Magnesium research最新文献_第10页

Effect of magnesium on the osteogenesis of normal human osteoblasts. 镁对正常人成骨细胞成骨的影响。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-05-01 DOI: 10.1684/mrh.2017.0422

Wei-Chen Lu, Ekaterini Pringa, Laisheng Chou

{"title":"Effect of magnesium on the osteogenesis of normal human osteoblasts.","authors":"Wei-Chen Lu, Ekaterini Pringa, Laisheng Chou","doi":"10.1684/mrh.2017.0422","DOIUrl":"https://doi.org/10.1684/mrh.2017.0422","url":null,"abstract":"Biomaterials containing magnesium are used for implants and bone regeneration. However, mechanisms underlying the biologic effects of magnesium are still largely unknown and have not been examined on normal human osteoblasts. This study was designed to test the effect of supplemented Mg2+ concentrations between 0.5 mM and 16 mM on the osteogenic behaviors of normal human primary osteoblasts. Human primary osteoblasts were cultured in the groups with various concentrations of supplemented magnesium for various time intervals. Cell proliferation was measured using crystal violet staining. Degree of Alkaline Phosphatase (ALP) activity was measured by fluorometric assay. Expression of osteocalcin was measured by immunosorbent assay. Mineralization of cultures was determined by Alizarin Red S staining. Results showed that initial cell attachment efficiency was not affected by supplemented Mg2+ (P > 0.05). At 21 days, proliferation rates increased in groups containing 0.5 mM-4 mM supplemented Mg2+ and decreased in groups of supplemented 8 mM and 16 mM Mg2+. ALP activity and osteocalcin expression were upregulated in groups of supplemented Mg2+ between 0.5 mM-2.0 mM (P < 0.05), but downregulated in groups with supplemented Mg2+ concentrations of 4mM and above (P < 0.05). Cultures with 1 mM and 2 mM supplemented Mg2+ showed upregulated mineralization activity compared to the control (P < 0.05), but downregulated in groups with supplemented Mg2+ concentrations of 4 mM and above (P < 0.05). The present study based on an experimental design demonstrated the impact of 2 mM supplemented Mg2+ on induced-proliferation and differentiation of normal human osteoblasts.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 2","pages":"42-52"},"PeriodicalIF":3.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0422","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35376062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Effect of magnesium supplementation on muscular damage markers in basketball players during a full season. 补充镁对篮球运动员整个赛季肌肉损伤指标的影响。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-05-01 DOI: 10.1684/mrh.2017.0424

Alfredo Córdova Martínez, Diego Fernández-Lázaro, Juan Mielgo-Ayuso, Jesús Seco Calvo, Alberto Caballero García

{"title":"Effect of magnesium supplementation on muscular damage markers in basketball players during a full season.","authors":"Alfredo Córdova Martínez, Diego Fernández-Lázaro, Juan Mielgo-Ayuso, Jesús Seco Calvo, Alberto Caballero García","doi":"10.1684/mrh.2017.0424","DOIUrl":"https://doi.org/10.1684/mrh.2017.0424","url":null,"abstract":"Although it has been widely accepted that Mg has a positive effect on muscle function, studies on the efficacy of Mg supplementation in young athletes have generated contrasting results. The aim of this work was to examine the effect of Mg supplementation on muscular damage markers and the association between serum Mg levels with these muscular markers. Twelve elite male basketball players (PB) from a team of Spanish Professional Basketball League and a control group (CG) comprising twelve university students who practiced regularly recreational basketball and competed in minor university leagues participated in this study. The athletes were supplemented with 400 mg/day of Mg, in the form of Mg lactate. Blood samples were taken four times during the season, each separated by eight weeks: T1: October, T2: December, T3: March, and T4: April. Serum Mg concentrations showed a significant decrease in T3 (1.56 ± 0.03 mg/dL), with respect to T1 (1.69 ± 0.04 mg/dL) and T2 (1.69 ± 0.04 mg/L). At the end of the study, serum Mg concentration was significantly higher (T4: 1.79 ± 0.06 mg/dL) than at T3. Levels of muscle damage parameters remained the same during the entire season (P > 0.05), except for creatinine, which significantly decreased after T2, and then increased significantly in T3 and T4 compared to T2. In conclusion, these results suggest that the supplementation with Mg during the season of competition may prevent associated tissue damage.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 2","pages":"61-70"},"PeriodicalIF":3.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35277415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Oral magnesium supplementation reduces the incidence of gastrointestinal complications following cardiac surgery: a randomized clinical trial. 口服镁补充剂减少心脏手术后胃肠道并发症的发生率:一项随机临床试验。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-02-01 DOI: 10.1684/mrh.2017.0420

