{"title":"Erratum: Correction of Figures in the Article \"<i>UPF1</i> Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating <i>SMURF2</i>-Mediated Ubiquitination Degradation of <i>FOXA2</i>\".","authors":"Aixin Li, Peng Li, Chunling Mu, Dong Li, Keyan Chen, Zhaoguang Liang","doi":"10.4070/kcj.2025.0997","DOIUrl":"10.4070/kcj.2025.0997","url":null,"abstract":"<p><p>This corrects the article on p. 305 in vol. 55, PMID: 39962965.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"55 7","pages":"655-657"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiesuck Park, Hong-Mi Choi, Ji Hyun Lee, Hye Jung Choi, In-Chang Hwang, Youngjin Cho, Yeonyee E Yoon, Il-Young Oh, Goo-Yeong Cho
{"title":"Influence of Rhythm Control on Functional Mitral and Tricuspid Regurgitation Severity and Clinical Outcome in Patients With Atrial Fibrillation: A Propensity-Matched Cohort Study.","authors":"Jiesuck Park, Hong-Mi Choi, Ji Hyun Lee, Hye Jung Choi, In-Chang Hwang, Youngjin Cho, Yeonyee E Yoon, Il-Young Oh, Goo-Yeong Cho","doi":"10.4070/kcj.2025.0041","DOIUrl":"https://doi.org/10.4070/kcj.2025.0041","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study evaluated the efficacy of atrial fibrillation (AF) rhythm control therapy in improving functional mitral regurgitation (MR) and tricuspid regurgitation (TR) and its association with clinical outcomes.</p><p><strong>Methods: </strong>Among 2,574 patients with AF screened from 2003 to 2023, 817 pairs of patients were selected through propensity matching to compare rhythm control therapy (antiarrhythmic drugs, catheter ablation, or electrical cardioversion) with no rhythm control. MR and TR severity were assessed at baseline and follow-up echocardiography conducted at least 3-month intervals. Clinical outcomes included all-cause mortality and heart failure-related hospitalizations.</p><p><strong>Results: </strong>Rhythm control was associated with a reduction in moderate or greater MR (7.3% to 4.9%, p=0.008) and attenuation of TR progression (9.1% to 9.3%, p=0.796), contrary to the worsening trends in the no rhythm control group. Sinus restoration was more frequent in the rhythm control group compared to the no rhythm control group (60.2% vs. 48.1%, p<0.001). Patients maintaining sinus rhythm after rhythm control showed the greatest MR improvement (7.3% to 3.5%, p=0.002). Rhythm control was also associated with reverse cardiac remodeling, including reductions in left atrial volume index and improved left ventricular ejection fraction (both p<0.001). Clinical outcomes were more favorable in the rhythm control group, particularly among patients with improved regurgitation or restored sinus rhythm.</p><p><strong>Conclusions: </strong>AF rhythm control therapy is associated with improved functional MR, attenuated TR progression, enhanced sinus rhythm maintenance, and favorable clinical outcomes. Echocardiography can provide valuable information for identifying the optimal timing of rhythm control intervention and assessing treatment response.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soongu Kwak, Jihoon Kim, Chan-Soon Park, Hyun-Jung Lee, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Hyung-Kwan Kim, Sang-Chol Lee, Andrew Wang
{"title":"Prognostic Implication of Left Ventricular Global Longitudinal Strain in Patients With Hypertrophic Cardiomyopathy and Coexisting Hypertension.","authors":"Soongu Kwak, Jihoon Kim, Chan-Soon Park, Hyun-Jung Lee, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Hyung-Kwan Kim, Sang-Chol Lee, Andrew Wang","doi":"10.4070/kcj.2024.0213","DOIUrl":"10.4070/kcj.2024.0213","url":null,"abstract":"<p><strong>Background and objectives: </strong>The prognostic implication of coexisting hypertension in patients with hypertrophic cardiomyopathy (HCM) is poorly defined. This study aimed to evaluate the association between left ventricular global longitudinal strain (LV-GLS) and adverse cardiovascular (CV) events in patients with HCM and coexisting hypertension.</p><p><strong>Methods: </strong>We analyzed consecutive patients with HCM from 2 tertiary HCM referral centers. The primary outcome was CV events, defined as a composite of CV death, heart failure, and stroke. All LV-GLS measurements were conducted in a core laboratory.