Magnetic resonance imaging最新文献

{"title":"Microvascular functional and structural changes in early-stage CADASIL","authors":"Shan Tian ,&nbsp;Hongwei Li ,&nbsp;Junting Yang ,&nbsp;Yuna Li ,&nbsp;Yuan Qiao ,&nbsp;Chaohua Cong ,&nbsp;Lei Zhao ,&nbsp;Panlong Li ,&nbsp;He Wang ,&nbsp;Jingjing Su","doi":"10.1016/j.mri.2025.110402","DOIUrl":"10.1016/j.mri.2025.110402","url":null,"abstract":"<div><h3>Background</h3><div>Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of hereditary cerebral small vessel disease (CSVD). While studies have demonstrated heterogeneous alterations in cerebrovascular reactivity (CVR) and gray matter structure in CADASIL patients, the diagnostic utility of CVR and brain structural imaging in identifying CADASIL remains uncertain.</div></div><div><h3>Methods</h3><div>This study investigated CVR and gray matter density (GMD) in 22 CADASIL patients compared to 21 age- and sex-matched healthy controls. Resting-state functional magnetic resonance imaging (fMRI) assessed regional CVR changes, while voxel-based morphometry (VBM) analyzed GMD differences. The study further explored the correlation between CVR and GMD alterations with clinical scores in CADASIL patients. Finally, receiver operating characteristic (ROC) curve analysis, including the area under curve (AUC) calculation, determined the diagnostic accuracy of CVR and morphological indices for CADASIL.</div></div><div><h3>Results</h3><div>Compared to controls, CADASIL patients exhibited significantly lower CVR in the left substantia nigra and higher CVR in the bilateral proximal anterior cerebral artery (ACA). VBM revealed reduced GMD in bilateral thalamic subregions in CADASIL patients, significantly correlating with several clinical measures. CVR indicators demonstrated superior diagnostic accuracy for CADASIL (AUC = 0.853) compared to GMD (AUC = 0.654).</div></div><div><h3>Conclusion</h3><div>The significant changes in CVR indices observed in CADASIL patients suggest that these indices may serve as potential biomarkers for CADASIL diagnosis.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"122 ","pages":"Article 110402"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging of the renal allograft vasculature without gadolinium contrast: Intraindividual comparison between relaxation-enhanced angiography without contrast and triggering (REACT) and 4D contrast-enhanced MR-angiography","authors":"Carsten Gietzen ,&nbsp;Juliana Tristram ,&nbsp;Jan Paul Janssen ,&nbsp;Marielle Hummels ,&nbsp;Johannes Bremm ,&nbsp;Kenan Kaya ,&nbsp;Thorsten Gietzen ,&nbsp;Henry Pennig ,&nbsp;Roman Gertz ,&nbsp;Thorsten Persigehl ,&nbsp;Dirk Stippel ,&nbsp;Kilian Weiss ,&nbsp;Lenhard Pennig","doi":"10.1016/j.mri.2025.110423","DOIUrl":"10.1016/j.mri.2025.110423","url":null,"abstract":"<div><h3>Background</h3><div>Complications after kidney transplantation include transplant renal artery stenosis (TRAS), which can be assessed using Doppler ultrasonography, computed tomography angiography, and magnetic resonance angiography (MRA). Contrast-enhanced MRA (CE-MRA) has limitations, including potential allergic reactions, limited use in kidney failure, and uncertain long-term effects of gadolinium retention.</div></div><div><h3>Purpose</h3><div>To evaluate Relaxation-Enhanced Angiography without Contrast and Triggering (REACT), a novel 3D isotropic flow-independent non-CE-MRA pulse sequence, for imaging of the renal allograft vasculature by performing an intraindividual comparison to 4D CE-MRA at 3Tesla.</div></div><div><h3>Methods</h3><div>Forty studies of 39 patients were included in this retrospective, single-centre study. Two board-certified radiologists independently evaluated MRA datasets for TRAS and rated their diagnostic confidence and the image quality of pelvic vessels using 5-point Likert scales (5 = excellent). Apparent signal- and contrast-to-noise ratios (aSNR/aCNR) were measured for arterial and venous graft vessels.