Magnesium research最新文献

{"title":"The role of magnesium in otology - A narrative review.","authors":"Jens Büntzel, Klaus Kisters, Judith Büntzel, Oliver Micke","doi":"10.1684/mrh.2026.0553","DOIUrl":"https://doi.org/10.1684/mrh.2026.0553","url":null,"abstract":"<p><p>Magnesium is believed to have a positive and protective effect on inner ear disorders. We conducted a systematic literature search on the topic. The mesh terms \"magnesium\", \"tinnitus\", \"sudden hearing loss\", \"vestibular disorders\", \"ototoxicity\", and \"otoprotection\" were used for the Medline search. Based on this approach, a narrative review with a structured literature search was conducted. There is good evidence that supplementation with >200 mg magnesium daily protects against the development of age-related hearing loss. A similar protective effect can be assumed for protection against noise, thus the dietary supplement can also be used on an evidence-based basis in addition to other basic measures (hearing protection, noise level reduction). In cases of acute hearing loss and tinnitus, there is evidence that magnesium may have additional benefits alongside basic therapy (corticosteroids, CO2 inhalation). Derived from the use of magnesium in migraine treatment, there are individual studies (phase II, case series) that report positive effects on vestibular disorders with 1-2 g magnesium sulfate as intravenous treatment for acute situations and 400 mg oral magnesium for prophylaxis. There are only case reports on the prevention of cisplatin ototoxicity by magnesium. Despite a wealth of experimental data, the evidence for the clinical benefits of magnesium in otology is limited. Good data is available exclusively for the prevention of presbycusis. Any other therapeutic use must still be classified as experimental/individual.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"38 4","pages":"126-135"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum magnesium level and contrast-induced nephropathy in patients undergoing percutaneous coronary intervention for acute coronary syndromes.","authors":"Eser Açıkgöz, Sadık Kadri Açıkgöz, Murat Oğuz Özilhan","doi":"10.1684/mrh.2026.0555","DOIUrl":"https://doi.org/10.1684/mrh.2026.0555","url":null,"abstract":"<p><p>Contrast-induced nephropathy (CIN) remains a frequent and clinically significant complication following percutaneous coronary intervention (PCI), particularly in patients with acute coronary syndromes (ACS). In this study of 2,696 ACS patients undergoing PCI, we investigated the association between baseline serum magnesium (Mg) levels and development of CIN. CIN occurred in 27.2% of patients. Those who developed CIN were older and had higher rates of male gender, diabetes, STEMI, Killip class >1, and contrast volume, along with lower left ventricular ejection fraction. Serum Mg levels were significantly lower in the CIN group (1.826±0.208 vs. 2.091±0.183 mg/dL, p<0.001). In addition, patients were stratified into quintiles based on serum Mg levels and a clear stepwise increase in the incidence of CIN with decreasing Mg levels was demonstrated (Q5: 8.8%, Q4: 13.9%, Q3: 21.9%, Q2: 48.8%, Q1: 57.7%; p for trend <0.001). In ROC curve analysis, Mg level <1.92 predicted CIN with 72.1% sensitivity and 73.2% specificity. Mg <1.92 was found as an independent predictor of CIN in logistic regression analysis (OR: 2.992, 95% CI: 1.611-5.232, p<0.001). These findings suggest that serum Mg may serve as a novel biomarker for CIN risk stratification. Further studies are warranted to clarify the role of Mg screening and supplementation in reducing CIN risk among ACS patients.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"38 4","pages":"136-144"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of estimated ionized magnesium for mechanical ventilation in children with asthma: a single-centre retrospective cohort, 2016-2024.","authors":"Yurie Yamaga, Soichiro Tanimura, Hiroki Kato, Shotaro Matsumoto","doi":"10.1684/mrh.2026.0554","DOIUrl":"10.1684/mrh.2026.0554","url":null,"abstract":"<p><p>Asthma exacerbations are a frequent cause of paediatric intensive care admissions, and early identification of patients at risk of respiratory failure is essential. Because direct ionized magnesium measurement is not routinely available, we evaluated whether estimated ionized magnesium derived from routinely available biochemical data was associated with subsequent invasive mechanical ventilation. We conducted a retrospective observational study of children admitted to a paediatric intensive care unit in Japan between 2016 and 2024 with asthma. Primary exposure was considered as the admission-phase estimated ionized magnesium value, defined as the earliest available value before initiation of invasive ventilation, and applied consistently to ventilated and non-ventilated children. The primary outcome was the need for mechanical ventilation. Receiver operating characteristic analysis and multivariable