Laboratory Animals最新文献_第5页

Fin clipping does not increase opercular beat rate in tricaine-treated zebrafish. 剪鳍不会增加三卡因处理斑马鱼的厣搏率。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-19 DOI: 10.1177/00236772241252551

Martin D Burkhalter, Melanie Philipp

引用次数: 0

Comparison of two bedding types on the breeding fecundity of C57BL/6J mice. 两种垫料对 C57BL/6J 小鼠繁殖力的影响比较

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-19 DOI: 10.1177/00236772241249783

Jessica L Pinckard, Lauren A Gibson, Wendy R Williams

{"title":"Comparison of two bedding types on the breeding fecundity of C57BL/6J mice.","authors":"Jessica L Pinckard, Lauren A Gibson, Wendy R Williams","doi":"10.1177/00236772241249783","DOIUrl":"https://doi.org/10.1177/00236772241249783","url":null,"abstract":"One of the favored options for generating complex transgenic laboratory mice is through in-house breeding and management strategies. One consideration in the management of these colonies is how the animals' environment may affect reproductive success. Several aspects of the microenvironment can be controlled or manipulated, including cage type, bedding, enrichment, diet, and temperature and humidity. This study sought to evaluate reproductive outcomes for C57BL/6J mice that were randomly assigned to one of two different bedding types: paper based or corncob bedding. Our hypothesis was there would be no significant difference in reproductive outcomes between the two bedding types. A total of 10 males and 10 females were paired at 45 days of age. Animals were allowed to breed for 15 consecutive weeks. Cages were checked daily for the presence of pups and a pup count was performed at 7 days of age. Weaning occurred at 20 or 21 days of age, at which time a final pup count, pup weight, and sex were recorded. All litters born and pups weaned in the 15-week timeframe were used for data analysis. Statistical analysis compared cannibalization between the two groups and the results showed no statistical difference between groups (p > 0.05). Other parameters analyzed included average litter size, average weaning weight, and number of litters per group. All pups counted at Day 7 survived to weaning age in both groups. We concluded that both bedding types produced similar success regarding breeding fecundity in C57BL/6J mice.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"236772241249783"},"PeriodicalIF":1.3,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refining urine collection in mice: Development of an innovative urine collection device. 改进小鼠的尿液收集：开发创新型尿液收集装置

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-19 DOI: 10.1177/00236772231219828

Mélodie Douté, Céline Monzali, Antonino Nicoletti, Giuseppina Caligiuri, Marc Clement

引用次数: 0

Facility design and management. Strategies for high level biocontainment. 设施设计和管理。高水平生物隔离战略。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-09 DOI: 10.1177/00236772241247104

Mike Dennis, Michael Charlton, Samantha Elam, Sarah Wolfensohn

{"title":"Facility design and management. Strategies for high level biocontainment.","authors":"Mike Dennis, Michael Charlton, Samantha Elam, Sarah Wolfensohn","doi":"10.1177/00236772241247104","DOIUrl":"https://doi.org/10.1177/00236772241247104","url":null,"abstract":"UK Health Security Agency is required to investigate the pathogenesis of emerging or re-emerging infections and to test novel interventions, such as vaccines and therapeutics against these and other diseases, such as tuberculosis and Ebola, that have a significant impact on human health world-wide. Research into the causative agents (mainly BSL 3 and 4) using a wide range of animal species as pre-clinical models brings a number of challenges in terms of effective biocontainment to address human safety whilst optimising delivery of scientific objectives and the welfare of the animals. Here we describe the strategies used for high containment of species that include mice, ferrets, hamsters, rabbits and macaques that have been infected with high consequence pathogens. To ensure relevance of these models we frequently challenge by the aerosol route and monitor the development of disease and protective or therapeutic efficacy by methodologies similar to those used in the clinic. We have devised methods of sampling that can inform on pathogenesis and immune function that include lung lavage and medical imaging such as computed tomography and positron emission tomography-computed tomography. Imaging assists our assessment of progression to disease whilst providing refinement in application of early humane endpoints. We have developed directional flow containment systems that provide quantifiable operator protection whilst allowing group housing and a wide range of enrichment strategies appropriate for each species. Furthermore, we have demonstrated our improvements in animal welfare through use of a software-based Animal Welfare Assessment Grid that was developed with help of NC3Rs funding and enables us to quantify the lifetime experience of animals.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"236772241247104"},"PeriodicalIF":1.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LAS Around the Globe - United States of America. 全球各地的 LAS - 美国。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1177/00236772231225896

Jennie Lofgren, Kelly Metcalf-Pate

引用次数: 0

Lethal Gram-negative sepsis in healthy pigs during anaesthesia with contaminated propofol. 健康猪在使用受污染的异丙酚进行麻醉期间发生致命的革兰氏阴性败血症。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1177/00236772231200524