</p><p><strong>Results: </strong>Of 1,139 patients with HCM, 522 (45.8%) had hypertension. Patients with hypertension were older, had more CV comorbidities, and showed a lower LV-GLS (13.7% vs. 14.4%, p=0.001). During a median 6.6-year follow-up, 155 CV events occurred, with a significantly higher crude incidence in patients with hypertension than in those without (p=0.005). Lower LV-GLS was independently associated with a higher risk of CV events in patients with hypertension (per 1% decrease in LV-GLS, adjusted hazard ratio [HR], 1.07; 95% confidence interval [CI], 1.01-1.13; p=0.013). When stratified by four groups based on hypertension and LV-GLS, CV events most frequently occurred in patients with both hypertension and a lower LV-GLS (<13.1%), with a significantly higher risk compared to those without hypertension and a higher LV-GLS (≥13.1%) (adjusted HR, 1.60; 95% CI, 1.01-2.54; p=0.044).</p><p><strong>Conclusions: </strong>Patients with HCM and coexisting hypertension were older, had more prevalent CV comorbidities, and exhibited a lower LV-GLS compared to those without hypertension. LV-GLS provides important prognostic information in patients with both HCM and hypertension.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"584-596"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dong-Seon Kang, Pil-Sung Yang, Jun-Hyung Kim, Ki-Hun Kim, Ju Youn Kim, So-Ryoung Lee, Junbeom Park, Sung Ho Lee, Chang Hee Kwon, Myung-Jin Cha, Jaemin Shim, Il-Young Oh, Sang-Jin Han, Hong Euy Lim
{"title":"Cryoballoon Ablation for Elderly Patients With Atrial Fibrillation: Results From the Korean Cryoballoon Registry.","authors":"Dong-Seon Kang, Pil-Sung Yang, Jun-Hyung Kim, Ki-Hun Kim, Ju Youn Kim, So-Ryoung Lee, Junbeom Park, Sung Ho Lee, Chang Hee Kwon, Myung-Jin Cha, Jaemin Shim, Il-Young Oh, Sang-Jin Han, Hong Euy Lim","doi":"10.4070/kcj.2024.0308","DOIUrl":"10.4070/kcj.2024.0308","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cryoballoon ablation (CBA) is considered an effective rhythm control treatment for atrial fibrillation (AF) and is increasing exponentially. However, data regarding the efficacy and safety of CBA in elderly patients are limited.</p><p><strong>Methods: </strong>A total of 2,652 patients (55.2% with non-paroxysmal AF) from the Korean CBA registry database with follow-up of ≥12-months after de novo CBA were divided into 2 groups based on age (<75 and ≥75 years old). Procedure related complications and clinical outcomes were compared.</p><p><strong>Results: </strong>Compared to the control group (n=2,403), the elderly group (n=249) had female predominance (41.8% vs. 21.1%, p<0.001), a higher CHA₂DS₂-VASc scores (4.0 [3.0-5.0] vs. 2.0 [1.0-3.0]; p<0.001), and a higher prevalence of heart failure (33.3% vs. 21.9%; p<0.001) and chronic kidney disease (42.2% vs. 10.4%; p<0.001). A total of 120 procedure-related minor complications were reported, but no significant difference was observed between the 2 groups (6.4% vs. 4.3%; p=0.18). Recurrence of atrial tachyarrhythmias was observed in 67 patients (27.2%) in the elderly group and 788 patients (33.3%) in the control group. After adjusting for confounding variables, the freedom from atrial tachyarrhythmias during 24-month was similar between the 2 groups (67.0% vs. 62.7%; adjusted hazard ratio, 0.91; 95% confidence interval, 0.62-1.34; p=0.63).</p><p><strong>Conclusions: </strong>CBA showed a reasonable efficacy and safety profile in elderly population with AF, comparable to that in younger patients.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"614-623"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
So-Young Lee, Hae Ok Jung, Kyung An Kim, Gyu Chul Oh, Mi-Hyang Jung, Jong-Chan Youn, Woo-Baek Chung, Ho-Joong Youn
