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Progress in the treatment of Hailey-Hailey disease 海莉病的治疗进展
International Journal of Biology and Life Sciences Pub Date : 2023-02-15 DOI: 10.54097/ijbls.v2i1.5239
Wei Jiang, Xueyong Wang, N. Li, Shan Li, Zhiguo Xu
{"title":"Progress in the treatment of Hailey-Hailey disease","authors":"Wei Jiang, Xueyong Wang, N. Li, Shan Li, Zhiguo Xu","doi":"10.54097/ijbls.v2i1.5239","DOIUrl":"https://doi.org/10.54097/ijbls.v2i1.5239","url":null,"abstract":"Familial benign chronic pemphigus, also known as Hailey-Hailey disease, is an autosomal dominant disease having genetic features that follow Mendelian inheritance principles. HHD is a rare disease that affects approximately one out of every 50,000 people. Clinically, it presents as blisters, fissures, erosions, and vegetations with significant pruritus or pain in skin folds or reversal areas of the skin. In the presence of heat, localized sweating, or exercise, patients with HHD may suffer repeated or worsened symptoms. Furthermore, concurrent bacterial, fungal, and viral infections may aggravate localized lesions. HHD may raise the likelihood of problems such as insomnia, anxiety, and depression. There are no treatment guidelines or large clinical trials for HHD. This could be attributed to the low prevalence of HHD. Although the pathogenesis of HHD is well understood, there are no specific or curative treatment options available. The majority of current treatment focuses on symptomatic relief. In this article, we will discuss the most recent advancements in HHD research.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114638268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accurate Implantation and Long-term Stability with the Assistance of Computer-aided Design 计算机辅助设计下的精确植入和长期稳定性
International Journal of Biology and Life Sciences Pub Date : 2023-02-14 DOI: 10.54097/ijbls.v2i1.5224
Nancy Wang
{"title":"Accurate Implantation and Long-term Stability with the Assistance of Computer-aided Design","authors":"Nancy Wang","doi":"10.54097/ijbls.v2i1.5224","DOIUrl":"https://doi.org/10.54097/ijbls.v2i1.5224","url":null,"abstract":"With the constant development of radiation and computer technology, the field of implant dentistry is also experiencing a digital revolution, including digitalized data acquisition, computer-aided virtual planning, computer-guided implant surgery and restoration, etc. The digitalized clinical protocol promotes a more standardized and accurate dental implant treatment, which certainly will reduce the occurrence of complications for dental implant treatment, and achieve more predictable long-term stability in both function and aesthetics, This paper summarized the digital collection, digital smile design, computer-guided surgery planning, and implant supported prosthesis design in combined with the development status of digital technique, and the future trend.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114353553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A meta-analysis of cyp2c19 gene testing on the prognosis of patients aged 60 years and older with acute coronary syndrome cyp2c19基因检测对60岁及以上急性冠脉综合征患者预后的meta分析
International Journal of Biology and Life Sciences Pub Date : 2023-02-14 DOI: 10.54097/ijbls.v2i1.5222
Binbin Zhen
{"title":"A meta-analysis of cyp2c19 gene testing on the prognosis of patients aged 60 years and older with acute coronary syndrome","authors":"Binbin Zhen","doi":"10.54097/ijbls.v2i1.5222","DOIUrl":"https://doi.org/10.54097/ijbls.v2i1.5222","url":null,"abstract":"Objective Whether cyp2c19 gene testing is clinically beneficial for patients aged 60 years and older with acute coronary syndrome. Methods A computerized search of WIFANG, CNKI, CBM and Vipul databases was performed to comprehensively collect RCTs on cyp2c19 gene-guided selection of different antiplatelet regimens or placebo or blank control comparisons. Results A total of 8 RCTs were included. cyp2c19 gene-guided prognosis regarding antiplatelet regimens in the elderly was better in the tigretol group than in the clopidogrel group, with statistically significant differences. CONCLUSION: Current evidence suggests that in the context of acute coronary syndromes in patients, with reference to the cyp2c19 gene and age, the overall clinical benefit of tigretol may be much better than clopidogrel, although patients may be at greater risk of bleeding.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"60 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114005791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise regulates TFEB expression to influence body metabolism 运动调节TFEB表达，影响机体代谢
International Journal of Biology and Life Sciences Pub Date : 2023-02-14 DOI: 10.54097/ijbls.v2i1.5223
Jiaxin Li
