Magnesium research最新文献_第10页

Jean Durlach (1925-2017). 让·杜拉赫（1925-2017）。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-11-01 DOI: 10.1684/mrh.2018.0432

Yves Rayssiguier

引用次数: 0

Magnesium enhances the beneficial effects of NK1 antagonist administration on blood-brain barrier permeability and motor outcome after traumatic brain injury. 镁增强了NK1拮抗剂对创伤性脑损伤后血脑屏障通透性和运动预后的有益作用。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-08-01 DOI: 10.1684/mrh.2017.0427

Joshua L Ameliorate, Mounir N Ghabriel, Robert Vink

{"title":"Magnesium enhances the beneficial effects of NK1 antagonist administration on blood-brain barrier permeability and motor outcome after traumatic brain injury.","authors":"Joshua L Ameliorate, Mounir N Ghabriel, Robert Vink","doi":"10.1684/mrh.2017.0427","DOIUrl":"https://doi.org/10.1684/mrh.2017.0427","url":null,"abstract":"The current study investigated whether adding magnesium to an NK1 tachykinin receptor antagonist after traumatic brain injury would enhance efficacy to further reduce blood-brain barrier permeability and improve functional recovery compared to either treatment alone. Sprague-Dawley rats were injured using the impact acceleration model of diffuse brain injury, and received either no treatment, MgSO4 (30 mg/kg IV), the NK1 antagonist n-acetyl L tryptophan (2.5 mg/kg IP), or both agents combined. Animals were then killed at either 1, 5, or 24 h postinjury for determination of blood-brain barrier permeability using previously administered Evans blue dye or assessed for functional outcome over a 1-week period using the rotarod motor test. As expected, both MgSO4 and n-acetyl L tryptophan significantly reduced blood-brain barrier permeability and improved functional outcome. However, combined n-acetyl L tryptophan and MgSO4 was more effective at reducing blood-brain barrier permeability (P < 0.05) and improving functional outcome (P < 0.001) compared to the individual compounds. Our results demonstrate that combination therapy with magnesium and an NK1 antagonist may be a more effective therapy for TBI than either compound administered alone.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 3","pages":"88-97"},"PeriodicalIF":3.2,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35670187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1 in individuals newly diagnosed of pre-hypertension. A randomized, double-blind, placebo-controlled trial. 口服镁补充剂对新诊断的高血压前期个体TRPM6、TRPM7和SLC41A1转录的影响一项随机、双盲、安慰剂对照试验。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-08-01 DOI: 10.1684/mrh.2017.0426

Mariana Rodríguez-Ramírez, Martha Rodríguez-Morán, Miguel A Reyes-Romero, Fernando Guerrero-Romero

{"title":"Effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1 in individuals newly diagnosed of pre-hypertension. A randomized, double-blind, placebo-controlled trial.","authors":"Mariana Rodríguez-Ramírez, Martha Rodríguez-Morán, Miguel A Reyes-Romero, Fernando Guerrero-Romero","doi":"10.1684/mrh.2017.0426","DOIUrl":"https://doi.org/10.1684/mrh.2017.0426","url":null,"abstract":"A stringent regulation of influx and efflux of magnesium by cation transporters seems to play an important role in the regulation of blood pressure (BP). With this regard, we evaluate the effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1, in individuals with incident pre-hypertension (preHTN). For such purpose, we conducted a randomized, double-blind, placebo-controlled trial that compared 18 individuals who received oral magnesium lactate (360 mg elemental magnesium) versus 18 individuals who received placebo, during 4 months. Diagnosis of hypertension or normal BP, diabetes, alcohol intake, chronic diarrhea, use of diuretics, intake of magnesium supplementation, and reduced renal function were exclusion criteria. Regarding the transcription analysis of TRPM6, TRPM7, and SLC41A1 using RT-qPCR, leukocyte-rich plasma was obtained and total RNA was isolated with the kit Direct-zol™ RNA MiniPrep (Zymo). The leukocyte TRPM6 mRNA relative expression showed a significant increase (2.1 ± 1.37 and 0.8 ± 0.4, P<0.05), whereas the mRNA relative expression of both leukocyte TRPM7 (0.8 ± 1.1 and 0.9 ± 0.6, pNS) and SLC41A1 (0.9 ± 1.0 and 0.7 ± 0.6, pNS) showed no significant differences, between the magnesium and placebo groups, respectively. Oral magnesium supplementation increases the leukocyte TRPM6 mRNA relative expression, in subjects with new diagnosis of preHTN.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 3","pages":"80-87"},"PeriodicalIF":3.2,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35670186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Magnesium deficiency affects HNF1β expression in rat liver in vivo and in vitro. 缺镁对体内外大鼠肝脏HNF1β表达的影响。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-08-01 DOI: 10.1684/mrh.2017.0428