logistic regression were used to evaluate the predictive performance of estimated ionized magnesium while adjusting for arterial pH and arterial carbon dioxide tension. Among 115 eligible children, 51 (44.3%) required invasive mechanical ventilation. Estimated ionized magnesium was lower in ventilated than in non-ventilated children (median 0.467 vs 0.632 mmol/L; p < 0.001). The area under the receiver operating characteristic curve was 0.90, with a 95% confidence interval of 0.83 to 0.96. Each 0.1-mmol/L decrease in estimated ionized magnesium remained associated with higher odds of mechanical ventilation after adjustment for pH and arterial carbon dioxide tension (adjusted odds ratio: 9.46; 95% confidence interval: 3.94 to 22.71; p < 0.001). Admission-phase estimated ionized magnesium was strongly associated with invasive mechanical ventilation in children with asthma exacerbations and may provide a practical early risk marker.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"38 4","pages":"113-117"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of magnesium taurate-potassium citrate on blood pressure and vascular stiffness in low-risk adults with elevated blood pressure.","authors":"Seçkin Dereli","doi":"10.1684/mrh.2026.0552","DOIUrl":"10.1684/mrh.2026.0552","url":null,"abstract":"<p><p>Elevated blood pressure (BP) is a key modifiable cardiovascular risk factor. In low-risk individuals, guidelines recommend lifestyle interventions before pharmacotherapy. Evidence for magnesium taurate-potassium citrate supplementation in this setting is lacking. This prospective, single-arm observational study enrolled 121 adults with elevated BP or stage 1 hypertension and low cardiovascular risk (SCORE2/SCORE2-OP), per 2024 ESC guidelines, who declined antihypertensive drugs. All received lifestyle counselling plus magnesium taurate-potassium citrate (121 mg elemental magnesium, 180 mg elemental potassium daily) for three months. The per-protocol cohort included 110 patients. Primary outcomes were BP changes at work, at home (HBPM), and ambulatory BP (ABPM). Secondary outcomes were pulse-wave velocity (PWV), augmentation index (AIx), renal function, and serum electrolytes. At three months, BP at work fell by -12/-9 mmHg, HBPM by -11/-8 mmHg, and ABPM by -11/-8 mmHg (all p<0.001). PWV and AIx improved by -0.9 m/s and -4.0% (p<0.001). Serum magnesium rose by +0.1 mg/dL (p=0.003) without changes in sodium, potassium, or renal function. No serious adverse events occurred. In low-risk adults with elevated BP, magnesium taurate-potassium citrate plus lifestyle advice significantly reduced BP and arterial stiffness over three months, supporting magnesium taurate-potassium citrate as a safe non-pharmacological option. As this was a single-arm observational study with routine lifestyle counselling, causal inference was limited, underscoring the need for randomized trials.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"38 4","pages":"118-125"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between magnesium deficiency scores and hip bone health in adults: a population-based study.","authors":"Shuxiang Li, Wenliao Chang, Guofeng Wu, Kun Wang, Xiaoliang Sun, Han Sun, Jian Zhou","doi":"10.1684/mrh.2025.0549","DOIUrl":"https://doi.org/10.1684/mrh.2025.0549","url":null,"abstract":"<p><p>Studies on magnesium and bone health in the literature are conflicting. This study was conducted to evaluate the relationship between Magnesium Deficiency Score (MDS) and indicators of hip bone health in adults. This study analysed data from the NHANES in 13,259 US adults aged ≥20 years. Outcome measures included bone mineral density (BMD) (total femur, femoral neck, trochanter, intertrochanter, and Ward's triangle), osteoporosis, history of hip fracture, and FRAX (Fracture Risk Assessment Tool) score. Weighted linear regression and logistic regression models were used to assess the association between MDS and the outcomes. Trend tests were also performed to analyse the presence of a dose-response relationship. Subgroup analyses were performed by age and sex. After adjusting for all covariates, we found a significant age-stratified effect between MDS and hip bone health. In the elderly population aged ≥60 years, there was a higher risk of decline in Ward's triangle and femoral neck BMD, a higher risk of osteoporosis (OR =1.27, 95% CI: 1.07, 1.50; P trend =0.006), and higher FRAX scores as MDS scores increased. However, this negative effect was significantly attenuated in individuals <60 years. No association was found between MDS and a history of hip fracture. In addition, no sex-stratified effect was found between MDS and the outcome measures described above. The risk of severe magnesium deficiency significantly affects hip bone health in older adults, increasing the risk of subsequent fractures. Future studies should explore more detailed mechanisms associated with the role of magnesium in skeletal physiology and pathology.