Laboratory Animals最新文献

Facility as a tool, program as the driver: Aligning infrastructure with a high-quality animal care and use program. 设施作为工具，计划作为驱动力：将基础设施与高质量的动物护理和使用计划相结合。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2026-09-02 DOI: 10.1177/00236772261472332

Javier Guillén, Sarah Wolfensohn

{"title":"Facility as a tool, program as the driver: Aligning infrastructure with a high-quality animal care and use program.","authors":"Javier Guillén, Sarah Wolfensohn","doi":"10.1177/00236772261472332","DOIUrl":"https://doi.org/10.1177/00236772261472332","url":null,"abstract":"Research animal facilities are often perceived as the defining element of high-quality animal care and use; however, international standards and accreditation practices increasingly emphasize that the animal care and use program (ACUP), rather than the physical infrastructure, is the central determinant of animal welfare, scientific quality, and ethical and legal oversight. This paper examines the relationship between the animal facility and a robust ACUP, arguing that the facility should be understood primarily as an enabling component of a broader institutional system. There is no universal 'ideal' facility design. Instead, infrastructure must be fit for purpose, reflecting the species housed, the nature of the research, institutional scale, available expertise, and staffing. A performance-based approach provides the most appropriate framework for evaluating facility adequacy, focusing on measurable welfare and operational outcomes rather than prescriptive engineering standards alone. The facility should actively support the implementation of the 3Rs (Replacement, Refinement, and Reduction) and the culture of care, promote operational efficiency, and incorporate principles of environmental and financial sustainability. Continual evaluation and improvement are essential to ensure that facilities and ACUPs evolve alongside animal, scientific, and institutional needs. General observations commonly made during AAALAC International accreditation site visits further illustrate how programmatic strength can compensate for infrastructure limitations, while well-designed facilities cannot substitute for weak governance or oversight. Ultimately, excellence in research animal care arises from the alignment of infrastructure, institutional culture of care, ethical responsibility, and programmatic management, with the facility serving as a flexible tool that supports, rather than defines, a high-quality animal care and use program.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"236772261472332"},"PeriodicalIF":1.3,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts from the 62nd Scientific Conference of GV-SOLAS, September 16-18 2026, Bonn, Germany. 第62届GV-SOLAS科学会议摘要，2026年9月16-18日，德国波恩。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2026-09-01 Epub Date: 2026-09-03 DOI: 10.1177/00236772261469706

引用次数: 0

Pain in laboratory fishes: What we know and what we need to know. 实验鱼的疼痛：我们知道的和我们需要知道的。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2026-08-31 DOI: 10.1177/00236772261474220

Lynne U Sneddon, Lisa Carlsson, Ana Maria Valentim

{"title":"Pain in laboratory fishes: What we know and what we need to know.","authors":"Lynne U Sneddon, Lisa Carlsson, Ana Maria Valentim","doi":"10.1177/00236772261474220","DOIUrl":"https://doi.org/10.1177/00236772261474220","url":null,"abstract":"The scientific exploration of the capacity of fishes to experience pain has grown since the first identification of nociceptors in rainbow trout in 2002. In the early years up to 2010 anatomical and electrophysiological evidence was gathered that demonstrated that the characteristics of peripheral and central nervous system responses were comparable to mammals. Combined with behavioural investigations where fishes exhibited anomalous responses to painful treatment that were ameliorated by pain-relieving drugs subsequent studies were fuelled by this convincing evidence. More contemporary studies have explored several species and investigated a wider variety of pain types, with zebrafish proposed as a model for the study of nociception and pain. Both operational and laboratory welfare indicators are detailed for several species which can be evaluated by the tank side or by additional behavioural scoring software and laboratory equipment. Even with this progress over the last 24 years many aspects still need to be uncovered. For efficient pain management for fishes used in science, a wider range of species need to be assessed during invasive procedures; the mechanism of action and pharmacokinetics of pain-relieving drugs must be elucidated so scientists can make informed choices, as well as identifying any possible side-effects; combinatorial strategies where more than one drug is administered at lower doses to reduce side-effects should be investigated; and pain assessment tools using intensity scales or monitoring using artificial intelligence evaluation software provides promise as an aid to identifying pain and allowing researchers to intervene to improve fish welfare.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"236772261474220"},"PeriodicalIF":1.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bipolar vessel sealing as a refinement in fowl cecectomy. 双极血管密封在鸡盲肠切除术中的应用。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2026-08-31 DOI: 10.1177/00236772261477459

