The use of performance-based outcomes in achieving better global harmonisation in the care and use of animals in research.

IF 1.3 4区农林科学 Q2 VETERINARY SCIENCES

Laboratory Animals Pub Date : 2025-02-28 DOI:10.1177/00236772241309745

Dewi K Rowlands, Javier Guillén

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引用次数: 0

Abstract

Animal research remains a crucial component in our efforts to enhance both human and animal health. To better ensure research reproducibility and welfare of animals in research, harmonisation must be improved globally. This review explores the current state of harmonisation in animal research and the associated challenges, along with the roles of existing animal welfare principles, legislative guidelines, codes of practice, international and national organizations, and professional bodies in facilitating harmonisation. We discuss the current obstacles to harmonisation and suggest a performance-based solution. Examples of attainable performance-based outcomes are examined, encompassing areas such as ethical review and oversight, animal housing, environment, training, veterinary care, experimental design and reporting, and openness/transparency in research. In conclusion, the establishment of harmonised performance standards and the promotion of performance-based outcomes hold the potential to significantly improve global animal welfare in research and contribute to scientific advancement.

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来源期刊

Laboratory Animals 生物-动物学

CiteScore

4.90

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.