{"title":"Impact of the New Definition on the Prognosis of Patients With Pulmonary Hypertension Compared to the Classic Definition.","authors":"So-Young Lee, Hae Ok Jung, Kyung An Kim, Gyu Chul Oh, Mi-Hyang Jung, Jong-Chan Youn, Woo-Baek Chung, Ho-Joong Youn","doi":"10.4070/kcj.2024.0416","DOIUrl":"https://doi.org/10.4070/kcj.2024.0416","url":null,"abstract":"<p><strong>Background and objectives: </strong>The 2022 European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines updated the definition of pulmonary hypertension (PH). This study aimed to evaluate implications of the new PH definition.</p><p><strong>Methods: </strong>A retrospective analysis of a single-center right heart catheterization registry (April 2016-July 2023) was conducted. Patients were classified using the classic definition (mean pulmonary arterial pressure [mPAP] ≥25 mmHg, pulmonary vascular resistance [PVR] >3 Wood units [WU]) and the new definition (mPAP >20 mmHg, PVR >2 WU). The primary outcome was a composite of cardiovascular death or heart failure (HF) hospitalization over a maximum follow-up of 5 years.</p><p><strong>Results: </strong>Among 314 patients (median age, 62.5 years; male, 50.3%), the new definition led to a 9.6% increase in diagnosis of pre-capillary PH (Pre-PH) and a 10.5% increase in combined pre- and post-capillary PH (Cpc-PH). Event discrimination was comparable between the 2 definitions, as assessed by the C-index and net reclassification improvement. Multivariable Cox regression, adjusted for age and sex, showed a lower risk of cardiovascular death or HF hospitalization under the new definition. Spline analyses indicated that risk increased from mPAP >20 mmHg and PVR >2 WU.</p><p><strong>Conclusions: </strong>The new definition increased PH diagnoses, particularly in Pre-PH and Cpc-PH, while maintaining comparable discriminative performance. Improved 5-year event-free survival observed under the new definition may be partly attributable to the inclusion of patients with milder disease. Notably, the risk progressively increased beyond mPAP >20 mmHg and PVR >2 WU, reinforcing the prognostic significance of the new thresholds.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Revisiting the Prognostic Landscape of Hypertrophic Cardiomyopathy and Hypertension: The Critical Role of Left Ventricular Global Longitudinal Strain.","authors":"So-Ree Kim, Mi-Na Kim","doi":"10.4070/kcj.2025.0214","DOIUrl":"10.4070/kcj.2025.0214","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"55 7","pages":"597-599"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Update on Surgery for Complex Transposition of the Great Arteries: Focusing on Aortic Root Translocation.","authors":"Chang-Ha Lee","doi":"10.4070/kcj.2025.0164","DOIUrl":"https://doi.org/10.4070/kcj.2025.0164","url":null,"abstract":"<p><p>Transposition of the great arteries (TGA) is a congenital heart defect (CHD) characterized by discordance between the ventricles and great arteries. The arterial switch operation generally provides excellent early and long-term outcomes in cases in which both great arteries are well developed. Furthermore, various surgical techniques, including the Rastelli procedure, réparation à l'étage ventriculaire (REV) procedure, and pulmonary root translocation have been introduced to improve the outcomes in patients with complex TGA accompanied by significant left ventricular (LV) outflow tract obstruction. A common feature of these 3 techniques is the intraventricular tunneling of the LV to the aorta through the ventricular septal defect while maintaining the original position of the aortic root. Recently, aortic root translocation (ART), which reconstructs the biventricular outflow tracts by repositioning the aortic root toward the pulmonary side, has been reevaluated as an alternative to conventional techniques. Early experiences with ART have reported technical challenges, in addition to high surgical mortality and morbidity rates. Nevertheless, with an increase in surgical experience, early outcomes comparable to those of non-ART procedures have been reported, along with improved long-term results. A key principle of ART is to preserve the integrity of the aortic root geometry. Various modifications have been introduced to achieve this. As a potential solution, we propose an aortic root reconstruction technique, which we briefly introduce here. Furthermore, ART has been applied in patients with complex congenitally corrected TGA, and we anticipate that this technique will facilitate safer and more feasible biventricular repair in patients with complex CHDs.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}