{"title":"Exercise regulates TFEB expression to influence body metabolism","authors":"Jiaxin Li","doi":"10.54097/ijbls.v2i1.5223","DOIUrl":"https://doi.org/10.54097/ijbls.v2i1.5223","url":null,"abstract":"Skeletal muscle is the largest organ in the body. It is also the regulator of glucose homeostasis and is responsible for 80% of postprandial glucose uptake from the circulation. Skeletal muscle is crucial to metabolism, both for its role in glucose uptake and for its importance in exercise and metabolic disease. In this article, we outline the importance of skeletal muscle in metabolism, describe its role in glucose uptake and the diseases associated with dysmetabolism of skeletal muscle. We focus on the role of skeletal muscle in peripheral insulin resistance and the potential of skeletal muscle-targeted therapies in combating insulin resistance and diabetes, as well as other metabolic diseases such as ageing and obesity. In particular, we outline the molecular mechanisms underlying the beneficial effects of exercise on metabolic diseases, including a focus on the TFEB nucleus, which is an important regulator of glucose transport to skeletal muscle. In this article, we give an overview to summarise and discuss the important role of TFEB in metabolic and adaptive responses during exercise.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"83 1 Pt 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133895405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of Early Diagnosis and Treatment for Diabetes Mellitus Type 1 1型糖尿病早期诊断与治疗的探讨
International Journal of Biology and Life Sciences Pub Date : 2023-02-09 DOI: 10.54097/ijbls.v2i1.5161
Jiayong Zhang
{"title":"Investigation of Early Diagnosis and Treatment for Diabetes Mellitus Type 1","authors":"Jiayong Zhang","doi":"10.54097/ijbls.v2i1.5161","DOIUrl":"https://doi.org/10.54097/ijbls.v2i1.5161","url":null,"abstract":"Type I diabetes mellitus (TIDM) is a kind of chronic disease, which caused by autoimmune disorders which result in hyperglycemia and inadequate insulin secretion. Over the past 25 years, knowledge about T1DM has advanced rapidly. These recent progressions in researching T1DM help us better understand the disease in various aspects including genetics, epidemiology, immunology, and pancreatic cancer. Epidemiology, immunology, beta cell phenotype, and disease burden. Why is T1DM thought to be preventable? Several areas of diabetes research have been brought together to suggest therapeutic targets. This article introduces T1DM from its basic definition, world impact, pathology, current existing drug-assistant treatment, and now existing diagnostic tools such as OGTT. This article is based on literature across several fields including Medications, Epidemics, and Statistics. Also, several anti-diabetic drugs that have the potential in participating T1DM treatment as assistance were listed as well. For example, metformin has been recognized as having a huge potential in reducing blood sugar level company with insulin. This article mainly focused on showing information about T1DM and attempting to make several predictions on potential treatments that may be helpful for future patients.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130642226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of combined microbial-plant remediation on soil physical properties in mining area 微生物-植物复合修复对矿区土壤物理性质的影响
International Journal of Biology and Life Sciences Pub Date : 2023-02-09 DOI: 10.54097/ijbls.v2i1.5164
Shenglan Ye, Juan Li, Dan Wu
{"title":"Effect of combined microbial-plant remediation on soil physical properties in mining area","authors":"Shenglan Ye, Juan Li, Dan Wu","doi":"10.54097/ijbls.v2i1.5164","DOIUrl":"https://doi.org/10.54097/ijbls.v2i1.5164","url":null,"abstract":" In view of the problems of vegetation damage, soil water and fertilizer shortage, soil heavy metal pollution, ecosystem damage and other problems existing in the long-term mining of the coal mine area, this study uses micro-organism-plant to bioremediation the coal mine area. The changes of soil physical properties were studied through pot experiment. The results show that the combined remediation can change the physical properties of soil to a certain extent, but the effect is not significant in the short term.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"189 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134115196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiological Risk Assessment and Its Use in Food Industry 微生物风险评价及其在食品工业中的应用
International Journal of Biology and Life Sciences Pub Date : 2023-02-09 DOI: 10.54097/ijbls.v2i1.5163
Lu Li, Cheng Wang
{"title":"Microbiological Risk Assessment and Its Use in Food Industry","authors":"Lu Li, Cheng Wang","doi":"10.54097/ijbls.v2i1.5163","DOIUrl":"https://doi.org/10.54097/ijbls.v2i1.5163","url":null,"abstract":"Risk assessment is a novel approach, which is the estimation of the impact of hazards and the identification of components. The process in risk assessment is hazard identification, hazard characterisation, exposure assessment and risk characterisation. As a means of hazard evaluation, microbiological risk assessment links food and risk factors, such as food-borne bacteria, through data to predict their hazards relatively accurately and reliably, thereby reducing their impact on public health. This study mainly introduces the scientific information about risk assessment and the quantitative microbiological risk assessment in the instant food，mainly to evaluate the level of Listeria in foods. Meat products cause 60% of Listeria monocytogenes.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125610588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic antidepressant effect of Schisandra lignans and Schisandra polysaccharides 五味子脂素与五味子多糖的协同抗抑郁作用
