Magnesium research最新文献

{"title":"Differential effect of nanoparticle and standard forms of ZnO on serum zinc and magnesium levels in rats.","authors":"Magdalena Olbert,&nbsp;Mirosław Krośniak,&nbsp;Joanna Gdula-Argasińska,&nbsp;Gabriel Nowak,&nbsp;Tadeusz Librowski","doi":"10.1684/mrh.2018.0438","DOIUrl":"https://doi.org/10.1684/mrh.2018.0438","url":null,"abstract":"<p><p>This study examined the effect of chronic (2 weeks) administration of zinc oxide nanoparticles (NPs-ZnO) and standard zinc oxide (S-ZnO) on the levels of zinc (Zn), magnesium (Mg) and calcium (Ca) in rat serum. S-ZnO and NPs-ZnO were administered either per os (p.o.) or intraperitoneally (i.p.) at doses of 7 mg/kg or 14 mg/kg. Neither form of ZnO administered p.o. altered serum zinc concentration. However, different effects dependent upon either S-ZnO or NPs-ZnO forms were noticed after i.p. administration. Namely, while S-ZnO increased serum zinc concentration (by 136%) only at the higher dose (14 mg/kg), both doses of NPs-ZnO increased zinc concentration (by 97% at 7 mg/kg and by 564% at 14 mg/kg). The form-dependence of the ZnO effect was also demonstrated in the effect on the serum magnesium level. Only the S-ZnO form (at the dose of 14 mg/kg) reduced serum magnesium concentration (by 14% p.o., 6% i.p.). No influence of NPs-ZnO on the serum calcium level was observed. The present study demonstrated effects on the serum Zn and Mg levels, which differed between the standard and nanoparticle forms of ZnO. This may contribute to the different functional effects of these ZnO forms shown previously.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 2","pages":"58-64"},"PeriodicalIF":3.2,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0438","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36650911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine and magnesium common pathway of antidepressant action.","authors":"Natalia Górska,&nbsp;Wiesław Jerzy Cubała,&nbsp;Jakub Słupski,&nbsp;Maria Gałuszko-Węgielnik","doi":"10.1684/mrh.2018.0440","DOIUrl":"https://doi.org/10.1684/mrh.2018.0440","url":null,"abstract":"<p><p>Depression is one of the major causes of disability worldwide. A proportion of adults with major depression fail to achieve remission with first-line treatment. Magnesium influences the neurotransmission involved in emotional processes, such as the serotonergic, noradrenergic, dopaminergic, GABAergic and glutamatergic systems. It has been reported that the mechanism of antidepressants' action is involved in the glutamatergic system. Theories about the role of magnesium ions in pathophysiology of major depressive disorder include blocking the glutamatergic N-methyl-D-aspartate receptor (NMDAR). Ketamine, NMDAR antagonist, was found to promote fast-acting antidepressant and antisuicidal effects. Magnesium and ketamine seem to be involved in key mechanisms of the major depression pathophysiology. The evidence in the paper discussed may indicate the synergistic interaction between magnesium and ketamine pharmacodynamic activity being of particular importance in mood disorders.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 2","pages":"33-38"},"PeriodicalIF":3.2,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36650907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractional excretion of magnesium and kidney function parameters in nondiabetic chronic kidney disease.","authors":"Radmila Žeravica,&nbsp;Branislava Ilinčić,&nbsp;Velibor Čabarkapa,&nbsp;Isidora Radosavkić,&nbsp;Jelena Samac,&nbsp;Katarina Nikoletić,&nbsp;Zoran Stošić","doi":"10.1684/mrh.2018.0437","DOIUrl":"https://doi.org/10.1684/mrh.2018.0437","url":null,"abstract":"<p><strong>Aim: </strong>Elevated fractional excretion of magnesium (FEMg) is a noninvasive biomarker of kidney damage, but its association with kidney functional parameters in nondiabetic chronic kidney disease (CKD) patients has not been sufficiently explored thus far.