Research Progress of Combined Application of All-trans Retinoic Acid and Bone Morphogenetic Protein in Bone Metabolism

Zifan Yu, Yiwei Yuan, Yanan Ma, Lei Jiang, Yicheng Zhou, Wenjuan Bi
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Abstract

All-trans retinoic acid (ATRA) can both promote and inhibit osteogenic differentiation of cells, which is closely related to the concentration, dose and cell type. Low dose of ATRA inhibited the function of osteoclasts and promoted the differentiation of osteoblasts, thus achieving bone remodeling: Bone formation is achieved through the coordination of osteoblasts and osteoclasts. ATRA can be combined with various factors to produce different effects, among which, when combined with bone morphogenetic protein (BMP), the bone formation effect is significant. Compared with homologous dimer, BMP heterodimer can repair the bone defect area more effectively with a smaller dose, and promote the formation of bone tissue. Reduce the probability of secondary lesions such as swelling in the operative area and excessive osteogenesis, and greatly reduce the economic burden of patients. In addition, in vitro experiments showed that ATRA and BMP2/7 combined with mouse embryonic osteoblast precursor cells (MC3T3-E1) had synergistic effect on osteogenesis. This article reviews the recent progress in the studies on the combined effects of ATRA and BMP in bone metabolism.
全反式维甲酸与骨形态发生蛋白在骨代谢中的联合应用研究进展
全反式维甲酸(All-trans retinoic acid, ATRA)既能促进细胞成骨分化又能抑制细胞成骨分化,其作用与ATRA的浓度、剂量和细胞类型密切相关。低剂量ATRA抑制破骨细胞的功能,促进成骨细胞的分化,从而实现骨重塑:成骨细胞与破骨细胞协同作用实现骨形成。ATRA可与多种因素联合产生不同的作用,其中与骨形态发生蛋白(bone morphogenetic protein, BMP)联合时,成骨作用显著。与同源二聚体相比,BMP异源二聚体能以更小的剂量更有效地修复骨缺损区域,促进骨组织的形成。减少手术区肿胀、成骨过度等继发病变的发生概率,大大减轻患者的经济负担。此外,体外实验表明,ATRA和BMP2/7与小鼠胚胎成骨前体细胞(MC3T3-E1)联合具有协同成骨作用。本文就ATRA和BMP在骨代谢中的联合作用的研究进展作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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