Noise reduction in magnitude diffusion-weighted images using spatial similarity and diffusion redundancy.

Abstract

Purpose: Diffusion-weighted imaging (DWI) has significant value in clinical application, which however suffers from a serious low signal-to-noise ratio (SNR) problem, especially at high spatial resolution and/or high diffusion sensitivity factor.

Methods: Here, we propose a denoising method for magnitude DWI. The method consists of two modules: pre-denoising and post-filtering, the former mines the diffusion redundancy by local kernel principal component analysis, and the latter fully mines the non-local self-similarity using patch-based non-local mean.

Results: Validated by simulation and in vivo datasets, the experiment results show that the proposed method is capable of improving the SNR of the whole brain, thus enhancing the performance for diffusion metrics estimation, crossing fiber discrimination, and human brain fiber tractography tracking compared with the different three state-of-the-art comparison methods. More importantly, the proposed method consistently exhibits superior performance to comparison methods when used for denoising diffusion data acquired with sensitivity encoding (SENSE).

Conclusion: The proposed denoising method is expected to show significant practicability in acquiring high-quality whole-brain diffusion data, which is crucial for many neuroscience studies.