Magnesium research最新文献_第10页

Correlations between feeding type and blood ionized magnesium levels in Japanese preterm infants. 日本早产儿喂养方式与血离子镁水平的相关性

IF 3.2 4区医学

Magnesium research Pub Date : 2018-11-01 DOI: 10.1684/mrh.2019.0444

Akiko Watanabe, Hiromichi Shoji, Atsuko Awaji, Naho Ikeda, Natsuki Ohkawa, Hiroki Suganuma, Masato Kantake, Toshiaki Shimizu

{"title":"Correlations between feeding type and blood ionized magnesium levels in Japanese preterm infants.","authors":"Akiko Watanabe, Hiromichi Shoji, Atsuko Awaji, Naho Ikeda, Natsuki Ohkawa, Hiroki Suganuma, Masato Kantake, Toshiaki Shimizu","doi":"10.1684/mrh.2019.0444","DOIUrl":"https://doi.org/10.1684/mrh.2019.0444","url":null,"abstract":"Although magnesium (Mg) contents are different between breast milk and formula, few studies have investigated the blood Mg level in breast fed or formula fed preterm infants. We examined the influence of feeding type on serum Mg and whole blood ionized Mg (iMg) levels in preterm infants soon after birth. We included 115 preterm infants born between gestational weeks 32 and 35. Infants were separated into two groups: breast milk (BM) dominant group (n = 30) receiving ≥70% of Mg intake from BM and mixed-fed (MF) group (n = 85) receiving ≥30% of Mg intake from formula. Blood levels of Mg, iMg, Ca, and iCa at day 1 of age and at discharge from the hospital were compared between the groups. No differences in the Mg and iMg levels at day 1 of age were observed between the two groups. The Mg and iMg levels at discharge were significantly lower (P < 0.05) in the BM group than in the MF group; 0.86 (interquartile range 0.81-0.91) versus 0.91 (0.86-0.99) mmol/L and 0.46 (0.41-0.51) versus 0.52 (0.47-0.57) mmol/L, respectively. There were no differences in the Ca and iCa levels between the two groups. By stepwise multiple regression analysis, the percentage of BM intake was a significant independent predictor of the Mg and iMg levels. The feeding type influenced serum Mg and blood iMg levels in preterm infants soon after birth. Further studies are needed to investigate the influence of Mg on growth and the optimal range of blood Mg levels.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 4","pages":"110-116"},"PeriodicalIF":3.2,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37238229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of magnesium gluconate administration on lipid metabolism, antioxidative status, and related gene expression in rats fed a high-fat diet. 葡萄糖酸镁对高脂饮食大鼠脂质代谢、抗氧化状态及相关基因表达的影响

IF 3.2 4区医学

Magnesium research Pub Date : 2018-11-01 DOI: 10.1684/mrh.2019.0445

Qian Zhang, Peng-Hui Zhou, Xiao-Li Zhou, Da-Long Zhang, Qing Gu, Shu-Jing Zhang, Jing Zhang, Jing-Shu Zhang, Zhi-Yong Qian

