镁与体外血脑屏障:对通透性和镁转运的影响。

IF 1.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Magnesium research Pub Date : 2019-02-01 DOI:10.1684/mrh.2019.0454

Valentina Romeo, A. Cazzaniga, J. Maier

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引用次数: 10

摘要

血脑屏障(BBB)严格调节中枢神经系统的稳态，其功能障碍已被描述为几种神经系统疾病。由于镁在大脑中具有保护作用，我们评估了不同镁盐的超生理浓度是否会调节大鼠和人血脑屏障的通透性和镁的转运。在测试的各种配方中，碘酸镁在降低渗透性和增强镁通过屏障的运输方面是最有效的。然后，我们比较了在实验模型和临床实践中广泛使用的盐——碘酸镁和硫酸镁。在防止脂多糖引起的体外血脑屏障损伤方面，pidolate镁的表现也优于硫酸盐。我们的结论是，在保护血脑屏障和维持正确的脑内镁浓度方面，碘酸镁作为一种有趣的替代硫酸盐出现。

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Magnesium and the blood-brain barrier in vitro: effects on permeability and magnesium transport.

The blood-brain barrier (BBB) tightly regulates the homeostasis of the central nervous system, and its dysfunction has been described in several neurological disorders. Since magnesium exerts a protective effect in the brain, we assessed whether supraphysiological concentrations of different magnesium salts modulate the permeability and magnesium transport in in vitro models of rat and human BBB. Among various formulations tested, magnesium pidolate was the most efficient in reducing the permeability and in enhancing magnesium transport through the barrier. We then compared magnesium pidolate and magnesium sulfate, a widely used salt in experimental models and in clinical practice. Magnesium pidolate performs better than sulfate also in preventing lipopolysaccharide-induced damage to in vitro generated BBB. We conclude that magnesium pidolate emerges as an interesting alternative to sulfate to protect BBB and maintain correct intracerebral concentrations of magnesium.

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来源期刊

Magnesium research 医学-内分泌学与代谢

CiteScore

3.50

自引率

9.40%

发文量

审稿时长

>12 weeks

期刊介绍： Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.