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Cullin 3/with No Lysine [K] Kinase/Ste20/SPS-Related Proline Alanine Rich Kinase Signaling: Impact on NaCl Cotransporter Activity in BP Regulation. Cullin3/WNK/SPAK 信号：对血压调节中 NaCl 共转运体活性的影响
IF 3.2
Kidney360 Pub Date : 2024-09-01 Epub Date: 2024-08-09 DOI: 10.34067/KID.0000000000000527
Kingsley Omage, James A McCormick
{"title":"Cullin 3/with No Lysine [K] Kinase/Ste20/SPS-Related Proline Alanine Rich Kinase Signaling: Impact on NaCl Cotransporter Activity in BP Regulation.","authors":"Kingsley Omage, James A McCormick","doi":"10.34067/KID.0000000000000527","DOIUrl":"10.34067/KID.0000000000000527","url":null,"abstract":"<p><p>The sodium chloride cotransporter (NCC) fine-tunes Na + balance and indirectly affects the homeostasis of other ions including K + , Mg 2+ , and Ca 2+ . Owing to its effects on Na + balance, BP is significantly affected by alterations in NCC activity. Several factors have been reported to influence the expression and activity of NCC. One critical factor is NCC phosphorylation/dephosphorylation that occurs at key serine-threonine amino acid residues of the protein. Phosphorylation, which results in increased NCC activity, is mediated by the with no lysine [K] (WNK)-SPS-related proline alanine rich kinase (SPAK)/OSR1 kinases. NCC activation stimulates reabsorption of Na + , increasing extracellular fluid volume and hence BP. On the other hand, proteasomal degradation of WNK kinases after ubiquitination by the Cullin 3-Kelch-like 3 E3 ubiquitin ligase complex and dephosphorylation pathways oppose WNK-SPAK/OSR1-mediated NCC activation. Components of the Cullin 3/Kelch-like 3-WNK-SPAK/OSR1 regulatory pathway may be targets for novel antihypertensive drugs. In this review, we outline the impact of these regulators on the activity of NCC and the consequent effect on BP.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141909935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Kidney Injury in a Young Woman after Dilation and Curettage. 一名年轻女性在扩张和刮宫术后出现急性肾损伤。
IF 3.2
Kidney360 Pub Date : 2024-09-01 DOI: 10.34067/KID.0000000000000519
Sandipan Shringi, Boris Sinayuk, Eric Kerns
{"title":"Acute Kidney Injury in a Young Woman after Dilation and Curettage.","authors":"Sandipan Shringi, Boris Sinayuk, Eric Kerns","doi":"10.34067/KID.0000000000000519","DOIUrl":"10.34067/KID.0000000000000519","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The COVID-19 Vaccination and IgA Nephropathy: Further Cause for Reassurance. COVID-19 疫苗接种与 IgA 肾病：更多保证
IF 3.2
Kidney360 Pub Date : 2024-09-01 DOI: 10.34067/KID.0000000000000530
Haresh Selvaskandan, Jonathan Barratt
{"title":"The COVID-19 Vaccination and IgA Nephropathy: Further Cause for Reassurance.","authors":"Haresh Selvaskandan, Jonathan Barratt","doi":"10.34067/KID.0000000000000530","DOIUrl":"10.34067/KID.0000000000000530","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Present and Imagining the Future Landscape of Onconephrology. 探索肿瘤肾脏病学的现状并畅想未来。
IF 3.2
Kidney360 Pub Date : 2024-09-01 Epub Date: 2024-08-26 DOI: 10.34067/KID.0000000000000544
Abinet M Aklilu, Anushree C Shirali
{"title":"Exploring the Present and Imagining the Future Landscape of Onconephrology.","authors":"Abinet M Aklilu, Anushree C Shirali","doi":"10.34067/KID.0000000000000544","DOIUrl":"10.34067/KID.0000000000000544","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Access to Expensive Therapies and Diagnostics for Kidney Care in Switzerland. 在瑞士，肾脏护理可获得昂贵的治疗和诊断。
IF 3.2
Kidney360 Pub Date : 2024-09-01 Epub Date: 2024-07-19 DOI: 10.34067/KID.0000000000000522
Valerie A Luyckx, Paul de Zwart, Giuseppina Spartà, Thomas F Mueller
{"title":"Access to Expensive Therapies and Diagnostics for Kidney Care in Switzerland.","authors":"Valerie A Luyckx, Paul de Zwart, Giuseppina Spartà, Thomas F Mueller","doi":"10.34067/KID.0000000000000522","DOIUrl":"10.34067/KID.0000000000000522","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Second Opinions after Adverse Determination of Kidney Transplant Evaluation. 肾移植评估结果不佳后的第二意见结果。
IF 3.2
Kidney360 Pub Date : 2024-09-01 Epub Date: 2024-08-02 DOI: 10.34067/KID.0000000000000529
Danielle S Kroll, Kyle J Woodward, Adarsh Ramakrishnan, Miko Yu, Heather K Morris, Joel T Adler, Lloyd E Ratner, Sumit Mohan, Syed Ali Husain
{"title":"Outcomes of Second Opinions after Adverse Determination of Kidney Transplant Evaluation.","authors":"Danielle S Kroll, Kyle J Woodward, Adarsh Ramakrishnan, Miko Yu, Heather K Morris, Joel T Adler, Lloyd E Ratner, Sumit Mohan, Syed Ali Husain","doi":"10.34067/KID.0000000000000529","DOIUrl":"10.34067/KID.0000000000000529","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pruritus Severity and Serum Phosphate in CKD: A Post Hoc Analysis of Difelikefalin Studies. 慢性肾脏病患者的瘙痒严重程度和血清磷酸盐：Difelikefalin 研究的事后分析。
