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Research Progress of Combined Application of All-trans Retinoic Acid and Bone Morphogenetic Protein in Bone Metabolism 全反式维甲酸与骨形态发生蛋白在骨代谢中的联合应用研究进展
International Journal of Biology and Life Sciences Pub Date : 2023-05-25 DOI: 10.54097/ijbls.v3i1.9606
Zifan Yu, Yiwei Yuan, Yanan Ma, Lei Jiang, Yicheng Zhou, Wenjuan Bi
{"title":"Research Progress of Combined Application of All-trans Retinoic Acid and Bone Morphogenetic Protein in Bone Metabolism","authors":"Zifan Yu, Yiwei Yuan, Yanan Ma, Lei Jiang, Yicheng Zhou, Wenjuan Bi","doi":"10.54097/ijbls.v3i1.9606","DOIUrl":"https://doi.org/10.54097/ijbls.v3i1.9606","url":null,"abstract":"All-trans retinoic acid (ATRA) can both promote and inhibit osteogenic differentiation of cells, which is closely related to the concentration, dose and cell type. Low dose of ATRA inhibited the function of osteoclasts and promoted the differentiation of osteoblasts, thus achieving bone remodeling: Bone formation is achieved through the coordination of osteoblasts and osteoclasts. ATRA can be combined with various factors to produce different effects, among which, when combined with bone morphogenetic protein (BMP), the bone formation effect is significant. Compared with homologous dimer, BMP heterodimer can repair the bone defect area more effectively with a smaller dose, and promote the formation of bone tissue. Reduce the probability of secondary lesions such as swelling in the operative area and excessive osteogenesis, and greatly reduce the economic burden of patients. In addition, in vitro experiments showed that ATRA and BMP2/7 combined with mouse embryonic osteoblast precursor cells (MC3T3-E1) had synergistic effect on osteogenesis. This article reviews the recent progress in the studies on the combined effects of ATRA and BMP in bone metabolism.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128485758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on the Effect of Traction Combined with Acupuncture and Massage Function Exercise on Patients with Lumbar Disc Herniation 牵引配合针刺推拿功能锻炼治疗腰椎间盘突出症的疗效研究
International Journal of Biology and Life Sciences Pub Date : 2023-05-25 DOI: 10.54097/ijbls.v3i1.9617
Bingshuang Liang, Ting Wu, Yucheng Yang
{"title":"Research on the Effect of Traction Combined with Acupuncture and Massage Function Exercise on Patients with Lumbar Disc Herniation","authors":"Bingshuang Liang, Ting Wu, Yucheng Yang","doi":"10.54097/ijbls.v3i1.9617","DOIUrl":"https://doi.org/10.54097/ijbls.v3i1.9617","url":null,"abstract":"To study the clinical effect of traction combined with acupuncture and massage function exercise in the Treatment of lumbar disc herniation. Methods A total of 180 patients with lumbar intervertebral disc herniation were selected and randomly divided into traction group, acupuncture group, combined group, and control group, with 60 cases in each group. The traction group was treated with traction, while the acupuncture group and the combined group were treated with traction combined with acupuncture and massage. Results After Treatment, the total effective rate was 76.56% in the traction group, 62.3% in the control group, and 98.44% in the acupuncture and combined groups. Comparing the curative effects of the three groups, the traction group was better than the control group (P<0.05), and the traction combined with acupuncture and massage was better than the traction group (P<0.05). It shows that traction therapy is better than acupuncture and massage, and the efficacy rate of traction therapy combined with acupuncture and massage is better than that of traction therapy. Conclusion Traction combined with acupuncture and massage function exercise has a better curative effect on patients with lumbar intervertebral disc herniation, which is worthy of popularization and application, is safe, and has high clinical value.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134467660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Allocation Strategies of Specialized Physicians 专科医师配置策略比较
International Journal of Biology and Life Sciences Pub Date : 2023-05-22 DOI: 10.54097/ijbls.v2i3.8646
Xuan Zhang
{"title":"Comparison of Allocation Strategies of Specialized Physicians","authors":"Xuan Zhang","doi":"10.54097/ijbls.v2i3.8646","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8646","url":null,"abstract":"As an aging population increases the demand for medical care, hospitals will have to increase the number of medical equipment and examiners to cope with the surge in demand for medical tests due to increased dependence on diagnostic equipment. However, doctors have different abilities and patients have a variety of diseases. Therefore, less skilled physicians cannot serve patients with complex diseases and need to consult jointly with more skilled physicians. This paper considers the influence of setting the service ability of physician system separately, studies the waiting time and queue length of patients in two systems with and without specialized physicians, and optimizes the configuration mode of physicians. It is found that when the consultation rate is higher than the threshold value, the optimal decision under the condition of not overloading is not to set a specialist. When the consultation rate is below the threshold, a specialist is appointed.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129859524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Model and Influencing Factors for Breast Cancer Patients 乳腺癌患者预后模型及影响因素分析
