Kidney360最新文献

{"title":"Association of Symptoms and Collaborative Care Intervention with Systemic Inflammation Biomarkers in ESKD.","authors":"Cramer J Kallem, Alaa A Alghwiri, Jonathan G Yabes, Maria-Eleni Roumelioti, Sarah Erickson, Bruce L Rollman, Steven Weisbord, Mark Unruh, Yoram Vodovotz, Manisha Jhamb, Jennifer L Steel","doi":"10.34067/KID.0000000000000512","DOIUrl":"10.34067/KID.0000000000000512","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Δ Anion Gap/Δ Bicarbonate Ratio in Lactic Acidosis: Time for a New Baseline?","authors":"Deborah Lu, Hubert Song, In-Lu Amy Liu, Jiaxiao Shi, Richard M Treger","doi":"10.34067/KID.0000000000000513","DOIUrl":"10.34067/KID.0000000000000513","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IFTA Foci Density: An Unrecognized Highly Prognostic Measurement of Fibrosis in Kidney Transplant Biopsies.","authors":"Aleksandar Denic, Andrew D Rule, Walter D Park, Byron H Smith, Mateo Velasquez Mejia, Aleksandra Kukla, Joseph P Grande, Mark D Stegall","doi":"10.34067/KID.0000000000000514","DOIUrl":"10.34067/KID.0000000000000514","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacotherapy and Stone Mineral Subtype Influence Long-Term Recurrence Rates in Calcium Stone Formers.","authors":"Rupam Ruchi, Elizabeth A Di Valerio, Shahab Bozorgmehri, Michael Waseer Bacchus, Benjamin K Canales, Russell Terry, John Michael DiBianco, Vincent G Bird","doi":"10.34067/KID.0000000000000526","DOIUrl":"10.34067/KID.0000000000000526","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifiable Factors Associated with Prolonged Dialysis Recovery Time and Fatigue in Hemodialysis Patients.","authors":"Mabel Aoun, Eric Laruelle, Gabrielle Duneau, Simon Duquennoy, Bruno Legendre, Simona Baluta, Thérèse Maroun, Aldjia Lamri, Morgane Gosselin, Jonathan Chemouny, Béatrice Champtiaux-Dechamps, Juliette Baleynaud, Lionel Le Mouellic, Céline Bellier, Marion Gritti, Claire Cain, Juliette Hervé, Pauline Colin, Sandrine Fleury, Christel Floch, Philippe Jousset, Thibault Dolley-Hitze","doi":"10.34067/KID.0000000000000532","DOIUrl":"10.34067/KID.0000000000000532","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dialysis Recovery Time-Can We Do Better?","authors":"Peter G Kerr","doi":"10.34067/KID.0000000000000533","DOIUrl":"10.34067/KID.0000000000000533","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onconephrology Fellowship Training: Current Status and Future Outlook.","authors":"Macro Bonilla, Abdallah S Geara","doi":"10.34067/KID.0000000000000495","DOIUrl":"10.34067/KID.0000000000000495","url":null,"abstract":"<p><p>Onconephrology, an emerging discipline nestled at the intersection of nephrology and oncology, has experienced remarkable growth over the past 15 years. This evolution has been punctuated by pivotal events, including establishing the American Society of Onconephrology, dedicated forums, and journals, highlighting its increasing significance. The clinical landscape of onconephrology is diverse, encompassing AKI in patients with cancer, toxicity from anticancer treatments, and a spectrum of electrolyte disorders, necessitating close collaboration between nephrologists and oncologists. However, trainees and mentors encounter various challenges surrounding its status as a distinct subspecialty. To overcome these barriers, there is a pressing need for streamlined training pathways, enhanced interdisciplinary collaboration, and targeted research efforts to elucidate the effect of onconephrology on patient outcomes. By addressing these challenges head-on, the field of onconephrology can continue its trajectory of growth and better serve patients with cancer with complex kidney needs.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Tolerability of ADR-001 Therapy for Immunoglobulin A Nephropathy.","authors":"Akihito Tanaka, Kazuhiro Furuhashi, Kumiko Fujieda, Asuka Horinouchi, Kayaho Maeda, Shoji Saito, Tetsushi Mimura, Yosuke Saka, Tomohiko Naruse, Takuji Ishimoto, Noritoshi Kato, Tomoki Kosugi, Fumie Kinoshita, Yachiyo Kuwatsuka, Yasuhiro Nakai, Shoichi Maruyama","doi":"10.34067/KID.0000000000000563","DOIUrl":"https://doi.org/10.34067/KID.0000000000000563","url":null,"abstract":"<p><strong>Background: </strong>Immunoglobulin A nephropathy often requires kidney replacement therapy because of its refractoriness and because corticosteroids pose infection risks. However, mesenchymal stem cells offer clinical benefits because of their regenerative and immunomodulatory properties. This prospective clinical trial assessed the safety and tolerability of adipose-derived mesenchymal stem cell therapy and evaluated its therapeutic efficacy.</p><p><strong>Methods: </strong>This phase 1 study included adult patients with refractory immunoglobulin A nephropathy that was difficult to treat with traditional therapies. Adipose-derived mesenchymal stem cell therapy comprising one intravenous dose of 1 × 108 cells was administered to three to six patients in cohort 1. The same intravenous dose was administered twice with a 2-week interval to six patients in cohort 2. Heparin was administered simultaneously. This study continued for 52 weeks, and the primary endpoints were safety and tolerability during the 6-week period after treatment administration. Secondary endpoints included adverse events and efficacy measures such as clinical remission, partial remission, urine protein remission, hematuria remission, time to remission, changes in the urine protein and hematuria levels, and changes in the estimated glomerular filtration rate.