Laboratory Animals最新文献_第10页

Causal mediation analysis: How to avoid fooling yourself that X causes Y. 因果中介分析：如何避免自欺欺人地认为 X 会导致 Y。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-10-01 Epub Date: 2024-08-11 DOI: 10.1177/00236772231217777

Stanley E Lazic

引用次数: 0

Incorporating sources of correlation between outcomes: An introduction to mixed models. 纳入结果之间的相关性来源：混合模型简介。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-10-01 Epub Date: 2024-09-20 DOI: 10.1177/00236772241259518

Limeng Liu, Ashley Petersen

{"title":"Incorporating sources of correlation between outcomes: An introduction to mixed models.","authors":"Limeng Liu, Ashley Petersen","doi":"10.1177/00236772241259518","DOIUrl":"10.1177/00236772241259518","url":null,"abstract":"Animal research often involves measuring the outcomes of interest multiple times on the same animal, whether over time or for different exposures. These repeated outcomes measured on the same animal are correlated due to animal-specific characteristics. While this repeated measures data can address more complex research questions than single-outcome data, the statistical analysis must take into account the study design resulting in correlated outcomes, which violate the independence assumption of standard statistical methods (e.g. a two-sample t-test, linear regression). When standard statistical methods are incorrectly used to analyze correlated outcome data, the statistical inference (i.e. confidence intervals and p-values) will be incorrect, with some settings leading to null findings too often and others producing statistically significant findings despite no support for this in the data. Instead, researchers can leverage approaches designed specifically for correlated outcomes. In this article, we discuss common study designs that lead to correlated outcome data, motivate the intuition about the impact of improperly analyzing correlated outcomes using methods for independent data, and introduce approaches that properly leverage correlated outcome data.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"463-469"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulation methodologies to determine statistical power in laboratory animal research studies. 确定实验动物研究统计能力的模拟方法。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI: 10.1177/00236772241273002

Angela Jeffers, Kathryn Konrad, Gary Larson, Katherine Allen-Moyer, Helen Cunny, Keith Shockley

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Murine astrovirus (MuAstV) infection in mouse facilities in Brazil: First South American report 巴西小鼠设施中的鼠星状病毒（MuAstV）感染：南美首份报告

IF 2.4 4区农林科学

Laboratory Animals Pub Date : 2024-09-11 DOI: 10.1177/00236772241257132

Marcia S C Oliveira, Tatiana X Castro, Camila F Baez, Simone Ramos, Gabriel R Azevedo, Carolina M de Castro, Ana Clara SS de Paula, Laura MB Levy, Emanuelle da S do Nascimento, Rafael B Varella

引用次数: 0

Non-invasive acquisition of vital data in anesthetized rats using laser and radar application 利用激光和雷达应用无创采集麻醉大鼠的生命数据

IF 2.4 4区农林科学

Laboratory Animals Pub Date : 2024-09-11 DOI: 10.1177/00236772241265541

Toshiaki Kawabe, Shota Kita, Isao Ohmura, Ryuji Michino, Hidenori Watanabe, Guanghao Sun, Seiya Inoue

{"title":"Non-invasive acquisition of vital data in anesthetized rats using laser and radar application","authors":"Toshiaki Kawabe, Shota Kita, Isao Ohmura, Ryuji Michino, Hidenori Watanabe, Guanghao Sun, Seiya Inoue","doi":"10.1177/00236772241265541","DOIUrl":"https://doi.org/10.1177/00236772241265541","url":null,"abstract":"The aim of this study was to verify the possibility of obtaining vital sign information using a laser and radar sensor in a manner that is non-invasive and painless for test animals. A dataset was obtained from respiratory movement of anaesthetized male F344 rats, signals of laser and radar sensors were recorded simultaneously with vital data acquired with an integrated multiple-channel intraoperative monitor. In addition, respiratory movements were also video recorded, and used as reference data of respiration rate (RR; ref-RR). Reference data for heart rate (HR; ref-HR) were obtained from the R wave of electrocardiogram data for each epoch. Signals recorded from the radar sensor (I- and Q-signals) were input to a computer, and HR (radar-HR) and RR (radar-RR) were estimated using the frequency analysis method. Among the six positions where respiratory movements were measured by the laser sensor, the number of peak counts matched the visual counts of respiratory movements in the video records. The respiratory movements were significantly the greatest over the most caudal rib in the dorsal ( p < 0.001). The average radar-RR and ref-RR values showed correspondence (ref-RR, 69 ± 6.2 breaths/min; radar-RR, 68 ± 5.7 breaths/min ( p = 0.04–1.00); equivalence ratio, 86%). The radar-HR data showed slight variability; however, there was 80% homology compared with the ref-HR values (ref-HR, 336 ± 19.6 beats/min; radar-HR, 348 ± 34.1 ( p = 0.10–0.95)). Although comparison of the data under noradrenaline administration failed to track drug-induced changes in some cases, the HR and RR data of anesthetized rats measured from the radar sensor system showed comparable accuracy to other conventional methods.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":"133 1","pages":"236772241265541"},"PeriodicalIF":2.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lethal Gram-negative sepsis in healthy pigs during anaesthesia with contaminated propofol. 健康猪在使用受污染的异丙酚进行麻醉期间发生致命的革兰氏阴性败血症。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1177/00236772231200524

