Innovative care protocol successfully rehabilitates non-human primates after MPTP-induced parkinsonism: Preliminary evidence from a restricted cohort of African Green Monkeys (Chlorocebus sabaeus).

IF 1.3 4区农林科学 Q2 VETERINARY SCIENCES

Laboratory Animals Pub Date : 2025-03-13 DOI:10.1177/00236772241302576

Tamar Ravins Yaish, Noa Eshkol Noy, Rony Kalman, Jing Guang, Halen Baker Erdman, Orilia Ben-Yishay Nizri, Shimon Firman, Xiaowei Liu, Marc Deffains, Uri Werner-Reiss, Galith Abourbeh, Zvi Israel, Hagai Bergman, Lily Iskhakova

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引用次数: 0

Abstract

The MPTP-animal model of Parkinson's disease has significantly advanced our understanding of Parkinson's disease and the dopaminergic system, helping to establish disease mechanisms and develop therapeutic targets. The non-human primate (NHP) MPTP model is particularly valuable for replicating core Parkinson's disease motor symptoms, anatomical changes and electrophysiological variations seen in humans. However, MPTP-injection protocols often cause substantial suffering, leading to euthanasia. While some post-MPTP primates recovered spontaneously, purposefully induced recovery was considered unattainable. Our team developed a novel intensive care protocol (NICP) promoting complete recovery from MPTP-induced severe parkinsonism in NHPs. NICP provides therapeutic, nutritional and social support, enabling behavioral recovery and subsequent retirement to a primate sanctuary. This innovation enhances animal welfare and opens new prospects for veterinary care, emphasizing the need to explore recovery mechanisms for other chronic conditions induced for research.

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创新的护理方案成功地恢复非人类灵长类动物在mptp诱导的帕金森病：来自非洲绿猴（绿猴）的初步证据。

帕金森病mptp动物模型的建立极大地推进了我们对帕金森病和多巴胺能系统的认识，有助于建立疾病机制和开发治疗靶点。非人灵长类动物（NHP） MPTP模型在复制核心帕金森病运动症状、解剖变化和人类电生理变化方面特别有价值。然而，mptp注射方案经常造成巨大的痛苦，导致安乐死。虽然一些mptp后灵长类动物可以自发恢复，但有目的的诱导恢复被认为是不可能实现的。我们的团队开发了一种新的重症监护方案（NICP），促进mptp诱导的NHPs严重帕金森病的完全康复。NICP提供治疗，营养和社会支持，使行为恢复和随后退休到灵长类动物保护区。这一创新提高了动物福利，为兽医护理开辟了新的前景，强调了探索其他慢性疾病的恢复机制的必要性。

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来源期刊

Laboratory Animals 生物-动物学

CiteScore

4.90

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.