Reactive oxygen species are implicated in altering magnesium homeostasis in endothelial cells exposed to high glucose.

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Roberta Scrimieri, Laura Locatelli, Roberta Cazzola, Jeanette A M Maier, Alessandra Cazzaniga
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引用次数: 6

Abstract

Transient Receptor Potential Melastatin (TRPM)7 is important in maintaining the intracellular homeostasis of magnesium (Mg), which is instrumental for vital cellular functions. Since the upregulation of TRPM7 has been proposed as a marker of endothelial dysfunction, we evaluated the effects of high glucose, which markedly impacts endothelial performance, on TRPM7 and intracellular Mg homeostasis in human macrovascular endothelial cells. We show that glucose-induced free radicals increase the amounts of TRPM7 as well as total intracellular magnesium. On the contrary, the highly selective Mg transporter MagT1 is not modulated by high glucose, hydrogen peroxide and low extracellular magnesium. We conclude that in endothelial cells high glucose alters Mg homeostasis through the upregulation of TRPM7.

活性氧参与了高糖环境下内皮细胞镁稳态的改变。
短暂受体电位美拉他汀(TRPM)7在维持细胞内镁(Mg)的稳态中起着重要作用,这对重要的细胞功能至关重要。由于TRPM7的上调被认为是内皮功能障碍的标志,我们评估了高糖对人大血管内皮细胞TRPM7和细胞内Mg稳态的影响,高糖显著影响内皮功能。我们发现葡萄糖诱导的自由基增加了TRPM7的数量以及细胞内镁的总量。相反,高选择性的镁转运体MagT1不受高葡萄糖、过氧化氢和低细胞外镁的调节。我们得出结论,在内皮细胞中,高葡萄糖通过上调TRPM7改变Mg稳态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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