利用激光和雷达应用无创采集麻醉大鼠的生命数据

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Toshiaki Kawabe, Shota Kita, Isao Ohmura, Ryuji Michino, Hidenori Watanabe, Guanghao Sun, Seiya Inoue
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引用次数: 0

摘要

本研究旨在验证使用激光和雷达传感器获取生命体征信息的可能性,这种方式对试验动物来说是非侵入性和无痛的。研究人员从麻醉后的雄性 F344 大鼠的呼吸运动中获取了数据集,同时记录了激光和雷达传感器的信号以及术中多通道综合监护仪获取的生命体征数据。此外,还对呼吸运动进行了录像,并将其作为呼吸频率(RR;ref-RR)的参考数据。心率(HR;ref-HR)的参考数据来自每个时间段的心电图 R 波数据。雷达传感器记录的信号(I 信号和 Q 信号)被输入计算机,并使用频率分析方法估算心率(雷达-心率)和呼吸频率(雷达-呼吸频率)。在激光传感器测量到呼吸运动的六个位置中,峰值次数与视频记录中呼吸运动的目视次数相吻合。背侧最尾肋骨上的呼吸运动明显最大(p < 0.001)。雷达-RR 和 ref-RR 的平均值显示出对应关系(ref-RR,69 ± 6.2 次/分钟;雷达-RR,68 ± 5.7 次/分钟(p = 0.04-1.00);等效比,86%)。雷达-HR 数据显示出轻微的变异性;然而,与 ref-HR 值(ref-HR,336 ± 19.6 次/分钟;雷达-HR,348 ± 34.1 次/分钟(p = 0.10-0.95))相比,有 80% 的同源性。虽然在服用去甲肾上腺素的情况下进行的数据比较在某些情况下无法跟踪药物引起的变化,但雷达传感器系统测量的麻醉大鼠心率和心率数据显示出与其他传统方法相当的准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-invasive acquisition of vital data in anesthetized rats using laser and radar application
The aim of this study was to verify the possibility of obtaining vital sign information using a laser and radar sensor in a manner that is non-invasive and painless for test animals. A dataset was obtained from respiratory movement of anaesthetized male F344 rats, signals of laser and radar sensors were recorded simultaneously with vital data acquired with an integrated multiple-channel intraoperative monitor. In addition, respiratory movements were also video recorded, and used as reference data of respiration rate (RR; ref-RR). Reference data for heart rate (HR; ref-HR) were obtained from the R wave of electrocardiogram data for each epoch. Signals recorded from the radar sensor (I- and Q-signals) were input to a computer, and HR (radar-HR) and RR (radar-RR) were estimated using the frequency analysis method. Among the six positions where respiratory movements were measured by the laser sensor, the number of peak counts matched the visual counts of respiratory movements in the video records. The respiratory movements were significantly the greatest over the most caudal rib in the dorsal ( p < 0.001). The average radar-RR and ref-RR values showed correspondence (ref-RR, 69 ± 6.2 breaths/min; radar-RR, 68 ± 5.7 breaths/min ( p = 0.04–1.00); equivalence ratio, 86%). The radar-HR data showed slight variability; however, there was 80% homology compared with the ref-HR values (ref-HR, 336 ± 19.6 beats/min; radar-HR, 348 ± 34.1 ( p = 0.10–0.95)). Although comparison of the data under noradrenaline administration failed to track drug-induced changes in some cases, the HR and RR data of anesthetized rats measured from the radar sensor system showed comparable accuracy to other conventional methods.
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来源期刊
Laboratory Animals
Laboratory Animals 生物-动物学
CiteScore
4.90
自引率
8.30%
发文量
64
审稿时长
6-12 weeks
期刊介绍: The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.
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