecular Response","authors":"Akiko Mita, K. Miyamura, M. Hino, K. Watakabe, Keita Takahashi, Michiko Yoshimoto, N. Takahashi","doi":"10.4172/2155-9864.1000314","DOIUrl":"https://doi.org/10.4172/2155-9864.1000314","url":null,"abstract":"Objective: Tyrosine kinase inhibitors (TKIs) are the standard of care for patients with chronic myeloid leukemia (CML). Recent studies demonstrated that some patients with CML could sustain remission under discontinuation of TKIs. The clinical decision to discontinue such therapy depends on the patient’s molecular response (MR), derived from the international scale of BCR-ABL1 transcripts per internal control gene transcripts (BCR-ABL1IS), with MR4.5 (i.e., BCR-ABL1IS ≤0.0032%) commonly used as a threshold for discontinuation of TKI. However, it remains controversial whether all methods for determining BCR-ABL1IS have sufficient sensitivity for measuring MR4.5. \u0000Methods: Probit analysis with reference to CLSI EP-17-A2 was used for the kit-specific limit of detection (LoD) of BCR-ABL1 transcripts measured by the ipsogen BCR-ABL1 Mbcr IS-MMR DX Kit. In total, 50 samples of peripheral blood (PB) were collected from CML patients across three sites, with each 21-ml sample split into 7- and 14-ml volumes. \u0000Results: The kit-specific LoD was determined as 3 copies/assay. The sample measurements of 94% (7-ml PB group) and 96% (14-ml PB group) showed over 94 000 copies/assay of ABL1 transcripts, which is the level required to score MR4.5 considering kit-specific LoD of 3 copies/assay. \u0000Conclusion: This result demonstrated that the ipsogen BCR-ABL1 Mbcr IS-MMR DX Kit possesses sufficient sensitivity for stable scoring at MR4.5, with strict conditions set for avoiding false-negative results.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128515803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Artificial Blood- A Game Changer for Future Medicine: Where are we Today? 人工血液——改变未来医学的游戏规则:我们今天在哪里?

Journal of Blood Disorders and Transfusion Pub Date : 2015-10-05 DOI: 10.4172/2155-9864.1000312

M. Mozafari, Arash Ramedani, Aboulfazl Yazdanpanah

引用次数: 4

Evaluation of Different Thromboplastins and Coagulometers on International Normalize Ratio (INR) Readings for Patients under Stable Oral Anticoagulant Therapy 不同凝血酶和凝血仪对稳定口服抗凝治疗患者国际正常化比率(INR)读数的评价

Journal of Blood Disorders and Transfusion Pub Date : 2015-10-05 DOI: 10.4172/2155-9864.1000313

Rasha M. Ahmed, A. M. Muddathir

{"title":"Evaluation of Different Thromboplastins and Coagulometers on International Normalize Ratio (INR) Readings for Patients under Stable Oral Anticoagulant Therapy","authors":"Rasha M. Ahmed, A. M. Muddathir","doi":"10.4172/2155-9864.1000313","DOIUrl":"https://doi.org/10.4172/2155-9864.1000313","url":null,"abstract":"Background: Variations between various thromboplastin preparations have in the past led to decreased accuracy of INR readings. Because thromboplastin reagents vary widely in composition and manner of preparation, their sensitivity in monitoring oral anticoagulant therapy also vary widely. This study aimed to evaluate different thromboplastins and coagulometers on INR reading for patients under stable oral anticoagulant therapy. \u0000Materials and Methods: This was descriptive cross-sectional study; it was conducted in three hospitals (Alshaab teaching hospital, Khartoum teaching hospital, and Turkish hospital). A total of 50 citrated platelets poor plasma samples were collected from 50 Sudanese patients under stable oral anticoagulant therapy then prothrombin time (PT) and INR measurements were performed on three separated laboratories, using different coagulometers and thromboplastins reagents. \u0000Results: INR results showed that there was significant difference between INR of the three laboratories (P value=0.00), inspite of there was significant difference observed between INR in Khartoum hospital and Alshaab hospital, also between Alshaab and Turkish hospital (p-value=0.00). There was insignificant difference between INR in Khartoum hospital and Trukish hospital (p-value=0.178). Discussion and \u0000Conclusion: our investigation showed that some further efforts are needed to achieve harmonization of INR results among different laboratories because variation would most probably induce the clinician to make a change in warfarin dose. Standardization of instruments, reagents, and controls is warranted to decrease this variation.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130573499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0