Hélène Martin, Delphine Antoine, Lise Coste-Sarguet, Fatimata Seydou Sarr, Lysiane Richert, Alain Berthelot

{"title":"Magnesium deficiency affects HNF1β expression in rat liver in vivo and in vitro.","authors":"Hélène Martin, Delphine Antoine, Lise Coste-Sarguet, Fatimata Seydou Sarr, Lysiane Richert, Alain Berthelot","doi":"10.1684/mrh.2017.0428","DOIUrl":"https://doi.org/10.1684/mrh.2017.0428","url":null,"abstract":"Hepatocyte nuclear factor 1β (HNF1β) is a transcription factor that is involved in embryonic development and tissue-specific gene expression in several organs, including the kidney and the liver. HNF1β mutations are associated with hypomagnesemia and renal magnesium wasting; however, to date, the exact molecular mechanism involved in this regulation is unclear. Furthermore, it is not known whether the Mg concentration could per se participate to this regulation by modifying HNF1β expression. We have studied in rats the effects of a 6-week diet with deficient or supplemented Mg concentrations compared to a diet with a standard Mg concentration on HNF1β protein expression. HNF1β expression was increased in the Mg-deficient group as compared to the other groups in the liver but not in the kidney. No changes in tissue Mg level were obtained in both organs. By contrast, a significant correlation between plasma Mg concentration and HNF1β level in the rat liver was evidenced. In rat hepatocyte cultures exposed for 72h to various extracellular Mg concentrations, HNF1β expression was modified after 72h of treatment of the hepatocytes with the lowest Mg concentrations as compared to the other Mg conditions. Moreover, these changes were correlated with extracellular but not intracellular Mg concentrations. In conclusion, HNF1β expression is modified by the extracellular Mg concentration in the liver, both in vivo and in vitro, suggesting regulations with membrane events in hepatocytes.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 3","pages":"98-105"},"PeriodicalIF":3.2,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35670188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnesium supplementation affects gene expression related to insulin and lipid in patients with gestational diabetes. 补充镁对妊娠糖尿病患者胰岛素和脂质相关基因表达的影响。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-08-01 DOI: 10.1684/mrh.2017.0425

Mehri Jamilian, Mansooreh Samimi, Afshar Ebrahimi Faraneh, Esmat Aghadavod, Hashemi Dizaji Shahrzad, Maryam Chamani, Alireza Mafi, Zatollah Asemi