</div></div><div><h3>Results</h3><div>REACT (median acquisition time 04:33 min [IQR 3:58–5:20 min]) showed 90.0 % sensitivity and 100.0 % specificity for TRAS in almost perfect agreement (<em>r</em> = 0.97) with 4D CE-MRA (03:41 min [3:38–4:46 min], <em>p</em> = 0.001) and similar diagnostic confidence (REACT: 4.0 [4.0–4.0] vs. 4D CE-MRA: 4.0 [3.0–4.0], <em>p</em> = 0.54). Arterial image quality was comparable (4.0 [3.7–4.4] vs. 4.0 [4.0–4.4], <em>p</em> = 0.49) whereas veins yielded higher scores in REACT (3.2 [3.0–3.5] vs. 2.4 [2.0–3.0], <em>p</em> &lt; 0.001). Transplant renal artery (mean ± SD; 44.5 ± 18.2 vs. 45.9 ± 21.0, <em>p</em> = 0.71; 36.3 ± 15.0 vs. 41.0 ± 20.0, <em>p</em> = 0.16) and vein (37.1 ± 19.8 vs. 30.3 ± 15.2, <em>p</em> = 0.06; 29.4 ± 17.1 vs. 25.0 ± 14.7, <em>p</em> = 0.17) showed no difference in aSNR and aCNR.</div></div><div><h3>Conclusion</h3><div>REACT provides accurate detection of TRAS with image quality comparable to 4D CE-MRA, offering a risk-free alternative for imaging after renal transplantation.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"122 ","pages":"Article 110423"},"PeriodicalIF":2.1,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of synthetic images derived from a neural network in pediatric brain magnetic resonance imaging","authors":"Usha D. Nagaraj ,&nbsp;Jakob Meineke ,&nbsp;Aakanksha Sriwastwa ,&nbsp;Jean A. Tkach ,&nbsp;James L. Leach ,&nbsp;Mariya Doneva","doi":"10.1016/j.mri.2025.110427","DOIUrl":"10.1016/j.mri.2025.110427","url":null,"abstract":"<div><div>Synthetic MRI (SyMRI) is a technique used to estimate tissue properties and generate multiple MR sequence contrasts from a single acquisition. However, image quality can be suboptimal.</div></div><div><h3>Purpose</h3><div>To evaluate a neural network approach using artificial intelligence-based direct contrast synthesis (AI-DCS) of the multi-contrast weighted images to improve image quality.</div></div><div><h3>Materials and methods</h3><div>This prospective, IRB approved study enrolled 50 pediatric patients undergoing clinical brain MRI. In addition to the standard of care (SOC) clinical protocol, 2D multi-delay multi-echo (MDME) sequence was obtained. SOC 3D T1-weighted (T1W), 2D T2-weighted (T2W) and 2D T2W fluid-attenuated inversion recovery (FLAIR) images from 35 patients were used to train a neural network generating synthetic T1W, T2W, and FLAIR images. Quantitative analysis of grey matter (GM) and white matter (WM) apparent signal to noise (aSNR) and grey-white matter (GWM) apparent contrast to noise (aCNR) ratios was performed.</div></div><div><h3>Results</h3><div>8 patients were evaluated. When compared to SyMRI, T1W AI-DCS had better overall image quality, reduced noise/artifacts, and better subjective SNR in 100 % (16/16) of evaluations. When compared to SyMRI, T2W AI-DCS overall image quality and diagnostic confidence was better in 93.8 % (15/16) and 87.5 % (14/16) of evaluations, respectively. When compared to SyMRI, FLAIR AI-DCS was better in 93.8 % (15/16) of evaluations in overall image quality and in 100 % (16/16) of evaluations for noise/artifacts and subjective SNR. Quantitative analysis revealed higher WM aSNR compared with SyMRI (<em>p</em> &lt; 0.05) for T1W, T2W and FLAIR.</div></div><div><h3>Conclusion</h3><div>AI-DCS demonstrates better overall image quality than SyMRI on T1W, T2W and FLAIR.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"121 ","pages":"Article 110427"},"PeriodicalIF":2.