Nadine Nautscher, Katharina Euchner, Martin Steffl, Jens Hartung

引用次数: 0

Laboratory animal science cannot afford sex bias: Aligning the 3Rs with sex-inclusive research. 实验动物科学不能承受性别偏见：将3r与性别包容性研究结合起来。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2026-08-30 DOI: 10.1177/00236772261481143

Fernando Gonzalez-Uarquin, Paulin Jirkof, Annemarie Lang, Ivana Jaric, Jordi L Tremoleda, Natasha A Karp, Rafael Frias Beneyto

引用次数: 0

Implementing refinements: Attitudes, experiences, barriers, and solutions identified by laboratory animal professionals. 实施改进：由实验动物专业人员确定的态度、经验、障碍和解决方案。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2026-08-30 DOI: 10.1177/00236772261476754

Anna S Ratuski, Michael W Brunt, Catherine A Schuppli, Daniel M Weary

{"title":"Implementing refinements: Attitudes, experiences, barriers, and solutions identified by laboratory animal professionals.","authors":"Anna S Ratuski, Michael W Brunt, Catherine A Schuppli, Daniel M Weary","doi":"10.1177/00236772261476754","DOIUrl":"https://doi.org/10.1177/00236772261476754","url":null,"abstract":"Refinements to improve the lives of animals used in science are generally endorsed by research institutions and regulatory bodies, but laboratory animal professionals face many barriers in implementing refinements. We sought to understand 1) attitudes and perceptions of barriers and solutions, and 2) how implementation of refinement may be influenced by norms and perceived behavioural control. We conducted three focus groups with 32 attendees at a Canadian laboratory animal science symposium, using semi-structured, open-ended questions. Five themes emerged: evidence and impact on research outcomes, regulatory oversight, operational limitations, institutional culture, and responsibility. Each of these themes was seen as influencing individual capacity to implement refinements. Overall, participants expressed positive attitudes towards refinement combined with frustration due to their limited ability to enact change. Barriers included decision-makers being disconnected from animal facility operations, an institutional culture that does not adequately value refinement, lack of time and money, concerns about impacts on data, and resistance to change among colleagues and animal users. Regulations were seen as both a barrier (when decision-makers did not support refinements beyond minimally required practices) and a solution (when refinements were explicitly required). Potential solutions included updates to regulations, assessments from oversight bodies, integration of the 3Rs into funding and grant review processes, greater inclusion of laboratory animal professionals in decision-making, and promotion of refinements during personnel training. Cultivating an institutional culture that prioritises refinement and addressing barriers to the perceived behavioural control of laboratory animal professionals could help to increase refinement uptake.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"236772261476754"},"PeriodicalIF":1.3,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multicystic renal dysplasia with ureteral anomaly and arteritis in a C3-deficient mouse. c3缺陷小鼠多囊肾发育不良伴输尿管异常和动脉炎。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2026-08-17 DOI: 10.1177/00236772261469961

Dhanushka Hewapathirana, Christine Goepfert

引用次数: 0

From incidents to insights: Fostering error cultures in laboratory animal science. 从事件到洞察：培养实验动物科学中的错误文化。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2026-08-12 DOI: 10.1177/00236772261470997