{"title":"Magnesium supplementation affects gene expression related to insulin and lipid in patients with gestational diabetes.","authors":"Mehri Jamilian, Mansooreh Samimi, Afshar Ebrahimi Faraneh, Esmat Aghadavod, Hashemi Dizaji Shahrzad, Maryam Chamani, Alireza Mafi, Zatollah Asemi","doi":"10.1684/mrh.2017.0425","DOIUrl":"https://doi.org/10.1684/mrh.2017.0425","url":null,"abstract":"Magnesium is known to exert several beneficial effects, including antiglycemic and antilipidemic properties. The aim of this study was to evaluate the effects of magnesium supplementation on gene expression related to insulin and lipid metabolism in women with gestational diabetes (GDM) who were not on oral hypoglycemic agents. This randomized double-blind, placebo-controlled trial was conducted among 40 patients diagnosed with GDM, aged 18-40 years. Participants were randomly allocated into two groups to take either 250 mg/day of magnesium supplements in the form of magnesium oxide (n = 20) or placebo (n = 20) for 6 weeks. Gene expression related to insulin and lipid metabolism was assessed in peripheral blood mononuclear cells (PBMCs) of women with GDM using RT-PCR method. Compared with the placebo, magnesium supplementation to women with GDM resulted in a significant decrease in levels of fasting plasma glucose (FPG) (-9.7 ± 5.6 vs. -0.1 ± 8.5 mg/dL, P<0.001). Quantitative results of RT-PCR demonstrated that compared with the placebo, magnesium supplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) (P = 0.003) and glucose transporter 1 (GLUT-1) (P = 0.004) and downregulated gene expression of oxidized low-density lipoprotein receptor (LDLR) (P = 0.001) in PBMCs of women with GDM. In addition, a trend toward a greater decrease in gene expression of lipoprotein (a) [LP(a)] was observed in the patients belonging to magnesium group compared to placebo group (P = 0.08). Overall, magnesium supplementation for 6 weeks in women with GDM significantly improved FPG levels, and gene expression of PPAR-γ, GLUT-1, and LDLR.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 3","pages":"71-79"},"PeriodicalIF":3.2,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35670294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Factors associated with magnesemia in patients with chronic kidney disease. 慢性肾病患者镁血症的相关因素

IF 3.2 4区医学

Magnesium research Pub Date : 2017-05-01 DOI: 10.1684/mrh.2017.0423

Chien-Te Lee, Yueh-Ting Lee, Wei-Hung Kuo, Terry Ting-Yu Chiou, Long-Chih Li, Hwee-Yeong Ng, Chia-An Chou, Wen-Chin Lee

{"title":"Factors associated with magnesemia in patients with chronic kidney disease.","authors":"Chien-Te Lee, Yueh-Ting Lee, Wei-Hung Kuo, Terry Ting-Yu Chiou, Long-Chih Li, Hwee-Yeong Ng, Chia-An Chou, Wen-Chin Lee","doi":"10.1684/mrh.2017.0423","DOIUrl":"https://doi.org/10.1684/mrh.2017.0423","url":null,"abstract":"Previous studies have indicated diabetes was associated with lower serum magnesium (Mg) level. Patients with renal impairment usually have higher Mg concentration due to reduced renal excretion. Whether Mg level in diabetics with chronic kidney disease (CKD) is altered remains undermined. In this study, we analyzed serum Mg concentration in patients with CKD and also compared diabetics with non-diabetics. Factors associated with Mg levels were explored. A total of 939 patients were included and 717 were with CKD. Their serum Mg concentration increased progressively, as their glomerular filtration rate (GFR) decreased in both diabetics and non-diabetics. Compared with non-diabetics, diabetes was significantly associated with lower serum Mg concentration in patients without CKD than in patients with CKD in all stages of disease. Multivariate regression analysis identified that both diabetes and serum albumin were independent factors of serum Mg concentration in patients without CKD. Age, diabetes, serum albumin concentration, GFR and macroproteinuria were significantly associated with serum Mg concentration in patients with early-stage CKD. In patients with moderate-to-severe CKD, diabetes, serum albumin and GFR were independent factors related to the serum Mg level.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 2","pages":"53-60"},"PeriodicalIF":3.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0423","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35376063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Serum magnesium and calcium levels in infertile women during a cycle of reproductive assistance. 不孕妇女在辅助生殖周期中的血清镁和钙水平。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-05-01 DOI: 10.1684/mrh.2017.0421

Elena Grossi, Sara Castiglioni, Claudia Moscheni, Patrizio Antonazzo, Irene Cetin, Valeria Maria Savasi

