International Journal of Biology and Life Sciences最新文献

Effect of Apatinib Mesylate on Clinical Remission Rate and Adverse Reactions in Patients with Advanced Primary Hepatocellular Carcinoma 甲磺酸阿帕替尼对晚期原发性肝细胞癌患者临床缓解率和不良反应的影响

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/t3s4wp88

Xixi Tian, Qi Yang, Jianfei Wu

{"title":"Effect of Apatinib Mesylate on Clinical Remission Rate and Adverse Reactions in Patients with Advanced Primary Hepatocellular Carcinoma","authors":"Xixi Tian, Qi Yang, Jianfei Wu","doi":"10.54097/t3s4wp88","DOIUrl":"https://doi.org/10.54097/t3s4wp88","url":null,"abstract":"Objective: To investigate the effect of apatinib mesylate on the clinical remission rate and adverse reactions in patients with advanced primary hepatocellular carcinoma. Methods: A total of 60 patients with advanced primary hepatocellular carcinoma admitted to our hospital from January 2021 to September 2022 were selected. They were divided into two groups using a random number table. The control group (n=30) underwent drug-eluting beads transarterial chemoembolization (DEB-TACE), while the observation group (n=30) was treated with apatinib mesylate in combination with the treatment method of the control group. The short-term clinical effects, adverse reaction rates, pre- and post-treatment serum levels of Vascular Endothelial Growth Factor (VEGF) and Hypoxia-Inducible Factor-1α (HIF-1α), and survival times were compared between the two groups. Results: The short-term clinical efficacy in the observation group was significantly better than in the control group (P<0.05). The incidence rates of fever, abdominal pain, nausea and vomiting, and bone marrow suppression were comparable between the two groups (P>0.05). The observation group had a higher incidence of general fatigue, hypertension, proteinuria, hand-foot syndrome, and rash than the control group (P<0.05). Before treatment, the levels of VEGF and HIF-1α were comparable between the two groups (P>0.05). After treatment, the VEGF and HIF-1α levels in the observation group were lower than those in the control group (P<0.05). The survival time of patients in the observation group was longer than that of the control group (P<0.05). Conclusion: Treatment of patients with advanced primary hepatocellular carcinoma with apatinib mesylate can improve clinical outcomes, reduce the incidence of adverse reactions, and extend patient survival. The effect is promising and worth promoting.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"44 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Different Types of Periodontitis on CBCT Morphology of Dental Tissue in Two Ethnic Groups 不同类型牙周炎对两个种族牙组织 CBCT 形态学的影响

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/gvs9ry19

Ting Ma, Maimaiti· Yasen

引用次数: 0

Exploring the Pathogenesis of Clostridium difficile Infection Based on Weighted Gene Co-expression Network Analysis 基于加权基因共表达网络分析探索艰难梭菌感染的发病机制

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/4qczm689

Yankun Li

{"title":"Exploring the Pathogenesis of Clostridium difficile Infection Based on Weighted Gene Co-expression Network Analysis","authors":"Yankun Li","doi":"10.54097/4qczm689","DOIUrl":"https://doi.org/10.54097/4qczm689","url":null,"abstract":"Clostridioides difficile, a Gram-positive, spore-forming, anaerobic bacterium, is a leading cause of antibiotic-associated diarrhea and colitis. Its infections, often linked to antibiotic use in healthcare settings, range from mild diarrhea to pseudomembranous colitis. This study explores the pathogenic and toxin action mechanisms of Clostridioides difficile, particularly its toxins TcdA and TcdB, which disrupt host cells through glycosyltransferase activity, affecting cell structure and intestinal integrity, while also triggering inflammation and immune responses. Treatment strategies for Clostridioides difficile infection continue to evolve, encompassing antibiotics, microbiota replacement, monoclonal antibodies, and emerging therapies. The study employs Weighted Gene Co-expression Network Analysis (WGCNA)to analyze the GSE29008 dataset, categorizing samples into normal, toxin A, and toxin B groups. Notably, the 'midnightblue' module shows a strong positive correlation with toxin B, indicating its significant role in severe inflammation and tissue damage, emphasizing the importance of understanding the toxin action mechanisms for developing effective treatments and public health policies.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"8 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140439995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Polyamine Metabolism-related Gene Signature Predicts Breast Cancer Prognosis 预测乳腺癌预后的多胺代谢相关基因新特征

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/3rt49z65

Ruiqi Liu, Xiaoqian Huang, Xiaozhou Chen

引用次数: 0

Analysis of Survival Rate and Influencing Factors in Surgical Treatment of Primary Hepatocellular Carcinoma 原发性肝细胞癌手术治疗的存活率及影响因素分析