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-body magnetic resonance imaging in myxoid liposarcoma: Toward a new standard?","authors":"Tania Moussa ,&nbsp;Tarek Assi ,&nbsp;Samy Ammari ,&nbsp;Ines Kasraoui ,&nbsp;Axel Le Cesne ,&nbsp;Corinne Balleyguier","doi":"10.1016/j.mri.2025.110422","DOIUrl":"10.1016/j.mri.2025.110422","url":null,"abstract":"<div><div>Myxoid/Round cell liposarcoma (MLPS) is the second most common subtype of liposarcoma (LPS), accounting for approximately 5 % of all soft tissue sarcomas (STS). Unlike other LPS subtypes, MLPS is characterized by a distinct pattern of metastasis, often involving bones and soft tissues rather than the lungs. Skeletal metastasis occurs in a significant proportion of MLPS patients, particularly those with high-grade tumors, making early detection critical for optimal management. While MLPS tumors are known to be highly radiosensitive and chemosensitive, current screening strategies for bone metastases remain suboptimal. Recent advancements in imaging, particularly Whole-body magnetic resonance imaging (WBMRI), offer promising potential for enhancing the detection of both bone and soft tissue metastases in MLPS patients. This article explores the clinical utility of WBMRI in MLPS, reviewing its ability to detect metastatic lesions, discussing various imaging protocols, and highlighting supporting data from recent studies. The paper emphasizes the role of WBMRI in improving disease staging, thereby guiding more personalized therapeutic strategies for MLPS patients.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"121 ","pages":"Article 110422"},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can arginine, glutamate and glutamine serve as surrogates of intestinal mucosal healing in the patients with celiac disease following gluten-free diet? An NMR based metabolomics study","authors":"Deepti Upadhyay ,&nbsp;Prasenjit Das ,&nbsp;Siddhartha Dattagupta ,&nbsp;Govind K. Makharia ,&nbsp;Naranamangalam R. Jagannathan ,&nbsp;Uma Sharma","doi":"10.1016/j.mri.2025.110421","DOIUrl":"10.1016/j.mri.2025.110421","url":null,"abstract":"<div><div>Celiac disease (CeD) is a chronic small intestinal autoimmune disease initiated by dietary gluten in genetically predisposed individuals. Till date, the only effective treatment for CeD is the gluten-free diet (GFD). However, not all patients achieve full histological recovery despite GFD. Thus, it is crucial to assess the treatment response and improvement in the villous architecture following GFD. Therefore, present study investigated the potential of NMR-based metabolomics for identifying non-invasive biomarkers for assessing treatment response. Comprehensive metabolic profiling of 120 biological samples comprising of small intestinal mucosal biopsies, blood plasmas and urines collected at two time points (before and after 6–8 months of GFD) from CeD patients (<em>n</em> = 20) was carried out using proton NMR spectroscopy. The levels of arginine glutamate, and glutamine were significantly reduced in both intestinal mucosa and blood plasma of CeD patients after GFD compared to their baseline values. These amino acids play an important role in intestinal energy metabolism, and alleviating inflammation, thereby contributing to healing mechanisms of small intestinal mucosa, following GFD. A logistic regression statistical model based on the combination of the above three blood plasma metabolites demonstrated AUC of 0.980, Youden index 0.900 with a sensitivity and a specificity of 90 % and 100 % for monitoring treatment response in CeD patients after GFD. The study revealed a panel of non-invasive plasma biomarkers (arginine, glutamate and glutamine) which may serve as surrogates of mucosal healing and treatment response in CeD patients, however, the findings need to be validated in a large cohort of patients.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"121 ","pages":"Article 110421"},"PeriodicalIF":2.