氧化镁的抗菌作用，相关机制，以及在减少骨科植入物相关感染方面的应用前景。

IF 1.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Magnesium research Pub Date : 2025-06-26 DOI:10.1684/mrh.2025.0543

Yu Wang, Dongqin Xiao, Liqun Hu, Zhuohan Li, Zhong Li, Ke Duan, Kui He

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引用次数: 0

摘要

骨科植入物相关感染（IRIs）是严重的术后并发症，难以通过清创或抗生素治疗清除。氧化镁（MgO）有效抑制或杀死广泛的细菌，与安全问题的关联最小，并且不会产生诱导抗生素耐药性的风险。因此，人们积极研究MgO在环境、卫生以及IRIs管理等临床应用方面的应用。本文综述了MgO的抗菌特性、相关机制以及与骨科虹膜相关的最新研究。提出了存在的问题和进一步研究的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antibacterial effects of magnesium oxide, related mechanisms, and prospective applications for reducing orthopaedic implant-related infections.

Orthopaedic implant-related infections (IRIs) are severe postoperative complications that are difficult to clear by debridement or antibiotic treatments. Magnesium oxide (MgO) effectively inhibits or kills a broad spectrum of bacteria, is minimally associated with safety issues, and poses no risk of inducing antibiotic resistance. Therefore, MgO has been actively studied for environmental, hygienic, as well as clinical applications such as the management of IRIs. This narrative review discusses the antibacterial properties of MgO, related mechanisms, and recent studies related to orthopaedic IRIs. Existing problems and potential possibilities for further research are also suggested.

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来源期刊

Magnesium research 医学-内分泌学与代谢

CiteScore

3.50

自引率

9.40%

发文量

审稿时长

>12 weeks

期刊介绍： Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.