International Journal of Biology and Life Sciences最新文献_第6页

Research on the Application of Blockchain Technology in the Design of Analgesic Drug Supply Chain 区块链技术在镇痛药供应链设计中的应用研究

International Journal of Biology and Life Sciences Pub Date : 2023-05-20 DOI: 10.54097/ijbls.v2i3.8657

Linyu Liu

{"title":"Research on the Application of Blockchain Technology in the Design of Analgesic Drug Supply Chain","authors":"Linyu Liu","doi":"10.54097/ijbls.v2i3.8657","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8657","url":null,"abstract":"The supply chain of analgesic drugs has many circulation links and trading levels, and the trading channels are complex; Information asymmetry and low logistics efficiency; Wholesale links account for a large proportion of costs. Too many trading links and complicated trading channels make the trading information asymmetric, opaque and disorderly, which will inevitably lead to the loss of efficiency and benefit in the circulation process. In this paper, the application of blockchain technology in the design of analgesic drug supply chain is studied. The analgesic drug data management center is maintained by the pharmaceutical enterprises themselves or the third party, which is mainly responsible for distributing the unique identification code of drugs, backing up all records of the whole cycle of drug production, storage, circulation and sales, and realizing the two-way traceability function of drugs. In the production process, pharmaceutical enterprises attach electronic labels from single products and outer packaging boxes to realize the traceability and anti-counterfeiting of drugs throughout their life cycle. Correspondingly, it also integrates the advantages and disadvantages of self-management and outsourcing. At this stage, enterprises can choose to subcontract non-core logistics business first, so that enterprises can focus on their core business and avoid wasting too much money and energy in logistics.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134407678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marketing of Niche Product: Stwics Non-Surgical Breast Shaping Brassiere 利基产品的市场营销:Stwics非手术乳房塑形胸罩

International Journal of Biology and Life Sciences Pub Date : 2023-05-20 DOI: 10.54097/ijbls.v2i3.8664

Macus Kutscher

{"title":"Marketing of Niche Product: Stwics Non-Surgical Breast Shaping Brassiere","authors":"Macus Kutscher","doi":"10.54097/ijbls.v2i3.8664","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8664","url":null,"abstract":"With the upgrading of consumption power of Chinese women, the women’s brassiere market has become a new economic growth point and more and more businesses have begun to target the women’s brassiere market. Stwics is committed to making it easy for women to have amazing breasts, and to providing women with safer and healthier options to avoid the risks of traditional breast enhancement. Stwics launched non-surgical breast shaping brassiere in the world. The researcher analyzes the product design principle, experimental process and results, product applicable population, product effect and brand background of Stwics non-surgical breast shaping brassiere. To test the effects of Stwics, the research team studied the effects of regular Stwics on three random groups of people: rapid responders, moderate responders, and slow responders. The results showed that different participants responded differently to Stwics use. Everyone reacts differently to the same amount of clothing, and different doses have different effects on different people. According to the Stwics team, there are three typical reactions among users of Stwics devices. Over the course of four to eight hours a day, tension can cause breast tissue to gradually enlarge. Over the next 14 hours, the reversible edema gradually subsided, but a small amount of residual real tissue growth remained. The next day, repeat the wear, increasing the wear effect with each cycle. Stwics Breast Enhancement and Shaping Device is currently the only scientifically proven non-surgical method of breast enhancement. Stwics devices stimulate natural breast growth without drugs, creams or implants. The result is the growth of the user's own breast tissue, which makes the breasts bigger and straighter.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115855143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of New Coronavirus Vaccines and Virus Detection Methods 新型冠状病毒疫苗及检测方法研究进展

International Journal of Biology and Life Sciences Pub Date : 2023-05-20 DOI: 10.54097/ijbls.v2i3.8653

Lin Liu, Yun Liu

引用次数: 0

Research Progress on RGMb and its Signaling Pathway RGMb及其信号通路的研究进展

International Journal of Biology and Life Sciences Pub Date : 2023-05-20 DOI: 10.54097/ijbls.v2i3.8650

Shucheng Li, Rongrong Zhang, Lei Zhang, Xinyue Qin

引用次数: 0

Preparation and Properties of Nano Platinum/Carbon Nanotubes/Bacterial Cellulose Conductive Hydrogel Electrode Films 纳米铂/碳纳米管/细菌纤维素导电水凝胶电极膜的制备及性能研究

International Journal of Biology and Life Sciences Pub Date : 2023-05-20 DOI: 10.54097/ijbls.v2i3.8660

