Kidney360最新文献

{"title":"The Association Between Diabetes and Mortality is Not Modified by Living Arrangements in Hemodialysis Patients in Japan.","authors":"Mutsumi Uesugi, Anna Tsutsui, Yoshitaka Murakami","doi":"10.34067/KID.0000000784","DOIUrl":"https://doi.org/10.34067/KID.0000000784","url":null,"abstract":"<p><strong>Background: </strong>Living arrangements, such as living alone or with a spouse, may affect mortality risk in hemodialysis patients with diabetes. This study investigated whether living arrangements modify the association between diabetes and mortality in community-dwelling hemodialysis patients in Japan.</p><p><strong>Methods: </strong>Using data from 27 outpatient dialysis units, this retrospective cohort study analysed 2799 community-dwelling hemodialysis patients (women: 33.7%) aged 40-89 years between April 2016 and March 2021. Each patient was placed into one of three categories according to living arrangements: living alone, with a spouse, or with others (excluding spouses). Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality. Interaction analyses were performed to assess the potential effect measure modification of the association between diabetes and mortality by living arrangements. The analyses were also conducted according to sex and age groups (40-64 and 65-89 years).</p><p><strong>Results: </strong>A total of 835 deaths were observed during a mean follow-up period of 3.9 years. Diabetes showed a significantly higher mortality risk (HR: 1.63, 95% CI: 1.42-1.89) in all patients. However, patients living alone did not have a significantly higher mortality risk than those living with a spouse (HR: 1.04, 95% CI: 0.87-1.24). There was no significant interaction between diabetes and living arrangements (P=0.73). Women aged 65-89 years who were living with others had a significantly higher mortality risk than those living with a spouse (HR: 1.41, 95% CI: 1.04-1.92).</p><p><strong>Conclusions: </strong>Living arrangements did not modify the association between diabetes and mortality in community-dwelling hemodialysis patients. Frequent clinic visits and lifestyle support by medical staff related to hemodialysis treatment may have facilitated diabetes management and mitigated the negative influence of social isolation, thereby reducing mortality risk.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxyurea and Regression of Sickle Cell Nephropathy: Open Clinical Trial in a Pediatric Population in DR Congo.","authors":"Dieumerci Betukumesu Kabasele, Arriel Makembi Bunkete, Gloire Mbayabo, Paul Lumbala, Odio Matondo, Michel Aloni, Orly Kazadi, Tite Mikobi, Joseph Bodi Mabiala, François Kajingulu, Jean-Robert Makulo Rissassi, Ernest Sumaili, Prosper Lukusa, Jean-Lambert Gini Ehungu","doi":"10.34067/KID.0000000805","DOIUrl":"https://doi.org/10.34067/KID.0000000805","url":null,"abstract":"<p><strong>Background: </strong>Renal complications of sickle cell disease are becoming very common, and patients generally do not respond to conventional nephroprotective treatments. Among the drugs used, hydroxyurea (HU) seems to have produced good results according to some studies. This molecule has not yet been evaluated in the DR Congo for this purpose. To evaluate albuminuria and the glomerular filtration rate (GFR) after 9 months of HU treatment in a population of children with incipient sickle cell nephropathy.</p><p><strong>Methods: </strong>This was an open clinical trial involving sickle cell syndrome children under 18 years of age followed by incipient sickle cell nephropathy (glomerular hyperfiltration =GHF and/or microalbuminuria). A mean HU dose of 20 mg/kg/d was administered to each child, with quarterly clinical and biological controls. GHF (new Schwartz formula) was defined as a rate > 130 ml/min/1.73 m2 for girls and > 140 ml/min/1.73 m2 for boys; albuminuria was defined as the albuminuria/creatinuria ratio (ACR) in mg/g. The Wilcoxon and McNemar tests were used to compare the results at admission and at the 9th month of treatment.</p><p><strong>Results: </strong>In total, 30 children (mean age 8.9±4.1 years; 40% boys) whose mean fetal hemoglobin (HbF) level increased from 10±7.4 to 18.8±4.9% (p˂0.001), whose mean number of blood transfusions ranged from 7.4±6.7 to 0.1±0.3 bags/month (p˂0.001), and whose number of VOCs ranged from 1.8±1.1 to 0.2±0.4/month (p˂0.03) were included. The frequency of GHF decreased from 30% to 3.3% (p˂0.001). The mean albuminuria decreased from 122.5 ± 16.3 mg/g to 30 ± 2.4 mg/g.</p><p><strong>Conclusions: </strong>HU improved the course of sickle cell nephropathy. The mechanism of action behind this result appears to be an improvement in blood rheology.