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"38 3","pages":"81-94"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between magnesium level and triglyceride-glucose index in type 2 diabetes mellitus.","authors":"Müslüm Güneş","doi":"10.1684/mrh.2025.0550","DOIUrl":"https://doi.org/10.1684/mrh.2025.0550","url":null,"abstract":"<p><p>Triglyceride-glucose index (TyGI) is a novel biomarker for diagnostic and prognostic processes. TyGI, together with magnesium level and The Charlson Comorbidity Index (CCI; used to predict long-term survival), is associated with morbidity and mortality. As type 2 diabetes mellitus (T2DM) is associated with hypomagnesaemia, magnesium may therefore be related to TyGI and CCI in patients with T2DM. To compare hypomagnesemia and normomagnesemia in terms of TyGI and CCI, and to investigate the correlation of magnesium with TyGI and CCI in patients with T2DM. T2DM patients (n=194) were divided into hypomagnesaemia (n=58) and normomagnesaemia (n=136) groups depending on serum magnesium level. TyGI was calculated with the formula, Ln[fasting triglyceride (mg/dL)×fasting glucose (mg/dL)/2]. TyGI, CCI, and laboratory parameters were compared between the groups. Correlation analysis was performed between magnesium and other parameters. There was no significant difference between the groups in terms of age, gender, BMI, T2DM duration, medication, comorbidities, or laboratory parameters (p>0.05). However, the hypomagnesaemia group had significantly increased TyGI (p=0.014) and CCI (p=0.044). There was also a significant negative correlation between magnesium and parameters including T2DM duration (r:-155; p=0.031), glucose (r:-214; p=0.003), HbA1c (r:-195; p=0.007), TyGI (r:-0.207; p=0.004), and CCI (r:-0.177; p=0.014). TyGI and CCI are increased in T2DM patients with hypomagnesaemia, and magnesium is associated with TyGI and CCI. These novel findings should be further investigated in future studies.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"38 3","pages":"95-101"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of magnesium sulfate on intraoperative body temperature changes in patients undergoing laparoscopic gynaecological surgery under propofol-based total intravenous anaesthesia: a retrospective analysis.","authors":"Ji-Na Kim, Subin Yim, Jin-Woo Park, Hyo-Seok Na, Young-Jin Lim, Sang-Hwan Do","doi":"10.1684/mrh.2025.0551","DOIUrl":"https://doi.org/10.1684/mrh.2025.0551","url":null,"abstract":"<p><p>The objective of this study was to investigate the effects of intravenous magnesium sulfate (MgSO4) administration on core body temperature (BT) changes in patients undergoing laparoscopic gynaecological surgery under propofol-based total intravenous anaesthesia (TIVA). Data from 120 female patients, aged 20-65, who underwent laparoscopic gynaecological surgery between March 2021 and February 2024, were analysed retrospectively. Patients were divided into Mg (n=49) and non-Mg (n=71) groups. The Mg group received MgSO4 (50 mg/kg in 100-mL isotonic saline over 15 minutes) during induction, followed by a continuous infusion (15 mg/kg/h). Core BT was recorded using tympanic thermometer and oesophageal probes: pre-anaesthesia (BT0), 5 minutes post-induction (BT5), every 15 minutes (BT15 ~ BT105), and at emergence (BT120). All patients were warmed using both a circulating-water mattress and a forced-air warming blanket. BT0 was comparable between groups. BT decreased over time in both groups (p < 0.001). The Mg group had significantly lower BT at BT5 (p = 0.031), BT15 (p = 0.004), BT30 (p = 0.011), and BT45 (p = 0.016). However, the rate of temperature change over time between groups was comparable. The incidence of post-anaesthetic shivering was significantly lower in the Mg group (19.7% vs 6.1%, p = 0.036). During propofol-based TIVA, MgSO4 administration reduced BT at early time points during surgery, while the rate of temperature change over time was not significantly affected by MgSO4 administration. Notably, the incidence of shivering was significantly lower in the Mg group.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"38 3","pages":"102-112"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial effects of magnesium oxide, related mechanisms, and prospective applications for reducing orthopaedic implant-related infections.","authors":"Yu Wang, Dongqin Xiao, Liqun Hu, Zhuohan Li, Zhong Li, Ke Duan, Kui He","doi":"10.1684/mrh.2025.0543","DOIUrl":"https://doi.org/10.1684/mrh.2025.0543","url":null,"abstract":"<p><p>Orthopaedic implant-related infections (IRIs) are severe postoperative complications that are difficult to clear by debridement or antibiotic treatments. Magnesium oxide (MgO) effectively inhibits or kills a broad spectrum of bacteria, is minimally associated with safety issues, and poses no risk of inducing antibiotic resistance. Therefore, MgO has been actively studied for environmental, hygienic, as well as clinical applications such as the management of IRIs. This narrative review discusses the antibacterial properties of MgO, related mechanisms, and recent studies related to orthopaedic IRIs. Existing problems and potential possibilities for further research are also suggested.