{"title":"Effect of magnesium gluconate administration on lipid metabolism, antioxidative status, and related gene expression in rats fed a high-fat diet.","authors":"Qian Zhang, Peng-Hui Zhou, Xiao-Li Zhou, Da-Long Zhang, Qing Gu, Shu-Jing Zhang, Jing Zhang, Jing-Shu Zhang, Zhi-Yong Qian","doi":"10.1684/mrh.2019.0445","DOIUrl":"https://doi.org/10.1684/mrh.2019.0445","url":null,"abstract":"To explore the effect of magnesium gluconate (MgG) on lipid metabolism and its regulation mechanism through animal experiments, and to provide basis for MgG dietary intervention in hyperlipidemia. The first four weeks was hyperlipidemia-inducing period through high-fat diet and the following eight weeks was the MgG supplementation. At the end of the experiment, blood and liver samples were collected for the measurements of lipid profile, antioxidative indexes, pathological examination, and cholesterol metabolism-related gene expression. Oral administration of MgG notably decreased the blood levels of TC, TG, LDL-C and liver function index ALT and AST of hyperlipidemic rats. The rats supplemented with magnesium showed a huge increase in the GSH-Px and SOD activities, and reduced the heart weight and liver lipid accumulation of high-fat diet fed rats. MgG remarkably up-regulated the mRNA expression levels of LDLR and CYP7A1 of liver enzymes related to cholesterol metabolism. Oral magnesium supplementation inhibited an increase in lipid profile and liver function index by a high-fat diet, and enhanced the activity of the antioxidant enzymes. Magnesium has lipid-lowering and antioxidative effects that protect the liver against hyperlipidemia.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 4","pages":"117-130"},"PeriodicalIF":3.2,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37252863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Magnesium in addiction - a general view. 镁在成瘾中的作用——一般观点。

IF 3.2 4区医学

Magnesium research Pub Date : 2018-08-01 DOI: 10.1684/mrh.2018.0443

Mihai Nechifor

{"title":"Magnesium in addiction - a general view.","authors":"Mihai Nechifor","doi":"10.1684/mrh.2018.0443","DOIUrl":"https://doi.org/10.1684/mrh.2018.0443","url":null,"abstract":"Addiction is a dysregulation of brain reward systems that progressively increases, resulting in compulsive drug use and loss of control over drug-taking. Addiction is a brain disease. There is evidence that magnesium deficit is involved in addiction to various addictive substances (heroin, morphine, cocaine, nicotine, alcohol, caffeine, and others). Magnesium is involved in all the stages of addiction. Magnesium deficit enhances the vulnerability to psychoactive substance addiction. Stress and trauma reduce the brain magnesium level and at the same time favor addiction development. In experimental studies, administration of magnesium while inducing morphine dependence in rats reduced the dependence intensity. Magnesium reduces the NMDA receptor activity and the glutamatergic activity. Because stress and trauma induce hypomagnesemia with increased vulnerability to addiction, magnesium intake by people who are under prolonged stress could be a way to reduce this vulnerability and the development of addiction to different psychoactive substances. Anxiety and depression appear to be associated with increases in drug-related harm and addictive substance use. Magnesium anxiolytic effect could be important for the antiaddictive action. Addiction is characterized by relapses. Magnesium deficiency may be a contributing factor to these relapses.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 3","pages":"90-98"},"PeriodicalIF":3.2,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36915249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The role of magnesium and zinc in depression: similarities and differences. 镁和锌在抑郁症中的作用:异同。

IF 3.2 4区医学

Magnesium research Pub Date : 2018-08-01 DOI: 10.1684/mrh.2018.0442

Bernadeta Szewczyk, Aleksandra Szopa, Anna Serefko, Ewa Poleszak, Gabriel Nowak

{"title":"The role of magnesium and zinc in depression: similarities and differences.","authors":"Bernadeta Szewczyk, Aleksandra Szopa, Anna Serefko, Ewa Poleszak, Gabriel Nowak","doi":"10.1684/mrh.2018.0442","DOIUrl":"https://doi.org/10.1684/mrh.2018.0442","url":null,"abstract":"Antidepressant therapy exhibits low clinical efficacy and produces a variety of unwanted side effects. Therefore, the search for more effective antidepressants is still in progress. Antidepressant properties of magnesium and zinc have been demonstrated in animal screen tests/models and clinical studies. Moreover, these bio-elements enhance antidepressant activity of conventional antidepressants in these behavioral paradigms. As for magnesium, clinical studies demonstrated equivocal results concerning its supplementary effectiveness in the treatment of depression. Generally, some depressed patients with hypomagnesemia responded very well to such supplementation, whereas response of other patients was weaker. Clinical data on the effectiveness of zinc supplementation in the therapy of depression are much more robust. A number of studies demonstrated enhancement of the efficacy of pharmacotherapy by zinc supplementation in major depression. What is important, recent studies demonstrate that zinc supplementation augments efficacy of antidepressants also in treatment-resistant patients. All the available data indicate the importance of magnesium and zinc in the therapy of depression.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 3","pages":"78-89"},"PeriodicalIF":3.2,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36915248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs). 不同镁浓度引起人脐静脉内皮细胞(HUVECs)炎症反应的变化。

