Magnesium research最新文献

{"title":"Mild magnesium deficiency affects the urinary metabolome in rats.","authors":"Takashi Futami, Shozo Tomonaga","doi":"10.1684/mrh.2024.0537","DOIUrl":"https://doi.org/10.1684/mrh.2024.0537","url":null,"abstract":"<p><p>Low magnesium (Mg) intake increases the risk of various diseases such as anxiety disorder, depression, and diabetes. However, a reliable biomarker of mild Mg deficiency due to low Mg intake has not yet been identified. We speculate that metabolomics will be effective for biomarker discovery because Mg can affect various metabolic processes in the body. In the present study, we evaluated whether mild Mg deficiency affects growth, behaviour, and plasma and urinary metabolomes in rats. Mg levels in plasma and the femur, and urinary Mg excretion decreased by consuming a mildly low Mg diet, whereas body weight and food intake were not affected. Also, anxiety- and depression-like behaviours were not affected by Mg deficiency. These results indicate that the negative effects observed here are milder than those for severe Mg deficiency, as previously reported. Of the 93 annotated metabolites in plasma, only glycylglycine was moderately affected. Of the 122 annotated metabolites in urine, 29 were affected. A marked decrease in urinary excretion of some organic acids of the tricarboxylic acid cycle, particularly citric acid, was noticed. This study identifies urinary metabolites that may be useful biomarkers of mild Mg deficiency.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"73-82"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of magnesium intake on the association between vitamin D deficiency and severe hepatic steatosis in overweight and obese individuals.","authors":"Yanqiu Wang, Jianhong Jin, Sisi Chen, Youkui Shen","doi":"10.1684/mrh.2024.0536","DOIUrl":"https://doi.org/10.1684/mrh.2024.0536","url":null,"abstract":"<p><p>This study aimed to explore the association between serum vitamin D and/or dietary magnesium intake levels and severe hepatic steatosis. This cross-sectional study collected data from 2,874 individuals in the NHNAES database between 2017 and 2018. Variables were subjected to weighted univariate logistic regression analysis, and variables with p<0.05 were selected for weighted multivariate logistic regression analysis. The stepwise backward method was then used, and variables with p<0.05 in the weighted multivariate logistic model were retained as confounding factors. Univariable and multivariable logistic regression models were applied to explore the effect of magnesium intake and/or vitamin D level on the risk of hepatic steatosis in overweight and obese individuals. Subgroup analysis was stratified by age, gender, BMI, and complications. The respective odds ratio (OR) and confidence interval (CI) were calculated. The risk of severe hepatic steatosis in overweight and obese individuals was increased in those with deficient serum vitamin D levels (OR: 1.71, 95% CI: 1.13-2.57). No significant correlation between dietary magnesium intake level and severe hepatic steatosis was observed in overweight and obese individuals (all p>0.05). However, an increased risk of severe hepatic steatosis in overweight and obese individuals was found in those with deficient dietary magnesium intake and deficient serum vitamin D compared to those with sufficient serum vitamin D (OR: 1.86, 95% CI: 1.20-2.89). Deficient magnesium intake in overweight and obese patients with low serum vitamin D levels may increase the risk of severe hepatic steatosis, however, future studies are required to verify our findings.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"58-72"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intraoperative magnesium sulphate on acute kidney injury following robot-assisted radical prostatectomy: a retrospective propensity score-matched analysis.","authors":"Jung-Hee Ryu, Young-Tae Jeon, Jung Hyun Bang, Ah-Young Oh, Chang-Hoon Koo","doi":"10.1684/mrh.2024.0533","DOIUrl":"https://doi.org/10.1684/mrh.2024.0533","url":null,"abstract":"<p><p>Although intraoperative magnesium sulphate administration has various advantages, its influence on the occurrence of postoperative acute kidney injury (AKI) remains unclear, particularly in patients undergoing robot-assisted radical prostatectomy (RARP). The steep