Meredith P Schuh, Russel Griffin, Cara Slagle, David Selewski, Danielle E Soranno, Megan J Turner, Jennifer Varner, David Askenazi, Shina Menon, Katja M Gist
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引用次数: 0
摘要
背景:早产与低肾元禀赋相关,并增加以后生活中慢性肾脏疾病(CKD)的风险。几乎所有有早产风险的孕妇都给予产前皮质类固醇(ANS)以加速早产新生儿的肺成熟。与ANS类似,产后也给予皮质类固醇以改善肺功能,但对肾功能的影响尚不清楚。本研究的目的是确定早产儿在出生后使用皮质类固醇的时间和持续时间是否会影响24个月矫正年龄时的肾功能。方法:对PENUT试验(新生儿)的二次分析结果:在838名存活的婴儿中,397名(47%)暴露于任何出生后类固醇。地塞米松是最常见的暴露(n = 238,中位起始时间为生命日(DOL) 27,中位持续时间为8天),其次是氢化可的松(n = 232,中位起始时间为13,中位持续时间为17天)。在22-26个月的随访中对348名婴儿进行了评估,其中61名婴儿GFR降低。氢化可的松持续1-7天使24个月矫正年龄GFR降低的几率增加2.8倍(95% CI = 1.06-7.62)。虽然总体类固醇暴露与随访时的GFR无关,但与≥29周时给予地塞米松的患者相比,在≤25周时开始使用地塞米松的患者GFR降低的几率增加9.39 (95% CI = 1.61-54.71)。结论:虽然是观察性的,但本研究支持产后类固醇时间、持续时间和GFR降低之间的关联。进一步的研究是必要的,以更好地了解这种联系,以保护长期肾脏健康。