Relationship of dietary magnesium intake and serum magnesium with hypertension: a review.

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Nikolina Banjanin, Goran Belojevic
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引用次数: 6

Abstract

The relationship between magnesium and hypertension has been intensively investigated in the last few decades. Most of the so far reviews were focused on either dietary magnesium or serum magnesium or magnesium supplements. Our goal was to merge these findings with a more comprehensive approach. Internet search was performed in PubMed database without date limits, using the following search terms "dietary magnesium," "serum magnesium," "magnesium supplements," "hypertension," "drinking water," "food," "endothelial dysfunction," "arterial smooth muscle," and "arterial spasms." In general, there exists an inverse dose-dependent relationship between dietary magnesium intake and serum magnesium and the risk of hypertension. A negative correlation has been found between the serum magnesium concentration and Framingham risk score and intima-media carotid thickness and cardiovascular mortality. On the other hand, concentration of extracellular magnesium in the normal range acts as a natural calcium channel blocker, eliminates endothelial dysfunction, increases nitric oxide, and induces direct and indirect vasodilatation. In conclusion, an average magnesium dietary intake is below the recommended values and magnesium supplementation in the prevention and treatment of hypertension might be justified.

膳食镁摄入量和血清镁与高血压的关系综述。
在过去的几十年里,镁和高血压之间的关系已经被深入研究。到目前为止,大多数评论都集中在膳食镁或血清镁或镁补充剂上。我们的目标是将这些发现与更全面的方法结合起来。在PubMed数据库中进行互联网搜索,没有日期限制,使用以下搜索词“膳食镁”,“血清镁”,“镁补充剂”,“高血压”,“饮用水”,“食物”,“内皮功能障碍”,“动脉平滑肌”和“动脉痉挛”。总的来说,膳食镁摄入量和血清镁与高血压风险之间存在负剂量依赖关系。血清镁浓度与Framingham风险评分、颈动脉内膜-中膜厚度和心血管死亡率呈负相关。另一方面,正常范围内的细胞外镁浓度作为天然钙通道阻滞剂,消除内皮功能障碍,增加一氧化氮,诱导直接和间接血管舒张。总之,膳食镁的平均摄入量低于推荐值,补充镁预防和治疗高血压可能是合理的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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