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/6yjb4825

Jianfei Wu, Guodong Yu, Xixi Tian, Quan Zhang

{"title":"Analysis of Survival Rate and Influencing Factors in Surgical Treatment of Primary Hepatocellular Carcinoma","authors":"Jianfei Wu, Guodong Yu, Xixi Tian, Quan Zhang","doi":"10.54097/6yjb4825","DOIUrl":"https://doi.org/10.54097/6yjb4825","url":null,"abstract":"Objective: To study the survival rate of patients with primary hepatocellular carcinoma (HCC) undergoing clinical surgical treatment and various influencing factors, with the aim of further improving the survival rate of primary HCC patients. Methods: Sixty patients with primary hepatocellular carcinoma who underwent liver cancer resection surgery between January 2020 and December 2022 in our hospital were selected. A retrospective analysis was conducted on the patients' clinical characteristics (family medical history, alpha-fetoprotein levels, degree of liver cirrhosis, vascular invasion), treatment methods (surgical techniques, adjunctive therapies), and prognosis. The survival rate of patients and the influencing factors on the postoperative survival rate were analyzed. Results: There was a statistically significant difference in the five-year survival rate comparisons between different liver cirrhosis statuses, tumor sizes, preoperative alpha-fetoprotein levels, vascular invasion statuses, adjunctive treatment methods, and family medical histories (P < 0.05). Comparisons between different genders, ages, tumor locations, tumor pathological types, hepatitis B surface antigens, Child-Pugh classifications of liver function, tumor numbers, and methods of liver cancer resection showed no statistically significant differences (P > 0.05). Liver cirrhosis, tumor size ≥ 5cm, preoperative alpha-fetoprotein level > 400ng/ml, change in alpha-fetoprotein levels pre-and post-surgery, vascular invasion, adjunctive treatment methods, and PLC family medical history are independent factors influencing the survival rate of surgical treatment in primary HCC patients. Conclusion: There are several factors affecting the postoperative survival rate of primary HCC patients. Clinicians need to take a comprehensive approach. For high-risk patients, regular follow-ups are necessary, coupled with early diagnosis and treatment, to improve the prognosis. This approach is worth promoting. ","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Genetic Variation on Human Disease: From Genomics to Phenotype 遗传变异对人类疾病的影响：从基因组学到表型

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/tq1bbt82

Xiaohui Shi

{"title":"Impact of Genetic Variation on Human Disease: From Genomics to Phenotype","authors":"Xiaohui Shi","doi":"10.54097/tq1bbt82","DOIUrl":"https://doi.org/10.54097/tq1bbt82","url":null,"abstract":"The impact of genetic variation on human disease is a multifaceted phenomenon involving genomics, epigenetics, and phenotype relationships. Advances in human genetic analysis technology have revolutionized our understanding of genetic disorders, enabling large-scale screens to explore associations between sequence variants and disease susceptibility. Environmental stimuli also contribute to epigenetic modifications that shape gene expression and phenotypic traits. Recent research on monozygotic twins highlights the role of non-genetic factors in phenotypic differences, underscoring the complex interplay between genetics and environment. The literature review highlights seminal studies that elucidate genetic and evolutionary mechanisms underlying human disease, providing insights for personalized medicine. Methods such as pharmacogenetics and immunomics provide avenues for precision therapies and immunological research. The Heterogeneity Weighted U test and the Gaussian random effects model facilitate the exploration of phenotype-genotype relationships and help to assess genetic heterogeneity in disease models. Simulation experiments deepen our understanding of the impact of genetic variation on disease manifestation. The interdisciplinary approaches are crucial to unravel the complex genetic landscape of human diseases and to develop tailored therapeutic interventions.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory Exercise Solutions in Precision Radiation Therapy for Lung Cancer 肺癌精准放射治疗中的呼吸运动解决方案

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/ma4sej44

Fei Chu

{"title":"Respiratory Exercise Solutions in Precision Radiation Therapy for Lung Cancer","authors":"Fei Chu","doi":"10.54097/ma4sej44","DOIUrl":"https://doi.org/10.54097/ma4sej44","url":null,"abstract":"Objective: To study the intervention effect of incorporating respiratory motion solutions in precision radiotherapy for lung cancer. Methods: In the survey sample collected by the enterprise from 2022 to 2023, we selected 60 patients for sample study. They were randomly divided into two groups. Both groups received precision radiotherapy. The control group (n=30) received health education to help patients understand the importance of cervical radiotherapy for lung cancer. The observation group (n=30) received resistance respiratory training and lung function training. The lung function indicators, Piper fatigue scale, cancer-related quality of life score, and symptom score were compared before and after intervention in both groups. Results: Before intervention, there were no significant differences in lung function indicators, Piper fatigue scale, cancer-related quality of life score between the two groups (P>0.05). After intervention, the lung function indicators, Piper fatigue scale, and cancer-related quality of life score were significantly better in the observation group than in the control group (P<0.05). The observation group also had a lower symptom score than the control group (P<0.05). Conclusion: Incorporating resistance respiratory training and lung function training during precision radiotherapy for lung cancer can improve respiratory motion, enhance treatment effectiveness, and improve lung function. These findings are worth promoting.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlates of Cardiology Nurses' Clinical First Aid Competence in a Selected Hospital in Shandong, China 中国山东某医院心内科护士临床急救能力的相关因素

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/3pk1xe86

Baichuan Yin, Jeffrey Valdez. Esteron

引用次数: 0

Bioinformatics Analysis of Immunoglobulin ε (IgE) Heavy Chain 免疫球蛋白ε（IgE）重链的生物信息学分析

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/9yvrbm43

Dongying Wang

引用次数: 0

Prediction Analysis of the Number of Patients with Respiratory Diseases based on SVR 基于 SVR 的呼吸系统疾病患者人数预测分析

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/87pq5a76

Xiaotian Ma, Yinghua Li

引用次数: 0