International Journal of Biology and Life Sciences最新文献_第2页

Mechanisms of Atherosclerotic Plaque Instability 动脉粥样硬化斑块不稳定性的机理

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/83r6jq74

Jinhua Huang, Jinping Liang, Lijia Huang, Tingting Li

{"title":"Mechanisms of Atherosclerotic Plaque Instability","authors":"Jinhua Huang, Jinping Liang, Lijia Huang, Tingting Li","doi":"10.54097/83r6jq74","DOIUrl":"https://doi.org/10.54097/83r6jq74","url":null,"abstract":"Cardiovascular disease (CVD) is the leading cause of mortality in humans worldwide. The main cause of CVD is the formation of thrombi due to by unstable atherosclerotic plaque rupture on the arterial wall. Long-term accumulation of thrombi results in vascular remodeling, and subsequent-stenosis of the lumen obstructs the blood flow, thereby leading to myocardial tissue ischemia and hypoxia. Sustained ischemia and hypoxia lead to myocyte necrosis, resulting in irreversible myocardial injury. Many molecular and cellular mechanisms are associated with atherosclerotic plaque instability (API). For example, macrophages can produce various inflammatory factors, adhesion factors, chemokines and matrix metalloproteinases (MMPs), which play important roles in the pathophysiological mechanisms of API and in maintaining plaque stability. These molecules may help predict unstable atherosclerotic plaques. If the plaque is stable, it will not be prone to rupture or thrombosis. Accordingly, in this review, we will discuss the different pathophysiological mechanisms of API and the related roles of macrophages in the mechanisms of API mainly in animal models and humans. We believe this review will provide a theoretical basis for the development of treatments and diagnostic approaches for the management of API.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"5 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of HIF1-α/NF-κB/MMP2 Signaling Pathways Mediated by ALDH2 on Chronic Intermittent Hypoxia Induced Myocardial Injury in Rats ALDH2 介导的 HIF1-α/NF-κB/MMP2 信号通路对慢性间歇性缺氧诱导的大鼠心肌损伤的影响

International Journal of Biology and Life Sciences Pub Date : 2024-02-22 DOI: 10.54097/wxcz8y41

Bin Chen

{"title":"The Effect of HIF1-α/NF-κB/MMP2 Signaling Pathways Mediated by ALDH2 on Chronic Intermittent Hypoxia Induced Myocardial Injury in Rats","authors":"Bin Chen","doi":"10.54097/wxcz8y41","DOIUrl":"https://doi.org/10.54097/wxcz8y41","url":null,"abstract":" (1) Objective: To investigate the effect of HIF1-α/NF-κB/MMP2 signaling pathways mediated by ALDH2 on chronic intermittent hypoxia induced myocardial injury in rats. (2) Methods: Thirty SD rats were randomly assigned to three groups (10 rats in each group): control group (CONTROL), chronic intermittent hypoxia group (CIH), and CIH + ALDH2 group. Rats in the CIH + ALDH2 group were established by an intraperitoneal injection of the ALDH2 activator, Alda-1 (20 mg/kg), once a day for three consecutive days. After three months, changes in ventricular function were determined by ultrasound. The expressions of HIF1-α, NF-κB, and MMP2 proteins were detected by protein blotting, and the concentration of 4-HNE in myocardial tissue was measured. (3) Results: Compared with the control group, echocardiography showed that rats in the CIH group had significantly reduced myocardial function, elevated protein levels of HIF1-α, NF-κB, and MMP2 in myocardial tissues, and increased the expression of 4-HNE in myocardial tissues (P<0.01); Compared with the CIH group, rats in the CIH + ALDH2 group showed significant improvement in myocardial function, decreased protein levels of HIF1-α, NF-κB, and MMP2 in myocardial tissue, and decreased the expression of 4-HNE in myocardial tissue (P<0.01). (4) Conclusion: Chronic intermittent hypoxia increases the expression of HIF1-α to damage the myocardium and affect cardiac function, and ALDH2 inhibits the expression of HIF1-α to protect the myocardium.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"51 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of tumor-associated Macrophages in Tumor Development 肿瘤相关巨噬细胞在肿瘤发展中的作用

International Journal of Biology and Life Sciences Pub Date : 2023-07-25 DOI: 10.54097/ijbls.v3i2.11451

Lu Fang

引用次数: 0

Research Progress on the Change Trend and Pollution Characteristics of Ambient Air Quality 环境空气质量变化趋势及污染特征研究进展

International Journal of Biology and Life Sciences Pub Date : 2023-07-25 DOI: 10.54097/ijbls.v3i2.11452

Jiangshen Huang, Xiyuan Wei

引用次数: 0

Finger Vein Recognition Technology: Principles, Applications, and Future Prospects 手指静脉识别技术:原理、应用和未来展望

International Journal of Biology and Life Sciences Pub Date : 2023-07-20 DOI: 10.54097/ijbls.v3i2.10852

Lizhen Zhou

引用次数: 0

Effect of Resistance Exercise with Moderate and Low Intensity on Quality of Life and Mental Health in Maintenance Hemodialysis Patients 中低强度阻力运动对维持性血液透析患者生活质量和心理健康的影响