Trendelenburg position and a high intra-abdominal pressure can render patients susceptible to AKI after surgery. This study aimed to evaluate the effects of intraoperative magnesium sulphate administration on postoperative AKI in patients who underwent RARP. This retrospective study used a propensity score-matched analysis to evaluate the medical records of patients who underwent RARP between May 2013 and December 2021 in a single institution. In total, 3,239 cases were reviewed. After propensity score matching, 456 patients were each included in the magnesium and control groups. Univariate and multivariate logistic regression analyses were conducted to identify risk factors for postoperative AKI, as defined by the Kidney Disease Improving Global Outcomes criteria, within seven days after surgery. The incidence of postoperative AKI did not differ significantly between the magnesium and control groups (30.7% versus 31.4%). The univariate logistic regression analysis revealed that intraoperative magnesium sulphate administration was not associated with AKI after RARP (p=0.83). In the multivariate analysis, body mass index (odds ratio [OR], 1.069; p=0.018) and duration of surgery (OR, 1.005; p=0.027) were independent risk factors, while total intravenous anaesthesia (OR, 0.448; p=0.005) and intraoperative fluid replacement (OR, 0.856; p=0.012) were protective factors for postoperative AKI. Intraoperative magnesium sulphate administration had no significant effect on the occurrence of postoperative AKI in patients undergoing RARP.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"28-39"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium level and impulsivity during ketamine administration for treatment-resistant mood disorders.","authors":"Jakub Słupski, Adam Włodarczyk, Natalia Górska, Joanna Szarmach, Anita Słupska, Karolina Pilecka, Aleksander Kwaśny, Żaneta Kowalska, Wiesław Jerzy Cubała","doi":"10.1684/mrh.2024.0534","DOIUrl":"https://doi.org/10.1684/mrh.2024.0534","url":null,"abstract":"<p><p>Impulsive behaviours affect patients with major depressive disorder (MDD) and bipolar disorder (BP), increasing suicide risk and mood instability. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, has been reported to promote fast-acting antidepressive and antisuicidal effects. Magnesium administered contemporarily with low-dose NMDA antagonists has been shown to cause a reduction in anxiety-related and depressive-like behaviours. This observational study investigated the possible association between magnesium levels and impulsivity, measured using the Barratt Impulsiveness Scale (BIS-11), during ketamine treatment. Forty-nine inpatients with treatment-resistant mood disorders were involved in the study. The study therapeutic intervention was based on the administration of eight ketamine intravenous infusions over four weeks. The BIS-11 and magnesium levels were assessed for every subject before the first, third, fifth and seventh ketamine infusion and one week after the last infusion. The concentration of magnesium ions during the ketamine treatment was not associated with BIS-11 changes. The study does not provide evidence for a relationship between magnesium concentration and impulsivity, measured using the BIS-11, during ketamine treatment.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"40-48"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selected Abstracts from from the XVII International Magnesium Symposium, Grottaferrata 5-6 September 2024.","authors":"Rhian M Touyz","doi":"10.1684/mrh.2024.0532","DOIUrl":"https://doi.org/10.1684/mrh.2024.0532","url":null,"abstract":"","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"7-27"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial.","authors":"Martha Rodríguez-Morán, Fernando Guerrero-Romero, Jazel Barragán-Zuñiga, Claudia I Gamboa-Gómez, Yessika Weyman-Vela, Mariana Arce-Quiñones, Luis E Simental-Mendía, Gerardo Martínez-Aguilar","doi":"10.1684/mrh.2024.0535","DOIUrl":"https://doi.org/10.1684/mrh.2024.0535","url":null,"abstract":"<p><p>Individuals with long-COVID exhibit a higher frequency of hypomagnesemia, vitamin D deficiency, and depression. Objective. To evaluate the efficacy and safety of oral supplementation with magnesium chloride plus vitamin D in alleviating depressive symptoms related to