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerating prostate rs-EPI DWI with deep learning: Halving scan time, enhancing image quality, and validating in vivo","authors":"Peipei Zhang ,&nbsp;Zhaoyan Feng ,&nbsp;Shu Chen ,&nbsp;Jie Zhu ,&nbsp;Chanyuan Fan ,&nbsp;Liming Xia ,&nbsp;Xiangde Min","doi":"10.1016/j.mri.2025.110418","DOIUrl":"10.1016/j.mri.2025.110418","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to evaluate the feasibility and effectiveness of deep learning-based super-resolution techniques to reduce scan time while preserving image quality in high-resolution prostate diffusion-weighted imaging (DWI) with readout-segmented echo-planar imaging (rs-EPI).</div></div><div><h3>Methods</h3><div>We retrospectively and prospectively analyzed prostate rs-EPI DWI data, employing deep learning super-resolution models, particularly the Multi-Scale Self-Similarity Network (MSSNet), to reconstruct low-resolution images into high-resolution images. Performance metrics such as structural similarity index (SSIM), Peak signal-to-noise ratio (PSNR), and normalized root mean squared error (NRMSE) were used to compare reconstructed images against the high-resolution ground truth (HR_GT). Additionally, we evaluated the apparent diffusion coefficient (ADC) values and signal-to-noise ratio (SNR) across different models.</div></div><div><h3>Results</h3><div>The MSSNet model demonstrated superior performance in image reconstruction, achieving maximum SSIM values of 0.9798, and significant improvements in PSNR and NRMSE compared to other models. The deep learning approach reduced the rs-EPI DWI scan time by 54.4 % while maintaining image quality comparable to HR_GT. Pearson correlation analysis revealed a strong correlation between ADC values from deep learning-reconstructed images and the ground truth, with differences remaining within 5 %. Furthermore, all models showed significant SNR enhancement, with MSSNet performing best across most cases.</div></div><div><h3>Conclusions</h3><div>Deep learning-based super-resolution techniques, particularly MSSNet, effectively reduce scan time and enhance image quality in prostate rs-EPI DWI, making them promising tools for clinical applications.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"121 ","pages":"Article 110418"},"PeriodicalIF":2.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Less is more? Performance of loops without distributed capacitors for 7 T MRI applications","authors":"G. Costa ,&nbsp;M.M. Paulides ,&nbsp;S. Güler ,&nbsp;I. Zivkovic","doi":"10.1016/j.mri.2025.110420","DOIUrl":"10.1016/j.mri.2025.110420","url":null,"abstract":"<div><div>We present an exploration of loops without distributed capacitors (i.e. plain loops) for their suitability as RF coils in 7 T MRI applications. Herein, we report on the differences between a circular -i.e. round- plain loop, an elliptic -i.e. elongated- plain loop, a conventional loop - i.e. a loop with distributed capacitors - and a dipole. This comparison highlights the benefits and limitations of plain loops, providing insights into their viability as an alternative to more complex coil designs for the construction of RF coil arrays at 7 T. We characterized the coils in terms of surface current distribution, robustness to loading, transmit efficiency, <span><math><mi>max</mi><mfenced><mrow><mi>SA</mi><msub><mi>R</mi><mrow><mn>10</mn><mi>g</mi></mrow></msub></mrow></mfenced></math></span>, coupling, and “<em>flexibility</em>” - defined as the ability of a coil to stay tuned (<span><math><msub><mi>S</mi><mn>11</mn></msub><mo>≤</mo><mo>−</mo><mn>10</mn><mi>dB</mi></math></span>) after mechanical deformation at a constant distance from the load. Additionally, we discussed the best practice to fabricate plain loops. A 12 cm round plain loop was more sensitive to the coil load distance than a conventional loop, but it was flexible and can be operated at a roughly constant distance from different patients. The antenna showed similar transmit properties to a 12 cm round conventional loop but with lower coupling (∼44 % less) when the loops were gapped or overlapped less than 20 %. A 62 mmx280mm elongated plain loop was more robust than a dipole to the coil-load distance, providing similar transmit efficiency for imaging of the prostate, with lower worst case <span><math><mi>max</mi><mfenced><mrow><mi>SA</mi><msub><mi>R</mi><mrow><mn>10</mn><mi>g</mi></mrow></msub></mrow></mfenced></math></span> (∼25 % less), but higher coupling (S₂₁ ∼ -15 dB). This paper provides the groundwork for further optimizing plain loops in UHF-MRI coil arrays.