IF 3.2
Kidney360 Pub Date : 2024-09-01 Epub Date: 2024-07-22 DOI: 10.34067/KID.0000000000000520
Steven N Fishbane, Geoff A Block, Pieter Evenepoel, Jeffrey Budden, Isabelle Morin, Frédérique Menzaghi, Warren Wen, Edgar V Lerma
{"title":"Pruritus Severity and Serum Phosphate in CKD: A Post Hoc Analysis of Difelikefalin Studies.","authors":"Steven N Fishbane, Geoff A Block, Pieter Evenepoel, Jeffrey Budden, Isabelle Morin, Frédérique Menzaghi, Warren Wen, Edgar V Lerma","doi":"10.34067/KID.0000000000000520","DOIUrl":"10.34067/KID.0000000000000520","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Proton Pump Inhibitors, Immune Checkpoint Inhibitors, and Acute Kidney Injury: A Nested Case-Control Study. 质子泵抑制剂、免疫检查点抑制剂与急性肾损伤之间的关系：一项嵌套病例对照研究。
IF 3.2
Kidney360 Pub Date : 2024-09-01 Epub Date: 2024-08-01 DOI: 10.34067/KID.0000000000000528
Chinami Yamawaki, Shunsaku Nakagawa, Keiko Ikuta, Yurie Katsube, Natsuki Imayoshi, Yuki Shigetsura, Daiki Hira, Shinya Yamamoto, Takeshi Matsubara, Motoko Yanagita, Tomohiro Terada
{"title":"Association between Proton Pump Inhibitors, Immune Checkpoint Inhibitors, and Acute Kidney Injury: A Nested Case-Control Study.","authors":"Chinami Yamawaki, Shunsaku Nakagawa, Keiko Ikuta, Yurie Katsube, Natsuki Imayoshi, Yuki Shigetsura, Daiki Hira, Shinya Yamamoto, Takeshi Matsubara, Motoko Yanagita, Tomohiro Terada","doi":"10.34067/KID.0000000000000528","DOIUrl":"10.34067/KID.0000000000000528","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lupus Nephritis: Immune Cells and the Kidney Microenvironment. 狼疮肾炎：免疫细胞与肾脏微环境
IF 3.2
Kidney360 Pub Date : 2024-09-01 Epub Date: 2024-08-09 DOI: 10.34067/KID.0000000000000531
Irene Chernova
{"title":"Lupus Nephritis: Immune Cells and the Kidney Microenvironment.","authors":"Irene Chernova","doi":"10.34067/KID.0000000000000531","DOIUrl":"10.34067/KID.0000000000000531","url":null,"abstract":"<p><p>Lupus nephritis (LN) is the most common major organ manifestation of the autoimmune disease SLE (lupus), with 10% of those afflicted progressing to ESKD. The kidney in LN is characterized by a significant immune infiltrate and proinflammatory cytokine milieu that affects intrinsic renal cells and is, in part, responsible for the tissue damage observed in LN. It is now increasingly appreciated that LN is not due to unidirectional immune cell activation with subsequent kidney damage. Rather, the kidney microenvironment influences the recruitment, survival, differentiation, and activation of immune cells, which, in turn, modify kidney cell function. This review covers how the biochemical environment of the kidney ( i.e ., low oxygen tension and hypertonicity) and unique kidney cell types affect the intrarenal immune cells in LN. The pathways used by intrinsic renal cells to interact with immune cells, such as antigen presentation and cytokine production, are discussed in detail. An understanding of these mechanisms can lead to the design of more kidney-targeted treatments and the avoidance of systemic immunosuppressive effects and may represent the next frontier of LN therapies.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141909937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gross Hematuria after the COVID-19 mRNA Vaccination: Nationwide Multicenter Prospective Cohort Study in Japan. 接种 COVID-19 mRNA 疫苗后出现血尿：日本全国多中心前瞻性队列研究。
IF 3.2
Kidney360 Pub Date : 2024-09-01 Epub Date: 2024-07-08 DOI: 10.34067/KID.0000000000000498
Ryousuke Aoki, Yoshihito Nihei, Keiichi Matsuzaki, Hitoshi Suzuki, Masao Kihara, Asa Ogawa, Tomoya Nishino, Satoru Sanada, Shinya Yokote, Masahiro Okabe, Sayuri Shirai, Akihiro Fukuda, Junichi Hoshino, Daisuke Kondo, Takashi Yokoo, Naoki Kashihara, Ichiei Narita, Yusuke Suzuki
{"title":"Gross Hematuria after the COVID-19 mRNA Vaccination: Nationwide Multicenter Prospective Cohort Study in Japan.","authors":"Ryousuke Aoki, Yoshihito Nihei, Keiichi Matsuzaki, Hitoshi Suzuki, Masao Kihara, Asa Ogawa, Tomoya Nishino, Satoru Sanada, Shinya Yokote, Masahiro Okabe, Sayuri Shirai, Akihiro Fukuda, Junichi Hoshino, Daisuke Kondo, Takashi Yokoo, Naoki Kashihara, Ichiei Narita, Yusuke Suzuki","doi":"10.34067/KID.0000000000000498","DOIUrl":"10.34067/KID.0000000000000498","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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