Marit G Maaland, Marianne Oropeza-Moe, Silje K Nes, Frode Myrland, Cecilie Ersdal, Nils P Oveland

引用次数: 0

LAS Around the Globe - United States of America. 全球各地的 LAS - 美国。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1177/00236772231225896

Jennie Lofgren, Kelly Metcalf-Pate

引用次数: 0

Evaluation of a gel-based versus micro-pellet diet for adult zebrafish (Danio rerio). 评估成年斑马鱼（Danio rerio）的凝胶型和微颗粒型食物。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-08-05 DOI: 10.1177/00236772241244834

Christine L Archer, Nikki K Tsuji, Molly H Waters, Jennifer L Brazzell, Derek L Fong, Jori K Leszczynski, Christopher A Manuel, Lauren M Habenicht

引用次数: 0

Retrospective analysis on the occurrence of kidney cysts in mice in a central animal facility in the years 2009-2019. 2009-2019 年中央动物设施小鼠肾囊肿发生率的回顾性分析。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-08-05 DOI: 10.1177/00236772241242538

Katrin Becker

{"title":"Retrospective analysis on the occurrence of kidney cysts in mice in a central animal facility in the years 2009-2019.","authors":"Katrin Becker","doi":"10.1177/00236772241242538","DOIUrl":"10.1177/00236772241242538","url":null,"abstract":"Kidney cysts in humans are mainly caused by inheritable polycystic kidney disease. Although they are a regular finding in laboratory mice, their occurrence upon dissection has not been systematically investigated, yet. Therefore, the aim of this report was to investigate on prevalence, phenotype and aetiology of spontaneously occurring kidney cysts in mice by retrospectively analysing the laboratory-receipt tables of the in-house laboratory of a central animal facility in North Rhine-Westphalia, Germany, years 2009-2019. A percentage of 0.4% of dissected mice displayed kidney cysts, with more male than female animals affected and average age equal to that of all dissected animals. Preliminary report in half of the cases was distended abdomen, and a few individuals displayed additional pathologic alterations of kidneys, most commonly dilated renal pelvis, or extrarenal comorbidities. Kidney cysts occurred independently of a renal phenotype of the transgenic strain or presence of infectious agents in health monitoring. To conclude, kidney cysts were characterized as harmless for affected mice but, as inheritability is suggested according with the literature, affected animals should be excluded from breeding.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"380-386"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory enrichment with different genres of music for colony queens. 用不同类型的音乐丰富殖民地皇后的听觉。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-07-29 DOI: 10.1177/00236772241238264

María C García Mitacek, Romina G Praderio, Micaela Tebes, Florencia García, María C Stornelli, Rodolfo Luzbel de la Sota, María A Stornelli

{"title":"Auditory enrichment with different genres of music for colony queens.","authors":"María C García Mitacek, Romina G Praderio, Micaela Tebes, Florencia García, María C Stornelli, Rodolfo Luzbel de la Sota, María A Stornelli","doi":"10.1177/00236772241238264","DOIUrl":"10.1177/00236772241238264","url":null,"abstract":"The aim was to determine changes in clinical parameters, glucose concentration, cortisol and behavior in colony queens in no music conditions compared with exposing to different genres of music. Mixed breed clinically healthy queens (N = 9) were used. Queens were studied under no music conditions (control=CON) and auditory enrichment: Soft Rock (M1), Motown (M2), Pop (M3), Frenchcore (M4) and music that was composed to be species-appropriate for cats (M5). The queens underwent auditory enrichment, including three days of silence (D1-3), five consecutive days of auditory enrichment (D4-8) and three days of silence (D9-11). We recorded clinical parameters, glucose, cortisol and behavior. Data were analyzed with GLIMMIX. Queens showed a significant increase of femoral pulse during exposure to M1, M2 and M4; and respiratory rate during exposure to M1, M2, M3 and M4 compared with CON. There was a significant increase in glucose during exposure to M2 and M5 compared with CON. However, there was a significant decrease in glucose during exposure to M4 compared with CON. There was a significant decrease in cortisol during exposure to M2 and M5 compared with CON. When we evaluated the ethogram, we observed a significant decrease in the percentage of interaction with other cats in M1 and M2 compared with CON. In addition, we found a significant decrease in the purring in M1 and M3 compared with CON. Auditory enrichment can be beneficial in situations that cause discomfort and distress in colony cats, such as in feline hospitalization; however, it should be acknowledged that there are limits to direct extrapolation.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"302-312"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0