Magnesium research最新文献

Association between dietary magnesium intake, magnesium depletion score and hyperuricemia-related all-cause mortality or cardiovascular mortality in patients with coronary heart disease. 冠心病患者膳食镁摄入量、镁耗尽评分与高尿酸血症相关全因死亡率或心血管死亡率之间的关系

IF 1.5 4区医学

Magnesium research Pub Date : 2024-12-01 DOI: 10.1684/mrh.2024.0538

Yu Liu, Shiqiang Wang, Huaidong Chen, Ximing Qian

{"title":"Association between dietary magnesium intake, magnesium depletion score and hyperuricemia-related all-cause mortality or cardiovascular mortality in patients with coronary heart disease.","authors":"Yu Liu, Shiqiang Wang, Huaidong Chen, Ximing Qian","doi":"10.1684/mrh.2024.0538","DOIUrl":"https://doi.org/10.1684/mrh.2024.0538","url":null,"abstract":"Hyperuricemia is associated with an increased risk of mortality in coronary heart disease (CHD) patients. Magnesium intake is related to reduced mortality due to cardiovascular disease. This study aimed to investigate the association between dietary magnesium intake, magnesium depletion score (MDS) and hyperuricemia-related all-cause mortality or cardiovascular mortality in patients with CHS. In this retrospective cohort study, 1,823 CHD patients were selected from the National Health and Nutrition Examination Survey (NHANES). Dietary magnesium intake was determined based on 24-hour dietary recall interviews. MDS was assessed considering four factors: use of diuretics, use of proton pump inhibitors, estimated glomerular filtration rate, and alcohol consumption. Weighted univariate and multivariate Cox regression models were applied to explore the association between dietary magnesium intake, MDS, hyperuricemia, and all-cause mortality or cardiovascular mortality. The results were presented as hazard ratios (HRs) and 95% confidence intervals (CIs). The Kaplan-Meier survival curves were used to explore survival status relative to magnesium intake or MDS. After an average of 81 months of follow-up, 879 CHD patients died. After adjusting for covariates, MDS ≥2 (HR=1.34, 95% CI: 1.13-1.60) and hyperuricemia (HR=1.25, 95% CI: 1.01-1.55) were associated with increased odds of all-cause mortality. Moreover, MDS affected the association between hyperuricemia and all-cause mortality (HR=1.41, 95% CI: 1.09-1.84) or cardiovascular mortality (HR=1.44, 95% CI: 1.02-2.03) in CHD patients. MDS influences mortality in patients with hyperuricemia, highlighting the potential importance of magnesium status in managing the risks associated with hyperuricemia in CHD patients.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 4","pages":"177-188"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mild magnesium deficiency affects the urinary metabolome in rats. 轻度镁缺乏影响大鼠尿液代谢组。

IF 1.5 4区医学

Magnesium research Pub Date : 2024-12-01 DOI: 10.1684/mrh.2024.0537

Takashi Futami, Shozo Tomonaga

{"title":"Mild magnesium deficiency affects the urinary metabolome in rats.","authors":"Takashi Futami, Shozo Tomonaga","doi":"10.1684/mrh.2024.0537","DOIUrl":"10.1684/mrh.2024.0537","url":null,"abstract":"Low magnesium (Mg) intake increases the risk of various diseases such as anxiety disorder, depression, and diabetes. However, a reliable biomarker of mild Mg deficiency due to low Mg intake has not yet been identified. We speculate that metabolomics will be effective for biomarker discovery because Mg can affect various metabolic processes in the body. In the present study, we evaluated whether mild Mg deficiency affects growth, behaviour, and plasma and urinary metabolomes in rats. Mg levels in plasma and the femur, and urinary Mg excretion decreased by consuming a mildly low Mg diet, whereas body weight and food intake were not affected. Also, anxiety- and depression-like behaviours were not affected by Mg deficiency. These results indicate that the negative effects observed here are milder than those for severe Mg deficiency, as previously reported. Of the 93 annotated metabolites in plasma, only glycylglycine was moderately affected. Of the 122 annotated metabolites in urine, 29 were affected. A marked decrease in urinary excretion of some organic acids of the tricarboxylic acid cycle, particularly citric acid, was noticed. This study identifies urinary metabolites that may be useful biomarkers of mild Mg deficiency.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"73-82"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of magnesium intake on the association between vitamin D deficiency and severe hepatic steatosis in overweight and obese individuals. 超重和肥胖人群中维生素D缺乏和严重肝脂肪变性之间镁摄入量的调节