IF 3.2 4区医学

Magnesium research Pub Date : 2018-08-01 DOI: 10.1684/mrh.2018.0439

Lujain A Almousa, Andrew M Salter, Simon C Langley-Evans

{"title":"Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs).","authors":"Lujain A Almousa, Andrew M Salter, Simon C Langley-Evans","doi":"10.1684/mrh.2018.0439","DOIUrl":"https://doi.org/10.1684/mrh.2018.0439","url":null,"abstract":"The aims of this study were to determine whether low concentrations of magnesium in vitro exacerbated the human umbilical vein endothelial cell (HUVEC) response to inflammatory challenge, and whether expression of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) through the toll-like receptor 4 (TLR4) played a role in this process. HUVECs were incubated with different concentrations of Mg (low- 0.1mM, control- 1mM, high- 5mM) for 72 h before being stimulated with bacterial lipopolysaccharide (LPS) for 4 h. The response of cells to LPS was greater in cells cultured in low Mg, relative to control cells and suppressed in high Mg. Expression of NF-κB was increased in low-Mg and decreased with high Mg. Low Mg increased the expression of TLR4 mRNA, but only in the presence of LPS. Antibody blockade of TLR4 but not TLR2 blunted the response of cells to LPS in low Mg, such that they were similar to unblocked 1mM Mg cells. Associations of Mg with cardiovascular disease may therefore relate to inflammatory responses mediated through the TLR4/NF-κB pathway.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 3","pages":"99-109"},"PeriodicalIF":3.2,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0439","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36763508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Differential effect of nanoparticle and standard forms of ZnO on serum zinc and magnesium levels in rats. 纳米颗粒和标准形式氧化锌对大鼠血清锌和镁水平的差异影响。

IF 3.2 4区医学

Magnesium research Pub Date : 2018-05-01 DOI: 10.1684/mrh.2018.0438

Magdalena Olbert, Mirosław Krośniak, Joanna Gdula-Argasińska, Gabriel Nowak, Tadeusz Librowski

{"title":"Differential effect of nanoparticle and standard forms of ZnO on serum zinc and magnesium levels in rats.","authors":"Magdalena Olbert, Mirosław Krośniak, Joanna Gdula-Argasińska, Gabriel Nowak, Tadeusz Librowski","doi":"10.1684/mrh.2018.0438","DOIUrl":"https://doi.org/10.1684/mrh.2018.0438","url":null,"abstract":"This study examined the effect of chronic (2 weeks) administration of zinc oxide nanoparticles (NPs-ZnO) and standard zinc oxide (S-ZnO) on the levels of zinc (Zn), magnesium (Mg) and calcium (Ca) in rat serum. S-ZnO and NPs-ZnO were administered either per os (p.o.) or intraperitoneally (i.p.) at doses of 7 mg/kg or 14 mg/kg. Neither form of ZnO administered p.o. altered serum zinc concentration. However, different effects dependent upon either S-ZnO or NPs-ZnO forms were noticed after i.p. administration. Namely, while S-ZnO increased serum zinc concentration (by 136%) only at the higher dose (14 mg/kg), both doses of NPs-ZnO increased zinc concentration (by 97% at 7 mg/kg and by 564% at 14 mg/kg). The form-dependence of the ZnO effect was also demonstrated in the effect on the serum magnesium level. Only the S-ZnO form (at the dose of 14 mg/kg) reduced serum magnesium concentration (by 14% p.o., 6% i.p.). No influence of NPs-ZnO on the serum calcium level was observed. The present study demonstrated effects on the serum Zn and Mg levels, which differed between the standard and nanoparticle forms of ZnO. This may contribute to the different functional effects of these ZnO forms shown previously.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 2","pages":"58-64"},"PeriodicalIF":3.2,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0438","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36650911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ketamine and magnesium common pathway of antidepressant action. 氯胺酮和镁是抗抑郁作用的共同途径。

