Kidney360最新文献

{"title":"Classifying Severe Acute Kidney Injury in Cirrhosis: Implications for Mortality?","authors":"Daniel Pascal Msilanga, Yuenting Diana Kwong","doi":"10.34067/KID.0000000637","DOIUrl":"10.34067/KID.0000000637","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"6 2","pages":"182-184"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Outcomes Requires Understanding the Problem: The Need for Mechanistic Approaches to Solute Dysregulation in Hemodialysis.","authors":"Timothy E Yen, Tariq Shafi","doi":"10.34067/KID.0000000718","DOIUrl":"10.34067/KID.0000000718","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"6 2","pages":"185-186"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Onconephrology Fellowship Training: Current Status and Future Outlook.","authors":"Marco Bonilla, Abdallah S Geara","doi":"10.34067/KID.0000000715","DOIUrl":"10.34067/KID.0000000715","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"336"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Disease and Hematopoietic Stem Cell Transplantation.","authors":"Amanda DeMauro Renaghan, José Maximino Costa, Alexandra Esteves","doi":"10.34067/KID.0000000692","DOIUrl":"10.34067/KID.0000000692","url":null,"abstract":"<p><p>Hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for patients with hematologic malignancies and certain solid tumors and nonmalignant hematologic conditions. Both AKI and CKD occur commonly after HSCT and are associated with significant morbidity and mortality. AKI and CKD in this setting may result from direct effects of the transplant or be caused by pretransplant bone marrow conditioning regimens and/or nephrotoxic agents administered in the post-transplant period. In this article, we review the epidemiology, risk factors, etiologies, pathophysiology, diagnosis, prevention, and treatment of post-HSCT AKI and CKD, with special attention to recent advances in this fast-moving and evolving field.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"317-330"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage-Specific Lactate Dehydrogenase Expression Modulates Inflammatory Function In Vitro.","authors":"Yan Lu, Gunars Osis, Anna A Zmijewska, Amie Traylor, Saakshi Thukral, Landon Wilson, Stephen Barnes, James F George, Anupam Agarwal","doi":"10.34067/KID.0000000630","DOIUrl":"10.34067/KID.0000000630","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"197-207"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Acceptability of a Palliative Care Intervention among Older Adults with Advanced CKD and Their Caregivers.","authors":"Fahad Saeed, Robert K Horowitz, Rebecca J Allen, Peggy Auinger, Ronald M Epstein, Kevin A Fiscella, Peter J Veazie, Paul R Duberstein","doi":"10.34067/KID.0000000622","DOIUrl":"10.34067/KID.0000000622","url":null,"abstract":"<p><strong>Background: </strong>In non-nephrology settings, specialty palliative care (PC) improves decision making, patient's quality of life (QoL), advance care planning, and certain indicators of the quality of end-of-life (EoL) care. This pilot randomized control trial (RCT) explored the feasibility and acceptability of a PC intervention, CKD-EDU, for adults aged 75 years and older with eGFR ≤25 ml/min and their caregivers.</p><p><strong>Methods: </strong>Participants randomized to the control group received standard nephrology care and routine kidney therapy education, whereas those randomized to CKD-EDU received a decision aid and met with a PC clinician up to three times to discuss kidney therapy decisions and EoL planning. Patients were assessed at baseline, 4–6, 12–14, and 24–26 weeks. Main outcomes included intervention feasibility and acceptability, decision conflict, and patient QoL. The mediating effects of reduced decision conflict on improved QoL were explored, as were the effects of CKD-EDU on advance care planning, EoL treatment intensity, and 6-month hospitalization. Statistical analyses encompassed descriptive analyses, adjusted repeated-measure models, mediation analyses, and logistic regression models.</p><p><strong>Results: </strong>Among the 127 eligible patients screened, 58 (46%) consented: 30 were randomized to CKD-EDU and 28 to the control arm. All patients completed baseline assessments and 89% completed at least 1 intervention session (n=26/29), underscoring intervention adherence and feasibility. Similarly, assessment completion rates at 4 (83%, n=45/54), 12 (93%, n=42/45), and 24 (95%, n=40/42) weeks were high. The intervention received over 85% acceptability ratings for all questions. Patients exposed to CKD-EDU exhibited significant improvement in Decisional Conflict Scale scores (P = 0.003) at 4–6 weeks and improvements in QoL at 24–26 weeks (P = 0.02). Exploratory analyses were not statistically significant in this pilot study, but all effect sizes were in the predicted direction.