{"title":"创新的护理方案成功地恢复非人类灵长类动物在mptp诱导的帕金森病:来自非洲绿猴(绿猴)的初步证据。","authors":"Tamar Ravins Yaish, Noa Eshkol Noy, Rony Kalman, Jing Guang, Halen Baker Erdman, Orilia Ben-Yishay Nizri, Shimon Firman, Xiaowei Liu, Marc Deffains, Uri Werner-Reiss, Galith Abourbeh, Zvi Israel, Hagai Bergman, Lily Iskhakova","doi":"10.1177/00236772241302576","DOIUrl":null,"url":null,"abstract":"<p><p>The MPTP-animal model of Parkinson's disease has significantly advanced our understanding of Parkinson's disease and the dopaminergic system, helping to establish disease mechanisms and develop therapeutic targets. The non-human primate (NHP) MPTP model is particularly valuable for replicating core Parkinson's disease motor symptoms, anatomical changes and electrophysiological variations seen in humans. However, MPTP-injection protocols often cause substantial suffering, leading to euthanasia. While some post-MPTP primates recovered spontaneously, purposefully induced recovery was considered unattainable. Our team developed a novel intensive care protocol (NICP) promoting complete recovery from MPTP-induced severe parkinsonism in NHPs. NICP provides therapeutic, nutritional and social support, enabling behavioral recovery and subsequent retirement to a primate sanctuary. This innovation enhances animal welfare and opens new prospects for veterinary care, emphasizing the need to explore recovery mechanisms for other chronic conditions induced for research.</p>","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"236772241302576"},"PeriodicalIF":1.3000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Innovative care protocol successfully rehabilitates non-human primates after MPTP-induced parkinsonism: Preliminary evidence from a restricted cohort of African Green Monkeys (<i>Chlorocebus sabaeus</i>).\",\"authors\":\"Tamar Ravins Yaish, Noa Eshkol Noy, Rony Kalman, Jing Guang, Halen Baker Erdman, Orilia Ben-Yishay Nizri, Shimon Firman, Xiaowei Liu, Marc Deffains, Uri Werner-Reiss, Galith Abourbeh, Zvi Israel, Hagai Bergman, Lily Iskhakova\",\"doi\":\"10.1177/00236772241302576\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The MPTP-animal model of Parkinson's disease has significantly advanced our understanding of Parkinson's disease and the dopaminergic system, helping to establish disease mechanisms and develop therapeutic targets. The non-human primate (NHP) MPTP model is particularly valuable for replicating core Parkinson's disease motor symptoms, anatomical changes and electrophysiological variations seen in humans. However, MPTP-injection protocols often cause substantial suffering, leading to euthanasia. While some post-MPTP primates recovered spontaneously, purposefully induced recovery was considered unattainable. Our team developed a novel intensive care protocol (NICP) promoting complete recovery from MPTP-induced severe parkinsonism in NHPs. NICP provides therapeutic, nutritional and social support, enabling behavioral recovery and subsequent retirement to a primate sanctuary. This innovation enhances animal welfare and opens new prospects for veterinary care, emphasizing the need to explore recovery mechanisms for other chronic conditions induced for research.</p>\",\"PeriodicalId\":18013,\"journal\":{\"name\":\"Laboratory Animals\",\"volume\":\" \",\"pages\":\"236772241302576\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-03-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Laboratory Animals\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/00236772241302576\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laboratory Animals","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/00236772241302576","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Innovative care protocol successfully rehabilitates non-human primates after MPTP-induced parkinsonism: Preliminary evidence from a restricted cohort of African Green Monkeys (Chlorocebus sabaeus).
The MPTP-animal model of Parkinson's disease has significantly advanced our understanding of Parkinson's disease and the dopaminergic system, helping to establish disease mechanisms and develop therapeutic targets. The non-human primate (NHP) MPTP model is particularly valuable for replicating core Parkinson's disease motor symptoms, anatomical changes and electrophysiological variations seen in humans. However, MPTP-injection protocols often cause substantial suffering, leading to euthanasia. While some post-MPTP primates recovered spontaneously, purposefully induced recovery was considered unattainable. Our team developed a novel intensive care protocol (NICP) promoting complete recovery from MPTP-induced severe parkinsonism in NHPs. NICP provides therapeutic, nutritional and social support, enabling behavioral recovery and subsequent retirement to a primate sanctuary. This innovation enhances animal welfare and opens new prospects for veterinary care, emphasizing the need to explore recovery mechanisms for other chronic conditions induced for research.
期刊介绍:
The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.