</p><p><strong>Methods: </strong>We enrolled 111 adult patients with nondiabetic CKD and 30 controls. To precisely investigate kidney function, the following parameters were assessed measured glomerular filtration rate (mGFR), effective renal plasma flow (ERPF), Cystatin C, albuminuria, and fractional excretion of magnesium (FEMg). All the CKD patients were divided into two groups according to the values of mGFR (mL/min/1.73m²): the first group consisted of those with GFR≥ 60 mL/min/1.73m², whereas the second group included those with GFR< 60 mL/min/1.73m².</p><p><strong>Results: </strong>FEMg (%) was significantly higher in the group of nondiabetic patients with CKD compared to the healthy subjects [6.3 vs. 5.3 %, P=0.013]. There was also significant difference in the value of FEMg between the first and second groups of CKD patients. Increased FEMg was significantly correlated with all the investigated kidney function parameters, mGFR, ERPF, Cystatin C and albuminuria (r=-0.62; r=-0.60; r=0.77; r=0.39; p<0.01 for all). In multiple regression analyses based on observed parameters of kidney function, only cystatin C was independently and significantly associated with FEMg (multiple correlation coefficients: 0.738, p < 0.001)). Nondiabetic CKD patients with GFR< 60 mL/min/1.73m² have increased FEMg above 6.1% with 78.7 % specificity and 83.7% sensitivity.</p><p><strong>Conclusion: </strong>Highly significant association between kidney functional parameters and FEMg may indicate significance of this parameter in clinical practice.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 2","pages":"49-57"},"PeriodicalIF":3.2,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36650910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium deficiency heightens lipopolysaccharide-induced inflammation and enhances monocyte adhesion in human umbilical vein endothelial cells.","authors":"Lujain A Almousa,&nbsp;Andrew M Salter,&nbsp;Simon C Langley-Evans","doi":"10.1684/mrh.2018.0436","DOIUrl":"https://doi.org/10.1684/mrh.2018.0436","url":null,"abstract":"<p><p>Given a possible anti-inflammatory role of magnesium in endothelial cells, the aim of this study was to investigate the effects of magnesium on human umbilical vein endothelial cell (HUVEC) viability, gene expression, and the pro-inflammatory response caused by a bacterial endotoxin (LPS). HUVECs were cultured at three different concentrations of magnesium sulphate (0.1 mM; control-1 mM; 5 mM) for 72 hours. Exposing the cells to LPS reduced cell viability in culture with low magnesium, but high magnesium protected the HUVECs from LPS-induced cell death. LPS-treated HUVECs cultured in low magnesium showed up-regulation of mRNA expression for pro-inflammatory factors and the expression of cytokine proteins, including IL-2, IL-3, IL-8, IL-15 and MCP-1. This was associated with greater adhesion of monocytes to the cells. In contrast, high magnesium decreased the expression of inflammatory factors and cytokines. The study found that LPS activation of the expression of many pro-inflammatory factors is exacerbated in the presence of low magnesium concentration whilst a high magnesium concentration partly inhibited the inflammatory response to LPS.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 2","pages":"39-48"},"PeriodicalIF":3.2,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36650909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal pancreatic elastase-1 and erythrocyte magnesium levels in diabetes type 1 and type 2.","authors":"Velibor Čabarkapa,&nbsp;Mirjana Djerić,&nbsp;Milena Mitrović,&nbsp;Sunčica Kojić-Damjanov,&nbsp;Ivana Isakov,&nbsp;Bojan Vuković,&nbsp;Djordje Popović","doi":"10.1684/mrh.2018.0433","DOIUrl":"https://doi.org/10.1684/mrh.2018.0433","url":null,"abstract":"<p><p>In both types of diabetes mellitus (DM), type 1 and type 2 (T1DM and T2DM), there are both endocrine and exocrine dysfunctions of the pancreas (PED), as well as disturbances in serum magnesium levels. The aim of this study was to examine the frequency of PED according to the level of fecal elastase-1 (FE-1) in patients with T1DM and T2DM, determining the correlation of the level of FE-1 with certain anthropometric parameters, certain indicators of metabolic regulation of diabetes, and certain nutritive markers of PED.