{"title":"Serum magnesium and calcium levels in infertile women during a cycle of reproductive assistance.","authors":"Elena Grossi, Sara Castiglioni, Claudia Moscheni, Patrizio Antonazzo, Irene Cetin, Valeria Maria Savasi","doi":"10.1684/mrh.2017.0421","DOIUrl":"https://doi.org/10.1684/mrh.2017.0421","url":null,"abstract":"Magnesium (Mg) and calcium (Ca) are essential cations for women's preconception health. It is well known that, in blood, the concentration of ionized form of these two cations is temporally altered during menstrual cycle, suggesting a correlation between sex steroid hormones and serum calcium and magnesium levels. Evidence from literature suggests that in assisted reproductive technology increasing estrogens during ovarian hyperstimulation may also modulate serum magnesium and calcium levels. Therefore, we first examined total serum magnesium and calcium levels during follicular phase in a large population of infertile patients who underwent intrauterine insemination (IUI). The results were compared to a group of fertile women. Successively, we studied the total serum magnesium and calcium concentrations in infertile patients before and after ovarian hyperstimulation for in vitro fertilization (IVF). Results highlight that total serum concentration of magnesium and calcium does not seem altered in infertile women. During stimulation with gonadotropins, the values of the two cations do not change significantly in ovarian-stimulated women. However, we found a downward trend in the total magnesium and calcium levels in relation to the rising estrogens.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 2","pages":"35-41"},"PeriodicalIF":3.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35376061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Effect of magnesium on the osteogenesis of normal human osteoblasts. 镁对正常人成骨细胞成骨的影响。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-05-01 DOI: 10.1684/mrh.2017.0422

Wei-Chen Lu, Ekaterini Pringa, Laisheng Chou

{"title":"Effect of magnesium on the osteogenesis of normal human osteoblasts.","authors":"Wei-Chen Lu, Ekaterini Pringa, Laisheng Chou","doi":"10.1684/mrh.2017.0422","DOIUrl":"https://doi.org/10.1684/mrh.2017.0422","url":null,"abstract":"Biomaterials containing magnesium are used for implants and bone regeneration. However, mechanisms underlying the biologic effects of magnesium are still largely unknown and have not been examined on normal human osteoblasts. This study was designed to test the effect of supplemented Mg2+ concentrations between 0.5 mM and 16 mM on the osteogenic behaviors of normal human primary osteoblasts. Human primary osteoblasts were cultured in the groups with various concentrations of supplemented magnesium for various time intervals. Cell proliferation was measured using crystal violet staining. Degree of Alkaline Phosphatase (ALP) activity was measured by fluorometric assay. Expression of osteocalcin was measured by immunosorbent assay. Mineralization of cultures was determined by Alizarin Red S staining. Results showed that initial cell attachment efficiency was not affected by supplemented Mg2+ (P > 0.05). At 21 days, proliferation rates increased in groups containing 0.5 mM-4 mM supplemented Mg2+ and decreased in groups of supplemented 8 mM and 16 mM Mg2+. ALP activity and osteocalcin expression were upregulated in groups of supplemented Mg2+ between 0.5 mM-2.0 mM (P < 0.05), but downregulated in groups with supplemented Mg2+ concentrations of 4mM and above (P < 0.05). Cultures with 1 mM and 2 mM supplemented Mg2+ showed upregulated mineralization activity compared to the control (P < 0.05), but downregulated in groups with supplemented Mg2+ concentrations of 4 mM and above (P < 0.05). The present study based on an experimental design demonstrated the impact of 2 mM supplemented Mg2+ on induced-proliferation and differentiation of normal human osteoblasts.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 2","pages":"42-52"},"PeriodicalIF":3.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0422","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35376062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Effect of magnesium supplementation on muscular damage markers in basketball players during a full season. 补充镁对篮球运动员整个赛季肌肉损伤指标的影响。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-05-01 DOI: 10.1684/mrh.2017.0424

Alfredo Córdova Martínez, Diego Fernández-Lázaro, Juan Mielgo-Ayuso, Jesús Seco Calvo, Alberto Caballero García