</p><p><strong>Results: </strong>The three patients in cohort 1 and six patients in cohort 2 who received adipose-derived mesenchymal stem cell therapy achieved the primary endpoints. No severe adverse clinical events were observed. Therefore, the safety and tolerability of adipose-derived mesenchymal stem cells were confirmed. Improvements such as significantly decreased kidney damage markers and urinary protein levels were observed immediately after adipose-derived mesenchymal stem cell administration.</p><p><strong>Conclusions: </strong>The safety and tolerability of adipose-derived mesenchymal stem cells are acceptable for patients with immunoglobulin A nephropathy.</p><p><strong>Trial registration: </strong>This trial was registered with the Japan Registry of Clinical Trials (jRCT2043200002; registration date: April 14, 2020) and ClinicalTrials.gov (NCT04342325; registration date: April 13, 2020).</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AKI Associated with Anti-cancer Therapies: Small Molecules and Targeted Therapies.","authors":"Jaya Kala, Teresa Joseph, Marta Pirovano, Roberta Fenoglio, Laura Cosmai","doi":"10.34067/KID.0000000566","DOIUrl":"https://doi.org/10.34067/KID.0000000566","url":null,"abstract":"<p><p>Molecular targeted therapy has revolutionized cancer treatment by significantly improving the patient survival compared to standard conventional chemotherapies. The use of these drugs targets specific molecules or targets which block growth and spread of cancer cells. Many of these therapies have been approved for use with remarkable success in breast, leukemia colorectal, lung and ovarian cancers. The advantage over conventional chemotherapy is its ability to deliver drug effectively with high specificity while being less toxic. Although known as \"targeted,\" many of these agents lack specificity and selectivity, and they tend to inhibit multiple targets including those in the kidneys. The side effects usually arise because of dysregulation of targets of the inhibited molecule in normal tissue. The \"off target\" effects are caused by drug binding to unintended targets. The \"on target\" effects are associated with inhibition towards the pathway reflecting inappropriate inhibition or activation of the intended drug target. Early detection and correct management of kidney toxicities is crucial to preserve kidney functions. The knowledge of these toxicities helps guide optimal and continued utilization of these potent therapies. This review summarizes the different types of molecular targeted therapies used in treatment of cancer, the incidence, severity and pattern of nephrotoxicity caused by them, with their plausible mechanism and proposed treatment recommendations.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palliative Care for Dialysis-Dependent Pediatric Patients: A Survey of Providers, Nurses, and Caregivers.","authors":"Joshua Lipsitz, Mark Stockton Beveridge, Katherine Maddox","doi":"10.34067/KID.0000000000000558","DOIUrl":"https://doi.org/10.34067/KID.0000000000000558","url":null,"abstract":"<p><strong>Background: </strong>Dialysis-dependent pediatric patients and their families face significant biopsychosocial burdens and low health-related quality of life. Palliative care consultations can alleviate some degree of suffering for patients and families but remain underutilized within pediatric nephrology. Little is known about how providers, nurses, and caregivers perceive palliative care integration into the multidisciplinary care of dialysis-dependent pediatric patients.</p><p><strong>Methods: </strong>This study surveyed pediatric nephrology providers (physicians and advanced practice providers), inpatient pediatric nephrology bedside nurses, and caregivers of dialysis-dependent pediatric patients at a freestanding tertiary care children's hospital in Dallas, Texas. Participants completed a survey regarding knowledge about, experiences with, and perceptions of palliative care in pediatric nephrology.</p><p><strong>Results: </strong>10 providers, 20 nurses, and 18 caregivers completed the survey. Although 80% of providers and all nurses agreed that palliative care would benefit dialysis-dependent pediatric patients, most believed that palliative care is not as important in pediatric nephrology as it should be. 70% of providers and 45% of nurses believed that they understand the scope of palliative care. 90% of providers and all nurses desired more palliative care education. Of the 22% of caregivers whose child had already received palliative care services, all found the consultation to be helpful. Many providers and nurses worried that a palliative care consultation would signal to families that the nephrology team would be giving up on their child and that their child is approaching the end of life. However, no caregivers thought that a consultation would mean that the nephrology team would be giving up on their child and only 6% worried that it would indicate that their child is approaching the end of life.</p><p><strong>Conclusions: </strong>These data support further palliative care education for pediatric nephrology providers and nurses and more robust and systematic involvement of subspecialty palliative care for dialysis-dependent pediatric patients.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}