新冠肺炎患者镁血症与心肌损害及死亡率的关系

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Seyda Gunay, Serhat Caliskan, Deniz Sigirli
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引用次数: 4

摘要

镁(Mg)是第二丰富的细胞内阳离子,在免疫系统和心脏保护中起着重要作用。镁缺乏导致慢性低度炎症导致心血管疾病,低镁水平加剧病毒诱导的炎症。本研究的目的是探讨血清镁水平是否与COVID-19心肌损伤和预后相关。这是一项针对COVID-19患者的单中心、观察性回顾性研究。根据住院死亡率将研究人群分为两组:幸存者组(SG)和非幸存者组(NSG)。心肌损伤定义为血液中心肌肌钙蛋白I (cTnI)水平高于参考上限的第99个百分位。比较两组之间的镁、炎症变量和心肌损伤。共纳入629例新冠肺炎患者。死亡率为11.85% (n = 82)。男性NSG组61例(74.4%),男性SG组294例(53.7%)(p = 0.001)。NSG的中位年龄为64.5岁(最小-最大值为37 ~ 93),SG的中位年龄为56.0岁(最小-最大值为22 ~ 92)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship of magnesemia with myocardial damage and mortality in patients with COVID-19.

Magnesium (Mg) is the second most abundant intracellular cation and plays a significant role in immune system and cardiac protection. Mg deficiency contributes to chronic low-grade inflammation leading to cardiovascular diseases, and low Mg level exacerbates virus-induced inflammation. The aim of the study was to investigate whether serum magnesium level is associated with myocardial damage and prognosis of COVID-19. This was a single-center, observational retrospective study of patients with COVID-19. The study population was divided into two groups according to in-hospital mortality: a survivor group (SG) and a non-survivor group (NSG). Myocardial damage was defined as blood levels of cardiac troponin I (cTnI) above the 99th percentile upper reference limit. Magnesium, variables regarding inflammation, and myocardial damage were compared between the groups. A total of 629 patients with COVID-19 were included. Mortality rate was 11.85% (n = 82). There were 61 (74.4%) and 294 male patients (53.7%) in NSG and SG, respectively (p = 0.001). The median age of NSG was 64.5 years (min-max: 37-93) and the median age of SG was 56.0 years (min-max: 22-92) (p < 0.001). Median serum magnesium levels of NSG and SG were 1.94 mg/dL (min-max: 1.04-2.87) and 2.03 mg/dL (min-max: 1.18-2.88), respectively (p = 0.027). Median cTnI levels of NSG and SG were 25.20 pg/mL (min-max: 2.10-2240.80) and 4.50 pg/mL (min-max: 0.50-984.3), respectively (p < 0.001). The cTnI levels were lower in those patients whose serum Mg levels were higher than 1.94. Although serum magnesium level was not a predictor for in-hospital mortality, there was a significant negative correlation between magnesemia and myocardial damage.

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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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