Magnesium citrate supplementation decreased blood pressure and HbA1c in normomagnesemic subjects with metabolic syndrome: a 12-week, placebo-controlled, double-blinded pilot trial.

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Kseniia Afitska, Julia Clavel, Klaus Kisters, Jürgen Vormann, Tanja Werner
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引用次数: 0

Abstract

Magnesium (Mg) supplementation was shown to improve metabolic syndrome (MetS) parameters in hypomagnesemic patients. The current study evaluated the role of Mg in normomagnesemic individuals with MetS. Patients were randomly assigned to 400 mg Mg as Mg citrate or placebo daily for 12 weeks. Blood pressure (BP), HbA1c, plasma concentrations of glucose, Mg and Ca, blood-ionized Mg, serum concentrations of cholesterol, triglycerides, vitamin D, creatinine, interleukin-6, and C-reactive protein were measured at baseline and after 12 weeks. Data were obtained from n = 13 in the Mg supplemented and n = 11 in the placebo group. Mg supplementation led to a significant increase in plasma Mg concentration (0.78 ± 0.07 mmol/L to 0.83 ± 0.07 mmol/L) and a decrease in systolic and diastolic BP (baseline: 145 ± 10/85 ± 3 mmHg; 12 weeks: 121 ± 5/79 ± 3 mmHg). HbA1c decreased significantly in the Mg group (6.43 ± 0.64% to 6.15 ± 0.55%), and the difference in change between placebo and Mg group was significant. Serum vitamin D levels significantly increased only in the Mg group. In normomagnesemic individuals with MetS, oral Mg citrate supplementation reduced HbA1c and BP.

补充柠檬酸镁可降低代谢综合征正常镁血症患者的血压和HbA1c:一项为期12周的安慰剂对照双盲先导试验。
镁(Mg)补充剂被证明可以改善低镁血症患者的代谢综合征(MetS)参数。目前的研究评估了镁在正常镁血症的MetS患者中的作用。患者被随机分配服用400毫克柠檬酸mg或安慰剂,持续12周。在基线和12周后测量血压(BP)、HbA1c、血浆葡萄糖、Mg和Ca浓度、血离子Mg、血清胆固醇、甘油三酯、维生素D、肌酐、白细胞介素-6和c反应蛋白浓度。数据来源于补充Mg组n = 13,安慰剂组n = 11。Mg补充导致血浆Mg浓度显著升高(0.78±0.07 mmol/L至0.83±0.07 mmol/L),收缩压和舒张压降低(基线:145±10/85±3 mmHg;12周:121±5/79±3 mmHg)。Mg组HbA1c明显降低(6.43±0.64% ~ 6.15±0.55%),安慰剂组与Mg组差异有统计学意义。血清维生素D水平仅在Mg组显著升高。在患有MetS的正常镁血症个体中,口服枸橼酸镁补充剂可降低HbA1c和血压。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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