{"title":"Effect of magnesium supplementation on muscular damage markers in basketball players during a full season.","authors":"Alfredo Córdova Martínez, Diego Fernández-Lázaro, Juan Mielgo-Ayuso, Jesús Seco Calvo, Alberto Caballero García","doi":"10.1684/mrh.2017.0424","DOIUrl":"https://doi.org/10.1684/mrh.2017.0424","url":null,"abstract":"Although it has been widely accepted that Mg has a positive effect on muscle function, studies on the efficacy of Mg supplementation in young athletes have generated contrasting results. The aim of this work was to examine the effect of Mg supplementation on muscular damage markers and the association between serum Mg levels with these muscular markers. Twelve elite male basketball players (PB) from a team of Spanish Professional Basketball League and a control group (CG) comprising twelve university students who practiced regularly recreational basketball and competed in minor university leagues participated in this study. The athletes were supplemented with 400 mg/day of Mg, in the form of Mg lactate. Blood samples were taken four times during the season, each separated by eight weeks: T1: October, T2: December, T3: March, and T4: April. Serum Mg concentrations showed a significant decrease in T3 (1.56 ± 0.03 mg/dL), with respect to T1 (1.69 ± 0.04 mg/dL) and T2 (1.69 ± 0.04 mg/L). At the end of the study, serum Mg concentration was significantly higher (T4: 1.79 ± 0.06 mg/dL) than at T3. Levels of muscle damage parameters remained the same during the entire season (P > 0.05), except for creatinine, which significantly decreased after T2, and then increased significantly in T3 and T4 compared to T2. In conclusion, these results suggest that the supplementation with Mg during the season of competition may prevent associated tissue damage.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 2","pages":"61-70"},"PeriodicalIF":3.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35277415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Oral magnesium supplementation reduces the incidence of gastrointestinal complications following cardiac surgery: a randomized clinical trial. 口服镁补充剂减少心脏手术后胃肠道并发症的发生率:一项随机临床试验。

IF 3.2 4区医学

Magnesium research Pub Date : 2017-02-01 DOI: 10.1684/mrh.2017.0420

Seyed Tayeb Moradian, Mohammad Saeid Ghiasi, Alireza Mohamadpour, Yadollah Siavash

{"title":"Oral magnesium supplementation reduces the incidence of gastrointestinal complications following cardiac surgery: a randomized clinical trial.","authors":"Seyed Tayeb Moradian, Mohammad Saeid Ghiasi, Alireza Mohamadpour, Yadollah Siavash","doi":"10.1684/mrh.2017.0420","DOIUrl":"https://doi.org/10.1684/mrh.2017.0420","url":null,"abstract":"Gastrointestinal complications are common after coronary artery bypass graft surgery. These complications are ranged from nausea and vomiting to mesenteric ischemia and liver failure. It seems that nausea, vomiting, and constipation are related to magnesium deficiency. This study was designed to examine the effect of oral magnesium supplementation on the incidence of gastrointestinal complications in patients undergoing cardiac surgery. In a single blinded randomized clinical trial, 102 patients who were undergoing coronary artery bypass graft surgery were randomly allocated into two groups, 52 patients in the intervention and 50 patients in control group. Patients in the experimental group received 800 milligram magnesium oxide (2 tablets each of them containing 240 mg elemental magnesium) daily from the admission to discharge from hospital. The incidence of post-operative nausea and vomiting, constipation, and atrial fibrillation was compared between the groups. Our results showed that postoperative hypomagnesemia is present in 41.20 and 70.80 percent of the patients in the intervention and control group patients, respectively. The overall incidence of constipation was 62%. Patients who received magnesium supplementation experienced less atrial fibrillation, nausea, vomiting, and constipation. Our data showed that oral magnesium supplementation could reduce the postoperative complications. Despite the better status in the intervention group, the hypomagnesemia was present in many of intervention group patients. It seems that supplementation with higher doses is needed.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 1","pages":"28-34"},"PeriodicalIF":3.2,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2017.0420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34919801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11