International Journal of Biology and Life Sciences Pub Date : 2023-05-22 DOI: 10.54097/ijbls.v2i3.8648
Qing Zhang
{"title":"Prognostic Model and Influencing Factors for Breast Cancer Patients","authors":"Qing Zhang","doi":"10.54097/ijbls.v2i3.8648","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8648","url":null,"abstract":"Breast cancer is a common disease that affects women's life and health. Survival analysis of breast cancer patients can help doctors and patients understand the prognosis of patients and provide guidance for clinical treatment. In this study, experiments were conducted based on SEER breast cancer patient data, and feature selection was performed first, followed by the construction of prognostic models using four survival analysis methods. the C-Index, BS, and IBS indexes of the RSF model were 0.8535, 0.0853, and 0.0512, respectively, which had the best predictive effect in the prognostic model for breast cancer patients. Based on the SHAP method to analyze the important factors affecting the prognosis of breast cancer patients, the results showed that tumor stage, TNM stage, grade and age have a great impact on the prognosis of breast cancer patients.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117313407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of Protein Secondary Structure based on Multi-scale Convolutional Neural Network 基于多尺度卷积神经网络的蛋白质二级结构预测
International Journal of Biology and Life Sciences Pub Date : 2023-05-22 DOI: 10.54097/ijbls.v2i3.8642
Yu Xiao, Xiaozhou Chen
{"title":"Prediction of Protein Secondary Structure based on Multi-scale Convolutional Neural Network","authors":"Yu Xiao, Xiaozhou Chen","doi":"10.54097/ijbls.v2i3.8642","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8642","url":null,"abstract":"In the field of bioinformatics, the prediction of secondary structure of proteins is very important. It can be obtained from the prediction of primary structure (amino acid sequence) and can provide reference for the prediction of tertiary structure of proteins. Amino acid sequences of proteins are encoded with several features and then combined into the prediction network. Convolutional neural network has excellent performance in text and sequence information extraction. The amino acid sequence of protein is also a special sequence, so the convolutional neural network can be used to extract the information in the sequence. Moreover, the influence of amino acids on the formation of secondary structure varies with different distances, so in the experiment, convolutional neural networks with convolution nuclei of different sizes were used to form multi-scale convolution blocks to extract amino acid sequence information. At the same time, the sliding window technique is also used to show the interaction between the sequences, and a long amino acid sequence is divided into some amino acid fragments and input into the model. Finally, the accuracy of Q8 on the dataset CB6133_filtered reaches 71%.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127076021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in the Application of Targeted Agents in Non-small Cell Cancer 靶向药物在非小细胞癌中的应用进展
International Journal of Biology and Life Sciences Pub Date : 2023-05-22 DOI: 10.54097/ijbls.v2i3.8645
Zhi-Xian Long
{"title":"Progress in the Application of Targeted Agents in Non-small Cell Cancer","authors":"Zhi-Xian Long","doi":"10.54097/ijbls.v2i3.8645","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8645","url":null,"abstract":"Research subject: primary targeted preparation, that is, the drug is released from the capillary bed into the target site; Secondary targeted preparation, that is, drug release from special cells (such as tumor cells) entering the target; Tertiary targeted preparations are drugs that act on certain parts of cells. Research methods: Compared with traditional preparations, targeted preparations can improve drug selectivity, reduce adverse reactions, enhance efficacy and improve patient compliance, and become the focus of new drug research and development. Therefore, scientific and reasonable targeted evaluation techniques and methods should be established based on this point to improve the safety, effectiveness and quality control of such drug preparations. Objective: This paper reviews the targeted application of anti-tumor targeting agents, and introduces the targeted technology and application from the aspects of targeting and pharmacology, so as to provide reference for the development trend of anti-tumor targeting agents in the future. Conclusion: According to the study, attention should be paid to improving the drug encapsulation rate and drug loading, and increasing the drug stability, so as to obtain drug preparations with large drug loading, good stability and strong targeting.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130396542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress of Salmonella Pathogenicity Island 沙门氏菌致病性岛研究进展
International Journal of Biology and Life Sciences Pub Date : 2023-05-22 DOI: 10.54097/ijbls.v2i3.8643
X. Liu, Zhaoxu Jiang, Zijun Liu, Donghui Li, Zhenhai Liu, Xiao-Dong Dong, Shigan Yan