long-COVID. A total of 60 subjects, aged 52.8±12.6 years, with a diagnosis of hypomagnesemia, vitamin D deficiency, and mild-to-moderate depression (MMD) related to long-COVID, were enrolled in an open-label randomized, controlled clinical trial. Participants were randomly allocated into an intervention group (n=30) that received magnesium chloride (1300 mg) plus vitamin D (4000 IU), or a control group (n=30) that received vitamin D (4000 IU), for four months. Using the Beck Depression Inventory (BDI), diagnosis of MMD was established based on a score of ≥11<30. The primary trial endpoint was improvement in depressive symptoms (BDI <11). Mild adverse events that did not require withdrawal from intervention were documented in six (20.0%) and three (10%) individuals of the intervention and control group, respectively. By comparing baseline vs. final measurements, the BDI score was significantly reduced in individuals in the intervention (28.8±3.7 to 9.2±7.5, p<0.01) and control (28.4±3.8 to 21.6±9.1, p<0.05) group. A total of 22 (73.2%) subjects in the intervention group and 10 (34.5%) in the control group reached a BDI <11, p=0.006. Our results show that, among patients with hypomagnesemia and vitamin D deficiency, combined oral supplementation with magnesium plus vitamin D is effective and safe in alleviating MMD related to long-COVID.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"49-57"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Road Map to the State of the Art of Magnesium Research - Highlights from the XVII International Magnesium Symposium, Grottaferrata 5-6 September 2024.","authors":"Federica I Wolf, Valentina Trapani, Jeanette A Maier","doi":"10.1684/mrh.2024.0531","DOIUrl":"https://doi.org/10.1684/mrh.2024.0531","url":null,"abstract":"","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 3","pages":"1-6"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018.","authors":"Ling Sun, Jingyuan Du","doi":"10.1684/mrh.2024.0528","DOIUrl":"https://doi.org/10.1684/mrh.2024.0528","url":null,"abstract":"<p><p>This study aimed to evaluate the relationship between magnesium (Mg) status, serum vitamin D (VD) concentration and mortality in congestive heart failure (CHF) patients. Data for this study were extracted from the National Health and Nutrition Examination Surveys 2007-2018. Magnesium depletion score (MDS) is a scoring system developed to predict the status of Mg deficiency that considers the pathophysiological factors influencing the reabsorption capability of the kidneys. The primary outcome was all-cause mortality of CHF patients and the secondary outcome was mortality due to cardiovascular disease (CVD). Weighted univariate and multivariate cox proportional hazards models were used to explore the association between Mg status, serum VD concentration and all-cause mortality or mortality due to CVD in CHF patients, using hazard ratios (HRs) and 95 % confidence intervals (CIs). Subgroup analyses based on age, physical activity (PA), course of CHF, race, and body mass index were further assessed with regards to the association analysis. In total, 1022 CHF patients were included, of whom 418 (40.90 %) died by 31st December 2019. After adjusting for all covariates, high MDS (>2 points) was related to a higher risk of all-cause mortality (HR = 1.72, 95 % CI: 1.30-2.29) and mortality due to CVD (HR = 1.71, 95 % CI: 1.29-2.25); a higher serum VD concentration was related to a lower risk of all-cause mortality (HR = 0.78, 95 %CI: 0.62-0.99) and mortality due to CVD (HR = 0.80, 95 % CI: 0.63-0.99). Compared to patients with high serum VD concentration and low MDS, patients with low serum VD concentration and high MDS had a high risk of all-cause mortality (HR = 2.44, 95 % CI: 1.54-3.85, p for trend = 0.043) and mortality due to CVD (HR = 2.41, 95 % CI: 1.32-4.40). Serum VD and Mg status may have a combined effect in improving the prognosis in CHF patients, thus an appropriate level of serum VD and Mg intake may be beneficial to maintain cardiovascular health, thereby improving outcome.