Magnesium research最新文献

{"title":"A potential protective role of magnesium in neuroCOVID","authors":"Valentina Cenacchi,&nbsp;Jeanette A Maier,&nbsp;Maria Paola Perini","doi":"10.1684/mrh.2022.0497","DOIUrl":"https://doi.org/10.1684/mrh.2022.0497","url":null,"abstract":"<p><p>Several recent studies support a role of dysregulated magnesium homeostasis in COVID-19. In the present narrative review, we focus on the neurological aspects of this disease, collectively known as neuroCOVID, and we propose some mechanisms by which alterations of magnesium may contribute to the involvement of the nervous system in the context of SARS-CoV-2 infection. Further fundamental, translational, and clinical research is needed to underpin the potential relationships between altered magnesium status and neuro-COVID, with potentially novel therapeutic implications.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":" ","pages":"18-26"},"PeriodicalIF":3.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33498376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing public health awareness of magnesium: one step at a time","authors":"Rebecca B Costello,&nbsp;Andrea Rosanoff","doi":"10.1684/mrh.2022.0494","DOIUrl":"https://doi.org/10.1684/mrh.2022.0494","url":null,"abstract":"","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"35 1","pages":"29-31"},"PeriodicalIF":3.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9557827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of dietary magnesium intake and serum magnesium with hypertension: a review.","authors":"Nikolina Banjanin,&nbsp;Goran Belojevic","doi":"10.1684/mrh.2021.0492","DOIUrl":"https://doi.org/10.1684/mrh.2021.0492","url":null,"abstract":"<p><p>The relationship between magnesium and hypertension has been intensively investigated in the last few decades. Most of the so far reviews were focused on either dietary magnesium or serum magnesium or magnesium supplements. Our goal was to merge these findings with a more comprehensive approach. Internet search was performed in PubMed database without date limits, using the following search terms \"dietary magnesium,\" \"serum magnesium,\" \"magnesium supplements,\" \"hypertension,\" \"drinking water,\" \"food,\" \"endothelial dysfunction,\" \"arterial smooth muscle,\" and \"arterial spasms.\" In general, there exists an inverse dose-dependent relationship between dietary magnesium intake and serum magnesium and the risk of hypertension. A negative correlation has been found between the serum magnesium concentration and Framingham risk score and intima-media carotid thickness and cardiovascular mortality. On the other hand, concentration of extracellular magnesium in the normal range acts as a natural calcium channel blocker, eliminates endothelial dysfunction, increases nitric oxide, and induces direct and indirect vasodilatation. In conclusion, an average magnesium dietary intake is below the recommended values and magnesium supplementation in the prevention and treatment of hypertension might be justified.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"34 4","pages":"166-171"},"PeriodicalIF":3.2,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between abnormal serum magnesium levels and prognosis of elderly patients with community-acquired pneumonia.","authors":"Si-Qiong Wang,&nbsp;Dong-Xi Lu,&nbsp;Jian-Dong Zhang,&nbsp;Zhi-Wei Wang,&nbsp;Xiao-Wei Li,&nbsp;Chun-Ming Ma","doi":"10.1684/mrh.2022.0493","DOIUrl":"https://doi.org/10.1684/mrh.2022.0493","url":null,"abstract":"<p><p>To investigate the association between abnormal serum magnesium levels and the prognosis of elderly patients with community-acquired pneumonia (CAP). Methods: A retrospective study was conducted on 1381 elderly patients with CAP in the First Hospital of Qinhuangdao between January 2015 and December 2018. Serum magnesium concentrations in the range of 0.75-1.25 mmol/L were defined as normal. Patients were assigned into normal, hypomagnesemia, and hypermagnesemia groups. The primary outcome was in-hospital mortality, indicating whether a patient died at the time of discharge from the hospital. The percentages of respiratory failure and mechanical ventilation were 18.6% and 10.6 % in the