</p><p><strong>Materials and methods: </strong>In the examinees, (56 with T1DM (F = 35 and M = 21), 62 with T2DM (F = 30 and M = 32), and 40 in the control group (F = 19 and M = 21)), we examined anthropometric parameters, and using standard biochemical methods, we measured the level of FE-1, magnesium concentration in blood and erythrocytes, and selected blood parameters.</p><p><strong>Results: </strong>FE-1 concentration < 200 μg/g was present in 14.2% of the examinees with T1DM, 20.9% with T2DM, and 2.5% in the control group. In all examinees with DM, there was a statistically significant correlation (P < 0.05) between the level of FE-1 and Mg concentration in the erythrocytes (R = 0.40).</p><p><strong>Conclusions: </strong>Prevalence of pancreatic exocrine insufficiency (PEI), according to the level of FE-1, is significantly higher in patients with DM than in the control group, while it is a bit higher in patients with T2DM than the ones with T1DM. In both types of DM, Mg concentration in erythrocytes is in a significant correlation with the level of FE-1.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 1","pages":"1-10"},"PeriodicalIF":3.2,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36394581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Down-regulation of magnesium transporting molecule, claudin-16, as a possible cause of hypermagnesiuria with the development of tubulo-interstitial nephropathy.","authors":"Taisuke Shimizu,&nbsp;Kaori Takayanagi,&nbsp;Takatsugu Iwashita,&nbsp;Akira Ikari,&nbsp;Naohiko Anzai,&nbsp;Shimpei Okazaki,&nbsp;Hiroaki Hara,&nbsp;Minoru Hatano,&nbsp;Tatsuro Sano,&nbsp;Tomonari Ogawa,&nbsp;Koichi Kanozawa,&nbsp;Hajime Hasegawa","doi":"10.1684/mrh.2018.0434","DOIUrl":"https://doi.org/10.1684/mrh.2018.0434","url":null,"abstract":"Tubulo-interstitial nephropathy (TIN) is a critical pathological setting for the renal prognosis, and an increase in the urine magnesium excretion is a well-known characteristic feature as one of clinical parametets for the assessment of TIN. We examined the correlation between the development of TIN and the changes in the mRNA expression of renal magnesium-transporting molecules in rats with unilateral ureter obstruction (UUO). Ureter-ligated kidney was sampled at day-0 (control), day-1 (early phase) and day-7 (late phase). The development of TIN was assessed by immunohistochemistry and the real-time PCR of fibrosis-related genes (MCP-1: 105.1 ± 14.8% on day-0, 132.9 ± 25.7% on day-1, 302.7 ± 32.7% on day-7, TGF-β: 101.1 ± 7.6% on day-0, 93.6 ± 4.1% on day-1, 338.9 ± 20.7% on day-7) . The respective expressions of claudin-10, 14, 16, 19, and transient receptor potential (TRP) M6 as magnesium-transporting molecules were also studied. The expression of calcium sensing receptor (CaSR) as an inhibitory regulator of claudin-14 was additionally studied. The gene expression of claudin-16 was decreased in the late phase of UUO (100.2 ± 2.9% at day-0, 90.3 ± 6.3% at day-1, 36.4 ± 1.6% at day-7) which was consistent with the increased urine magnesium excretion. Immunohistochemistry showed an apparent reduction of the immunoreactivity of claudin-16 in the late phase. The expression of TRPM6 was reduced even in the early phase. The immunohistochemistry and gene expression of MCP-1 and TGF-ß showed that TIN was not apparent in the early phase but was significant in the late phase of UUO. The density of peritubular capillaries was diminished in the late phase but not in the early phase. Expression of claudin-14 and CaSR was up- and down-regulated, respectively. Our findings may indicate that the characteristic hypermagnesiuria in TIN is principally caused by the dysfunction of magnesium reabsorption in the thick ascending limb of Henle resulting from a significant decrease in the claudin-16 expression. The down-regulation might be closely related to the development