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns in Heart Rate Variability during Hemodialysis.","authors":"Benjamin Lidgard, Nisha Bansal, Nathaniel Ashford, Leila R Zelnick, Ian H de Boer","doi":"10.34067/KID.0000000788","DOIUrl":"https://doi.org/10.34067/KID.0000000788","url":null,"abstract":"<p><strong>Background: </strong>Decreased Heart Rate Variability (HRV) is a measure of poor cardiovascular health and inability of the autonomic nervous system to respond to stress. Accumulation of uremic toxins in kidney failure, volume shifts, and clearance of uremic toxins by dialysis may impact HRV. We sought to evaluate how HRV changes over the course of hemodialysis sessions, and evaluate a novel HRV sensor.</p><p><strong>Methods: </strong>Among 22 participants treated with in-center hemodialysis, we evaluated time-domain and frequency-domain HRV metrics with a gold-standard ECG device (Schiller CARDIOVIT AT-10 Plus) and a novel fingertip sensor (EliteHRV CorSense) at five time points during 2 consecutive dialysis sessions. Changes over the session were evaluated by linear mixed models with random effect terms for participant and session. Devices were compared using correlation coefficients, Wilcoxon rank sum tests, and linear regression.</p><p><strong>Results: </strong>There were no significant changes in HRV metrics over the dialysis session (p-value for trend across ECG 0.11, across CorSense 0.58). Time-domain HRV metrics were moderately correlated between the two methods (correlation coefficient for SDNN 0.72 and for RMSSD 0.66), while frequency-domain methods were not. Linear models comparing CorSense and ECG readings suggested strong association for time-domain metrics.</p><p><strong>Conclusions: </strong>HRV metrics did not significantly change over the course of hemodialysis sessions, suggesting poor autonomic function during dialysis. A novel fingertip sensor accurately measured time-domain (but not frequency-domain) HRV metrics when compared to a gold-standard ECG device.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should Protocol Kidney Biopsies be a Part of Routine Post-Transplant Care? PRO.","authors":"George T John, Brian P Doucet","doi":"10.34067/KID.0000000000000419","DOIUrl":"10.34067/KID.0000000000000419","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"501-503"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing Meaningful Patient-Centered Outcomes with Relevance for Patients with Polycystic Kidney Disease: Patient, Caregiver, and Researcher Priorities for Research in Polycystic Kidney Disease.","authors":"Reem A Mustafa, Hassan Kawtharany, Mohamad A Kalot, Crystal Y Lumpkins, Kim S Kimminau, Cathy Creed, Kevin Fowler, Ronald D Perrone, Allison Jaure, Yeoungjee Cho, David Baron, Alan S L Yu","doi":"10.34067/KID.0000000695","DOIUrl":"10.34067/KID.0000000695","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"573-582"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensity of Glomerular C3 Deposits in IgA Nephropathy Predicts Early KRT.","authors":"João Venda, Beatriz Ferreira, Andreia Henriques, Pedro Castro, Rita Leal, Luís Rodrigues, Vitor Sousa, Ana Galvão, Rui Alves","doi":"10.34067/KID.0000000735","DOIUrl":"10.34067/KID.0000000735","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"645-647"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Kidney Injury and Nephrotic Syndrome in a Man Ingesting Traditional Indigenous Medications.","authors":"Vishal Ramteke, Niraj Kanchankar, Vrushali Deshpande","doi":"10.34067/KID.0000000655","DOIUrl":"10.34067/KID.0000000655","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"6 4","pages":"673-675"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Measurement of Calciprotein Particles with Different Assays and Clinical Outcomes in CKD.","authors":"Mark K Tiong, Stephen G Holt, Martin L Ford, Edward R Smith","doi":"10.34067/KID.0000000700","DOIUrl":"10.34067/KID.0000000700","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"6 4","pages":"550-560"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial Renal Glucosuria and Potential Pharmacogenetic Impact on Sodium-Glucose Cotransporter-2 Inhibitors.","authors":"Patrick Allaire, Jamie Fox, Terrie Kitchner, Rachel Gabor, Connie Folz, Shankar Bettadahalli, Scott Hebbring","doi":"10.34067/KID.0000000621","DOIUrl":"10.34067/KID.0000000621","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" 0","pages":"521-530"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Dialysis Perspective: Romania.","authors":"Gabriel Stefan, Gabriel Mircescu","doi":"10.34067/KID.0000000752","DOIUrl":"10.34067/KID.0000000752","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"6 4","pages":"648-651"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}