normal group, 29% and 16.5 % in the hypomagnesemia, and 42.9% and 35.7% in the hypermagnesemia groups. The occurrence of shock was 8.5% and 4.5% in the hypomagnesemia group and the normal group. The percentages of the length of stay at ICU were 14.9%, 18.8%, and 57.1% in the hypomagnesemia, normal, and hypermagnesemia groups. The in-hospital mortality rate was 5.3%, 9.1%, and 35.7% in the normal, hypomagnesemia, and hypermagnesemia groups, respectively. The results of univariate analysis showed that the in-hospital mortality in the hypomagnesemia group was 1.790 (95% confidence interval (CI): 1.009∼3.176, P=0.046) times higher than that in the normal group; in the hypermagnesemia group, it was 9.947 (95% CI: 3.238-30.556, P<0.001) times higher than that in the normal group. The results of multivariate logistic regression analysis showed that after adjusting for gender, age, diabetes, heart failure, cerebrovascular disease, cancer, estimated glomerular filtration rate (eGFR), glucose, and CURB-65 score, in the hypomagnesemia group, the in-hospital mortality was 1.746 (95% confidence interval (CI): 0.956∼3.186, P=0.070) times higher than that in the normal group, and 5.689 (95% CI: 1.583- 20.446, P=0.008) times higher in the hypermagnesemia group than that in the normal group. Abnormal serum magnesium levels are strongly associated with in-hospital mortality in elderly patients with CAP. The measurement of serum magnesium levels in elderly patients with CAP at admission may assist clinicians to determine the prognosis of such patients.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"34 4","pages":"159-165"},"PeriodicalIF":3.2,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of magnesemia with myocardial damage and mortality in patients with COVID-19.","authors":"Seyda Gunay,&nbsp;Serhat Caliskan,&nbsp;Deniz Sigirli","doi":"10.1684/mrh.2021.0485","DOIUrl":"https://doi.org/10.1684/mrh.2021.0485","url":null,"abstract":"<p><p>Magnesium (Mg) is the second most abundant intracellular cation and plays a significant role in immune system and cardiac protection. Mg deficiency contributes to chronic low-grade inflammation leading to cardiovascular diseases, and low Mg level exacerbates virus-induced inflammation. The aim of the study was to investigate whether serum magnesium level is associated with myocardial damage and prognosis of COVID-19. This was a single-center, observational retrospective study of patients with COVID-19. The study population was divided into two groups according to in-hospital mortality: a survivor group (SG) and a non-survivor group (NSG). Myocardial damage was defined as blood levels of cardiac troponin I (cTnI) above the 99^th percentile upper reference limit. Magnesium, variables regarding inflammation, and myocardial damage were compared between the groups. A total of 629 patients with COVID-19 were included. Mortality rate was 11.85% (n = 82). There were 61 (74.4%) and 294 male patients (53.7%) in NSG and SG, respectively (p = 0.001). The median age of NSG was 64.5 years (min-max: 37-93) and the median age of SG was 56.0 years (min-max: 22-92) (p < 0.001). Median serum magnesium levels of NSG and SG were 1.94 mg/dL (min-max: 1.04-2.87) and 2.03 mg/dL (min-max: 1.18-2.88), respectively (p = 0.027). Median cTnI levels of NSG and SG were 25.20 pg/mL (min-max: 2.10-2240.80) and 4.50 pg/mL (min-max: 0.50-984.3), respectively (p < 0.001). The cTnI levels were lower in those patients whose serum Mg levels were higher than 1.94. Although serum magnesium level was not a predictor for in-hospital mortality, there was a significant negative correlation between magnesemia and myocardial damage.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"34 3","pages":"93-102"},"PeriodicalIF":3.