IF 3.2 4区医学

Magnesium research Pub Date : 2018-05-01 DOI: 10.1684/mrh.2018.0440

Natalia Górska, Wiesław Jerzy Cubała, Jakub Słupski, Maria Gałuszko-Węgielnik

引用次数: 4

Fractional excretion of magnesium and kidney function parameters in nondiabetic chronic kidney disease. 非糖尿病性慢性肾病患者镁的部分排泄与肾功能参数的关系

IF 3.2 4区医学

Magnesium research Pub Date : 2018-05-01 DOI: 10.1684/mrh.2018.0437

Radmila Žeravica, Branislava Ilinčić, Velibor Čabarkapa, Isidora Radosavkić, Jelena Samac, Katarina Nikoletić, Zoran Stošić

{"title":"Fractional excretion of magnesium and kidney function parameters in nondiabetic chronic kidney disease.","authors":"Radmila Žeravica, Branislava Ilinčić, Velibor Čabarkapa, Isidora Radosavkić, Jelena Samac, Katarina Nikoletić, Zoran Stošić","doi":"10.1684/mrh.2018.0437","DOIUrl":"https://doi.org/10.1684/mrh.2018.0437","url":null,"abstract":"Aim: Elevated fractional excretion of magnesium (FEMg) is a noninvasive biomarker of kidney damage, but its association with kidney functional parameters in nondiabetic chronic kidney disease (CKD) patients has not been sufficiently explored thus far.Methods: We enrolled 111 adult patients with nondiabetic CKD and 30 controls. To precisely investigate kidney function, the following parameters were assessed measured glomerular filtration rate (mGFR), effective renal plasma flow (ERPF), Cystatin C, albuminuria, and fractional excretion of magnesium (FEMg). All the CKD patients were divided into two groups according to the values of mGFR (mL/min/1.73m2): the first group consisted of those with GFR≥ 60 mL/min/1.73m2, whereas the second group included those with GFR< 60 mL/min/1.73m2.Results: FEMg (%) was significantly higher in the group of nondiabetic patients with CKD compared to the healthy subjects [6.3 vs. 5.3 %, P=0.013]. There was also significant difference in the value of FEMg between the first and second groups of CKD patients. Increased FEMg was significantly correlated with all the investigated kidney function parameters, mGFR, ERPF, Cystatin C and albuminuria (r=-0.62; r=-0.60; r=0.77; r=0.39; p<0.01 for all). In multiple regression analyses based on observed parameters of kidney function, only cystatin C was independently and significantly associated with FEMg (multiple correlation coefficients: 0.738, p < 0.001)). Nondiabetic CKD patients with GFR< 60 mL/min/1.73m2 have increased FEMg above 6.1% with 78.7 % specificity and 83.7% sensitivity.Conclusion: Highly significant association between kidney functional parameters and FEMg may indicate significance of this parameter in clinical practice.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 2","pages":"49-57"},"PeriodicalIF":3.2,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36650910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Magnesium deficiency heightens lipopolysaccharide-induced inflammation and enhances monocyte adhesion in human umbilical vein endothelial cells. 缺镁可增加脂多糖诱导的炎症，增强人脐静脉内皮细胞单核细胞粘附。