IF 1.5 4区医学

Magnesium research Pub Date : 2024-12-01 DOI: 10.1684/mrh.2024.0536

Yanqiu Wang, Jianhong Jin, Sisi Chen, Youkui Shen

{"title":"Modulation of magnesium intake on the association between vitamin D deficiency and severe hepatic steatosis in overweight and obese individuals.","authors":"Yanqiu Wang, Jianhong Jin, Sisi Chen, Youkui Shen","doi":"10.1684/mrh.2024.0536","DOIUrl":"10.1684/mrh.2024.0536","url":null,"abstract":"This study aimed to explore the association between serum vitamin D and/or dietary magnesium intake levels and severe hepatic steatosis. This cross-sectional study collected data from 2,874 individuals in the NHNAES database between 2017 and 2018. Variables were subjected to weighted univariate logistic regression analysis, and variables with p<0.05 were selected for weighted multivariate logistic regression analysis. The stepwise backward method was then used, and variables with p<0.05 in the weighted multivariate logistic model were retained as confounding factors. Univariable and multivariable logistic regression models were applied to explore the effect of magnesium intake and/or vitamin D level on the risk of hepatic steatosis in overweight and obese individuals. Subgroup analysis was stratified by age, gender, BMI, and complications. The respective odds ratio (OR) and confidence interval (CI) were calculated. The risk of severe hepatic steatosis in overweight and obese individuals was increased in those with deficient serum vitamin D levels (OR: 1.71, 95% CI: 1.13-2.57). No significant correlation between dietary magnesium intake level and severe hepatic steatosis was observed in overweight and obese individuals (all p>0.05). However, an increased risk of severe hepatic steatosis in overweight and obese individuals was found in those with deficient dietary magnesium intake and deficient serum vitamin D compared to those with sufficient serum vitamin D (OR: 1.86, 95% CI: 1.20-2.89). Deficient magnesium intake in overweight and obese patients with low serum vitamin D levels may increase the risk of severe hepatic steatosis, however, future studies are required to verify our findings.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"58-72"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of intraoperative magnesium sulphate on acute kidney injury following robot-assisted radical prostatectomy: a retrospective propensity score-matched analysis. 术中硫酸镁对机器人辅助根治性前列腺切除术后急性肾损伤的影响：回顾性倾向评分匹配分析。

IF 1.5 4区医学

Magnesium research Pub Date : 2024-12-01 DOI: 10.1684/mrh.2024.0533

Jung-Hee Ryu, Young-Tae Jeon, Jung Hyun Bang, Ah-Young Oh, Chang-Hoon Koo

{"title":"Effect of intraoperative magnesium sulphate on acute kidney injury following robot-assisted radical prostatectomy: a retrospective propensity score-matched analysis.","authors":"Jung-Hee Ryu, Young-Tae Jeon, Jung Hyun Bang, Ah-Young Oh, Chang-Hoon Koo","doi":"10.1684/mrh.2024.0533","DOIUrl":"10.1684/mrh.2024.0533","url":null,"abstract":"Although intraoperative magnesium sulphate administration has various advantages, its influence on the occurrence of postoperative acute kidney injury (AKI) remains unclear, particularly in patients undergoing robot-assisted radical prostatectomy (RARP). The steep Trendelenburg position and a high intra-abdominal pressure can render patients susceptible to AKI after surgery. This study aimed to evaluate the effects of intraoperative magnesium sulphate administration on postoperative AKI in patients who underwent RARP. This retrospective study used a propensity score-matched analysis to evaluate the medical records of patients who underwent RARP between May 2013 and December 2021 in a single institution. In total, 3,239 cases were reviewed. After propensity score matching, 456 patients were each included in the magnesium and control groups. Univariate and multivariate logistic regression analyses were conducted to identify risk factors for postoperative AKI, as defined by the Kidney Disease Improving Global Outcomes criteria, within seven days after surgery. The incidence of postoperative AKI did not differ significantly between the magnesium and control groups (30.7% versus 31.4%). The univariate logistic regression analysis revealed that intraoperative magnesium sulphate administration was not associated with AKI after RARP (p=0.83). In the multivariate analysis, body mass index (odds ratio [OR], 1.069; p=0.018) and duration of surgery (OR, 1.005; p=0.027) were independent risk factors, while total intravenous anaesthesia (OR, 0.448; p=0.005) and intraoperative fluid replacement (OR, 0.856; p=0.012) were protective factors for postoperative AKI. Intraoperative magnesium sulphate administration had no significant effect on the occurrence of postoperative AKI in patients undergoing RARP.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"28-39"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnesium level and impulsivity during ketamine administration for treatment-resistant mood disorders. 氯胺酮治疗难治性情绪障碍期间镁水平和冲动性。

IF 1.5 4区医学

Magnesium research Pub Date : 2024-12-01 DOI: 10.1684/mrh.2024.0534

Jakub Słupski, Adam Włodarczyk, Natalia Górska, Joanna Szarmach, Anita Słupska, Karolina Pilecka, Aleksander Kwaśny, Żaneta Kowalska, Wiesław Jerzy Cubała

