靶向药物在非小细胞癌中的应用进展

Zhi-Xian Long
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引用次数: 0

摘要

研究课题:初级靶向制备,即药物从毛细管床释放到靶部位;二次靶向制备,即药物从进入靶标的特殊细胞(如肿瘤细胞)释放;三级靶向制剂是作用于细胞特定部位的药物。研究方法:与传统制剂相比,靶向制剂可提高药物选择性,减少不良反应,增强疗效,提高患者依从性,成为新药研发的重点。因此,应以此为基础,建立科学合理的针对性评价技术和方法,提高该类药物制剂的安全性、有效性和质量控制。目的:综述抗肿瘤靶向药物的靶向应用,从靶向和药理学方面介绍靶向技术及应用,为今后抗肿瘤靶向药物的发展趋势提供参考。结论:本研究应注意提高药物包封率和载药量,提高药物稳定性,以获得载药量大、稳定性好、靶向性强的药物制剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Progress in the Application of Targeted Agents in Non-small Cell Cancer
Research subject: primary targeted preparation, that is, the drug is released from the capillary bed into the target site; Secondary targeted preparation, that is, drug release from special cells (such as tumor cells) entering the target; Tertiary targeted preparations are drugs that act on certain parts of cells. Research methods: Compared with traditional preparations, targeted preparations can improve drug selectivity, reduce adverse reactions, enhance efficacy and improve patient compliance, and become the focus of new drug research and development. Therefore, scientific and reasonable targeted evaluation techniques and methods should be established based on this point to improve the safety, effectiveness and quality control of such drug preparations. Objective: This paper reviews the targeted application of anti-tumor targeting agents, and introduces the targeted technology and application from the aspects of targeting and pharmacology, so as to provide reference for the development trend of anti-tumor targeting agents in the future. Conclusion: According to the study, attention should be paid to improving the drug encapsulation rate and drug loading, and increasing the drug stability, so as to obtain drug preparations with large drug loading, good stability and strong targeting.
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