Laboratory Animals最新文献_第6页

Brakes and leverages for reducing the environmental impact of laboratory animal facilities: A case study at the Institut Pasteur. 减少实验动物设施对环境影响的刹车和杠杆：巴斯德研究所的案例研究。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2025-02-01 Epub Date: 2024-12-14 DOI: 10.1177/00236772241280008

Marion Berard, Hélène da Conceiçao, Sébastien Bedu, Jean-Philippe Mocho

{"title":"Brakes and leverages for reducing the environmental impact of laboratory animal facilities: A case study at the Institut Pasteur.","authors":"Marion Berard, Hélène da Conceiçao, Sébastien Bedu, Jean-Philippe Mocho","doi":"10.1177/00236772241280008","DOIUrl":"10.1177/00236772241280008","url":null,"abstract":"The Institut Pasteur has set the ambition to encourage all staff to get involved in sustainable development across all departments on campus. The animal facility staff joined the efforts of the sustainable development department to analyse current and future processes and identify potential solutions and related brakes and leverages for the reduction of the animal facilities' environmental impact. The first step was to collect the managers' experience on the local initiatives. Then, the managers attended a workshop to share information on networks and initiatives relevant to the topic and community, and to discuss the use of consumables, including personal protective equipment, single use plastics, bedding, feed, water, chemicals, and waste management. On the topics of interest, local initiatives were specifically detailed to assess their eventual implementation in all the institute's animal facilities, and tasks were set to pursue the managers' efforts in the longer term. A scenario was used to teach how to compare the carbon footprints of washing and disinfection equipment and process and to decide on the design of an animal facility. Finally, a summary is drawn of the brakes and leverages for the reduction of the environmental impact of the institute's animal facilities.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"47-57"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A communication pipeline for in vivo imaging core facilities. 一种用于体内成像核心设备的通信管道。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2025-02-01 Epub Date: 2025-03-02 DOI: 10.1177/00236772241309759

Vasileios Ntafis

引用次数: 0

Management of zoonoses in research institutions - lessons learned from a Coxiella burnetii outbreak case. 研究机构的人畜共患病管理--从一例烧伤柯西氏菌爆发中汲取的教训。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2025-02-01 Epub Date: 2024-11-19 DOI: 10.1177/00236772241271028

Pia Ks Ostach, André Dülsner, Anne Keil, Stefan Nagel-Riedasch

{"title":"Management of zoonoses in research institutions - lessons learned from a Coxiella burnetii outbreak case.","authors":"Pia Ks Ostach, André Dülsner, Anne Keil, Stefan Nagel-Riedasch","doi":"10.1177/00236772241271028","DOIUrl":"10.1177/00236772241271028","url":null,"abstract":"When biomedical research investigates the human surgical situation in the need of a chronic course, it is more often possible to do so using large animal models. The use of farm animals always poses special challenges for the institution conducting the research in terms of infection prevention and occupational safety. Especially for the zoonotic disease coxiellosis it is important to be aware of the constant risk of pathogen introduction by small ruminants and to take appropriate precautions. In this way, personal injury should be avoided or at least be kept to a minimum in the event of infection since then sustainable zoonosis control can be immediately initiated. Using the example of a Q fever outbreak at a research facility, we want to share with this extended case report the importance of central emergency structures, provisions and the inclusion of relevant experts and disciplines in a crisis team. Its primary purpose is to support the affected facility and coordinate the implementation of necessary cleaning, disinfection and decontamination measures in close contact with the responsible local authorities. The aim is to inactivate the pathogen in a systematic and controlled manner in few steps of action only and to keep the interruption of the facility's operations as short as possible.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"93-103"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facility design and management. Strategies for high level biocontainment. 设施设计和管理。高水平生物隔离战略。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2025-02-01 Epub Date: 2024-08-09 DOI: 10.1177/00236772241247104

