Prediction of metachronous liver metastasis in mid-low rectal cancer using quantitative perirectal fat content from high-resolution MRI

IF 2.1 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging Pub Date : 2025-01-29 DOI:10.1016/j.mri.2025.110338

Jiaming Qin , Wenjin Dong , Fengshu Zhao , Tianqi Liu , Mengxin Chen , Rui Zhang , Yumeng Zhao , Cheng Zhang , Wenhong Wang

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引用次数: 0

Abstract

Purpose

To investigate the relationship between perirectal fat content and metachronous liver metastasis (MLM) in patients with Mid-low rectal cancer (MLRC).

Materials and methods

A retrospective analysis was conducted on 254 patients who underwent curative surgery for MLRC between December 2016 and December 2021. Preoperative MRI measurements of the rectal mesenteric fat area (MFA), rectal posterior mesorectal thickness (PMT), and rectal mesenteric fascia envelopment volume (MFEV) were performed, along with collection of relevant clinical, pathological, and imaging data. Patients were categorized into the MLM group (Group A), other recurrence or metastasis group (Group B), and no recurrence and metastasis group (Group C). Analyze the differences between Group A and the other groups, and independent risk factors for MLM were explored. Kaplan-Meier analysis and log-rank test were used to validate independent predictive biomarkers for MLM.

Results

Patients with MLM from MLRC had later pathological and imaging T stages and lower perirectal fat content (all P < 0.05). Compared to patients with other types of recurrent metastasis, male gender, poorly differentiated tumors, and advanced tumor N stage were more likely to develop MLM (all P < 0.05). In Cox univariate and multivariate regression analysis, smaller rectal PMT (hazard ratio (HR) 0.361 [0.154–0.846], P = 0.019) and MFEV (HR 0.983 [0.968–0.998], P = 0.022) were independently associated with MLM in MLRC (HR 0.361;0.983). Kaplan-Meier analysis showed that patients with rectal PMT <1.43 cm and rectal MFEV <137.46 cm³ had a significantly higher risk of MLM compared to patients with rectal PMT ≥1.43 cm and rectal MFEV ≥137.46 cm³ (all P < 0.05).

Conclusion

Rectal PMT and rectal MFEV can serve as novel parameters for predicting MLM in patients with MLRC.

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利用高分辨率MRI定量直肠周围脂肪含量预测中低位直肠癌的异时性肝转移。

目的：探讨中低位直肠癌（MLRC）患者直肠周围脂肪含量与异时性肝转移（MLM）的关系。材料与方法：回顾性分析2016年12月至2021年12月接受根治性MLRC手术的254例患者。术前MRI测量直肠肠系膜脂肪区（MFA）、直肠后肠系膜厚度（PMT）、直肠肠系膜筋膜包膜体积（MFEV），收集相关临床、病理和影像学资料。将患者分为MLM组（A组）、其他复发或转移组（B组）、无复发和转移组（C组）。分析A组与其他组的差异，探讨MLM的独立危险因素。Kaplan-Meier分析和log-rank检验用于验证传销的独立预测生物标志物。结果：MLRC患者的病理和影像学T分期较晚，直肠周围脂肪含量较低（均P < 3），发生MLM的风险明显高于直肠PMT≥1.43 cm和直肠MFEV≥137.46 cm3的患者（均P < 3）。结论：直肠PMT和直肠MFEV可作为预测MLRC患者MLM的新参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic resonance imaging 医学-核医学

CiteScore

4.70

自引率

4.00%

发文量

194

审稿时长

83 days

期刊介绍： Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.