of TIN.","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 1","pages":"11-23"},"PeriodicalIF":3.2,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36297831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats.","authors":"Vedrana Đurić,&nbsp;Bojan Batinić,&nbsp;Jelena Petrović,&nbsp;Dušanka Stanić,&nbsp;Zorica Bulat,&nbsp;Vesna Pešić","doi":"10.1684/mrh.2018.0435","DOIUrl":"https://doi.org/10.1684/mrh.2018.0435","url":null,"abstract":"<p><p>Although a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 μg/animal), mimicking the stress- and depression-like conditions. A single dose of Mg-sulfate enhanced the LTM retrieval in the 24 h inter-trial NORT protocol, in healthy, as well as in rats acutely treated with ACTH. Memory enhancement was also detected after 4-week long Mg-sulfate intake, in both healthy and rats chronically treated with ACTH. While the present findings on procognitive effects of chronic Mg-sulfate treatment corroborate with those from studies on the therapeutic potential of Mg-threonate, the current study is the first to report on memory enhancement induced by a single dose of magnesium.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"31 1","pages":"24-32"},"PeriodicalIF":3.2,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36297833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of urine pH and magnesium on calcium oxalate saturation.","authors":"Silvia Ferrè,&nbsp;Jacob S Grange,&nbsp;Beverley Adams-Huet Ms,&nbsp;Orson W Moe,&nbsp;Naim M Maalouf","doi":"10.1684/mrh.2018.0429","DOIUrl":"https://doi.org/10.1684/mrh.2018.0429","url":null,"abstract":"<p><p>Hypomagnesiuria is a common biochemical finding in patients with calcium oxalate (CaOx) nephrolithiasis. Clinical trials using Mg supplements as therapy against CaOx stones have shown mixed results. We tested the effect of Mg administration in healthy subjects under conditions of controlled urine pH (UpH) on urinary Ca excretion rate (UCaV) and CaOx saturation. This is a 4-phase, double blind, placebo-controlled, metabolic crossover study performed in healthy volunteers. Mg lactate (MgLact₂) was used as Mg supplement. High UpH and low UpH were achieved by administration of potassium citrate (K₃Citrate) and ammonium chloride (NH₄Cl), respectively, with potassium balance maintained by KCl. Eight participants completed 4 phases of study. The interventions successfully modulated 24-h UpH (7.0 ± 0.4 vs. 5.7 ± 0.6 in high vs low pH phases; P<0.001). Administration of MgLact₂ increased UMgV [175.8 ± 40.2 vs 93.4 ± 39.7 mg/day (7.2 ± 1.7 vs 3.8 ± 1.6 mmol/day), high vs low Mg phase; P<0.001], and increased pH both at low (5.6 ± 0.5 to 5.8 ± 0.7; P = 0.02) and high UpH (6.9 ± 0.4 to 7.0 ± 0.3; P = 0.01). At a given urine pH, Mg supplementation marginally increased UCaV, but did not alter UOxV or CaOx saturation. Provision of an alkali load significantly lowered UCaV and saturation of CaOx at any level of UMgV. Compared to changes in UMgV, changes in UpH play a more significant role in determining urine CaOx saturation in healthy subjects. Mg supplements are likely to reduce CaOx saturation if they also raise urine pH.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 4","pages":"107-119"},"PeriodicalIF":3.2,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35998395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 6-month follow-up of disability, quality of life, and depressive and anxiety symptoms in pediatric migraine with magnesium prophylaxis.","authors":"Gordana Kovacevic,&nbsp;Dejan Stevanovic,&nbsp;Dragana Bogicevic,&nbsp;Dimitrije Nikolic,&nbsp;Slavica Ostojic,&nbsp;Biljana Vucetic Tadic,&nbsp;Blažo Nikolic,&nbsp;Ivana Bosiocic,&nbsp;Nikola Ivancevic,&nbsp;Kristina Jovanovic,&nbsp;Janko Samardzic,&nbsp;Jasna Jancic","doi":"10.1684/mrh.2018.0431","DOIUrl":"https://doi.org/10.1684/mrh.2018.0431","url":null,"abstract":"<p><p>Magnesium is frequently used for pediatric migraine prophylaxis. The aim of this study was to evaluate to which extent the disability levels, quality of life (QOL), and