Seyed Tayeb Moradian, Mohammad Saeid Ghiasi, Alireza Mohamadpour, Yadollah Siavash

{"title":"Oral magnesium supplementation reduces the incidence of gastrointestinal complications following cardiac surgery: a randomized clinical trial.","authors":"Seyed Tayeb Moradian, Mohammad Saeid Ghiasi, Alireza Mohamadpour, Yadollah Siavash","doi":"10.1684/mrh.2017.0420","DOIUrl":"https://doi.org/10.1684/mrh.2017.0420","url":null,"abstract":"Gastrointestinal complications are common after coronary artery bypass graft surgery. These complications are ranged from nausea and vomiting to mesenteric ischemia and liver failure. It seems that nausea, vomiting, and constipation are related to magnesium deficiency. This study was designed to examine the effect of oral magnesium supplementation on the incidence of gastrointestinal complications in patients undergoing cardiac surgery. In a single blinded randomized clinical trial, 102 patients who were undergoing coronary artery bypass graft surgery were randomly allocated into two groups, 52 patients in the intervention and 50 patients in control group. Patients in the experimental group received 800 milligram magnesium oxide (2 tablets each of them containing 240 mg elemental magnesium) daily from the admission to discharge from hospital. The incidence of post-operative nausea and vomiting, constipation, and atrial fibrillation was compared between the groups. Our results showed that postoperative hypomagnesemia is present in 41.20 and 70.80 percent of the patients in the intervention and control group patients, respectively. The overall incidence of constipation was 62%. Patients who received magnesium supplementation experienced less atrial fibrillation, nausea, vomiting, and constipation. Our data showed that oral magnesium supplementation could reduce the postoperative complications. Despite the better status in the intervention group, the hypomagnesemia was present in many of intervention group patients. It seems that supplementation with higher doses is needed.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 1","pages":"28-34"},"PeriodicalIF":3.2,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34919801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Production and Precipitation Hardening of Mg-Ca-Zn-Co Alloy for Tissue Engineering. 组织工程用Mg-Ca-Zn-Co合金的制备及沉淀硬化。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-02-01 DOI: 10.1684/mrh.2017.0417

Ilven Mutlu

引用次数: 1

Magnesium in the gynecological practice: a literature review. 镁在妇科实践中的应用:文献综述。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-02-01 DOI: 10.1684/mrh.2017.0419

Fabio Parazzini, Mirella Di Martino, Paolo Pellegrino

引用次数: 24

Burning magnesium, a sparkle in acute inflammation: gleams from experimental models. 燃烧的镁，急性炎症中的闪光:实验模型中的闪光。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-02-01 DOI: 10.1684/mrh.2017.0418

Sara Castiglioni, Alessandra Cazzaniga, Laura Locatelli, Jeanette Am Maier

引用次数: 15

Coordination between antioxidant defences might be partially modulated by magnesium status. 抗氧化防御之间的协调可能部分由镁状态调节。