Shumin Liu, Jing Chen, Jinpeng Sun

{"title":"Preparation and Properties of Nano Platinum/Carbon Nanotubes/Bacterial Cellulose Conductive Hydrogel Electrode Films","authors":"Shumin Liu, Jing Chen, Jinpeng Sun","doi":"10.54097/ijbls.v2i3.8660","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8660","url":null,"abstract":"Using the natural nanomesh structure of bacterial cellulose (BC), the good conductivity of multi-walled carbon nanotubes (MWCNTs) and the good electrocatalytic activity of nano platinum (PtNPs), a three-way porous conductive hydrogel of PtNPs and BC was designed. The infiltrating and doping of MWCNTs on BC thin films was realized by ultrasonic assisted electrophoretic deposition process, which ensured the dual characteristics of ionic and electronic conduction of electrode films. The adsorption capacity of BC for chloroplatinic acid and the strong reductivity of sodium borohydride were also used to realize the high-load PtNPs recombination on MWCNTs/BC porous layered conductive hydrogel electrode films. By testing the electrochemical performance of PtNPs/MWCNTs/BC conductive hydrogel electrode film and characterization of microstructure, the electrode film not only has high electroactive area, low surface charge transfer resistance and good diffusion permeability and other electrochemical characteristics, but also shows high catalytic activity for glucose in PBS solution. The most important finding is that the electrode film can selectively catalyze glucose in oxygen-rich PBS solution. The porous layered structure of PtNPs/MWCNTs/BC electrode membrane and the high load dispersion of PtNPs are the reasons for the selective catalytic ability of PtNPs/MWCNTs/BC conductive hydrogel electrode membrane, which can be used for the implanted surface glucose fuel cell.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"366 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127584974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graph Theory in DNA Sequencing: Unveiling Genetic Patterns 图论在DNA测序:揭示遗传模式

International Journal of Biology and Life Sciences Pub Date : 2023-05-20 DOI: 10.54097/ijbls.v3i1.9593

Banda Ashton

{"title":"Graph Theory in DNA Sequencing: Unveiling Genetic Patterns","authors":"Banda Ashton","doi":"10.54097/ijbls.v3i1.9593","DOIUrl":"https://doi.org/10.54097/ijbls.v3i1.9593","url":null,"abstract":"Graph theory, a branch of mathematics that studies the properties and relationships of graphs, has emerged as a powerful tool in addressing the complexities of DNA sequencing. This paper highlights the application of graph theory in DNA sequencing and its implications in various aspects of genomics research. One fundamental concept in graph theory applied to DNA sequencing is the construction of the de Bruijn graph. This graph represents overlapping k-mers, subsequences of length k, as nodes, with edges connecting adjacent k-mers. By constructing and analyzing the de Bruijn graph, researchers can infer the underlying DNA sequence, detect errors, resolve repetitive regions, and identify structural variations in the genome. Graph algorithms such as Overlap path, Eulerian path and Hamiltonian path have been adapted to reconstruct complete DNA sequences from fragmented reads obtained through sequencing. These algorithms leverage the connectivity information present in the de Bruijn graph to traverse and assemble the reads, enabling the reconstruction of long DNA sequences accurately. the application of graph theory in DNA sequencing has revolutionized the field of genomics by providing powerful computational tools for DNA assembly, sequence analysis, and functional annotation. By leveraging graph theory concepts and algorithms, researchers can unravel the intricate information embedded within DNA sequences, leading to deeper insights into the genetic basis of life and its applications in various fields, including medicine, agriculture, and evolutionary biology. Future developments in graph-based algorithms and computational techniques hold promise for further enhancing our ability to unlock the secrets encoded within the vast realm of DNA sequences.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130919175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pilot-scale Evaluation of an Anaerobic/Anoxic/Oxic Process for Nitrogen Removal from Sewage Using Metagenomic Sequencing 基于宏基因组测序的厌氧/缺氧/好氧污水脱氮工艺的中试评价

International Journal of Biology and Life Sciences Pub Date : 2023-05-20 DOI: 10.54097/ijbls.v2i3.8658

Dongyang Hu, Jie Zhao, Jiancheng Wang, Shenghu Yan, Chengrui Wang, Qing Qing, Jiegao Zhu, Wenping Tao, Liqun Wang