Sabine J Bischoff, Florian A Dehmelt

{"title":"From incidents to insights: Fostering error cultures in laboratory animal science.","authors":"Sabine J Bischoff, Florian A Dehmelt","doi":"10.1177/00236772261470997","DOIUrl":"https://doi.org/10.1177/00236772261470997","url":null,"abstract":"Where simulations are not enough to reveal biological processes, researchers in many fields choose to study animals. Among them, those working in laboratory animal science have unique insights and responsibilities, as their interactions with other species are never just a means to an end, but aimed towards understanding and improving those animals' welfare. In addition, its practitioners often hold key functions in between professional communities. Their attitudes and practices regarding errors thus affect those of many others. Despite growing recognition of the value of systematic error prevention and organisational learning, transparent and constructive error cultures are still rare in research facilities. This perspective article takes a brief look at the state of error reporting in laboratory animal science. We argue that the fragmented adoption of technological solutions reflects a deeper cultural deficit, and that changing it requires sustained effort by practitioners themselves. Genuine error cultures are not merely a compliance exercise, but a moral and institutional imperative - and as such, an integral part of Cultures of Care. Social science concepts like psychological safety or resilience engineering, as well as descriptive frameworks common to strategic management, provide tools to refocus attention on currently unresolved issues. With this in mind, we identify key challenges to be confronted at the level of individuals, institutions, and ecosystems. We outline a forward-looking vision in which error reporting becomes both an internalised cultural practice and standard operating procedure, employee wellbeing is structurally embedded and we engage proactively and responsibly with public expectations.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"236772261470997"},"PeriodicalIF":1.3,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inimitable leadership in animal care and program oversight. 在动物护理和项目监督方面具有无可比拟的领导能力。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2026-08-12 DOI: 10.1177/00236772261471002

F Claire Hankenson, Steven M Niemi

{"title":"Inimitable leadership in animal care and program oversight.","authors":"F Claire Hankenson, Steven M Niemi","doi":"10.1177/00236772261471002","DOIUrl":"https://doi.org/10.1177/00236772261471002","url":null,"abstract":"This reflective perspective on leadership in research animal care programs and the management of their operations aims to provide guiding principles, transferable across regulatory and institutional systems, for navigating current influences and future challenges. Inimitable leaders are those who embrace management with elevated professional standards, innovative insights, and sensitivity to the needs of multiple stakeholders. While a foundation in veterinary medicine and animal science is the most common background among directors of animal research programs, particularly those employed in the United States, managers and leaders everywhere need to be prepared for a future that will rely on clear communication, operational efficiency, skilled negotiations, overt investments in a Culture of Care and the 3Rs, and self-education for continuous improvement. As the future landscape of traditional animal models and translational research shifts irreversibly toward non-animal and novel alternative methodologies, so too should the inimitable leaders of tomorrow evolve to navigate the nuanced balance among animal welfare, biomedical discovery, and public scrutiny surrounding science for the benefit of humans and animals alike.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"236772261471002"},"PeriodicalIF":1.3,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From exposure to evidence: The present and future of rodent surgical training in laboratory animal science. 从暴露到证据：实验动物科学中啮齿动物外科训练的现在和未来。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2026-08-09 DOI: 10.1177/00236772261470979

Diego Celdran-Bonafonte, Petra Seebeck

{"title":"From exposure to evidence: The present and future of rodent surgical training in laboratory animal science.","authors":"Diego Celdran-Bonafonte, Petra Seebeck","doi":"10.1177/00236772261470979","DOIUrl":"https://doi.org/10.1177/00236772261470979","url":null,"abstract":"Surgical training remains one of the most consequential yet historically underexamined components of laboratory animal science (LAS). While advances in anesthesia, analgesia, asepsis, and oversight have improved welfare and scientific rigor, training has often relied on decentralized apprenticeship models with variable structure and assessment, sometimes leaving foundational surgical standards such as aseptic workflow, sterile gowning, and gloving insufficiently formalized. As regulatory expectations, societal scrutiny, and research complexity have increased, the limitations of exposure-based training have become more apparent. This perspective examines the evolution of rodent surgical training in LAS, highlighting both the strengths of the modern training ecosystem and persistent gaps in standardization, access, and competency assessment. Emerging simulation technologies, including 3D-printed and hybrid models, offer scalable opportunities to reduce training-related animal use, shorten learning curves, and introduce objective performance benchmarks before live procedures. Evidence from surgical education and experimental microsurgery supports a hybrid, competency-based approach in which simulation prepares trainees for supervised live animal work rather than replacing it. Looking ahead, coordinated validation frameworks, shared assessment tools, and institutional commitment will be essential to transition toward a structured, data-driven, and ethically aligned post-apprenticeship model of laboratory animal surgical training.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"236772261470979"},"PeriodicalIF":1.3,"publicationDate":"2026-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0