RGMb及其信号通路的研究进展

Shucheng Li, Rongrong Zhang, Lei Zhang, Xinyue Qin
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引用次数: 0

摘要

排斥引导分子b (RGMb)是RGM家族的一员,结构上由一个n端信号肽、一个vWFD结构域和一个c肽组成。RGMb在不同的系统中广泛表达,以调节各种生理和病理生理过程。因此RGMb涉及肿瘤进展、免疫调节、视网膜网络、神经网络重建等重要方面。近年来,大量研究反映了RGMb信号通路的多样性和复杂性。本文将以RGMb为重点,介绍其分子结构、功能、相关信号通路及其研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research Progress on RGMb and its Signaling Pathway
Repulsive guidance molecule b (RGMb) is a member of RGM family, which is structurally composed of an N-terminal signal peptide, a vWFD domain and a C-peptide. RGMb is widely expressed in different systems in order to regulate various physiological and pathophysiological processes. So RGMb involves in tumor progression, immune regulation, retinal network, neural network reconstruction and other important aspects. Recently, numerous studies reflect the diversity and complexity of RGMb signaling pathway. This paper will focus on RGMb, and introduce its molecule structure, function, related signaling pathway, and above all, the research progresses.
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