{"title":"Pilot-scale Evaluation of an Anaerobic/Anoxic/Oxic Process for Nitrogen Removal from Sewage Using Metagenomic Sequencing","authors":"Dongyang Hu, Jie Zhao, Jiancheng Wang, Shenghu Yan, Chengrui Wang, Qing Qing, Jiegao Zhu, Wenping Tao, Liqun Wang","doi":"10.54097/ijbls.v2i3.8658","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8658","url":null,"abstract":"A modified pilot plant with two sequencing batch reactors on the strength of utilizing the inner carbon supply and adding suspended carriers was operated for 280 d to analyze nitrogen removal performance and microorganism community. Despite a low chemical oxygen demand (COD)/total nitrogen (TN) ratio of 3.5, the TN in the effluent decreased from 37.2 to 10.4 mg N/L. High-throughput sequencing indicated signiﬁcant differences in the abundance of the phylum Actinobacteria (p<0.0001), Firmicutes (p<0.0001), Bacteroidetes (p<0.001), Uroviricota (p<0.0001) and Planctomycetes (p<0.0001) between the anoxic-carrier bioﬁlms and ﬂocculent sludge. Quantitative PCR revealed that denitrification and anammox genes were additional abundant in the anoxic-carrier bioﬁlms than ﬂocculent sludge (narG: p<0.0001; nirS: p<0.01; narH: p<0.01; norB: p<0.0001; hzsB: p<0.01; hdh: p<0.01). Thus, enrichment with denitrification and anammox bacteria might improve nitrogen removal; this was supported by KEGG pathway annotation. Collectively, this study suggests that anoxic-carrier bioﬁlms might enhance nitrogen removal through partial denitrification and anammox process in CWWTPs.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132185215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Sulphides Production Affecting the Fermentation Process of the Lager Beer 硫化物对贮藏啤酒发酵过程的影响研究

International Journal of Biology and Life Sciences Pub Date : 2023-05-20 DOI: 10.54097/ijbls.v3i1.9481

Hongyu Zhang, Yunqian Cui

引用次数: 0

PROTAC Pharmaceutical Research and its Applications PROTAC药物研究及其应用

International Journal of Biology and Life Sciences Pub Date : 2023-05-20 DOI: 10.54097/ijbls.v2i3.8663

Yixin Xu

{"title":"PROTAC Pharmaceutical Research and its Applications","authors":"Yixin Xu","doi":"10.54097/ijbls.v2i3.8663","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8663","url":null,"abstract":"At present, there are very few protein targets that can be used as drugs, with approximately 15% of proteins being regulated by small molecules and biomacromolecules, while 85% of proteins currently do not have drug targets and cannot be regulated by small molecules and biomacromolecules. Proteolytic targeting chimeras (protacs) can degrade many non-pharmacological target proteins through proteasomes, thereby regulating their regulatory effects. Protein degradation targeting chimeras is an emerging direction in drug research and development. Traditional inhibitors have a blocking effect, leading to drug resistance and off target phenomena. However, this technology degrades the target protein through a 26S protease system. Structurally, PROTAC consists of three parts: the left end is a ligand that binds to the target protein, the right end is a ligand that connects to ubiquitin ligase, and the middle is connected through a \"Linker\". In the patient's body, one end of PROTAC is connected to E3 ubiquitin ligase, and the other end is connected to the target protein to be degraded. Through multiple rounds of ubiquitination, a ubiquitin chain is formed, achieving the UPS system to degrade the target protein. PROTAC small molecules have great prospects in the treatment of diseases. Unlike traditional small molecule drugs, they do not destroy the function of proteins, but completely degrade them. And PROTAC can be recycled, and the proteins of interest are polyubiquitinated and degraded through proteasomes. The dissociated PROTAC can also initiate new degradation, which is an important breakthrough in the fight against cancer cells. For example, we can design a PROTAC to hijack the protein required for unlimited proliferation of cancer cells, so that it can be degraded and inhibit the growth of cancer cells. Further exploration is needed for the development and clinical application of PROTAC drugs.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133452718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on Cellular Immune Targeted Drug Therapy for Breast Cancer based on Bioinformatics 基于生物信息学的乳腺癌细胞免疫靶向药物治疗研究

International Journal of Biology and Life Sciences Pub Date : 2023-05-20 DOI: 10.54097/ijbls.v2i3.8662

Peilun Meng

{"title":"Research on Cellular Immune Targeted Drug Therapy for Breast Cancer based on Bioinformatics","authors":"Peilun Meng","doi":"10.54097/ijbls.v2i3.8662","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8662","url":null,"abstract":"Targeted therapy, because of its precise location, high efficiency and low toxicity, has become an important tumor treatment method besides traditional treatments such as surgery, radiotherapy and chemotherapy. Targeted drugs can deliver therapeutic drugs to target organs to the maximum extent, but have little effect on non-target organs, thus achieving high-efficiency and low-toxicity therapeutic effects, especially for treating diseases such as cancer. At the cellular and molecular level, molecular targeting means that drugs enter the body and specifically bind with carcinogenic sites on tumor cells, resulting in the death of tumor cells, but it does not affect the surrounding normal tissues and cells. Studying the pathogenesis and related genes of breast cancer plays an active role in the early diagnosis and treatment of breast cancer, and effectively relieves the current status of clinical breast cancer treatment. In-depth study on molecular typing of breast cancer can provide further reference for the selection of clinical treatment schemes more effectively. This paper discusses the cellular immune targeted drug therapy for breast cancer from the perspective of bioinformatics.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128028828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0