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"38 1","pages":"0"},"PeriodicalIF":1.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dysmagnesaemia and its correction on mortality of non-critically ill hospitalized medical patients.","authors":"Donna Gal, Eugene Feigin, Daniel Shepshelovich, Moshe Giladi","doi":"10.1684/mrh.2025.0542","DOIUrl":"https://doi.org/10.1684/mrh.2025.0542","url":null,"abstract":"<p><p>Magnesium is an essential electrolyte, regulating enzymatic function and membrane excitability. While dysmagnesaemia is common among hospitalized patients, its prognostic role and the potential clinical benefit of its correction remain debated.</p><p><strong>Methods: </strong>All adult patients admitted to internal medicine wards at the Tel-Aviv Sourasky Medical Center between June 1st, 2007, and July 31st, 2022, for whom magnesium levels were measured, were included. Data from 85,466 patients were obtained. Patients were divided into four subgroups according to magnesium level at admission: severe hypomagnesaemia (serum magnesium ≤1.2mg/dL), mild hypomagnesaemia (magnesium >1.2mg/dL≤1.8mg/dL), eumagnesaemia (magnesium >1.8/≤2.55mg/dL), and hypermagnesaemia (magnesium >2.55). The primary outcome was 30-day mortality risk.</p><p><strong>Results: </strong>Hypomagnesaemia was associated with the use of thiazides and proton pump inhibitors (p<0.001), while severe hypermagnesaemia was associated with reduced renal function (p<0.001). After adjusting for age, gender, the Charlson comorbidity index, creatinine, potassium, and calcium corrected for albumin, mild hypomagnesaemia was associated with lower 30-day mortality (HR: 0.87, 95% CI: 0.82-0.93, p<0.001), hypermagnesaemia was associated with higher 30-day mortality (HR: 2.86, 95% CI: 2.57-3.17, p<0.001), and severe hypomagnesaemia was not associated with survival change (HR: 0.82, 95% CI: 0.62-1.09, p=0.177). Hypermagnesaemia normalization (HR: 0.77, 95% CI: 0.63-0.93, p<0.001) and administration of magnesium supplements for mild (adjusted HR: 0.53, 95% CI: 0.36-0.79, p=0.002) or severe (HR: 0.34, 95% CI: 0.28-0.41, p<0.001) hypomagnesaemia were associated with reduced mortality.</p><p><strong>Conclusion: </strong>In hospitalized, non-critically ill medical patients, hypermagnesaemia confers a substantial 30-day mortality risk, which may be mitigated by its correction. Although hypomagnesaemia is not associated with worse outcome, its correction by supplementation may be of clinical benefit.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"38 1","pages":"17-25"},"PeriodicalIF":1.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of magnesium intake on the association between vitamin D deficiency and severe hepatic steatosis in overweight and obese individuals.","authors":"Yanqiu Wang, Jianhong Jin, Sisi Chen, Youkui Shen","doi":"10.1684/mrh.2024.0536","DOIUrl":"10.1684/mrh.2024.0536","url":null,"abstract":"<p><p>This study aimed to explore the association between serum vitamin D and/or dietary magnesium intake levels and severe hepatic steatosis. This cross-sectional study collected data from 2,874 individuals in the NHNAES database between 2017 and 2018. Variables were subjected to weighted univariate logistic regression analysis, and variables with p<0.05 were selected for weighted multivariate logistic regression analysis. The stepwise backward method was then used, and variables with p<0.05 in the weighted multivariate logistic model were retained as confounding factors. Univariable and multivariable logistic regression models were applied to explore the effect of magnesium intake and/or vitamin D level on the risk of hepatic steatosis in overweight and obese individuals. Subgroup analysis was stratified by age, gender, BMI, and complications. The respective odds ratio (OR) and confidence interval (CI) were calculated. The risk of severe hepatic steatosis in overweight and obese individuals was increased in those with deficient serum vitamin D levels (OR: 1.71, 95% CI: 1.13-2.57). No significant correlation between dietary magnesium intake level and severe hepatic steatosis was observed in overweight and obese individuals (all p>0.05). However, an increased risk of severe hepatic steatosis in overweight and obese individuals was found in those with deficient dietary magnesium intake and deficient serum vitamin D compared to those with sufficient serum vitamin D (OR: 1.86, 95% CI: 1.20-2.89). Deficient magnesium intake in overweight and obese patients with low serum vitamin D levels may increase the risk of severe hepatic steatosis, however, future studies are required to verify our findings.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"58-72"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}