Mike Dennis, Michael Charlton, Samantha Elam, Sarah Wolfensohn

{"title":"Facility design and management. Strategies for high level biocontainment.","authors":"Mike Dennis, Michael Charlton, Samantha Elam, Sarah Wolfensohn","doi":"10.1177/00236772241247104","DOIUrl":"10.1177/00236772241247104","url":null,"abstract":"UK Health Security Agency is required to investigate the pathogenesis of emerging or re-emerging infections and to test novel interventions, such as vaccines and therapeutics against these and other diseases, such as tuberculosis and Ebola, that have a significant impact on human health world-wide. Research into the causative agents (mainly BSL 3 and 4) using a wide range of animal species as pre-clinical models brings a number of challenges in terms of effective biocontainment to address human safety whilst optimising delivery of scientific objectives and the welfare of the animals. Here we describe the strategies used for high containment of species that include mice, ferrets, hamsters, rabbits and macaques that have been infected with high consequence pathogens. To ensure relevance of these models we frequently challenge by the aerosol route and monitor the development of disease and protective or therapeutic efficacy by methodologies similar to those used in the clinic. We have devised methods of sampling that can inform on pathogenesis and immune function that include lung lavage and medical imaging such as computed tomography and positron emission tomography-computed tomography. Imaging assists our assessment of progression to disease whilst providing refinement in application of early humane endpoints. We have developed directional flow containment systems that provide quantifiable operator protection whilst allowing group housing and a wide range of enrichment strategies appropriate for each species. Furthermore, we have demonstrated our improvements in animal welfare through use of a software-based Animal Welfare Assessment Grid that was developed with help of NC3Rs funding and enables us to quantify the lifetime experience of animals.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"104-112"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Streamlining model organisms facilities operation: The benefits of a unified management structure. 简化示范有机设施的运作：统一管理结构的好处。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2025-02-01 Epub Date: 2025-02-28 DOI: 10.1177/00236772241309744

Manuel Rebelo, Joana Bom, Ana C Borges, Rute Marques, Marília Pereira, Ana S Leocádio, Liliana Vieira, Ana Ribeiro, Liliana Vale, Inês Santos, Sandra Crisóstomo, Vera Nunes, Maysa Franco, Adérito Vieira, Pedro Pinto, Ana R Machado, Jocelyne Demengeot

{"title":"Streamlining model organisms facilities operation: The benefits of a unified management structure.","authors":"Manuel Rebelo, Joana Bom, Ana C Borges, Rute Marques, Marília Pereira, Ana S Leocádio, Liliana Vieira, Ana Ribeiro, Liliana Vale, Inês Santos, Sandra Crisóstomo, Vera Nunes, Maysa Franco, Adérito Vieira, Pedro Pinto, Ana R Machado, Jocelyne Demengeot","doi":"10.1177/00236772241309744","DOIUrl":"10.1177/00236772241309744","url":null,"abstract":"This article is dedicated to elucidating and showcasing the concept of a unified Core Facility for laboratory animals within a research institute specialized in basic biology and biomedical research. In many research centres, animal facilities operate as autonomous entities. Here, we discuss that the centralization of all animal model units within a consolidated organizational framework offers a multitude of benefits in terms of communication with a variety of institutional stakeholders, including the Direction Board, Operational Logistics (Maintenance, Lab Operations and Safety Units), Procurement and Accounting Offices, Research Funding Affairs, Institutional Communication, and IT Units. This integrated approach facilitates the implementation of consistent policies and service pricing strategies. Moreover, it promotes staff flexibility across species, allows for responsiveness to evolving research dynamics, emergence of new scientific areas and infrastructure challenges. This concept also inspires technical advancement within the animal facilities, supports training in Laboratory Animal Science, stimulates the standardization of animal welfare practices, and instils a culture of care transversal to all animal models, ultimately enhancing overall animal welfare. This strategy facilitated the integration of non-vertebrate animals and plant models into the Core Facility. Despite significant differences from vertebrate models, this expansion presented advantages, such as incorporation of specialized staff into a larger organizational structure, offering them new opportunities for skill development and enhancing the overall flexibility of the Core Facility's operations.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"11-22"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thanks to Reviewers. 感谢评论者。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2025-02-01 Epub Date: 2025-04-10 DOI: 10.1177/00236772251314743

引用次数: 0

The use of performance-based outcomes in achieving better global harmonisation in the care and use of animals in research. 利用基于绩效的结果在研究动物的护理和使用方面实现更好的全球协调。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2025-02-01 Epub Date: 2025-02-28 DOI: 10.1177/00236772241309745