Marit G Maaland, Marianne Oropeza-Moe, Silje K Nes, Frode Myrland, Cecilie Ersdal, Nils P Oveland

引用次数: 0

Evaluation of a gel-based versus micro-pellet diet for adult zebrafish (Danio rerio). 评估成年斑马鱼（Danio rerio）的凝胶型和微颗粒型食物。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-08-05 DOI: 10.1177/00236772241244834

Christine L Archer, Nikki K Tsuji, Molly H Waters, Jennifer L Brazzell, Derek L Fong, Jori K Leszczynski, Christopher A Manuel, Lauren M Habenicht

引用次数: 0

Retrospective analysis on the occurrence of kidney cysts in mice in a central animal facility in the years 2009-2019. 2009-2019 年中央动物设施小鼠肾囊肿发生率的回顾性分析。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-08-05 DOI: 10.1177/00236772241242538

Katrin Becker

{"title":"Retrospective analysis on the occurrence of kidney cysts in mice in a central animal facility in the years 2009-2019.","authors":"Katrin Becker","doi":"10.1177/00236772241242538","DOIUrl":"10.1177/00236772241242538","url":null,"abstract":"Kidney cysts in humans are mainly caused by inheritable polycystic kidney disease. Although they are a regular finding in laboratory mice, their occurrence upon dissection has not been systematically investigated, yet. Therefore, the aim of this report was to investigate on prevalence, phenotype and aetiology of spontaneously occurring kidney cysts in mice by retrospectively analysing the laboratory-receipt tables of the in-house laboratory of a central animal facility in North Rhine-Westphalia, Germany, years 2009-2019. A percentage of 0.4% of dissected mice displayed kidney cysts, with more male than female animals affected and average age equal to that of all dissected animals. Preliminary report in half of the cases was distended abdomen, and a few individuals displayed additional pathologic alterations of kidneys, most commonly dilated renal pelvis, or extrarenal comorbidities. Kidney cysts occurred independently of a renal phenotype of the transgenic strain or presence of infectious agents in health monitoring. To conclude, kidney cysts were characterized as harmless for affected mice but, as inheritability is suggested according with the literature, affected animals should be excluded from breeding.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"380-386"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMAFIRA: a literature-based web tool to assist researchers with retrieval of 3R-relevant information. SMAFIRA：协助研究人员检索 3R 相关信息的基于文献的网络工具。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-06-13 DOI: 10.1177/00236772241237608

Daniel Butzke, Bettina Bert, Konrad Gulich, Gilbert Schönfelder, Mariana Neves

引用次数: 0

Auditory enrichment with different genres of music for colony queens. 用不同类型的音乐丰富殖民地皇后的听觉。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-07-29 DOI: 10.1177/00236772241238264

María C García Mitacek, Romina G Praderio, Micaela Tebes, Florencia García, María C Stornelli, Rodolfo Luzbel de la Sota, María A Stornelli

{"title":"Auditory enrichment with different genres of music for colony queens.","authors":"María C García Mitacek, Romina G Praderio, Micaela Tebes, Florencia García, María C Stornelli, Rodolfo Luzbel de la Sota, María A Stornelli","doi":"10.1177/00236772241238264","DOIUrl":"10.1177/00236772241238264","url":null,"abstract":"The aim was to determine changes in clinical parameters, glucose concentration, cortisol and behavior in colony queens in no music conditions compared with exposing to different genres of music. Mixed breed clinically healthy queens (N = 9) were used. Queens were studied under no music conditions (control=CON) and auditory enrichment: Soft Rock (M1), Motown (M2), Pop (M3), Frenchcore (M4) and music that was composed to be species-appropriate for cats (M5). The queens underwent auditory enrichment, including three days of silence (D1-3), five consecutive days of auditory enrichment (D4-8) and three days of silence (D9-11). We recorded clinical parameters, glucose, cortisol and behavior. Data were analyzed with GLIMMIX. Queens showed a significant increase of femoral pulse during exposure to M1, M2 and M4; and respiratory rate during exposure to M1, M2, M3 and M4 compared with CON. There was a significant increase in glucose during exposure to M2 and M5 compared with CON. However, there was a significant decrease in glucose during exposure to M4 compared with CON. There was a significant decrease in cortisol during exposure to M2 and M5 compared with CON. When we evaluated the ethogram, we observed a significant decrease in the percentage of interaction with other cats in M1 and M2 compared with CON. In addition, we found a significant decrease in the purring in M1 and M3 compared with CON. Auditory enrichment can be beneficial in situations that cause discomfort and distress in colony cats, such as in feline hospitalization; however, it should be acknowledged that there are limits to direct extrapolation.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"302-312"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0