{"title":"Research Progress of Salmonella Pathogenicity Island","authors":"X. Liu, Zhaoxu Jiang, Zijun Liu, Donghui Li, Zhenhai Liu, Xiao-Dong Dong, Shigan Yan","doi":"10.54097/ijbls.v2i3.8643","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8643","url":null,"abstract":"Salmonella is a zoonotic and food-borne pathogen. The widespread spread and contamination of this pathogen poses a great threat to food safety and public health. The existence of Salmonella virulence island is closely related to its pathogenic effect. In this paper, five main virulence islands of Salmonella and their encoding genes and functions are systematically introduced. Further analysis of the characteristics of pathogenicity islands, virulence evolution and virulence gene expression regulation are helpful to explore the mechanism of interaction between various virulence factors and host in Salmonella, so as to provide new ideas for the prevention and treatment of salmonellosis.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129094193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Young and Senescent Cells: Distinct Nuclear F-actin Patterns Upon Latrunculin B Induction 年轻和衰老细胞:不同的核f -肌动蛋白模式在拉特库林B诱导
International Journal of Biology and Life Sciences Pub Date : 2023-05-22 DOI: 10.54097/ijbls.v2i3.8644
D. Huang
{"title":"Young and Senescent Cells: Distinct Nuclear F-actin Patterns Upon Latrunculin B Induction","authors":"D. Huang","doi":"10.54097/ijbls.v2i3.8644","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8644","url":null,"abstract":"Both cellular senescence and cytoskeleton are involved in the formation of many diseases and cell signaling pathways. Although recent studies have shown that F-actin is involved in DNA damage repair, chromatin decompression, gene transcription regulation, and cell fate determination. But studies on F-actin and aging are still absence. It is unclear whether nuclear F-actin is present during cellular senescence. Here, by confocal optical sectioning and time-lapse imaging, we found acitn chrommobody-TagGFP2-NLS shows the beneficial on investigating senescent human fibroblast IMR-90 cells. To induce the nuclear F-actin assembly in single cell, we uesd Latrunculin B (latB) which a cytoplasmic F-actin polymerization inhibitor. It is currently unknown whether the nuclear F-actin cytoskeleton in young and senescent cells responds differently to latB treatment. Here, latB application induces distinct nuclear F-actin patterns and dynamics in young and senescent cells. Thus, after analyzing the results of actin dynamic we demonstrate a diverse effect of latB on the nuclear F-actin cytoskeleton in young and senescent cells.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"34 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130736276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nuclear Actin Puncta in Senescent Cells 衰老细胞中的核肌动蛋白点
International Journal of Biology and Life Sciences Pub Date : 2023-05-22 DOI: 10.54097/ijbls.v2i3.8647
Haiying Mai
{"title":"Nuclear Actin Puncta in Senescent Cells","authors":"Haiying Mai","doi":"10.54097/ijbls.v2i3.8647","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8647","url":null,"abstract":"Both cellular senescence and the nuclear actin cytoskeleton participate in a plethora of physiological and pathological activities. However, their connection remains elusive. Recently, it is becoming increasingly apparent that filamentous actin plays important functions within the nucleus. Particularly, micron-scaled actin filaments (hereinafter referred to as F-actin) in the nucleus are of the essence in DNA damage repair, cell fate determination and age-related diseases etc. Latrunculin B (latB), a pharmaceutically applicable macrolide, can induce nuclear F-actin assembly. Now it is unclear how the nuclear actin skeleton responds to latB stimulation in senescent cells. Here, by time-lapse images, Doxo-induced senescent IMR-90 cells showed a large number of nuclear actin puncta, then the nuclear actin puncta become brighter and larger in size upon latB treatment. Some actin puncta even served as the elongation bases for the nuclear F-actin. Therefore, our results link the nuclear actin skeleton to cell aging and reveal the effect of latB treatment on the nuclear actin skeleton in aging cells.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115293874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug Resistance Mechanism and Detection Method of Salmonella 沙门氏菌耐药机制及检测方法
International Journal of Biology and Life Sciences Pub Date : 2023-05-20 DOI: 10.54097/ijbls.v2i3.8654
Chen-guang Li, Zhaoxu Jiang, Zhenhai Liu, Xiao-Dong Dong, Liping Zhu, Shigan Yan
{"title":"Drug Resistance Mechanism and Detection Method of Salmonella","authors":"Chen-guang Li, Zhaoxu Jiang, Zhenhai Liu, Xiao-Dong Dong, Liping Zhu, Shigan Yan","doi":"10.54097/ijbls.v2i3.8654","DOIUrl":"https://doi.org/10.54097/ijbls.v2i3.8654","url":null,"abstract":"As an important zoonotic food-borne pathogen, Salmonella is a concern for public health authorities. In particular, bacteria that are resistant to multiple antimicrobials can confuse the efficacy of treatment for infectious diseases. Drug-resistant bacteria have a variety of drug-resistant molecular and cellular mechanisms. These antimicrobial resistance mechanisms include antibiotic efflux, permeability changes in cell membranes, enzymatic drug inactivation, biofilm formation, drug target changes, and protection of antimicrobial targets. In this paper, the mechanisms of antimicrobial resistance in salmonella and the techniques of detecting antibiotic resistance by traditional and molecular methods are reviewed, with emphasis on their advantages and disadvantages, as well as the validity and reliability of the results.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125524936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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