Dewi K Rowlands, Javier Guillén

{"title":"The use of performance-based outcomes in achieving better global harmonisation in the care and use of animals in research.","authors":"Dewi K Rowlands, Javier Guillén","doi":"10.1177/00236772241309745","DOIUrl":"10.1177/00236772241309745","url":null,"abstract":"Animal research remains a crucial component in our efforts to enhance both human and animal health. To better ensure research reproducibility and welfare of animals in research, harmonisation must be improved globally. This review explores the current state of harmonisation in animal research and the associated challenges, along with the roles of existing animal welfare principles, legislative guidelines, codes of practice, international and national organizations, and professional bodies in facilitating harmonisation. We discuss the current obstacles to harmonisation and suggest a performance-based solution. Examples of attainable performance-based outcomes are examined, encompassing areas such as ethical review and oversight, animal housing, environment, training, veterinary care, experimental design and reporting, and openness/transparency in research. In conclusion, the establishment of harmonised performance standards and the promotion of performance-based outcomes hold the potential to significantly improve global animal welfare in research and contribute to scientific advancement.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"120-127"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facility design and management: modern challenges and sustainability. 设施设计与管理：现代挑战与可持续性。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2025-02-01 Epub Date: 2025-04-10 DOI: 10.1177/00236772241300775

Silvina L Diaz, Patrick Sharp, Xavier Warot

引用次数: 0

Single nucleotide polymorphism (SNP) characterisation of mouse inbred strains bred at MRC-National Institute for Medical Research. 英国国家医学研究所（MRC-National Institute for Medical Research）培育的小鼠近交系的单核苷酸多态性（SNP）特征。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2025-02-01 Epub Date: 2024-10-13 DOI: 10.1177/00236772241273070

José M Sánchez-Morgado

{"title":"Single nucleotide polymorphism (SNP) characterisation of mouse inbred strains bred at MRC-National Institute for Medical Research.","authors":"José M Sánchez-Morgado","doi":"10.1177/00236772241273070","DOIUrl":"10.1177/00236772241273070","url":null,"abstract":"Inbred mouse strains have long proved useful as tools for biomedical research. They remove the effects of genetic background as an experimental variable. Within all mouse colonies, genetic drift is a recognised phenomenon and monitoring and documenting changes is important for experimental design and consistency. This communication documents the initial characterisation through SNP analysis of the inbred mouse strains bred and used at the time at the Medical Research Council National Institute for Medical Research (MRC-NIMR), Mill Hill, now The Crick Institute. These inbred strains were part of the foundation colonies for the many genetically modified mouse strains made at Mill Hill. We found small genetic changes in four of the nine inbred strains. Although phenotypic differences have not yet been found between the NIMR and the correspondent parental strains, I cannot discard that these may arise or have already arisen. This work has also authenticated the 129/SvJEvNimr-Gpi1c strain that was widely used at MRC-NIMR for gene targeting. All these inbred strains have been renamed according to The International Committee on Standardized Genetic Nomenclature for Mice.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"83-92"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Murine chapparvovirus (MuCPV)/mouse kidney parvovirus (MKPV) eradication by cross foster rederivation. 小鼠细小病毒(MuCPV)/小鼠肾细小病毒（MKPV）的交叉培养再分化根除。

IF 1.3 4区农林科学

Laboratory Animals Pub Date : 2025-02-01 Epub Date: 2025-02-04 DOI: 10.1177/00236772241277591

Ibrahim Faseeh, Vatthana Vongphakham, Patrick Sharp

{"title":"Murine chapparvovirus (MuCPV)/mouse kidney parvovirus (MKPV) eradication by cross foster rederivation.","authors":"Ibrahim Faseeh, Vatthana Vongphakham, Patrick Sharp","doi":"10.1177/00236772241277591","DOIUrl":"10.1177/00236772241277591","url":null,"abstract":"When diagnostic tests became available for the detection of mouse kidney parvovirus (MKPV), also known as murine chapparvovirus (MuCPV), we undertook a facility-wide screening to determine the prevalence of this novel agent in the Animal Resources Centre. MKPV was present only in the Customs Strains, specific-pathogen-free (SPF) barrier area, which was the only animal holding area that received mice imports directly from non-approved vendors. Based on this information, the knowledge and understanding of the viral epizootiology, and the testing methods available, we decided to eradicate MKPV after consultation with the researchers impacted. To eradicate MKPV from the barrier, we took a multi-modal approach composed of testing and separating positive and negative cages; and cross-foster (XF) rederivation. The test and separate approach was unsuccessful due to the animal housing and husbandry set up in the SPF barrier area given that MKPV is an environmentally stable and highly infectious agent. However, with an XF rederivation method, we were able to successfully rederive 11 out of 16 litters of various genetically modified lines that remained MKPV negative over a 20-week testing period. Our trial indicates that XF rederivation techniques, coupled with strict disinfection, can be used for a growing list of viral and other infectious agents that are highly infectious and persistent in the environment.","PeriodicalId":18013,"journal":{"name":"Laboratory Animals","volume":" ","pages":"63-74"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0