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39565661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium citrate supplementation decreased blood pressure and HbA1c in normomagnesemic subjects with metabolic syndrome: a 12-week, placebo-controlled, double-blinded pilot trial.","authors":"Kseniia Afitska,&nbsp;Julia Clavel,&nbsp;Klaus Kisters,&nbsp;Jürgen Vormann,&nbsp;Tanja Werner","doi":"10.1684/mrh.2021.0489","DOIUrl":"https://doi.org/10.1684/mrh.2021.0489","url":null,"abstract":"<p><p>Magnesium (Mg) supplementation was shown to improve metabolic syndrome (MetS) parameters in hypomagnesemic patients. The current study evaluated the role of Mg in normomagnesemic individuals with MetS. Patients were randomly assigned to 400 mg Mg as Mg citrate or placebo daily for 12 weeks. Blood pressure (BP), HbA1c, plasma concentrations of glucose, Mg and Ca, blood-ionized Mg, serum concentrations of cholesterol, triglycerides, vitamin D, creatinine, interleukin-6, and C-reactive protein were measured at baseline and after 12 weeks. Data were obtained from n = 13 in the Mg supplemented and n = 11 in the placebo group. Mg supplementation led to a significant increase in plasma Mg concentration (0.78 ± 0.07 mmol/L to 0.83 ± 0.07 mmol/L) and a decrease in systolic and diastolic BP (baseline: 145 ± 10/85 ± 3 mmHg; 12 weeks: 121 ± 5/79 ± 3 mmHg). HbA1c decreased significantly in the Mg group (6.43 ± 0.64% to 6.15 ± 0.55%), and the difference in change between placebo and Mg group was significant. Serum vitamin D levels significantly increased only in the Mg group. In normomagnesemic individuals with MetS, oral Mg citrate supplementation reduced HbA1c and BP.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"34 3","pages":"130-139"},"PeriodicalIF":3.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39801189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum magnesium in patients with severe acute respiratory syndrome coronavirus 2 from Wuhan, China.","authors":"Linyun Zhu,&nbsp;Xingxing Bao,&nbsp;Junjie Bi,&nbsp;Yuhua Lin,&nbsp;Cuiting Shan,&nbsp;Xuanfei Fan,&nbsp;Junmei Bian,&nbsp;Xiongbiao Wang","doi":"10.1684/mrh.2021.0488","DOIUrl":"https://doi.org/10.1684/mrh.2021.0488","url":null,"abstract":"<p><p>The aim of the study was to evaluate the significance of hypomagnesemia in patients with coronavirus disease 2019 (COVID-19) and clarify its possible pathogenesis. A retrospective cohort study was conducted by reviewing 83 patients hospitalized in Guanggu district, Wuhan Third Hospital, China. Clinical histories, laboratory findings and outcome data were collected. Eighteen patients had hypomagnesemia during hospitalization. Fourteen patients were in the critical group and six died. In the critical group, serum magnesium (0.72 ± 0.15 mmol/L) was much lower than that in the moderate and severe groups. At the same time, we also found that several indicators are correlated with the level of magnesium. The level of magnesium was positively associated with the lymphocyte count (r = 0.203, P = 0.004) and platelet count (r = 0.217, P = 0.002) but negatively related to the levels of CRP (r = -0.277, P = 0.000), LDH (r = -0.185, P = 0.011) and α-hydroxybutyrate dehydrogenase (r = -0.198, P = 0.008) in the critical group. Hypomagnesemia might increase symptoms and may be associated with mortality in COVID-19 by affecting enzyme activity and activating the inflammatory response. Thus, magnesium might play a key role in the pathogenesis of COVID-19.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"34 3","pages":"103-113"},"PeriodicalIF":3.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39514835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium favors the capacity of vitamin D3 to induce the monocyte differentiation of U937 cells.","authors":"Sandra Parenti,&nbsp;Laura Sandoni,&nbsp;Monica Montanari,&nbsp;Tommaso Zanocco-Marani,&nbsp;Alexandre Anesi,&nbsp;Stefano Iotti,&nbsp;Rossella Manfredini,&nbsp;Chiara Frassineti,&nbsp;Pierpaola Davalli,&nbsp;Alexis Grande","doi":"10.1684/mrh.2021.0490","DOIUrl":"https://doi.org/10.1684/mrh.2021.0490","url":null,"abstract":"<p><p>The hematopoietic U937 cells are able to differentiate into monocytes, macrophages, or osteoclasts when stimulated, respectively, with vitamin D3 (VD3), phorbol 12-myristate 13-acetate (PMA) or PMA plus VD3. We have previously demonstrated that magnesium (Mg) strongly potentiates the osteoclastic differentiation of U937 cells. In this study, we investigated whether such an effect may be ascribed to a capacity of Mg to modulate the monocyte differentiation of U937 cells and/or to an ability of Mg and VD3 to act directly and independently on the early