IF 3.2 4区医学

Magnesium research Pub Date : 2016-12-01 DOI: 10.1684/mrh.2016.0414

C. Monteiro, C. Matias, M. Bicho, H. Santa-Clara, M. J. Laires

{"title":"Coordination between antioxidant defences might be partially modulated by magnesium status.","authors":"C. Monteiro, C. Matias, M. Bicho, H. Santa-Clara, M. J. Laires","doi":"10.1684/mrh.2016.0414","DOIUrl":"https://doi.org/10.1684/mrh.2016.0414","url":null,"abstract":"The aim of this study was to compare the redox balance in competitive adult swimmers against recreational practitioners, controlling for Mg intake. Fifteen, competitive swimmers and 16 recreational practitioners, all male and aged 18-25years, were recruited into the study. Oxidative and muscle damage markers, and antioxidant enzymes and non-enzymatic antioxidants were evaluated by photometry (except for thiobarbituric reactive substances (TBARS), which was assessed by fluorimetry). Controlling for the level of exercise, inverse correlations were observed for uric acid and glutathione reductase (GR) or susceptibility of red blood cells to peroxidation (RBCPx); plasma adrenaline oxidase activity (AdOx) and carotenoids; TBARS and GR or Vit E; and direct correlations were observed between AdOx and creatine kinase (CK) or TBARS; CK and superoxide dismutase activity; GR and RBCPx. Controlling for Mg intake in addition to exercise level revealed new inverse correlations: between carotenoids and TBARS or lactate, and new direct correlations between lactate and AdOx or TBARS; cortisol and AdOx, CK, lactate dehydrogenase, or methemoglobin reductase. The associations between uric acid and RBCPx; AdOx and CK or TBARS; and GR and RBCPx lost their significance. All others remained significant. These outcomes suggest that the coordination between antioxidant defences may be partially modulated by Mg, which may be the result of its ability to stabilize cell membranes and oxidation targets, such as adrenaline.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"29 4 1","pages":"161-168"},"PeriodicalIF":3.2,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2016.0414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67569394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Magnesium-based interventions for normal kidney function and chronic kidney disease. 镁对正常肾功能和慢性肾病的干预作用。

IF 3.2 4区医学

Magnesium research Pub Date : 2016-12-01 DOI: 10.1684/mrh.2016.0412

Z. Massy, I. Nistor, M. Apetrii, V. Brandenburg, J. Bover, P. Evenepoel, D. Goldsmith, S. Mazzaferro, P. Ureña-Torres, M. Vervloet, M. Cozzolino, A. Covic, On Behalf Of Ckd-Mbd Working Group Of Era-Edta

{"title":"Magnesium-based interventions for normal kidney function and chronic kidney disease.","authors":"Z. Massy, I. Nistor, M. Apetrii, V. Brandenburg, J. Bover, P. Evenepoel, D. Goldsmith, S. Mazzaferro, P. Ureña-Torres, M. Vervloet, M. Cozzolino, A. Covic, On Behalf Of Ckd-Mbd Working Group Of Era-Edta","doi":"10.1684/mrh.2016.0412","DOIUrl":"https://doi.org/10.1684/mrh.2016.0412","url":null,"abstract":"Magnesium (Mg) is one of the most important cations in the body, playing an essential role in biological systems as co-factor for more than 300 essential enzymatic reactions. In the general population, low levels of Mg are associated with a high risk of cardio-vascular disease (CVD). Despite the accumulating literature data, the effect of Mg administration on mortality in chronic kidney disease (CKD) patients has never been investigated as a primary end-point. We conducted a systematic search of studies assessing the benefits and harms of Mg in CKD (stages 1 to 5 and 5D), and considered all randomized controlled trials (RCTs) and quasi-RCTs evaluating Mg-based interventions in CKD. As a phosphate binder, Mg salts offer a plausible opportunity for doubly favorable effects via reduction of intestinal phosphate absorption and addition of potentially beneficial effects via increasing circulating Mg levels. Mg supplementation might have a favorable effect on vascular calcification, although evidence for this is very slight. Although longitudinal data describe an association between low serum Mg levels and increased total and cardiovascular mortality, in patients with CKD, the existing RCTs reporting the effect of Mg supplementation on mortality failed to demonstrate any favorable effect. As with many other variables that influence hard end-points in nephrology, the role of Mg in CKD patients needs to be investigated in more depth. Additional research that is well-designed and directly targeting the role of Mg is needed as a consequence of limited existing evidence.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"29 4 1","pages":"126-140"},"PeriodicalIF":3.2,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2016.0412","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67569755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Magnesium in metabolic syndrome: a review based on randomized, double-blind clinical trials. 镁在代谢综合征中的作用:基于随机双盲临床试验的综述。