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 2","pages":"61-75"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary magnesium deficiency and acute urinary retention.","authors":"Jose Ponce Díaz-Reixa, Paula Fernández Suárez, Fernando Toba Alonso, Paula Gómez Fernández, Ana Díaz Pedrouzo, Eduardo Martins Santos, Elisa Fernández Rodriguez, Lucia García Arco, Marcos Aller Rodríguez, Sara Martínez Breijo, Iria Rodríguez Valladares, Leticia Quintana Rio, Venancio Chantada Abal","doi":"10.1684/mrh.2024.0529","DOIUrl":"https://doi.org/10.1684/mrh.2024.0529","url":null,"abstract":"<p><p>This prospective case-control study explored the association between urinary magnesium levels and acute urinary retention (AUR) in individuals presenting to the emergency department. Forty-six participants, comprising 23 cases and 23 age- and sex-matched controls, underwent urine analysis for magnesium, calcium, and creatinine concentrations. The exclusion criteria mitigated potential confounding factors. AUR cases exhibited significantly lower magnesium (5.97 vs.3.87, p = 0.031), calcium (11.04 vs. 5.3, p = 0.022), and creatinine (149.9 vs. 66.0, p = 0.005) levels (mg/dL) compared to controls. After adjusting for creatinine levels, no intergroup differences were observed. An inverse linear correlation was noted between the International Prostate Symptom Score and magnesium level (R2 = 0.15, p = 0.009). A magnesium cut-off of 3.57 mg/dL demonstrated 82.6 % sensitivity, 56.5 % specificity, and an AUC of 0.70. Patients with magnesium levels below 3.57 mg/dL had an 80 % higher risk of AUR (OR: 1.80, 95 % CI: 1.08-3.01, p = 0.016). This study highlights urinary magnesium as a potential marker for risk of AUR, paving the way for larger prospective studies in this intriguing domain. Future interventions that manipulate magnesium levels may offer innovative avenues for managing lower urinary tract disorders.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 2","pages":"76-80"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of dietary magnesium intake on cognitive decline related to olfactory impairment in older adults: a cross-sectional study from the NHANES database.","authors":"Dong Wang, Jinxiong Yang, Bo Liu, Wenlong Luo","doi":"10.1684/mrh.2024.0530","DOIUrl":"https://doi.org/10.1684/mrh.2024.0530","url":null,"abstract":"<p><p>Olfactory impairment in the elderly has been shown to be associated with an increased risk of cognitive decline, and oxidative stress may be involved in this process. Dietary magnesium (Mg), as an antioxidant dietary nutrient, has been reported to be associated with cognitive decline. This study aimed to explore the effect of dietary Mg intake on cognitive decline related to olfactory impairment in older adults. Data were extracted from the National Health and Nutrition Examination Survey (NHANES) database 2013-2014. Information on dietary Mg intake was obtained from 24-hour interview. Assessment of cognitive decline included four evaluation dimensions: the Consortium to Establish a Registry for Alzheimer's Disease (including immediate and delayed), an animal fluency test, and a digit symbol substitution test. Weighted univariable and multivariable linear regression models were utilized to explore the effect of Mg on cognitive decline related to olfactory impairment, using β values and 95% confidence intervals (CIs). Subgroup analyses based on gender, history of diabetes, cardiovascular disease (CVD) and depression were further assessed. In total, 1,388 elderly people were included, of whom 319 (22.98%) had olfactory impairment. After adjusting for all covariates, there was an inverse relationship between high Mg intake and cognitive decline (β=-0.21, 95%CI: -0.37 to -0.04), and olfactory impairment was positively associated with cognitive decline (β=0.53, 95%CI: 0.28 to 0.77). Among the elderly with olfactory impairment, the odds of cognitive decline were reduced in the high Mg intake group (β=0.37, 95% CI: 0.04 to 0.71) compared to the low Mg intake group (β=0.67, 95%CI: 0.39 to 0.96), especially among the elderly who were female (β=0.53, 95% CI: 0.09 to 0.98), with diabetes (β=0.72, 95% CI: 0.46 to 0.99), and without CVD (β=0.33, 95% CI: 0.05 to 0.61) and depression (β=0.38, 95% CI: 0.06 to 0.70). Adequate dietary Mg intake may provide potential beneficial effects, improving cognitive function, among elderly patients with olfactory impairment, which should be confirmed by scale-large prospective studies.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"37 2","pages":"81-94"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}