International Journal of Biology and Life Sciences Pub Date : 2023-07-20 DOI: 10.54097/ijbls.v3i2.11362

Tong Ding, Jing Zhao

{"title":"Effect of Resistance Exercise with Moderate and Low Intensity on Quality of Life and Mental Health in Maintenance Hemodialysis Patients","authors":"Tong Ding, Jing Zhao","doi":"10.54097/ijbls.v3i2.11362","DOIUrl":"https://doi.org/10.54097/ijbls.v3i2.11362","url":null,"abstract":"It was to explore the effects of resistance exercise with moderate and low intensity on quality of life (QoL) and mental health of patients with maintenance hemodialysis (MHD). From June 2022 to December 2022, 90 patients receiving MHD treatment in Blood Purification Center of XXX Hospital were randomly divided into observation group and controls, with 45 patients in each group. The controls received routine hemodialysis care, and observation group received resistance exercise with moderate and low inte in addition to routine hemodialysis care. QoL measurement tool adopted 36-Item Short Form Health Survey (SF-36), Hamilton Rating Scale for Depression (HAMD), and Hamilton Anxiety Scale (HAMA) to evaluate patients. The physical function was 67.64±25.62 and mental health was 71.68±28.55 in controls, and those was 71.11±25.42 and 73.48±13.59 in observation group; in terms of physical function and mental health in QoL, observation group was obviously higher; and HAMD and HAMA scores in observation group were clearly lower as against controls (P < 0.05). The effect of resistance exercise with moderate and low inte was obvious on the physical function and mental state of QoL in MHD patients, but not obvious on other aspects. Resistance exercise with moderate and low inteis beneficial to improve patients’ mental health.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125331362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Ameliorative Effect of Dietary Interventions based on the Chinese Dietary Guidelines on Metabolic Syndrome 基于中国膳食指南的代谢综合征饮食干预的改善作用

International Journal of Biology and Life Sciences Pub Date : 2023-07-20 DOI: 10.54097/ijbls.v3i2.11364

Aanglin Lyu

引用次数: 0

Summary of Tyrosine Kinase STI-571 in the Treatment of Chronic Myeloid Leukemia 酪氨酸激酶STI-571治疗慢性髓系白血病的研究综述

International Journal of Biology and Life Sciences Pub Date : 2023-07-20 DOI: 10.54097/ijbls.v3i2.11363

Chang Gao

{"title":"Summary of Tyrosine Kinase STI-571 in the Treatment of Chronic Myeloid Leukemia","authors":"Chang Gao","doi":"10.54097/ijbls.v3i2.11363","DOIUrl":"https://doi.org/10.54097/ijbls.v3i2.11363","url":null,"abstract":"Chronic Myeloid Leukemia (CML) is a hematological malignancy characterized by the presence of the Philadelphia chromosome, which results in the formation of the BCR-ABL fusion protein with constitutive tyrosine kinase activity. The discovery and development of targeted therapies, such as the tyrosine kinase inhibitor STI-571 (Imatinib), revolutionized the treatment of CML by specifically inhibiting the BCR-ABL kinase activity. This abstract provides a summary of the therapeutic efficacy and clinical impact of STI-571 in the management of CML.Sti-571, a specific tyrosine kinase inhibitor, is a novel antitumor drug that has entered clinical trials and can effectively treat chronic myeloid leukemia caused by abnormal proliferation of hematopoietic stem cells. In this paper, the mechanism of action and regulation of cell cycle of this drug were summarized, and the problems of drug resistance were explored in depth and the development prospects of this drug were briefly introduced. The introduction of STI-571 has dramatically changed the management of CML, leading to a paradigm shift from conventional chemotherapy and allogeneic stem cell transplantation as the primary treatment options. The drug has shown superior efficacy compared to interferon-alpha therapy, the standard treatment before its introduction. STI-571 is generally well-tolerated, with fewer severe adverse effects, making it an attractive option for long-term therapy. Resistance to STI-571 has been observed in a subset of patients, primarily due to the emergence of BCR-ABL kinase domain mutations. However, the development of second-generation tyrosine kinase inhibitors, such as dasatinib and nilotinib, has provided alternative treatment options for patients who fail to respond to or develop resistance to STI-571.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"56 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121032244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Analysis of 2 Cases of Late-onset Myasthenia Gravis 迟发性重症肌无力2例临床分析

International Journal of Biology and Life Sciences Pub Date : 2023-07-12 DOI: 10.54097/ijbls.v3i2.10097

Yuxin Xiao, Huili Tang

引用次数: 0

Effect of Low-temperature Plasma on Polysaccharide Components of Pleurotus ostreatus Fungi 低温等离子体对平菇真菌多糖成分的影响

International Journal of Biology and Life Sciences Pub Date : 2023-07-12 DOI: 10.54097/ijbls.v3i2.10071

Xiaoyan Xu, Yan Guo, Youjun Wang, Jie Zhu

引用次数: 0