</p><p><strong>Conclusions: </strong>This study demonstrates the feasibility and acceptability of CKD-EDU. A larger scale trial is warranted to assess its effectiveness in improving key outcomes important to patients and families.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"6 2","pages":"236-246"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Low-Brilliance X-Ray Phase-Contrast Tomography and Contrast-Enhanced Attenuation-Contrast Micro-Computed Tomography of Rat Kidneys.","authors":"Henrik Mäkinen, Satu Kuure, Jukka Jernvall, Vilma Väänänen, Simo Huotari, Heikki Suhonen","doi":"10.34067/KID.0000000680","DOIUrl":"10.34067/KID.0000000680","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"303-310"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and Caregiver Perspectives on Gender Disparity in CKD: An Interview Study.","authors":"Michał J Lewandowski, Amelie Kurnikowski, Lenka Vanek, Philipp Bretschneider, Elisabeth Schwaiger, Simon Krenn, Sebastian Hödlmoser, Philipp Gauckler, Markus Pirklbauer, Sabine Horn, Maria Brunner, Emanuel Zitt, Bernhard Kirsch, Martin Windpessl, Ida Aringer, Martin Wiesholzer, Valentin Ritschl, Tanja Stamm, Allison Jauré, Manfred Hecking","doi":"10.34067/KID.0000000594","DOIUrl":"10.34067/KID.0000000594","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"227-235"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: A Pragmatic Low-Salt Diet in Patients with CKD.","authors":"Sunil Bhandari","doi":"10.34067/KID.0000000698","DOIUrl":"10.34067/KID.0000000698","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"6 2","pages":"335"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Language Processing Identifies Under-Documentation of Symptoms in Patients on Hemodialysis.","authors":"Yang Dai, Huei Hsun Wen, Joanna Yang, Neepa Gupta, Connie Rhee, Carol R Horowitz, Dinushika Mohottige, Girish N Nadkarni, Steven Coca, Lili Chan","doi":"10.34067/KID.0000000694","DOIUrl":"https://doi.org/10.34067/KID.0000000694","url":null,"abstract":"<p><strong>Background: </strong>Patients on hemodialysis (HD) have a high burden of emotional and physical symptoms. These symptoms are often under-recognized. NLP can be used to identify patient symptoms from the EHR. However, whether symptom documentation matches patient reported burden is unclear.</p><p><strong>Methods: </strong>We conducted a prospective study of patients seen at an ambulatory nephrology practice from September 2020 to April 2021. We collected symptom surveys from patients, nurses, and physicians. We then developed a natural language processing (NLP) algorithm to identify symptoms from the patients' electronic health records (EHR) and validated the performance of this algorithm using manual chart review and patient surveys as a reference standard. Using patient surveys as the reference standard, we compared symptom identification by 1) physicians, 2) nurses, 3) physicians or nurses, and 4) NLP.</p><p><strong>Results: </strong>We enrolled 97 patients into our study, 63% were female, 49% were Non-Hispanic Black, and 41% were Hispanic. The most common symptoms reported by patients were fatigue (61%), cramping (59%), dry skin (53%), muscle soreness (43%), and itching (41%). Physicians and nurses significantly under-recognized patients' symptoms (sensitivity 0.51 (95% CI 0.40-0.61) and 0.63 (95% CI 0.52-0.72) respectively). Nurses were better at identifying symptoms when patients reported more severe symptoms. There was no difference in results by patients' sex or ethnicity. NLP had a sensitivity of 0.92, specificity of 0.95, PPV of 0.75, and NPV of 0.99 with manual EHR review as the reference standard, and a sensitivity of 0.58 (95% CI 0.47-0.68), specificity of 0.73 (95% CI 0.48-0.89), PPV of 0.92 (95% CI 0.82-0.97), and NPV of 0.24 (95% CI 0.14-0.38) compared with patient surveys.</p><p><strong>Conclusions: </strong>While patients on HD report high prevalence of symptoms, symptoms are under-recognized and under-documented. NLP was accurate at identifying symptoms when they were documented. Larger studies in representative populations are needed to assess the generalizability of the results of the study.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}