phases of the osteoclastic differentiation. To address this issue, we subjected U937 cells to an individual and combined treatment with Mg and VD3 and then we analyzed, by flow cytometry and quantitative real-time polymerase chain reaction, the expression of a number of genes related to the early phases of the differentiation pathways under consideration. The results obtained indicated that Mg favors the monocyte differentiation of U937 cells induced by VD3 and at the same time, Mg contrasts the inhibitory effect that VD3 exerts on the osteoclastic differentiation in the absence of PMA. The crucial and articulated role played by Mg in diverse pathways of the osteoclastic differentiation of U973 cells is emphasized.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"34 3","pages":"114-129"},"PeriodicalIF":3.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39956049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The magnesium global network (MaGNet) to promote research on magnesium in diseases focusing on covid-19].","authors":"Federica I Wolf,&nbsp;Jeanette A Maier,&nbsp;Andrea Rosanoff,&nbsp;Mario Barbagallo,&nbsp;Shadi Baniasadi,&nbsp;Sara Castiglioni,&nbsp;Fu-Chou Cheng,&nbsp;Sherrie Colaneri Day,&nbsp;Rebecca B Costello,&nbsp;Ligia J Dominguez,&nbsp;Ronald J Elin,&nbsp;Claudia Gamboa-Gomez,&nbsp;Fernando Guerrero-Romero,&nbsp;Ka Kahe,&nbsp;Klaus Kisters,&nbsp;Martin Kolisek,&nbsp;Anton Kraus,&nbsp;Stefano Iotti,&nbsp;Andre Mazur,&nbsp;Moises Mercado-Atri,&nbsp;Lucia Merolle,&nbsp;Oliver Micke,&nbsp;Nana Gletsu-Miller,&nbsp;Forrest Nielsen,&nbsp;Jin O-Uchi,&nbsp;Ornella Piazza,&nbsp;Michael Plesset,&nbsp;Guitti Pourdowlat,&nbsp;Francisco J Rios,&nbsp;Martha Rodriguez-Moran,&nbsp;Giuliana Scarpati,&nbsp;Michael Shechter,&nbsp;Yiqing Song,&nbsp;Lisa A Spence,&nbsp;Rhian M Touyz,&nbsp;Valentina Trapani,&nbsp;Nicola Veronese,&nbsp;Bodo von Ehrlich,&nbsp;Juergen Vormann,&nbsp;Taylor C Wallace,&nbsp;Cmer Center For Magnesium Education Research,&nbsp;Gesellschaft Für Magnesium-Forschung E V Germany,&nbsp;Sdrm Society International Society For The Development Of Research On Magnesium","doi":"10.1684/mrh.2021.0479","DOIUrl":"10.1684/mrh.2021.0479","url":null,"abstract":"","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"34 2","pages":"90-92"},"PeriodicalIF":3.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9279635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium enhances cardiomyocyte proliferation and suppresses cardiac fibrosis induced by chronic ACTH exposure in rats.","authors":"Jelena Petrović,&nbsp;Milica Labudović-Borović,&nbsp;Sabine U Vorrink,&nbsp;Volker M Lauschke,&nbsp;Bojana Pejušković,&nbsp;Vesna Pešić","doi":"10.1684/mrh.2021.0484","DOIUrl":"https://doi.org/10.1684/mrh.2021.0484","url":null,"abstract":"<p><p>Chronic stress has been implicated in the development and progression of heart disease. In the past decade, a link between chronic stress and cardiac fibrosis has been described. Here, we focused on investigating the effects of one of the key molecular effectors of the stress response-adrenocorticotropic hormone (ACTH) on cardiac histopathology. More importantly, as the literature data support interplay between magnesium (Mg) and the hypothalamo-pituitary-adrenal (HPA) stress system, we explored potential cardioprotective effects of Mg supplementation in a rat model of ACTH-induced cardiac remodeling. Protracted ACTH exposure in rats resulted in a prominent increase in proliferation of fibroblasts and excessive collagen deposition in the heart, accompanied by enhanced proliferation of cardiomyocytes and vascular endothelial cells. Our results show, for the first time, that administration of Mg in rats was effective in ameliorating the development of ACTH-evoked cardiac fibrosis, while facilitating cardiomyocyte proliferation. Furthermore, we propose that Mg supplementation attenuates ACTH-induced HPA axis hyperactivity, as one of the underlying plausible mechanisms, which may contribute to its cardioprotective effects.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":" ","pages":"74-83"},"PeriodicalIF":3.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39372001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}