{"title":"Magnesium level and impulsivity during ketamine administration for treatment-resistant mood disorders.","authors":"Jakub Słupski, Adam Włodarczyk, Natalia Górska, Joanna Szarmach, Anita Słupska, Karolina Pilecka, Aleksander Kwaśny, Żaneta Kowalska, Wiesław Jerzy Cubała","doi":"10.1684/mrh.2024.0534","DOIUrl":"10.1684/mrh.2024.0534","url":null,"abstract":"Impulsive behaviours affect patients with major depressive disorder (MDD) and bipolar disorder (BP), increasing suicide risk and mood instability. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, has been reported to promote fast-acting antidepressive and antisuicidal effects. Magnesium administered contemporarily with low-dose NMDA antagonists has been shown to cause a reduction in anxiety-related and depressive-like behaviours. This observational study investigated the possible association between magnesium levels and impulsivity, measured using the Barratt Impulsiveness Scale (BIS-11), during ketamine treatment. Forty-nine inpatients with treatment-resistant mood disorders were involved in the study. The study therapeutic intervention was based on the administration of eight ketamine intravenous infusions over four weeks. The BIS-11 and magnesium levels were assessed for every subject before the first, third, fifth and seventh ketamine infusion and one week after the last infusion. The concentration of magnesium ions during the ketamine treatment was not associated with BIS-11 changes. The study does not provide evidence for a relationship between magnesium concentration and impulsivity, measured using the BIS-11, during ketamine treatment.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"40-48"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selected Abstracts from from the XVII International Magnesium Symposium, Grottaferrata 5-6 September 2024. 第十七届国际镁研讨会摘录，Grottaferrata， 2024年9月5日至6日。

IF 1.5 4区医学

Magnesium research Pub Date : 2024-12-01 DOI: 10.1684/mrh.2024.0532

Rhian M Touyz

引用次数: 0

Increased ionized calcium/magnesium ratio in elderly hypertensives. 老年高血压患者离子钙/镁比值升高。

IF 1.5 4区医学

Magnesium research Pub Date : 2024-12-01 DOI: 10.1684/mrh.2024.0541

Lukas Kisters, Uwe Gröber, Klaus Kisters

引用次数: 0

Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial. 联合口服补充镁和维生素D可缓解与长期covid相关的轻至中度抑郁症状：一项开放标签随机对照临床试验

IF 1.5 4区医学

Magnesium research Pub Date : 2024-12-01 DOI: 10.1684/mrh.2024.0535

Martha Rodríguez-Morán, Fernando Guerrero-Romero, Jazel Barragán-Zuñiga, Claudia I Gamboa-Gómez, Yessika Weyman-Vela, Mariana Arce-Quiñones, Luis E Simental-Mendía, Gerardo Martínez-Aguilar

{"title":"Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial.","authors":"Martha Rodríguez-Morán, Fernando Guerrero-Romero, Jazel Barragán-Zuñiga, Claudia I Gamboa-Gómez, Yessika Weyman-Vela, Mariana Arce-Quiñones, Luis E Simental-Mendía, Gerardo Martínez-Aguilar","doi":"10.1684/mrh.2024.0535","DOIUrl":"10.1684/mrh.2024.0535","url":null,"abstract":"Individuals with long-COVID exhibit a higher frequency of hypomagnesemia, vitamin D deficiency, and depression. Objective. To evaluate the efficacy and safety of oral supplementation with magnesium chloride plus vitamin D in alleviating depressive symptoms related to long-COVID. A total of 60 subjects, aged 52.8±12.6 years, with a diagnosis of hypomagnesemia, vitamin D deficiency, and mild-to-moderate depression (MMD) related to long-COVID, were enrolled in an open-label randomized, controlled clinical trial. Participants were randomly allocated into an intervention group (n=30) that received magnesium chloride (1300 mg) plus vitamin D (4000 IU), or a control group (n=30) that received vitamin D (4000 IU), for four months. Using the Beck Depression Inventory (BDI), diagnosis of MMD was established based on a score of ≥11<30. The primary trial endpoint was improvement in depressive symptoms (BDI <11). Mild adverse events that did not require withdrawal from intervention were documented in six (20.0%) and three (10%) individuals of the intervention and control group, respectively. By comparing baseline vs. final measurements, the BDI score was significantly reduced in individuals in the intervention (28.8±3.7 to 9.2±7.5, p<0.01) and control (28.4±3.8 to 21.6±9.1, p<0.05) group. A total of 22 (73.2%) subjects in the intervention group and 10 (34.5%) in the control group reached a BDI <11, p=0.006. Our results show that, among patients with hypomagnesemia and vitamin D deficiency, combined oral supplementation with magnesium plus vitamin D is effective and safe in alleviating MMD related to long-COVID.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"49-57"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Road Map to the State of the Art of Magnesium Research - Highlights from the XVII International Magnesium Symposium, Grottaferrata 5-6 September 2024. 镁研究现状的路线图——第十七届国际镁研讨会的亮点，Grottaferrata 2024年9月5-6日。

IF 1.5 4区医学

Magnesium research Pub Date : 2024-12-01 DOI: 10.1684/mrh.2024.0531

Federica I Wolf, Valentina Trapani, Jeanette A Maier

引用次数: 0

Protective effect of nano magnesium oxide on renal ischemia/reperfusion injury in male Wistar rats. 纳米氧化镁对雄性Wistar大鼠肾缺血再灌注损伤的保护作用。

IF 1.5 4区医学

Magnesium research Pub Date : 2024-12-01 DOI: 10.1684/mrh.2024.0539

Marzieh Minaei, Akram Eidi, Pejman Mortazavi, Ahmad Asghari

引用次数: 0