International Journal of Biology and Life Sciences Pub Date : 2023-02-09 DOI: 10.54097/ijbls.v2i1.5160
Zhengze Li
{"title":"Synergistic antidepressant effect of Schisandra lignans and Schisandra polysaccharides","authors":"Zhengze Li","doi":"10.54097/ijbls.v2i1.5160","DOIUrl":"https://doi.org/10.54097/ijbls.v2i1.5160","url":null,"abstract":"The CUMS（Chronic unpredictable mild stress） method was used to establish a depression model，and the combination of schisandra lignans and schisandra polysaccharides was used for drug treatment, and its effect on the depressive behavior of mice was observed through behavioral indicators, and then the synergistic anti-inflammatory effects of schisandra lignans and schisandra polysaccharides were explored. The study found that the food intake of the CUMS-induced model mice decreased significantly after depression, and major symptoms such as depression, anxiety, loss of libido, and weight loss appeared. After 28 days of administration, the depression symptoms of the positive control group, Schisandra lignan group, Schisandra polysaccharide group, Schisandra lignan and polysaccharide group gradually improved, while the model group showed obvious depression.  Schisandra lignans and Schisandra polysaccharides have synergistic antidepressant effects.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121824180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunogenic cell death-related classification to predict prognosis and immunotherapeutic response in hepatocellular carcinoma 肝细胞癌免疫原性细胞死亡相关分类预测预后和免疫治疗反应
International Journal of Biology and Life Sciences Pub Date : 2023-02-02 DOI: 10.54097/ijbls.v2i1.4894
Xinyang Cao, Zhang Yu
{"title":"Immunogenic cell death-related classification to predict prognosis and immunotherapeutic response in hepatocellular carcinoma","authors":"Xinyang Cao, Zhang Yu","doi":"10.54097/ijbls.v2i1.4894","DOIUrl":"https://doi.org/10.54097/ijbls.v2i1.4894","url":null,"abstract":"Immunogenic cell death (ICD) has been classified as a form of regulated cell death (RCD) sufficient to activate adaptive immune responses. There is growing evidence that ICD is capable of reshaping the tumor immune microenvironment through the release of danger signals or DAMPs, which may contribute to immunotherapy. Currently, identification of ICD-related biomarkers that allow patients to benefit from ICD immunotherapy would be of great help to classify patients. Here, we identified two subtypes associated with ICD by consensus clustering. high ICD subtypes were associated with good clinical outcome, immune cell infiltration and immune response signaling activity. In addition, we developed and validated an ICD-related prognostic model that predicted survival in HCC and correlated with the tumor immune microenvironment. In conclusion, we developed a new ICD subtype-based classification system for HCC. This classification has significant clinical outcomes for assessing prognosis and of immunotherapy of HCC patients.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130100050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between some species of parasites and cancer and their pathogenesis: A literature Review 几种寄生虫与肿瘤的关系及其发病机制:文献综述
International Journal of Biology and Life Sciences Pub Date : 2023-01-08 DOI: 10.54097/ijbls.v1i1.4603
Jiayin Liu
{"title":"The relationship between some species of parasites and cancer and their pathogenesis: A literature Review","authors":"Jiayin Liu","doi":"10.54097/ijbls.v1i1.4603","DOIUrl":"https://doi.org/10.54097/ijbls.v1i1.4603","url":null,"abstract":"Cancer is the second most common cause of death worldwide, and one of the pathogenesis is some species of parasites. At present, the main types of parasites for cancer are: Echinococcus granulosus (tapeworm), Toxoplasma gondii, Plasmodium, Trypanosoma cruzi, Schistosoma, liver fluke and so on. Different types of parasites cause different types of cancer. In recent years, many scholars have done related research and experiments on the mechanism of parasite-induced cancer infection, but the specific mechanism has not been clear so far. This article reviews the relationship between schistosomiasis, liver flukes and Toxoplasma gondii and cancer and their pathogenesis.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"19 3‐4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120860312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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