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"121 ","pages":"Article 110420"},"PeriodicalIF":2.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on predicting breast cancer Ki-67 expression using a combination of radiomics and deep learning based on multiparametric MRI","authors":"Wenjiang Wang ,&nbsp;Zimeng Wang ,&nbsp;Lei Wang ,&nbsp;Jiaojiao Li ,&nbsp;Zhiying Pang ,&nbsp;Yingwu Qu ,&nbsp;Shujun Cui","doi":"10.1016/j.mri.2025.110401","DOIUrl":"10.1016/j.mri.2025.110401","url":null,"abstract":"<div><h3>Purpose</h3><div>To develop a multiparametric breast MRI radiomics and deep learning-based multimodal model for predicting preoperative Ki-67 expression status in breast cancer, with the potential to advance individualized treatment and precision medicine for breast cancer patients.</div></div><div><h3>Methods</h3><div>We included 176 invasive breast cancer patients who underwent breast MRI and had Ki-67 results. The dataset was randomly split into training (70 %) and test (30 %) sets. Features from T1-weighted imaging (T1WI), diffusion-weighted imaging (DWI), T2-weighted imaging (T2WI), and dynamic contrast-enhanced MRI (DCE-MRI) were fused. Separate models were created for each sequence: T1, DWI, T2, and DCE. A multiparametric MRI (mp-MRI) model was then developed by combining features from all sequences. Models were trained using five-fold cross-validation and evaluated on the test set with receiver operating characteristic (ROC) curve area under the curve (AUC), accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and F1 score. Delong's test compared the mp-MRI model with the other models, with <em>P</em> &lt; 0.05 indicating statistical significance.</div></div><div><h3>Results</h3><div>All five models demonstrated good performance, with AUCs of 0.83 for the T1 model, 0.85 for the DWI model, 0.90 for the T2 model, 0.92 for the DCE model, and 0.96 for the mp-MRI model. Delong's test indicated statistically significant differences between the mp-MRI model and the other four models, with <em>P</em> values &lt; 0.05.</div></div><div><h3>Conclusions</h3><div>The multiparametric breast MRI radiomics and deep learning-based multimodal model performs well in predicting preoperative Ki-67 expression status in breast cancer.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"121 ","pages":"Article 110401"},"PeriodicalIF":2.1,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appropriate strength of acceleration selective-motion sensitized gradient for non-triggered, non-contrast enhanced magnetic resonance angiography of the lower extremities","authors":"Natsuo Konta ,&nbsp;Norio Hayashi ,&nbsp;Shuhei Shibukawa ,&nbsp;Tomohiko Horie ,&nbsp;Tetsu Niwa ,&nbsp;Makoto Obara ,&nbsp;Yui Kawamura ,&nbsp;Toshiaki Miyati","doi":"10.1016/j.mri.2025.110416","DOIUrl":"10.1016/j.mri.2025.110416","url":null,"abstract":"<div><div>Non-contrast enhanced magnetic resonance angiography (MRA) is useful for diagnosing peripheral arterial disease, especially in patients with renal insufficiency. Recently, non-triggered, non-contrast enhanced MRA using acceleration selective-motion sensitized gradient (AS-MSG), known as enhanced acceleration-selective arterial spin labeling (eAccASL), has been introduced. We aimed to investigate the appropriate