anxiety and depressive symptoms change after 6-month magnesium prophylaxis in pediatric migraine. This is a follow-up study of 34 children aged 7-17 years with migraine treated with oral magnesium. Disability due to migraine was assessed by the Pediatric Migraine Disability Assessment tool (PedMIDAS), QOL was assessed by the KIDSCREEN-27, and anxiety and depressive symptoms were assessed by the Revised Child Anxiety and Depression Scale (RCADS). PedMIDAS scores significantly decreased from baseline to end-point (F(df, df_error) = 11.10 (1.63, 50.49), p<0.001), as well as anxiety (F(df, df_error) = 8.95 (1.64, 50.67), p = 0.001) and depressive symptoms (F(df, df_error) = 8.91 (1.59, 49.29), p = 0.001). Considering the KIDSCREEN-27, scores for physical and psychological well-being and social support domain significantly increased from baseline to end-point (p≤0.01). After 6 months of magnesium prophylaxis, disability due to migraine significantly decreased, whereas physical and psychosocial well-being improved. Children also reported fewer anxiety and depressive symptoms. More follow-up and randomized controlled clinical trials are needed to propose clinical recommendations for magnesium prophylaxis in pediatric migraine.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 4","pages":"133-141"},"PeriodicalIF":3.2,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35998397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of magnesium supplementation on muscle fitness: a meta-analysis and systematic review.","authors":"Ru Wang,&nbsp;Cheng Chen,&nbsp;Wei Liu,&nbsp;Tang Zhou,&nbsp;Pengcheng Xun,&nbsp;Ka He,&nbsp;Peijie Chen","doi":"10.1684/mrh.2018.0430","DOIUrl":"https://doi.org/10.1684/mrh.2018.0430","url":null,"abstract":"<p><p>Increasing evidence supports a role of magnesium (Mg) in skeletal muscle function. However, no systematic review or meta-analysis has summarized data on Mg supplementation in relation to muscle fitness in humans. Thus, this study aimed to quantitatively assess the effect of Mg supplementation on muscle fitness. A meta-analysis and systematic review. Medline database and other sources were searched for randomized clinical trials through July 2017. Studies that reported results regarding at least one of the following outcomes: leg strength, knee extension strength, peak torque, muscle power, muscle work, jump, handgrip, bench press weights, resistant exercise, lean mass, muscle mass, muscle strength, walking speed, Repeated Chair Stands, and TGUG were included. Measurements of the association were pooled using a fixed-effects model and expressed as weighted mean differences (WMDs) with 95% confidence intervals (95% CIs). Fourteen randomized clinical trials targeting 3 different populations were identified: athletes or physically active individuals (215 participants; mean age: 24.9 years), untrained healthy individuals (95 participants; mean age: 40.2 years), and elderly or alcoholics (232 participants; mean age: 62.7 years). The beneficial effects of Mg supplementation appeared to be more pronounced in the elderly and alcoholics, but were not apparent in athletes and physically active individuals. The results of the meta-analysis suggested that no significant improvements in the supplementation group were observed regarding isokinetic peak torque extension [WMD = 0.87; 95% CI = (-1.43, 3.18)], muscle strength [WMD = 0.87; 95% CI = (-0.12, 1.86)] or muscle power [WMD = 3.28; 95% CI = (-14.94, 21.50)]. Evidence does not support a beneficial effect of Mg supplementation on muscle fitness in most athletes and physically active individuals who have a relatively high Mg status. But Mg supplementation may benefit individuals with Mg deficiency, such as the elderly and alcoholics.</p>","PeriodicalId":18159,"journal":{"name":"Magnesium research","volume":"30 4","pages":"120-132"},"PeriodicalIF":3.2,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/mrh.2018.0430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35998396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}