Shucheng Li, Rongrong Zhang, Lei Zhang, Xinyue Qin
{"title":"RGMb及其信号通路的研究进展","authors":"Shucheng Li, Rongrong Zhang, Lei Zhang, Xinyue Qin","doi":"10.54097/ijbls.v2i3.8650","DOIUrl":null,"url":null,"abstract":"Repulsive guidance molecule b (RGMb) is a member of RGM family, which is structurally composed of an N-terminal signal peptide, a vWFD domain and a C-peptide. RGMb is widely expressed in different systems in order to regulate various physiological and pathophysiological processes. So RGMb involves in tumor progression, immune regulation, retinal network, neural network reconstruction and other important aspects. Recently, numerous studies reflect the diversity and complexity of RGMb signaling pathway. This paper will focus on RGMb, and introduce its molecule structure, function, related signaling pathway, and above all, the research progresses.","PeriodicalId":182292,"journal":{"name":"International Journal of Biology and Life Sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Research Progress on RGMb and its Signaling Pathway\",\"authors\":\"Shucheng Li, Rongrong Zhang, Lei Zhang, Xinyue Qin\",\"doi\":\"10.54097/ijbls.v2i3.8650\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Repulsive guidance molecule b (RGMb) is a member of RGM family, which is structurally composed of an N-terminal signal peptide, a vWFD domain and a C-peptide. RGMb is widely expressed in different systems in order to regulate various physiological and pathophysiological processes. So RGMb involves in tumor progression, immune regulation, retinal network, neural network reconstruction and other important aspects. Recently, numerous studies reflect the diversity and complexity of RGMb signaling pathway. This paper will focus on RGMb, and introduce its molecule structure, function, related signaling pathway, and above all, the research progresses.\",\"PeriodicalId\":182292,\"journal\":{\"name\":\"International Journal of Biology and Life Sciences\",\"volume\":\"4 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Biology and Life Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.54097/ijbls.v2i3.8650\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biology and Life Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54097/ijbls.v2i3.8650","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Research Progress on RGMb and its Signaling Pathway
Repulsive guidance molecule b (RGMb) is a member of RGM family, which is structurally composed of an N-terminal signal peptide, a vWFD domain and a C-peptide. RGMb is widely expressed in different systems in order to regulate various physiological and pathophysiological processes. So RGMb involves in tumor progression, immune regulation, retinal network, neural network reconstruction and other important aspects. Recently, numerous studies reflect the diversity and complexity of RGMb signaling pathway. This paper will focus on RGMb, and introduce its molecule structure, function, related signaling pathway, and above all, the research progresses.