strength of the AS-MSG for this technique in the lower extremities. Non-triggered eAccASL with four acceleration encodings (AENCs; 0.17, 0.29, 0.58, and 0.87 m/s²) was compared with electrocardiography (ECG)-triggered eAccASL (AENC: 0.87 m/s²). In the flow phantom, signal intensities (SIs) were calculated. A higher SI was observed with a smaller AENC on non-triggered eAccASL. In eight volunteers, vessel-background contrasts (VBCs) were calculated, and arterial visibility and venous artifacts were assessed by two radiologists. A higher VBC was observed with a smaller AENC on non-triggered eAccASL. The VBCs of non-triggered eAccASL 0.87 were lower than those of ECG-triggered eAccASL 0.87 in the peroneal, and anterior and posterior tibial arteries (all <em>p</em> &lt; 0.05). Subjective scores for arterial visibility did not differ, with median scores within acceptable levels. The venous artifacts score of non-triggered eAccASL 0.17 was lower than those of non-triggered eAccASL 0.29, 0.58, and 0.87 and ECG-triggered eAccASL 0.87 (<em>p</em> &lt; 0.01, <em>p</em> &lt; 0.05, <em>p</em> &lt; 0.001, and <em>p</em> &lt; 0.01, respectively). In two clinical patients, arterial visibility on non-triggered eAccASL 0.29 was comparable or superior to that on ECG-triggered eAccASL 0.87. An AENC of 0.29–0.58 m/s² was considered appropriate for non-triggered, non-contrast enhanced lower-extremity MRA using eAccASL.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"121 ","pages":"Article 110416"},"PeriodicalIF":2.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancement of an automatic segmentation pipeline for metallic artifact removal in post-surgical ACL MRI","authors":"Dominique A. Barnes ,&nbsp;Crystal J. Murray ,&nbsp;Janine Molino ,&nbsp;Jillian E. Beveridge ,&nbsp;Ata M. Kiapour ,&nbsp;Martha M. Murray ,&nbsp;Braden C. Fleming","doi":"10.1016/j.mri.2025.110417","DOIUrl":"10.1016/j.mri.2025.110417","url":null,"abstract":"<div><div>Magnetic resonance imaging (MRI) has the potential to identify post-operative risk factors for re-tearing an anterior cruciate ligament (ACL) using a combination of imaging signal intensity (SI) and cross-sectional area measurements of the healing ACL. During surgery micro-debris can result from drilling the osseous tunnels for graft and/or suture insertion. The debris presents a limitation when using post-surgical MRI to assess reinjury risk as it causes rapid magnetic field variations during acquisition, leading to signal loss within a voxel. The present study demonstrates how K-means clustering can refine an automatic segmentation algorithm to remove the lost signal intensity values induced by the artifacts in the image. MRI data were obtained from 82 patients enrolled in three prospective clinical trials of ACL surgery. Constructive Interference in Steady State MRIs were collected at 6 months post-operation. Manual segmentation of the ACL with metallic artifacts removed served as the gold standard. The accuracy of the automatic ACL segmentations was compared using Dice coefficient, sensitivity, and precision. The performance of the automatic segmentation was comparable to manual segmentation (Dice coefficient = .81, precision = .81, sensitivity = .82). The normalized average signal intensity was calculated as 1.06 (±0.25) for the automatic and 1.04 (±0.23) for the manual segmentation, yielding a difference of 2%. These metrics emphasize the automatic segmentation model’s ability to precisely capture ACL signal intensity while excluding artifact regions. The automatic artifact segmentation model described here could enhance qMRI’s clinical utility by allowing for more accurate and time-efficient segmentations of the ACL.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"121 ","pages":"Article 110417"},"PeriodicalIF":2.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}