IF 3.2 4区医学

Magnesium research Pub Date : 2016-12-01 DOI: 10.1684/mrh.2016.0404

F. Guerrero‐Romero, Francia O Jaquez-Chairez, M. Rodríguez-Moran

{"title":"Magnesium in metabolic syndrome: a review based on randomized, double-blind clinical trials.","authors":"F. Guerrero‐Romero, Francia O Jaquez-Chairez, M. Rodríguez-Moran","doi":"10.1684/mrh.2016.0404","DOIUrl":"https://doi.org/10.1684/mrh.2016.0404","url":null,"abstract":"A growing body of evidence shows the effect of magnesium on serum glucose, HDL-cholesterol, and triglycerides levels, as well as on blood pressure, which strongly suggests that magnesium might play an important role in metabolic syndrome (MetS), a cluster of risk factors for cardiovascular disease and type 2 diabetes. We performed a systematic review of clinical evidence derived from randomized, double-blind, controlled clinical trials, regarding the efficacy of magnesium supplementation on the components of MetS. Using the electronic databases of Medline, Embase, and the Cochrane Controlled Trials Register up to May 2016, we looked for randomized controlled trials focused on the effects of oral magnesium supplementation on insulin sensitivity, glucose, triglyceride and HDL-cholesterol levels, as well as its effects on high blood pressure, irrespective of the magnesium salt used, and with a duration of at least four weeks. Crossover studies, irrespective of blinding criteria, were not included. Results of this review show that magnesium supplementation in individuals with hypomagnesemia can be effective in the treatment of MetS.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"29 4 1","pages":"146-153"},"PeriodicalIF":3.2,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2016.0404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67569727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Magnesium in the CNS: recent advances and developments. 镁在中枢神经系统:最近的进展和发展。

IF 3.2 4区医学

Magnesium research Pub Date : 2016-09-01 DOI: 10.1684/MRH.2016.0408

R. Vink

{"title":"Magnesium in the CNS: recent advances and developments.","authors":"R. Vink","doi":"10.1684/MRH.2016.0408","DOIUrl":"https://doi.org/10.1684/MRH.2016.0408","url":null,"abstract":"A potential neuroprotective role for magnesium in neurological disease has been appreciated for almost three decades, yet translation to the clinical arena has proven elusive. Accumulating experimental evidence continues to suggest that magnesium plays a critical role in a number of neurological conditions including headache, stress, alcohol/drug intoxication, acute brain injury, seizures, Parkinson's disease and Alzheimer's disease. Simple administration of a magnesium salt in these conditions has not always been therapeutically successful, with a number of studies showing poor penetration of serum magnesium across the blood brain barrier. Several studies have since demonstrated that using a carrier such as polyethylene glycol can address this, simultaneously reducing the dose of magnesium required to achieve the desired central effects while at the same time attenuating deleterious peripheral effects. Alternatively, administering a more permeable magnesium salt, such as magnesium threonate, is seen as the preferred option in more chronic neurological conditions, with positive results having been achieved in experimental models of Alzheimer's disease. Irrespective of the approach, improved central penetration of a magnesium compound that avoids peripheral side effects of high magnesium dosages is clearly a desirable outcome, and should now be investigated in animal models that accurately mimic the complex human condition.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"29 3 1","pages":"95-101"},"PeriodicalIF":3.2,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67569506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30