IF 3.2 4区医学

Magnesium research Pub Date : 2018-05-01 DOI: 10.1684/mrh.2018.0436

Lujain A Almousa, Andrew M Salter, Simon C Langley-Evans

{"title":"Magnesium deficiency heightens lipopolysaccharide-induced inflammation and enhances monocyte adhesion in human umbilical vein endothelial cells.","authors":"Lujain A Almousa, Andrew M Salter, Simon C Langley-Evans","doi":"10.1684/mrh.2018.0436","DOIUrl":"https://doi.org/10.1684/mrh.2018.0436","url":null,"abstract":"Given a possible anti-inflammatory role of magnesium in endothelial cells, the aim of this study was to investigate the effects of magnesium on human umbilical vein endothelial cell (HUVEC) viability, gene expression, and the pro-inflammatory response caused by a bacterial endotoxin (LPS). HUVECs were cultured at three different concentrations of magnesium sulphate (0.1 mM; control-1 mM; 5 mM) for 72 hours. Exposing the cells to LPS reduced cell viability in culture with low magnesium, but high magnesium protected the HUVECs from LPS-induced cell death. LPS-treated HUVECs cultured in low magnesium showed up-regulation of mRNA expression for pro-inflammatory factors and the expression of cytokine proteins, including IL-2, IL-3, IL-8, IL-15 and MCP-1. This was associated with greater adhesion of monocytes to the cells. In contrast, high magnesium decreased the expression of inflammatory factors and cytokines. The study found that LPS activation of the expression of many pro-inflammatory factors is exacerbated in the presence of low magnesium concentration whilst a high magnesium concentration partly inhibited the inflammatory response to LPS.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 2","pages":"39-48"},"PeriodicalIF":3.2,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36650909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Fecal pancreatic elastase-1 and erythrocyte magnesium levels in diabetes type 1 and type 2. 1型和2型糖尿病患者粪便胰腺弹性酶-1和红细胞镁水平。

IF 3.2 4区医学

Magnesium research Pub Date : 2018-02-01 DOI: 10.1684/mrh.2018.0433

Velibor Čabarkapa, Mirjana Djerić, Milena Mitrović, Sunčica Kojić-Damjanov, Ivana Isakov, Bojan Vuković, Djordje Popović

{"title":"Fecal pancreatic elastase-1 and erythrocyte magnesium levels in diabetes type 1 and type 2.","authors":"Velibor Čabarkapa, Mirjana Djerić, Milena Mitrović, Sunčica Kojić-Damjanov, Ivana Isakov, Bojan Vuković, Djordje Popović","doi":"10.1684/mrh.2018.0433","DOIUrl":"https://doi.org/10.1684/mrh.2018.0433","url":null,"abstract":"In both types of diabetes mellitus (DM), type 1 and type 2 (T1DM and T2DM), there are both endocrine and exocrine dysfunctions of the pancreas (PED), as well as disturbances in serum magnesium levels. The aim of this study was to examine the frequency of PED according to the level of fecal elastase-1 (FE-1) in patients with T1DM and T2DM, determining the correlation of the level of FE-1 with certain anthropometric parameters, certain indicators of metabolic regulation of diabetes, and certain nutritive markers of PED.Materials and methods: In the examinees, (56 with T1DM (F = 35 and M = 21), 62 with T2DM (F = 30 and M = 32), and 40 in the control group (F = 19 and M = 21)), we examined anthropometric parameters, and using standard biochemical methods, we measured the level of FE-1, magnesium concentration in blood and erythrocytes, and selected blood parameters.Results: FE-1 concentration < 200 μg/g was present in 14.2% of the examinees with T1DM, 20.9% with T2DM, and 2.5% in the control group. In all examinees with DM, there was a statistically significant correlation (P < 0.05) between the level of FE-1 and Mg concentration in the erythrocytes (R = 0.40).Conclusions: Prevalence of pancreatic exocrine insufficiency (PEI), according to the level of FE-1, is significantly higher in patients with DM than in the control group, while it is a bit higher in patients with T2DM than the ones with T1DM. In both types of DM, Mg concentration in erythrocytes is in a significant correlation with the level of FE-1.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 1","pages":"1-10"},"PeriodicalIF":3.2,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36394581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3